Validation set analysis to predict postoperative outcomes by technetium-99m galactosyl serum albumin scintigraphy for hepatectomy.


BACKGROUND:The indocyanine green retention rate at 15 min (ICGR15) is a gold standard parameter of liver function when deciding on the extent of hepatectomy. However, ICGR15 is influenced by several hepatic conditions. To evaluate auxiliary preoperative liver functional reserve, we examined the clinical significance of modified parameters by blood tests and technetium-99m galactosyl human serum albumin (Tc-GSA) scintigraphy. METHODS:We measured liver function parameters, including the hepatic uptake ratio (LHL15) and the blood pool clearance index (HH15) of Tc-GSA and their modified formulae [LHL/HH15, LHL minus HH15, and converted ICGR15 (cICGR15) from a preliminary study] in 229 patients, including 18 with biliary obstruction. RESULTS:The mean values of LHL15/HH15, LHL minus HH15, and cICGR15 were 1.646 ± 0.295, 0.347 ± 0.116, and 13.2 ± 5.3%, respectively. These parameters correlated significantly with other liver functions measured by blood tests except for the bilirubin level (P < 0.05) although the actual ICGR15 level correlated positively with the bilirubin level. The difference of ICGR15 (ICGR15 minus cICGR15) in patients with biliary obstruction tended to be higher in comparison with that in patients without biliary obstruction (P = 0.044). Values of LHL/HH15, LHL minus HH15, and the cICGR15 were not significantly associated with postoperative complications. CONCLUSION:The modified parameters of Tc-GSA were useful for evaluating hepatic function in patients with high bilirubinemia due to biliary obstruction. However, it remains difficult to establish a more reliable parameter as a standard hepatic function test instead of ICGR15.


Nucl Med Commun


Nanashima A,Hiyoshi M,Imamura N,Yano K,Hamada T,Wada T,Nishimuta M,Shimizu I,Mizutani Y




Has Abstract


2020-04-01 00:00:00












  • The effectiveness of low-dose versus high-dose 99mTc MIBI protocols for radioguided surgery in patients with primary hyperparathyroidism.

    abstract:OBJECTIVE:The aim of this study was to compare the efficacy of low-dose and high-dose (99m)Tc methoxy isobutyl isonitrile (MIBI) protocols in intraoperative localization of parathyroid adenomas by means of a gamma probe in patients with primary hyperparathyroidism (PHPT). PATIENTS AND METHODS:The study included 62 pat...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Gencoglu EA,Aras M,Moray G,Aktas A

    更新日期:2014-04-01 00:00:00

  • Depression and anxiety during isolation and radionuclide therapy.

    abstract::The combination of a diagnosis of malignancy and hospitalization, isolation and radioactivity of a radionuclide therapy may have an important effect on the psychological equilibrium of patients and may hamper compliance and acceptability. We performed a psychiatric evaluation in order to study psycho-pathological mani...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章


    authors: Brans B,van den Eynde F,Audenaert K,Vervaet M,van Daele K,van Heeringen C,Dierckx RA

    更新日期:2003-08-01 00:00:00

  • In vivo kinetics of 123I-labelled insulin: studies in normal subjects and patients with diabetes mellitus.

    abstract::Radioactive tracer techniques using 131I- and 125I-insulin have been applied to study insulin metabolism. A simple method to label human insulin with 123I to a high specific activity is described. We have used this radiotracer to study insulin kinetics in vivo in normal subjects and in two groups of diabetic patients....

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Sinclair AJ,Signore A,Bomanji J,Britton KE,Pozzilli P,Gale EA

    更新日期:1987-10-01 00:00:00

  • Quantification in clinical fluorodeoxyglucose positron emission tomography.

    abstract::Positron emission tomography (PET) is increasingly used clinically to provide functional information on disease processes, especially in oncology using the glucose analogue 2-[18F]fluoro-2-deoxy-D-glucose (F-FDG). In the clinical setting it has become standard practice to use simplified imaging protocols compared to t...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审


    authors: Hallett WA

    更新日期:2004-07-01 00:00:00

  • A study of the behaviour of cobalt chloride during the labelling of leukocytes with 99Tcm-HMPAO stabilised in vitro by the addition of cobalt chloride solution.

    abstract::The method described by Weisner et al. for stabilizing 99Tcm-hexamethylpropylene amine oxime (99Tcm-HMPAO) with cobalt chloride hexahydrate solution is the most promising developed to date. The aim of our work was to study the behaviour of cobalt during the labelling of leukocytes with 99Tcm-HMPAO stabilized in vitro ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Prangere T,Bowden AD,Beauchat V,Caulier MT,Ziegels P,Huglo D,Pickett RD,Steinling M

    更新日期:1997-03-01 00:00:00

  • The use of 18F-fluoromethylcholine PET/CT in differentiating focal nodular hyperplasia from hepatocellular adenoma: a prospective study of diagnostic accuracy.

    abstract:INTRODUCTION:Diagnosis of focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) using conventional imaging techniques can be difficult; however, it is important to differentiate between them as these benign liver tumors require different therapeutic strategies. The aim of our study was to prospectively evalu...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章


    authors: Bieze M,Bennink RJ,El-Massoudi Y,Phoa SS,Verheij J,Beuers U,van Gulik TM

    更新日期:2013-02-01 00:00:00

  • Immediate 201Tl reinjection: an alternative approach in myocardial perfusion scintigraphy? A comparison with contrast angiographic findings.

    abstract::Thallium-201 (201Tl) stress-redistribution/reinjection imaging provides a reliable diagnostic approach in patients evaluated for myocardial ischaemia. Immediate reinjection of 201Tl after completing the stress images followed by imaging 1 h later shortens the investigation time to 2.5 h and may provide a novel approac...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章


    authors: van Eck-Smit BL,van der Wall EE,Zwinderman AH,Pauwels EK

    更新日期:1995-10-01 00:00:00

  • The early plasma concentration of 51Cr-EDTA in patients with cirrhosis and ascites: a comparison of three models.

    abstract:OBJECTIVES:The aim of the study was to determine which of three two-parameter fitting functions (exponential, linear-log, and negative-power function of time) most accurately models early chromium-51-EDTA (51Cr-EDTA) plasma concentration data prior to 120 min in patients with cirrhosis and ascites and understand how th...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Wanasundara SN,Wesolowski MJ,Puetter RC,Burniston MT,Xirouchakis E,Giamalis IG,Babyn PS,Wesolowski CA

    更新日期:2015-04-01 00:00:00

  • Enhanced uptake of 99Tcm-MDP in skeletal metastases from prostate cancer following initiation of hormone treatment: potential for increasing delivery of therapeutic agents.

    abstract::Following androgen ablation therapy, skeletal metastases from prostate cancer appear in some instances to show an increase in 99Tcm-methylene diphosphonate (99Tcm-MDP) uptake. Such a phenomenon could represent a mechanism to increase delivery of bone-seeking therapeutic agents to skeletal metastatic sites. The aim of ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章


    authors: Bushnell DL,Madsen M,Kahn D,Nathan M,Williams RD

    更新日期:1999-10-01 00:00:00

  • Clinical evaluation of hypertrophic cardiomyopathy by myocardial scintigraphy using 123I-labelled 15-(p-iodophenyl)-3-R, S-methylpentadecanoic acid (123I-BMIPP).

    abstract::To evaluate the clinical utility of 123I-labelled 15-(p-iodophenyl)-3-R, S-methylpentadecanoic acid (123I-BMIPP), myocardial scintigraphy using 123I-BMIPP was performed in 13 patients with hypertrophic cardiomyopathy (HCM), and the findings were compared with those of 201Tl. The uptake of each tracer was scored visual...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Ohtsuki K,Sugihara H,Umamoto I,Nakamura T,Nakagawa T,Nakagawa M

    更新日期:1994-06-01 00:00:00

  • Acute effect of 3-(4-acetamido)-butyrril-lorazepam (DDS2700) on brain function assessed by PET at rest and during attentive tasks.

    abstract::The aim of this study was to assess, by positron emission tomography (PET), the effect on cerebral functional activity of a new lorazepam-gamma-aminobutyric acid (GABA) conjugate [3-(4-acetamido)-butyrril lorazepam (DDS2700)]. Ten healthy volunteers were studied by PET and [18F]fluoro-deoxy-D-glucose ([18F]FDG) under ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Moresco RM,Tettamanti M,Gobbo C,Del Sole A,Ravasi L,Messa C,Paulesu E,Lucignani G,Perani D,Fazio F

    更新日期:2001-04-01 00:00:00

  • Osteomyelitis.

    abstract::The use of 111In-labelled granulocyte scintigraphy is recognized as a reliable method for detecting osteomyelitis and has similar sensitivity and significantly increased specificity compared to bone scintigraphy and 67Ga studies. Recent published work using pure granulocytes labelled with 111In tropolonate to detect o...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Roddie ME,Peters AM,Osman S,Danpure HJ,Lavender JP,Neirinckx RD

    更新日期:1988-10-01 00:00:00

  • Functional nuclear medicine imaging of medullary thyroid cancer.

    abstract::Medullary thyroid cancer (MTC) originates from parafollicular C cells of the thyroid and accounts for 3-12% of all thyroid cancers. As opposed to other types of dedifferentiated thyroid tumours, MTC cells are highly functional, producing and secreting high amounts of calcitonin and carcinoembryonic antigen. As parafol...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审


    authors: Bozkurt MF,Uğur O,Banti E,Grassetto G,Rubello D

    更新日期:2008-11-01 00:00:00

  • Z-transform method for deconvolution as applied to the renogram.

    abstract::A method of deconvolution analysis involving the use of the z-transform has been developed. When compared to the matrix method, it is shown, under certain circumstances, to be identical. In order to study the validity of the method, simple mathematical models have been constructed. The curves obtained with the compute...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Bererhi H

    更新日期:1995-03-01 00:00:00

  • Evaluation of renal function following treatment with extracorporeal shock wave lithotripsy (ESWL): the use of whole-kidney, parenchymal and pelvic transit times.

    abstract::The aim of this prospective study was to assess the efficacy of using whole-kidney, mean parenchymal and pelvic transit times to evaluate renal function following treatment with extracorporeal shock wave lithotripsy (ESWL). Fifteen patients were evaluated 24-48 h before and after ESWL therapy using 99Tcm-DTPA renal sc...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Ilgin N,Iftehar SA,Vural G,Bozkirli I,Gokcora N

    更新日期:1998-02-01 00:00:00

  • A retrospective study comparing contrast-enhanced computed tomography with 18F-FDG-PET/CT in the early follow-up of patients with retroperitoneal sarcomas.

    abstract:OBJECTIVE:To compare 18-fluorine-labeled 2-deoxy-2-fluoro-D-glucose PET/computed tomography ((18)F-FDG-PET/CT) with contrast enhancement computed tomography (CECT) in the early follow-up of patients who had undergone treatment for primitive retroperitoneal sarcomas (RS). METHODS:This is a retrospective study on 24 pat...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Niccoli-Asabella A,Altini C,Notaristefano A,Merenda N,Altieri ML,Stabile-Ianora AA,Fanelli M,Rubini G

    更新日期:2013-01-01 00:00:00

  • Value of diuresis renography in the post-natal period of assumed physiological renal immaturity.

    abstract::The aim of this study was to determine if it is possible to exclude renal obstruction using diuresis renography in the first 6 weeks of life (the period of physiological renal immaturity), thus avoiding unnecessary invasive procedures, such as the Whitaker test or surgery. Diuresis renography with 123I-hippuran was pe...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Eising EG,Bonzel KE,Zander C,Farahati J,Reiners C

    更新日期:1997-11-01 00:00:00

  • Somatostatin and somatostatin analogues in medullary thyroid carcinoma.

    abstract::Medullary thyroid carcinoma (MTC) is a neuroendocrine tumour characterized by the production and secretion of calcitonin. MTC tumours may express functional somatostatin receptors (hSSTR). A significant proportion of hSSTR receptor-positive MTC tumours, including metastatic disease, may be visualized in vivo through 1...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: O'Byrne KJ,O'Hare N,Sweeney E,Freyne PJ,Cullen MJ

    更新日期:1996-09-01 00:00:00

  • Scintigraphic patterns of lymphocele in post-renal transplant.

    abstract::Lymphocele is a common cause of fluid collection in post-renal transplant patients. Most of these patients are routinely followed up with 99mTc diethylenetriaminepentaacetate renal dynamic scintigraphy. The present study retrospectively reviews the range of findings with renal dynamic scintigraphy in documented lympho...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Kumar R,Bharathi Dasan J,Choudhury S,Guleria S,Padhy AK,Malhotra A

    更新日期:2003-05-01 00:00:00

  • Evaluation of somatostatin receptors in large cell pulmonary neuroendocrine carcinoma with 99mTc-EDDA/HYNIC-TOC scintigraphy.

    abstract:OBJECTIVE:Large cell pulmonary neuroendocrine carcinoma (LCNEC) is a poorly differentiated and high-grade neoplasm. It is positioned between an atypical carcinoid and small cell neuroendocrine carcinoma of the lung in a distinct family of pulmonary neuroendocrine tumors. The aim of our study was to detect somatostatin ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Nocuń A,Chrapko B,Gołębiewska R,Stefaniak B,Czekajska-Chehab E

    更新日期:2011-06-01 00:00:00

  • 99mTc-depreotide tumour uptake in patients with non-Hodgkin's lymphoma.

    abstract:BACKGROUND:99mTc-depreotide (NeoTect) is a synthetic somatostatin analogue, which binds to somatostatin receptor (SSTR) subtypes 2, 3 and 5. Imaging patients with non-Hodgkin's lymphoma (NHL) using the somatostatin analogue In-pentetreotide (Octreoscan) has demonstrated the feasibility of identifying lymphoma sites wit...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章


    authors: Bushnell DL,Menda Y,Madsen MT,Link BK,Kahn D,Truhlar SM,Juweid M,Shannon M,Murguia JS

    更新日期:2004-08-01 00:00:00

  • A routine method for using sodium iodide to stabilize sodium pertechnetate [99Tcm] dispensed for the preparation of 99Tcm-exametazime.

    abstract::When preparing 99Tcm-exametazime, it is important to use sodium 99Tcm-pertechnetate that is less than 2 h old. The addition of sodium iodide (NaI) to 99Tcm-pertechnetate is known to extend this time to 6 h. This paper describes a technique for implementing this in routine practice. Sterile kits consisting of 440 micro...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Millar AM

    更新日期:1992-05-01 00:00:00

  • Evaluation of the (14)C-urea breath test using indigenously produced (14)C-urea capsules and a modified technique for trapping exhaled breath: a pilot study.

    abstract::The carbon urea breath test ((14)C-UBT) is a noninvasive technique used to detect Helicobacter pylori infection in patients presenting with dyspeptic symptoms. The present study was undertaken to determine the efficacy of indigenously produced (14)C-UBT capsules by the Board of Radiation and Isotope Technology, India....

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Tiwari BP,Nistala S,Patil SP,Kalgutkar DP,Jaychandran N,Chander H,Basu S

    更新日期:2014-03-01 00:00:00

  • Evaluation of three methods of platelet labelling.

    abstract::The study of the kinetics of labelled platelets makes sense only when the platelets preserve their viability after separation and labelling. The separation and labelling procedures described in the manual of two producers of 111In-oxinate (Amersham, Mallinckrodt) have been evaluated by in vitro aggregation tests. The ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Mortelmans L,Verbruggen A,De Roo M,Vermylen J

    更新日期:1986-07-01 00:00:00

  • Prediction of lymph node metastasis by PET/CT metabolic parameters in patients with esophageal squamous cell carcinoma.

    abstract:OBJECTIVE:The aim of this study was to investigate the capability of F-FDG PET/computed tomography (CT)-related metabolic parameters to predict lymph node metastasis (LNM) and occult lymph node metastasis (OLNM) in patients with esophageal squamous cell carcinoma (ESCC). METHODS:Totally 84 patients undergoing curative...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Xu M,Wang L,Ouyang M,Lin J,Wang L,Zheng X,Miao S,Tang K

    更新日期:2019-09-01 00:00:00

  • Assessment of adenosine, arbutamine and dobutamine as pharmacological stress agents during (99m)Tc-tetrofosmin SPECT imaging: a randomized study.

    abstract::We evaluated the use of adenosine, dobutamine and arbutamine with (99m)Tc-tetrofosmin myocardial perfusion imaging. Forty patients under investigation for suspected coronary artery disease were recruited. Each had a resting scan and two separate stress scans on different days, in a randomized cross-over study. Resulta...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wright DJ,Williams SG,Lindsay HS,Sheard KL,Thorley PJ,Sivananthan UM

    更新日期:2001-12-01 00:00:00

  • Preparation of radioactive praseodymium oxide as a multifunctional agent in nuclear medicine: expanding the horizons of cancer therapy using nanosized neodymium oxide.

    abstract:OBJECTIVE:Many studies have attempted to assess the significance of the use of the β(-)particle emitter praseodymium-142 ((142)Pr) in cancer treatment. As praseodymium oxide (Pr(2)O(3)) powder is not water soluble, it was dissolved in HCl solution and the resultant solution had to be pH adjusted to be in an injectable ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Bakht MK,Sadeghi M,Ahmadi SJ,Sadjadi SS,Tenreiro C

    更新日期:2013-01-01 00:00:00

  • Half-time myocardial perfusion SPECT imaging with attenuation and Monte Carlo-based scatter correction.

    abstract:PURPOSE:To test the potential of a new reconstruction algorithm with Monte Carlo-based scatter correction in half-time myocardial perfusion single-photon emission computed tomography (SPECT). MATERIALS AND METHODS:The mathematical four-dimensional NURBS-based Cardiac-Torso phantom and the SIMIND Monte Carlo simulation...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Kangasmaa TS,Kuikka JT,Vanninen EJ,Mussalo HM,Laitinen TP,Sohlberg AO

    更新日期:2011-11-01 00:00:00

  • Prevalence and risk factors of intraoperative identification failure of sentinel lymph nodes in patients affected by breast cancer.

    abstract:INTRODUCTION:Sentinel lymph node biopsy (SLNB) has progressively replaced complete axillary lymph node dissection in the evaluation of breast cancer patients with clinically node-negative disease. Our study investigates the rate of and risk factors involved in sentinel node identification failure. MATERIALS AND METHOD...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Bernardi S,Bertozzi S,Londero AP,Angione V,Petri R,Giacomuzzi F

    更新日期:2013-07-01 00:00:00

  • Diagnostic accuracy of 18F-FDG PET/CT in characterizing ovarian lesions and staging ovarian cancer: correlation with transvaginal ultrasonography, computed tomography, and histology.

    abstract:AIMS:To (a) assess the accuracy of 18F-FDG PET/CT in distinguishing malignant from benign pelvic lesions, compared to transvaginal ultrasonography (TVUS) and (b) to establish the role of whole-body 18F-FDG PET/CT, compared to contrast enhanced computed tomography (CT), in staging patients with ovarian cancer. PATIENTS...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章


    authors: Castellucci P,Perrone AM,Picchio M,Ghi T,Farsad M,Nanni C,Messa C,Meriggiola MC,Pelusi G,Al-Nahhas A,Rubello D,Fazio F,Fanti S

    更新日期:2007-08-01 00:00:00