Abstract:
:We performed in vitro aggregation and indium-111 labeled platelet kinetic and biodistribution studies in seven patients with diabetes mellitus and in five control subjects. All subjects were male. All diabetic patients were poorly controlled at the time of study with blood glucose greater than 140 mg % and hemoglobin A1c greater than 10%. In vivo kinetic and biodistribution studies were performed following reinjection of autologous platelets labeled with indium-111 oxine in a dose of approximately 50 microCi (42-67 microCi). Images obtained at 4 and 24 h were computer-analyzed to determine splenic and hepatic uptake, and platelet survival times were calculated using four mathematical models. Unexpectedly, diabetic patients with fewer vascular complications tended to have shorter platelet survival times than patients with advanced vascular disease. However, no significant differences were observed between diabetic and control groups for any of the parameters of platelet function evaluated.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Luikens B,Forstrom LA,Johnson T,Johnson Gdoi
10.1097/00006231-198803000-00006subject
Has Abstractpub_date
1988-03-01 00:00:00pages
223-34issue
3eissn
0143-3636issn
1473-5628journal_volume
9pub_type
杂志文章abstract::The carbon urea breath test ((14)C-UBT) is a noninvasive technique used to detect Helicobacter pylori infection in patients presenting with dyspeptic symptoms. The present study was undertaken to determine the efficacy of indigenously produced (14)C-UBT capsules by the Board of Radiation and Isotope Technology, India....
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000043
更新日期:2014-03-01 00:00:00
abstract::In 70 patients with angiographically confirmed coronary heart disease and in 10 controls, a 4 h exercise (E) (injection of 150 MBq 99Tcm-MIBI) rest (R) (800 MBq) protocol was employed. Of these, 10 patients with 21 myocardial defects after E received a third injection 24 h after. SPECT was used to image myocardial dis...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199002000-00002
更新日期:1990-02-01 00:00:00
abstract::Polyphosphonate ligands labelled with radioisotopes decaying by moderate energy beta emission have shown utility as palliative agents for painful bone metastasis. 177Lu (T(1/2)=6.71 d, Ebetamax=497 keV) has radionuclidic properties suitable for use in palliative therapy of bone metastasis. 177Lu was produced at a high...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200201000-00011
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Collecting positron emission tomography data in three-dimensional (3D) mode may potentially allow reduction of the tracer dose and/or the acquisition time without compromising image quality thereby making the procedure more patient-friendly and cost effective. The objective of our study was to compare VUE Poi...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/mnm.0b013e328315a22a
更新日期:2009-01-01 00:00:00
abstract:AIM:It has been reported that dyslipidaemia impairs left ventricular systolic (LVs) and diastolic (LVd) functions, irrespective of atherogenic effects, in the setting of coronary artery disease. The aim of the present study was to evaluate the effects of anti-lipidaemic therapy on LVs and LVd functions by means of mult...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/01.mnm.0000172740.98369.ed
更新日期:2005-09-01 00:00:00
abstract::123I-labelled 15-(p-iodophenyl)-9-(R,S)-methylpentadecanoic acid (9MPA) is a modified long-chain fatty acid that shows some beta-oxidation. Some basic aspects of this fatty acid, including myocardial uptake, distribution, clearance and differences from 201Tl myocardial perfusion, have yet to be evaluated. An average o...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199809000-00004
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To establish response patterns in PET following stereotactic body radiotherapy (SBRT) of malignant lung lesions. METHODS:Patients with malignant lung lesions treated with SBRT were retrospectively reviewed. All patients received 40-52 Gy in three to five equal fractions. An independent, blinded radiologist r...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3283512b08
更新日期:2012-06-01 00:00:00
abstract::Single photon emission computed tomography (SPECT) using N-isopropyl-p-(123I)iodoamphetamine (123I-IMP) and 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HMPAO) was performed in 25 patients with different clinical stages of AIDS encephalopathy. The average interval between the two examinations was 7 days. In 15 of the 2...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract::In order to perform automatically the thresholding of the amplitude image obtained by phase analysis, a filter based on the probability density of the amplitude is proposed. It generates the image of the significant amplitude by setting to zero the amplitude if its square is lower than 4a0 log(1/alpha)/N where a0 is t...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198710000-00005
更新日期:1987-10-01 00:00:00
abstract:AIMS:Peptide receptor radionuclide therapy (PRRT) has been shown to be useful in inoperable/metastatic medullary thyroid carcinoma (MTC). However, the role of concomitant PRRT and low-dose capecitabine therapy has not yet been studied in these patients. This study was conducted to evaluate the efficacy and safety of th...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001205
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:Differential renal function (DRF) calculation with 99mTc-diethylenetriamine-pentaacetic acid (DTPA) or mercaptoacetyltriglycine (MAG3) is gaining clinical importance in the evaluation of patients with ureteropelvic junction obstruction with hydronephrosis (HN). Although many decisions regarding surgery are b...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32830978af
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:The current study was performed to evaluate the impact of Tc-EDDA-tricine-HYNIC-Tyr-octreotate in the differentiation of active from inactive pulmonary tuberculosis lesions. PATIENTS AND METHODS:Ten consecutive patients (six male and four female, age range 24-83 years) with proven pulmonary tuberculosis (wit...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000206
更新日期:2014-12-01 00:00:00
abstract::High-quality positron emission tomographic (PET) cameras are expensive and, therefore, not available in many centres. To allow access to clinical 18F-fluorodeoxyglucose (18F-FDG) PET, we began working with an ADAC Vertex camera equipped with a molecular coincidence detection (MCD) module in February 1997. Here we give...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-199911000-00005
更新日期:1999-11-01 00:00:00
abstract::Neuroendocrine tumors (NETs) are rare in childhood. Neuroblastoma is the most common pediatric extracranial solid tumor, occurring >90% in children younger than 5 years of age. Pheochromocytoma and paraganglioma are rare NETs, causing hypertension in 0.5-2% of hypertensive children. Gastroenteropancreatic NETs can occ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001305
更新日期:2021-01-01 00:00:00
abstract::Our study was aimed at determining the validity of 99Tcm-HMPAO single photon emission computed tomography (SPECT) in the localization of the epileptogenic focus by correlating this diagnostic method with other auxiliary investigations such as surface EEG and X-ray transmission computed tomography (CT). Twenty-eight pa...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199203000-00002
更新日期:1992-03-01 00:00:00
abstract:PURPOSE:The aim of this study was to assess the prognostic capacity of three methods of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT analysis carried out after therapy in patients with extranodal natural killer/T-cell lymphoma (ENKTL). The three methods of PET/CT analysis included the International Harmonization Proje...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000731
更新日期:2017-11-01 00:00:00
abstract::Marked changes in cardiac function have been noted in patients with hyperthyroidism or hypothyroidism due both to changes in sympathetic system function and to biochemical modifications of myocardial tissue. Metaiodobenzylguanidine (MIBG), an analogue of norepinephrine, can be used to evaluate myocardial sympathetic t...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199908000-00006
更新日期:1999-08-01 00:00:00
abstract::A general method is presented for fitting experimental data to arbitrary linear compartmental models, based on readily available public domain software. The model is defined by input data so that the same program can be used for different compartmental models. Its use is exemplified by application to the four-compartm...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200108000-00009
更新日期:2001-08-01 00:00:00
abstract:PURPOSE:The aim of this study was to assess the diagnostic and prognostic value of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT in patients with breast cancer (BC) in the preoperative and the postoperative setting. PATIENTS AND METHODS:Between 2011 and 2015, we prospectively enrolled 275 patients (mean age: 53 years)...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000671
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to determine which of three two-parameter fitting functions (exponential, linear-log, and negative-power function of time) most accurately models early chromium-51-EDTA (51Cr-EDTA) plasma concentration data prior to 120 min in patients with cirrhosis and ascites and understand how th...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000255
更新日期:2015-04-01 00:00:00
abstract:AIM:The aim of this study was to investigate the value of cystatin C and beta-trace protein (BTP) levels in determination of the glomerular filtration rate (GFR) by accepting the technetium-99m diethylenetriamine pentaacetic acid (Tc-DTPA) method as the gold standard for GFR measurement in renal transplant patients wit...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000116
更新日期:2014-07-01 00:00:00
abstract:PURPOSE:Our study aims to assess the clinical relevance of fluorine-18 fluorodeoxyglucose (F-FDG) negative osteoblastic metastatic bone lesions noted on PET/computed tomography (CT) in breast cancer patients. PATIENTS AND METHODS:The medical records of breast cancer patients were reviewed retrospectively from January ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000481
更新日期:2016-06-01 00:00:00
abstract::We evaluated the clinical usefulness of 99Tcm-N,N-ethylenedicysteine (99Tcm-EC), a new renal tubular agent, in normal children and in children with various renal disorders and compared it with 99Tcm-mercaptoacetyltriglycine (99Tcm-MAG3). In a first group of children (Group 1), which included 15 patients and 4 normal c...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199701000-00009
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:Cardiac syndrome X defines patients with typical angina, a positive exercise ECG stress test and angiographically documented normal coronary arteries. In previous studies, post-stress prolonged left ventricular dysfunction (PLVD) using gated SPECT (G-SPECT) had been well correlated with myocardial perfusion a...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3282f52c49
更新日期:2008-03-01 00:00:00
abstract::A non-invasive technique for the assessment of hepatic haemodynamics using radiocolloid imaging with a computer, in which absolute values of hepatic, mesenteric and splenic arterial effective blood flows were assessed, is described. The technique was carried out on ten volunteers, before and after a standard meal. Aft...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198708000-00002
更新日期:1987-08-01 00:00:00
abstract::Although several hypotheses have been suggested regarding the accumulation of 99Tc(m)-sestamibi in tumours, the exact uptake mechanism is still a matter of discussion. We investigated ultrastructural cell type of thyroid tumours by electron microscopy (EM) and compared them with uptake of 99Tc(m)-sestamibi. Thyroid sc...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200101000-00006
更新日期:2001-01-01 00:00:00
abstract::The objectives of this study were to measure semi-quantitatively uptake of 99Tcm-sestamibi (99Tcm-MIBI) by tumour tissue in patients with lung cancer and to investigate its relationship with clinical response to chemotherapy. 99Tcm-MIBI single photon emission tomography was performed at the time of diagnosis in 31 pat...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199711000-00013
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:In-vivo quantitative cerebral blood flow (CBF) measurement using positron emission tomography (PET) has typically employed invasive arterial blood sampling procedure to determine the arterial input function (AIF). The present study was performed to provide a non-invasive quantitative CBF measurement technique...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200510000-00009
更新日期:2005-10-01 00:00:00
abstract::The purpose of this study was to evaluate whether an extension of the imaging time to 24 h post-injection improves the diagnostic accuracy of technetium-99m-hexamethylpropyleneamine oxime (99mTc-HMPAO) leucocyte imaging in detecting knee replacement infections. Thirty patients were studied, with infection confirmed in...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200110000-00015
更新日期:2001-10-01 00:00:00
abstract::Radioactive tracer techniques using 131I- and 125I-insulin have been applied to study insulin metabolism. A simple method to label human insulin with 123I to a high specific activity is described. We have used this radiotracer to study insulin kinetics in vivo in normal subjects and in two groups of diabetic patients....
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198710000-00003
更新日期:1987-10-01 00:00:00