Quantitation of skeletal muscle necrosis using 99Tcm-pyrophosphate with SPECT in a canine model.

Abstract:

:Patients with acute arterial occlusion may suffer from significant muscle necrosis. It is important to determine the amount of regional muscle necrosis for prognostic purposes and evaluation of therapy. We have used technetium-99m-pyrophosphate (PPi) with single photon emission computed tomography (SPECT) to quantitate muscle necrosis. A canine gracilis muscle ischaemia model was used. PPi was injected 1.5 h before the muscle preparation was removed from the dog. SPECT was performed on the muscle preparations. An automatic edge detection program using the threshold technique determined the number of pixels with significant PPi activity in each transaxial section. Volume was calculated by summing the number of pixels with significant PPi activity and multiplying by the voxel size. The results were compared with quantitation using computerized planimetry with nitroblue tetrazolium staining (correlation coefficient = 0.93). PPi with SPECT is an accurate method for quantiating muscle necrosis.

journal_name

Nucl Med Commun

authors

Yip TC,Houle S,Hayes G,Forrest I,Nelson L,Walker PM

doi

10.1097/00006231-199002000-00009

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

143-9

issue

2

eissn

0143-3636

issn

1473-5628

journal_volume

11

pub_type

杂志文章
  • The feasibility of 225Ac as a source of alpha-particles in radioimmunotherapy.

    abstract::This paper proposes the utilization of 225Ac for the alpha-radioimmunotherapy of cancer. The isotope decays with a radioactive half-life of 10 days into a cascade of short-lived alpha- and beta-emitting isotopes. In addition, when indicated by the pharmacokinetic requirements of particular clinical applications, 213Bi...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199302000-00009

    authors: Geerlings MW,Kaspersen FM,Apostolidis C,van der Hout R

    更新日期:1993-02-01 00:00:00

  • Importance of accurate ilio-inguinal quantification in lower extremity lymphoscintigraphy.

    abstract:AIMS:The aims of this study were to improve the quantification of lower extremity lymphoscintigraphy, determine its value and lower limit of normal, and determine whether intermediate postinjection time imaging is necessary. PATIENTS AND METHODS:This was a study of 102 consecutive patients undergoing routine lower ext...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000644

    authors: Keramida G,Winterman N,Wroe E,Aplin M,Peters AM

    更新日期:2017-03-01 00:00:00

  • Bone scan index as metastatic bone disease quantifier and predictor of radium-223-dichloride biochemical response.

    abstract:OBJECTIVES:This work aims to assess whether the biochemical response of radium-223-dichloride treatment can be predicted based on the pretherapy bone scan, and consequently if bone scan index (BSI) and maximum lesion intensity have a place as alternatives or as complements to extent of bone disease (EOBD) scoring in pr...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001005

    authors: Roque V,Jessop M,Pereira L,Gape P,Dizdarevic S,Sousa E,Carolino E

    更新日期:2019-06-01 00:00:00

  • A meta-analysis of scintimammography: an evidence-based approach to its clinical utility.

    abstract:BACKGROUND:Scintimammography using (99m)Tc-labelled isonitriles, sestamibi and tetrofosmin, has become a mature technique in the adjunctive setting for the diagnosis of primary breast cancer. To establish an evidence base for its use, clinically, a meta-analysis was performed on both single-site and multi-centre trials...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/00006231-200607000-00007

    authors: Hussain R,Buscombe JR

    更新日期:2006-07-01 00:00:00

  • Adrenal scintigraphy in Cushing's syndrome caused by bilateral hyperplasia, adenoma or carcinoma.

    abstract::The results of scintigraphy in 29 patients with Cushing's syndrome were evaluated. It was possible to separate bilateral hyperplasia from unilateral abnormality. In cases of unilateral abnormality correct localization of the tumour was accomplished and it was possible to visualize adrenocortical carcinoma. The many ad...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198501000-00005

    authors: Lindberg S,Ernest I,Fjälling M,Holmdahl C

    更新日期:1985-01-01 00:00:00

  • Preparation and properties of 99Tcm-exametazime using stannous ion augmentation of fractionated cold kits.

    abstract::Fractionation of 99Tcm-exametazime enables several patients doses to be prepared from one vial. To overcome the disadvantages of storage at -70 degrees C, storage at higher temperatures was investigated with replacement of stannous ions before use. Kits were fractionated using a nitrogen-purged 0.9% w/v sodium chlorid...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199903000-00013

    authors: Baker RJ

    更新日期:1999-03-01 00:00:00

  • FDG PET in lymphoma: the need for standardization of interpretation. An observer variation study.

    abstract:OBJECTIVE:To measure and describe patterns of interobserver variation in visual interpretation of 18-FDG PET in malignant lymphoma. METHODS:Eleven nuclear medicine physicians with different levels of PET experience independently reviewed 37 18F-FDG PET scans of lymphoma patients (10 obtained at presentation, 27 during...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3282eff2d5

    authors: Zijlstra JM,Comans EF,van Lingen A,Hoekstra OS,Gundy CM,Willem Coebergh J,Bongers V

    更新日期:2007-10-01 00:00:00

  • Observation of changes in peripheral T-lymphocyte subsets by flow cytometry in patients with liver cancer treated with radioimmunotherapy.

    abstract::An analysis of lymphocyte subsets was performed in 24 patients with surgically verified unresectable hepatocellular carcinoma (HCC). In all cases, the hepatic artery was cannulated and ligated and a single dose of 131I-Hepama-1 monoclonal antibody (MAb) was infused through a hepatic artery catheter. Blood samples were...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199505000-00010

    authors: Zeng ZC,Tang ZY,Liu KD,Yu YQ,Yang BH,Cai XJ,Xie H,Cao SL

    更新日期:1995-05-01 00:00:00

  • Improving radiopharmaceutical supply chain safety by implementing bar code technology.

    abstract::The aim of this study was to describe and evaluate an approach for improving radiopharmaceutical supply chain safety by implementing bar code technology. We first evaluated the current situation of our radiopharmaceutical supply chain and, by means of the ALARM protocol, analysed two dispensing errors that occurred in...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000177

    authors: Matanza D,Hallouard F,Rioufol C,Fessi H,Fraysse M

    更新日期:2014-11-01 00:00:00

  • Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging.

    abstract:BACKGROUND:Dual gating is a method of dividing the data of a cardiac PET scan into smaller bins according to the respiratory motion and the ECG of the patient. It reduces the undesirable motion artefacts in images, but produces several images for interpretation and decreases the quality of single images. By using motio...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000539

    authors: Klén R,Noponen T,Koikkalainen J,Lötjönen J,Thielemans K,Hoppela E,Sipilä H,Teräs M,Knuuti J

    更新日期:2016-09-01 00:00:00

  • Optimizing background correction when calculating differential renal function in the presence of hydroureteronephrosis using 99Tc(m)-DTPA.

    abstract::We performed a prospective study to establish the optimal background correction algorithm for the determination of differential renal function (DRF), using 99Tc(m)-diethylenetriamine pentaacetate (99Tc(m)-DTPA) in the presence of unilateral hydronephrosis, with 24 h 99Tc(m)-dimercaptosuccinic acid (99Tc(m)-DMSA) uptak...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199803000-00009

    authors: Van de Wiele C,De Sadeleer C,Koole M,D'Asseler Y,Everaert K,Dierckx RA

    更新日期:1998-03-01 00:00:00

  • Therapy using labelled somatostatin analogues: comparison of the absorbed doses with 111In-DTPA-D-Phe1-octreotide and yttrium-labelled DOTA-D-Phe1-Tyr3-octreotide.

    abstract:OBJECTIVE:We estimated the absorbed doses for (111)In-DTPA-D-Phe(1)-octreotide and (90)Y-DOTA-D-Phe(1)-Tyr(3)-octreotide in the same patients in order to compare the potential effectiveness (tumour dose) and safety (kidney and red marrow dose) of these drugs for peptide-targeted radiotherapy of somatostatin receptor po...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3282f3d03e

    authors: Barone R,Walrand S,Konijnenberg M,Valkema R,Kvols LK,Krenning EP,Pauwels S,Jamar F

    更新日期:2008-03-01 00:00:00

  • A method for estimating the integral of the input function for the quantification of cerebral blood flow with 123I-IMP using one-point arterial blood sampling.

    abstract::We have developed a new method to replace the conventional method of quantitatively measuring cerebral blood flow (CBF), in which octanol-extracted radioactivity counts are measured in continuous arterial blood samples. With the new method, the whole-brain time-activity curves early after the intravenous injection of ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199806000-00008

    authors: Fujioka H,Murase K,Inoue T,Ishimaru Y,Akamune A,Yamamoto Y,Ikezoe J

    更新日期:1998-06-01 00:00:00

  • A comparison between 11C-methionine PET/CT and MIBI SPECT/CT for localization of parathyroid adenomas/hyperplasia.

    abstract:OBJECTIVE:The purpose of this study was to compare the sensitivity of single-photon emission computed tomography/computed tomography (SPECT/CT) using 99mTc-sestamibi (MIBI) with that of PET/CT using 11C-methionine (MET) for localization of parathyroid adenomas/hyperplasia in primary hyperparathyroidism. MATERIALS AND ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000216

    authors: Hayakawa N,Nakamoto Y,Kurihara K,Yasoda A,Kanamoto N,Miura M,Inagaki N,Togashi K

    更新日期:2015-01-01 00:00:00

  • A 99Tcm-labelled leukotriene B4 receptor antagonist for scintigraphic detection of infection in rabbits.

    abstract::In a search for a rapid and accurate imaging agent for scintigraphic detection of infection and inflammation, an LTB4 receptor antagonist, 99Tcm-RP517, which contains the hydrazino nicotinamide moiety, has been developed recently. To study the in vivo behaviour of 99Tcm-RP517, rabbits with Escherichia coli infection w...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200011000-00010

    authors: Brouwers AH,Laverman P,Boerman OC,Oyen WJ,Barrett JA,Harris TD,Edwards DS,Corstens FH

    更新日期:2000-11-01 00:00:00

  • Thyroid lobe ablation with iodine- ¹³¹I in patients with differentiated thyroid carcinoma: a randomized comparison between 1.1 and 3.7 GBq activities.

    abstract:PURPOSE:The present study was undertaken to evaluate the ablation rate after administration of 1.1 or 3.7 GBq of iodine- (¹³¹I) to patients with low-risk differentiated thyroid carcinoma (DTC) primarily treated by lobectomy. PATIENTS AND METHODS:Enrolled were 136 consecutive patients affected by histologically proven ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MNM.0b013e3283622f3d

    authors: Giovanella L,Piccardo A,Paone G,Foppiani L,Treglia G,Ceriani L

    更新日期:2013-08-01 00:00:00

  • Correlation of PD-L1 expression on tumor cell and tumor infiltrating immune cell with 18F-fluorodeoxyglucose uptake on PET/computed tomography in surgically resected pulmonary adenocarcinoma.

    abstract:OBJECTIVE:The uptake of F-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) is known to be linked to programmed death ligand 1 (PD-L1) expression on tumor cells (TC). However, the association between PD-L1 expression on immune cells (IC) and F-FDG accumulation is still unclear. Here, we conducted a clinicopatholo...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001136

    authors: Hu B,Xiao J,Xiu Y,Fu Z,Shi H,Cheng D

    更新日期:2020-03-01 00:00:00

  • Effect of an additional atropine injection during dobutamine infusion for myocardial SPET.

    abstract::The aim of this study was to examine the value of an additional atropine injection in patients who do not achieve an adequate heart rate during dobutamine infusion for myocardial perfusion SPET (single photon emission tomography). Patients undergoing dobutamine myocardial SPET who failed to achieve > or = 85% of their...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199706000-00012

    authors: Caner B,Karanfil A,Uysal U,Tokgozoglu L,Aksoyek S,Ugur O,Ciftci I,Atalar E,Kes S,Bekdik C

    更新日期:1997-06-01 00:00:00

  • Myocardial perfusion imaging versus biochemical markers in acute coronary syndromes.

    abstract::The assessment and appropriate clinical management of patients with acute chest pain and non-diagnostic electrocardiograms remain a continuing clinical problem. Accordingly, there is considerable interest in evaluating new strategies to improve early diagnostic accuracy in patients with possible acute myocardial ischa...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200310000-00004

    authors: Anand DV,Lahiri A

    更新日期:2003-10-01 00:00:00

  • Does P-glycoprotein have a role in the lung clearances of inhaled 99mTc-sestamibi and 99mTc-tetrofosmin?

    abstract:OBJECTIVE:The clearance rate of inhaled 99mTc-sestamibi from the lungs of healthy nonsmoking individuals is much slower than would be expected from its physical properties. The clearance rate is even slower in healthy cigarette smokers. As 99mTc-sestamibi is a substrate for P-glycoprotein (P-gp), pulmonary P-gp may be ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e32832b9a2d

    authors: Cheow HK,Ruparelia P,Shankar S,Szczepura KR,Ballinger JR,Hartman NG,Chilvers ER,Peters AM

    更新日期:2009-08-01 00:00:00

  • 99Tcm-MIBI single photon emission tomography (SPET) for detecting myocardial ischaemia and necrosis in patients with significant coronary artery disease.

    abstract::The ability of 99Tcm-methoxyisobutylisonitrile (MIBI) single photon emission tomography (SPET) to detect myocardial ischaemia and necrosis was assessed in 56 patients (45 male, 11 female, aged 55 +/- 5 years), with clinically recognized ischaemic heart disease (IHD). All underwent coronary angiography (CA) and left ve...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199212000-00004

    authors: Sciammarella MG,Fragasso G,Gerundini P,Maffioli L,Cappelletti A,Margonato A,Savi A,Chierchia S

    更新日期:1992-12-01 00:00:00

  • Kinetic analysis of 99mTc-sestamibi evaluates the protective effects by ischaemic preconditioning on ischaemic myocardium in an isolated rabbit heart.

    abstract:OBJECTIVE:To analyse the kinetic changes of uptake, washout and retention of Tc-sestamibi in order to evaluate the protective effects and possible mechanism of ischaemic preconditioning and adenosine preconditioning on myocardium injured by ischaemia/reperfusion. METHODS:Isolated ischaemia/reperfusion rabbit heart mod...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3282f1781b

    authors: Liang J,Chen HL,Zhou Y,Xie M,Xu LM,Lin G

    更新日期:2007-11-01 00:00:00

  • Does lymph node localization affect prostate-specific membrane antigen uptake?

    abstract:OBJECTIVE:To investigate the relationship between lymph node (LN) size and localization and prostate-specific membrane antigen (PSMA) uptake in patients with prostate cancer. PATIENTS AND METHODS:Between February 2015 and February 2017, a total of 178 patients diagnosed with prostate adenocarcinoma by gallium-68 PSMA ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001032

    authors: Sönmezer B,Acar E,Erkoyun E,Capa Kaya G

    更新日期:2019-08-01 00:00:00

  • 67Ga-9N3 uptake by xenografts of human melanotic melanoma in mice.

    abstract::Tumour uptake of the inert, neutral complex 67Ga-9N3 and the tumour:blood concentration ratio (1,4,7,triazacyclononane-1,4,7, triacetic acid) were measured in mice bearing xenografts of the human melanotic melanoma HX118. Between 1 and 4 h after the injection the tumour:blood ratio increased from 3.5 to 21 and the con...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199209000-00006

    authors: Harrison A,Walker CA,Pereira KA,Parker D,Royle L,Matthews RC,Craig AS

    更新日期:1992-09-01 00:00:00

  • 18F-Fluorodeoxyglucose PET/CT and dynamic contrast-enhanced MRI as imaging biomarkers in malignant pleural mesothelioma.

    abstract:PURPOSE:The purpose of this study was to compare the use of fluorine-18-fluorodeoxyglucose (F-FDG) PET with computed tomography (CT) and dynamic contrast-enhanced (DCE) MRI to predict prognosis and monitor treatment in malignant pleural mesothelioma. PATIENTS AND METHODS:F-FDG PET/CT and DCE-MRI studies carried out as...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0000000000000789

    authors: Hall DO,Hooper CE,Searle J,Darby M,White P,Harvey JE,Braybrooke JP,Maskell NA,Masani V,Lyburn ID

    更新日期:2018-02-01 00:00:00

  • Totally automatic definition of renal regions of interest from 99mTc-MAG3 renograms: validation in patients with normal kidneys and in patients with suspected renal obstruction.

    abstract:INTRODUCTION:An image-processing algorithm (AUTOROI) has been developed to totally automatically (or with manual assistance) detect whole-kidney contours and generate renal regions of interest (ROI) for the extraction of the quantitative measurements used in the interpretation of Tc-mercaptoacetyltriglycine (Tc-MAG3) r...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3283362aa3

    authors: Garcia EV,Folks R,Pak S,Taylor A

    更新日期:2010-05-01 00:00:00

  • Measurement of the extravascular concentration of renal agents following intravenous bolus injection.

    abstract::The extravascular concentration (Ce) of some renal agents, in relation to the simultaneous plasma concentration (Ci), was calculated as a function of time after intravenous injection. Four agents were studied: 51Cr-ethylenediamine tetraacetate (EDTA) (n = 11), 125I-hippuran (n = 11), 99Tcm-dimercaptosuccinic acid (DMS...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199402000-00002

    authors: Peters AM,Brown H,Cosgriff P

    更新日期:1994-02-01 00:00:00

  • Efficacy and safety of concomitant 177Lu-DOTATATE and low-dose capecitabine in advanced medullary thyroid carcinoma: a single-centre experience.

    abstract:AIMS:Peptide receptor radionuclide therapy (PRRT) has been shown to be useful in inoperable/metastatic medullary thyroid carcinoma (MTC). However, the role of concomitant PRRT and low-dose capecitabine therapy has not yet been studied in these patients. This study was conducted to evaluate the efficacy and safety of th...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001205

    authors: Satapathy S,Mittal BR,Sood A,Verma R,Panda N

    更新日期:2020-07-01 00:00:00

  • Left ventricular ejection fraction determined with the nuclear stethoscope, gamma camera and contrast ventriculography.

    abstract::Left ventricular ejection fractions (EF) were measured with a nuclear stethoscope (NSt, beat-to-beat and ECG gated summation method) and contrast ventriculography (VG) immediately following one another (IFOA) (r X 0.96 and 0.95, respectively, n = 13). NSt and ECG gated gamma camera (MUGA) recordings IFOA were compared...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198605000-00003

    authors: Lund O,Rasmussen K,Jensen FT,Hansen HH

    更新日期:1986-05-01 00:00:00

  • New possibilities in erythrocyte survival studies with the application of a Well-type germanium semiconductor detector.

    abstract::The application of a Well-type germanium semiconductor detector creates new possibilities in erythrocyte survival studies. Using 51Cr, the effective dose equivalent in a standard procedure can be reduced from approximately 780 to 2 microSv. The properties of the detector, namely, high efficiency and high energy resolu...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199105000-00010

    authors: De Vries RA,Oldenburg SJ,Thelosen T,De Bruin M,Poortman J,Van de Wiel A

    更新日期:1991-05-01 00:00:00