Indium-111 platelet kinetics in patients with diabetes mellitus.

Abstract:

:We performed in vitro aggregation and indium-111 labeled platelet kinetic and biodistribution studies in seven patients with diabetes mellitus and in five control subjects. All subjects were male. All diabetic patients were poorly controlled at the time of study with blood glucose greater than 140 mg % and hemoglobin A1c greater than 10%. In vivo kinetic and biodistribution studies were performed following reinjection of autologous platelets labeled with indium-111 oxine in a dose of approximately 50 microCi (42-67 microCi). Images obtained at 4 and 24 h were computer-analyzed to determine splenic and hepatic uptake, and platelet survival times were calculated using four mathematical models. Unexpectedly, diabetic patients with fewer vascular complications tended to have shorter platelet survival times than patients with advanced vascular disease. However, no significant differences were observed between diabetic and control groups for any of the parameters of platelet function evaluated.

journal_name

Nucl Med Commun

authors

Luikens B,Forstrom LA,Johnson T,Johnson G

doi

10.1097/00006231-198803000-00006

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

223-34

issue

3

eissn

0143-3636

issn

1473-5628

journal_volume

9

pub_type

杂志文章
  • Evaluation of the (14)C-urea breath test using indigenously produced (14)C-urea capsules and a modified technique for trapping exhaled breath: a pilot study.

    abstract::The carbon urea breath test ((14)C-UBT) is a noninvasive technique used to detect Helicobacter pylori infection in patients presenting with dyspeptic symptoms. The present study was undertaken to determine the efficacy of indigenously produced (14)C-UBT capsules by the Board of Radiation and Isotope Technology, India....

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000043

    authors: Tiwari BP,Nistala S,Patil SP,Kalgutkar DP,Jaychandran N,Chander H,Basu S

    更新日期:2014-03-01 00:00:00

  • 99Tcm-methoxy-isobutyl-isonitrile SPECT to evaluate a perfusion index from regional myocardial uptake after exercise and at rest. Results of a four hour protocol in patients with coronary heart disease and in controls.

    abstract::In 70 patients with angiographically confirmed coronary heart disease and in 10 controls, a 4 h exercise (E) (injection of 150 MBq 99Tcm-MIBI) rest (R) (800 MBq) protocol was employed. Of these, 10 patients with 21 myocardial defects after E received a third injection 24 h after. SPECT was used to image myocardial dis...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199002000-00002

    authors: Buell U,Dupont F,Uebis R,Kaiser HJ,Kleinhans E,Reske SN,Hanrath P

    更新日期:1990-02-01 00:00:00

  • 177Lu labelled polyaminophosphonates as potential agents for bone pain palliation.

    abstract::Polyphosphonate ligands labelled with radioisotopes decaying by moderate energy beta emission have shown utility as palliative agents for painful bone metastasis. 177Lu (T(1/2)=6.71 d, Ebetamax=497 keV) has radionuclidic properties suitable for use in palliative therapy of bone metastasis. 177Lu was produced at a high...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200201000-00011

    authors: Chakraborty S,Das T,Unni PR,Sarma HD,Samuel G,Banerjee S,Venkatesh M,Ramamoorthy N,Pillai MR

    更新日期:2002-01-01 00:00:00

  • Comparison of 2D and 3D performance for FDG PET with different acquisition times in oncological patients.

    abstract:OBJECTIVE:Collecting positron emission tomography data in three-dimensional (3D) mode may potentially allow reduction of the tracer dose and/or the acquisition time without compromising image quality thereby making the procedure more patient-friendly and cost effective. The objective of our study was to compare VUE Poi...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/mnm.0b013e328315a22a

    authors: Komar G,Teräs M,Seppänen M,Hirvonen J,Vahlberg T,Bergman J,Minn H

    更新日期:2009-01-01 00:00:00

  • Long-term effects of antilipidaemic therapy on left ventricular function in patients with dyslipidaemia: multigated radionuclide ventriculography study.

    abstract:AIM:It has been reported that dyslipidaemia impairs left ventricular systolic (LVs) and diastolic (LVd) functions, irrespective of atherogenic effects, in the setting of coronary artery disease. The aim of the present study was to evaluate the effects of anti-lipidaemic therapy on LVs and LVd functions by means of mult...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.mnm.0000172740.98369.ed

    authors: Entok E,Unalir A,Cavusoglu Y,Timuralp B,Vardareli E

    更新日期:2005-09-01 00:00:00

  • Myocardial fatty acid imaging with 123I-labelled 9-methyl-branched pentadecanoic acid (9MPA) using SPET.

    abstract::123I-labelled 15-(p-iodophenyl)-9-(R,S)-methylpentadecanoic acid (9MPA) is a modified long-chain fatty acid that shows some beta-oxidation. Some basic aspects of this fatty acid, including myocardial uptake, distribution, clearance and differences from 201Tl myocardial perfusion, have yet to be evaluated. An average o...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199809000-00004

    authors: Nakajima K,Taki J,Yamamoto W,Takata S,Shimizu M,Tonami N

    更新日期:1998-09-01 00:00:00

  • The role of positron emission tomography following radiosurgical treatment of malignant lung lesions.

    abstract:OBJECTIVE:To establish response patterns in PET following stereotactic body radiotherapy (SBRT) of malignant lung lesions. METHODS:Patients with malignant lung lesions treated with SBRT were retrospectively reviewed. All patients received 40-52 Gy in three to five equal fractions. An independent, blinded radiologist r...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3283512b08

    authors: Gill BS,Rivandi AH,Sandhu SP,Jensen LG,Nobiensky PD,Hoh CK,Sandhu AP

    更新日期:2012-06-01 00:00:00

  • Double-tracer SPECT in patients with AIDS encephalopathy: a comparison of 123I-IMP with 99Tcm-HMPAO.

    abstract::Single photon emission computed tomography (SPECT) using N-isopropyl-p-(123I)iodoamphetamine (123I-IMP) and 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HMPAO) was performed in 25 patients with different clinical stages of AIDS encephalopathy. The average interval between the two examinations was 7 days. In 15 of the 2...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:

    authors: Pohl P,Riccabona G,Hilty E,Deisenhammer F,Rösslér H,Zangerle R,Gerstenbrand F

    更新日期:1992-08-01 00:00:00

  • Improvement of the amplitude image through statistical filtering.

    abstract::In order to perform automatically the thresholding of the amplitude image obtained by phase analysis, a filter based on the probability density of the amplitude is proposed. It generates the image of the significant amplitude by setting to zero the amplitude if its square is lower than 4a0 log(1/alpha)/N where a0 is t...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198710000-00005

    authors: Liehn JC,Valeyre J

    更新日期:1987-10-01 00:00:00

  • Efficacy and safety of concomitant 177Lu-DOTATATE and low-dose capecitabine in advanced medullary thyroid carcinoma: a single-centre experience.

    abstract:AIMS:Peptide receptor radionuclide therapy (PRRT) has been shown to be useful in inoperable/metastatic medullary thyroid carcinoma (MTC). However, the role of concomitant PRRT and low-dose capecitabine therapy has not yet been studied in these patients. This study was conducted to evaluate the efficacy and safety of th...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001205

    authors: Satapathy S,Mittal BR,Sood A,Verma R,Panda N

    更新日期:2020-07-01 00:00:00

  • Differential renal function estimation by dynamic renal scintigraphy: influence of background definition and radiopharmaceutical.

    abstract:OBJECTIVES:Differential renal function (DRF) calculation with 99mTc-diethylenetriamine-pentaacetic acid (DTPA) or mercaptoacetyltriglycine (MAG3) is gaining clinical importance in the evaluation of patients with ureteropelvic junction obstruction with hydronephrosis (HN). Although many decisions regarding surgery are b...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e32830978af

    authors: Caglar M,Gedik GK,Karabulut E

    更新日期:2008-11-01 00:00:00

  • Diagnostic utility of 99mTc-EDDA-tricine-HYNIC-Tyr3-octreotate SPECT for differentiation of active from inactive pulmonary tuberculosis.

    abstract:OBJECTIVE:The current study was performed to evaluate the impact of Tc-EDDA-tricine-HYNIC-Tyr-octreotate in the differentiation of active from inactive pulmonary tuberculosis lesions. PATIENTS AND METHODS:Ten consecutive patients (six male and four female, age range 24-83 years) with proven pulmonary tuberculosis (wit...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000206

    authors: Ahmadihosseini H,Abedi J,Ghodsi Rad MA,Zakavi SR,Knoll P,Mirzaei S,Sadeghi R

    更新日期:2014-12-01 00:00:00

  • One year's clinical experience of 18F-FDG PET with a modified SPET camera using molecular coincidence detection.

    abstract::High-quality positron emission tomographic (PET) cameras are expensive and, therefore, not available in many centres. To allow access to clinical 18F-fluorodeoxyglucose (18F-FDG) PET, we began working with an ADAC Vertex camera equipped with a molecular coincidence detection (MCD) module in February 1997. Here we give...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199911000-00005

    authors: Erler H,Zaknun J,Donnemiller E,Bacher-Stier C,Oberladstätter M,Riccabona G,Moncayo R

    更新日期:1999-11-01 00:00:00

  • A review of pediatric neuroendocrine tumors, their detection, and treatment by radioisotopes.

    abstract::Neuroendocrine tumors (NETs) are rare in childhood. Neuroblastoma is the most common pediatric extracranial solid tumor, occurring >90% in children younger than 5 years of age. Pheochromocytoma and paraganglioma are rare NETs, causing hypertension in 0.5-2% of hypertensive children. Gastroenteropancreatic NETs can occ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001305

    authors: Haddad T,Fard-Esfahani A,Vali R

    更新日期:2021-01-01 00:00:00

  • Focus localization in patients with partial epilepsy with 99Tcm-HMPAO SPECT under continuous surface EEG monitoring.

    abstract::Our study was aimed at determining the validity of 99Tcm-HMPAO single photon emission computed tomography (SPECT) in the localization of the epileptogenic focus by correlating this diagnostic method with other auxiliary investigations such as surface EEG and X-ray transmission computed tomography (CT). Twenty-eight pa...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199203000-00002

    authors: Verhoeff NP,Weinstein HC,Aldenkamp AP,Overweg J,Van Royen EA,Verbeeten B Jr

    更新日期:1992-03-01 00:00:00

  • Predictive approaches for post-therapy PET/CT in patients with extranodal natural killer/T-cell lymphoma: a retrospective study.

    abstract:PURPOSE:The aim of this study was to assess the prognostic capacity of three methods of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT analysis carried out after therapy in patients with extranodal natural killer/T-cell lymphoma (ENKTL). The three methods of PET/CT analysis included the International Harmonization Proje...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000731

    authors: Jiang C,Liu J,Li L,Kosik RO,Su M,Zou L,Tian R

    更新日期:2017-11-01 00:00:00

  • Myocardial 123I-MIBG kinetics in acutely hypothyroid patients with differentiated thyroid carcinoma.

    abstract::Marked changes in cardiac function have been noted in patients with hyperthyroidism or hypothyroidism due both to changes in sympathetic system function and to biochemical modifications of myocardial tissue. Metaiodobenzylguanidine (MIBG), an analogue of norepinephrine, can be used to evaluate myocardial sympathetic t...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199908000-00006

    authors: Maini CL,Tofani A,Sciuto R,Ferraironi A,Festa A,Rea S

    更新日期:1999-08-01 00:00:00

  • Fitting linear compartmental models by a matrix diagonalization method.

    abstract::A general method is presented for fitting experimental data to arbitrary linear compartmental models, based on readily available public domain software. The model is defined by input data so that the same program can be used for different compartmental models. Its use is exemplified by application to the four-compartm...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200108000-00009

    authors: Russell CD

    更新日期:2001-08-01 00:00:00

  • Diagnostic and prognostic impact of fluorine-18-fluorodeoxyglucose PET/CT in preoperative and postoperative setting of breast cancer patients.

    abstract:PURPOSE:The aim of this study was to assess the diagnostic and prognostic value of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT in patients with breast cancer (BC) in the preoperative and the postoperative setting. PATIENTS AND METHODS:Between 2011 and 2015, we prospectively enrolled 275 patients (mean age: 53 years)...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000671

    authors: Evangelista L,Cervino AR,Michieletto S,Saibene T,Ghiotto C,Guarneri V,Conte P,Reccia P,Saladini G

    更新日期:2017-06-01 00:00:00

  • The early plasma concentration of 51Cr-EDTA in patients with cirrhosis and ascites: a comparison of three models.

    abstract:OBJECTIVES:The aim of the study was to determine which of three two-parameter fitting functions (exponential, linear-log, and negative-power function of time) most accurately models early chromium-51-EDTA (51Cr-EDTA) plasma concentration data prior to 120 min in patients with cirrhosis and ascites and understand how th...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000255

    authors: Wanasundara SN,Wesolowski MJ,Puetter RC,Burniston MT,Xirouchakis E,Giamalis IG,Babyn PS,Wesolowski CA

    更新日期:2015-04-01 00:00:00

  • Clinical value of cystatin C and beta-trace protein in glomerular filtration rate in renal transplant cases with stable renal graft functions: comparison by the 99mTc-DTPA plasma sample method.

    abstract:AIM:The aim of this study was to investigate the value of cystatin C and beta-trace protein (BTP) levels in determination of the glomerular filtration rate (GFR) by accepting the technetium-99m diethylenetriamine pentaacetic acid (Tc-DTPA) method as the gold standard for GFR measurement in renal transplant patients wit...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000116

    authors: Oner AO,Aydin F,Demirelli S,Budak ES,Davran F,Akbas H,Kocak H,Suleymanlar G,Gungor F

    更新日期:2014-07-01 00:00:00

  • Clinical relevance of 18F-FDG-negative osteoblastic metastatic bone lesions noted on PET/CT in breast cancer patients.

    abstract:PURPOSE:Our study aims to assess the clinical relevance of fluorine-18 fluorodeoxyglucose (F-FDG) negative osteoblastic metastatic bone lesions noted on PET/computed tomography (CT) in breast cancer patients. PATIENTS AND METHODS:The medical records of breast cancer patients were reviewed retrospectively from January ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000481

    authors: Al-Muqbel KM,Yaghan RJ,Al-Omari MH,Rousan LA,Dagher NM,Al Bashir S

    更新日期:2016-06-01 00:00:00

  • 99Tcm-N,N-ethylenedicysteine scintigraphy in children with various renal disorders: a comparative study with 99Tcm-MAG3.

    abstract::We evaluated the clinical usefulness of 99Tcm-N,N-ethylenedicysteine (99Tcm-EC), a new renal tubular agent, in normal children and in children with various renal disorders and compared it with 99Tcm-mercaptoacetyltriglycine (99Tcm-MAG3). In a first group of children (Group 1), which included 15 patients and 4 normal c...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199701000-00009

    authors: Kibar M,Noyan A,Anarat A

    更新日期:1997-01-01 00:00:00

  • Evaluation of post-stress left ventricular dysfunction and its relationship with perfusion abnormalities using gated SPECT in patients with cardiac syndrome X.

    abstract:OBJECTIVE:Cardiac syndrome X defines patients with typical angina, a positive exercise ECG stress test and angiographically documented normal coronary arteries. In previous studies, post-stress prolonged left ventricular dysfunction (PLVD) using gated SPECT (G-SPECT) had been well correlated with myocardial perfusion a...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3282f52c49

    authors: Demir H,Kahraman G,Isgoren S,Tan YZ,Kilic T,Berk F

    更新日期:2008-03-01 00:00:00

  • Non-invasive assessment of absolute values of hepatic haemodynamics using radiocolloid scintigraphy.

    abstract::A non-invasive technique for the assessment of hepatic haemodynamics using radiocolloid imaging with a computer, in which absolute values of hepatic, mesenteric and splenic arterial effective blood flows were assessed, is described. The technique was carried out on ten volunteers, before and after a standard meal. Aft...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198708000-00002

    authors: Walmsley BH,Fleming JS,Ackery DM,Karran SJ

    更新日期:1987-08-01 00:00:00

  • The relationship between 99Tc(m)-sestamibi uptake and ultrastructural cell types of thyroid tumours.

    abstract::Although several hypotheses have been suggested regarding the accumulation of 99Tc(m)-sestamibi in tumours, the exact uptake mechanism is still a matter of discussion. We investigated ultrastructural cell type of thyroid tumours by electron microscopy (EM) and compared them with uptake of 99Tc(m)-sestamibi. Thyroid sc...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200101000-00006

    authors: Sarikaya A,Huseyinova G,Irfanoğlu ME,Erkmen N,Cermik TF,Berkarda S

    更新日期:2001-01-01 00:00:00

  • Semi-quantitative assessment of 99Tcm-sestamibi uptake in lung cancer: relationship with clinical response to chemotherapy.

    abstract::The objectives of this study were to measure semi-quantitatively uptake of 99Tcm-sestamibi (99Tcm-MIBI) by tumour tissue in patients with lung cancer and to investigate its relationship with clinical response to chemotherapy. 99Tcm-MIBI single photon emission tomography was performed at the time of diagnosis in 31 pat...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199711000-00013

    authors: Ceriani L,Giovanella L,Bandera M,Beghe B,Ortelli M,Roncari G

    更新日期:1997-11-01 00:00:00

  • Non-invasive quantification of cerebral blood flow for rats by microPET imaging of 15O labelled water: the application of a cardiac time-activity curve for the tracer arterial input function.

    abstract:OBJECTIVE:In-vivo quantitative cerebral blood flow (CBF) measurement using positron emission tomography (PET) has typically employed invasive arterial blood sampling procedure to determine the arterial input function (AIF). The present study was performed to provide a non-invasive quantitative CBF measurement technique...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200510000-00009

    authors: Yee SH,Jerabek PA,Fox PT

    更新日期:2005-10-01 00:00:00

  • Improved method for detecting knee replacement infections based on extended combined 99mTc-white blood cell/bone imaging.

    abstract::The purpose of this study was to evaluate whether an extension of the imaging time to 24 h post-injection improves the diagnostic accuracy of technetium-99m-hexamethylpropyleneamine oxime (99mTc-HMPAO) leucocyte imaging in detecting knee replacement infections. Thirty patients were studied, with infection confirmed in...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200110000-00015

    authors: Larikka MJ,Ahonen AK,Junila JA,Niemelä O,Hämäläinen MM,Syrjälä HP

    更新日期:2001-10-01 00:00:00

  • In vivo kinetics of 123I-labelled insulin: studies in normal subjects and patients with diabetes mellitus.

    abstract::Radioactive tracer techniques using 131I- and 125I-insulin have been applied to study insulin metabolism. A simple method to label human insulin with 123I to a high specific activity is described. We have used this radiotracer to study insulin kinetics in vivo in normal subjects and in two groups of diabetic patients....

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198710000-00003

    authors: Sinclair AJ,Signore A,Bomanji J,Britton KE,Pozzilli P,Gale EA

    更新日期:1987-10-01 00:00:00