A meta-analysis of scintimammography: an evidence-based approach to its clinical utility.

Abstract:

BACKGROUND:Scintimammography using (99m)Tc-labelled isonitriles, sestamibi and tetrofosmin, has become a mature technique in the adjunctive setting for the diagnosis of primary breast cancer. To establish an evidence base for its use, clinically, a meta-analysis was performed on both single-site and multi-centre trials performed since January 1997. METHODS:Using an on-line literature search all such trials containing 100 or more studies were identified. To prevent double counting of patients only the last published report from any centre was used. RESULTS:A total of 2424 patients were identified in the single-site trial group, the smallest study having 105 patients and the largest 353 patients. The overall sensitivity was 85% and the specificity was 84%. In the multi-centre trial studies, published data from 3049 patients were included. The overall sensitivity in this group was also 85% and the specificity was 83%. CONCLUSION:There is evidence that this is a robust imaging technique delivering high sensitivities and specificities in patients studied in both single-centre and multi-centre trials and, as such, can be relied on as an adjunctive method for the investigation of primary breast cancer.

journal_name

Nucl Med Commun

authors

Hussain R,Buscombe JR

doi

10.1097/00006231-200607000-00007

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

589-94

issue

7

eissn

0143-3636

issn

1473-5628

pii

00006231-200607000-00007

journal_volume

27

pub_type

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