Validation set analysis to predict postoperative outcomes by technetium-99m galactosyl serum albumin scintigraphy for hepatectomy.


BACKGROUND:The indocyanine green retention rate at 15 min (ICGR15) is a gold standard parameter of liver function when deciding on the extent of hepatectomy. However, ICGR15 is influenced by several hepatic conditions. To evaluate auxiliary preoperative liver functional reserve, we examined the clinical significance of modified parameters by blood tests and technetium-99m galactosyl human serum albumin (Tc-GSA) scintigraphy. METHODS:We measured liver function parameters, including the hepatic uptake ratio (LHL15) and the blood pool clearance index (HH15) of Tc-GSA and their modified formulae [LHL/HH15, LHL minus HH15, and converted ICGR15 (cICGR15) from a preliminary study] in 229 patients, including 18 with biliary obstruction. RESULTS:The mean values of LHL15/HH15, LHL minus HH15, and cICGR15 were 1.646 ± 0.295, 0.347 ± 0.116, and 13.2 ± 5.3%, respectively. These parameters correlated significantly with other liver functions measured by blood tests except for the bilirubin level (P < 0.05) although the actual ICGR15 level correlated positively with the bilirubin level. The difference of ICGR15 (ICGR15 minus cICGR15) in patients with biliary obstruction tended to be higher in comparison with that in patients without biliary obstruction (P = 0.044). Values of LHL/HH15, LHL minus HH15, and the cICGR15 were not significantly associated with postoperative complications. CONCLUSION:The modified parameters of Tc-GSA were useful for evaluating hepatic function in patients with high bilirubinemia due to biliary obstruction. However, it remains difficult to establish a more reliable parameter as a standard hepatic function test instead of ICGR15.


Nucl Med Commun


Nanashima A,Hiyoshi M,Imamura N,Yano K,Hamada T,Wada T,Nishimuta M,Shimizu I,Mizutani Y




Has Abstract


2020-04-01 00:00:00












  • Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging.

    abstract:BACKGROUND:Dual gating is a method of dividing the data of a cardiac PET scan into smaller bins according to the respiratory motion and the ECG of the patient. It reduces the undesirable motion artefacts in images, but produces several images for interpretation and decreases the quality of single images. By using motio...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Klén R,Noponen T,Koikkalainen J,Lötjönen J,Thielemans K,Hoppela E,Sipilä H,Teräs M,Knuuti J

    更新日期:2016-09-01 00:00:00

  • Radionuclide limb blood flow in peripheral vascular disease: a review of 1100 measurements.

    abstract::Radionuclide limb blood flow measurements using 99Tcm-labelled human serum albumin and a gamma camera have been performed on normal volunteers and on patients with suspected or confirmed peripheral arterial disease. The normal range of flow was found to be 10.0-22.3 ml per 100 ml tissue per min. Flow in the symptomati...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Parkin A,Robinson PJ,Martinez D,Wilkinson D,Kester RC

    更新日期:1991-10-01 00:00:00

  • Left ventricular ejection fraction determined with the nuclear stethoscope, gamma camera and contrast ventriculography.

    abstract::Left ventricular ejection fractions (EF) were measured with a nuclear stethoscope (NSt, beat-to-beat and ECG gated summation method) and contrast ventriculography (VG) immediately following one another (IFOA) (r X 0.96 and 0.95, respectively, n = 13). NSt and ECG gated gamma camera (MUGA) recordings IFOA were compared...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Lund O,Rasmussen K,Jensen FT,Hansen HH

    更新日期:1986-05-01 00:00:00

  • Long-term follow-up using 18F-FDG PET/CT for postoperative olfactory neuroblastoma.

    abstract:PURPOSE:The present study evaluated the usefulness of postoperative fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) in the management of olfactory neuroblastoma (ONB). MATERIALS AND METHODS:Ten patients (eight men and two women; mean age, 48.5 years) with histologically confirmed ONB who underwent ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Fujioka T,Toriihara A,Kubota K,Machida Y,Nakamura S,Kishimoto S,Ohashi I,Shibuya H

    更新日期:2014-08-01 00:00:00

  • In vivo evaluation of three different 99mTc-labelled radiopharmaceuticals for sentinel lymph node identification.

    abstract::This work was designed to compare sentinel lymph node (SLN) uptake of 99mTc-labelled human serum albumin colloid (99mTc-HSAC), 99mTc-labelled antimony sulphur colloid (99mTc-SC) and a 99mTc-labelled dextran 70 solution (99mTc-Dx) and their selectivity in the identification of this node in the right rear footpad (RRF) ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Edreira MM,Colombo LL,Perez JH,Sajaroff EO,de Castiglia SG

    更新日期:2001-05-01 00:00:00

  • Scintigraphic imaging of breast cancer: a review.

    abstract::Scintimammography is a recently verified technique that will expand the use of nuclear medicine to a new group of patients in whom scintigraphic imaging has not been widely used. If performed correctly, and in certain groups of patients, it delivers a sensitivity as high as X-ray mammography or magnetic resonance imag...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审


    authors: Buscombe JR,Cwikla JB,Thakrar DS,Hilson AJ

    更新日期:1997-08-01 00:00:00

  • Appropriate selection of background for 99Tcm-DTPA renography.

    abstract::Since 99Tcm-DTPA is diffusible and not significantly protein bound in plasma, it rapidly enters the extravascular space following injection. Therefore, during the first few minutes of the DTPA renogram, the period on which the measurements of individual kidney glomerular filtration rate and differential function are b...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Peters AM,George P,Ballardie F,Gordon I,Todd-Pokropek A

    更新日期:1988-12-01 00:00:00

  • Occipital lobe and posterior cingulate perfusion in the prediction of dementia with Lewy body pathology in a clinical sample.

    abstract:OBJECTIVE:The aim of this study was to investigate the diagnostic value of occipital lobe and posterior cingulate perfusion in predicting dopamine transporter imaging outcome using a quantitative measure of analysis. PATIENTS AND METHODS:In total, 99 patients with cognitive complaints who had undergone both technetium...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Prosser AMJ,Tossici-Bolt L,Kipps CM

    更新日期:2017-12-01 00:00:00

  • Stress-only myocardial perfusion scintigraphy: a prospective study on the accuracy and observer agreement with quantitative coronary angiography as the gold standard.

    abstract:OBJECTIVE:Patients with normal stress perfusion have an excellent prognosis. Prospective studies on the diagnostic accuracy of stress-only scans with contemporary, independent examinations as gold standards are lacking. PATIENTS AND METHODS:A total of 109 patients with typical angina and no previous coronary artery di...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章


    authors: Ejlersen JA,May O,Mortensen J,Nielsen GL,Lauridsen JF,Allan J

    更新日期:2017-11-01 00:00:00

  • Evaluation of the (14)C-urea breath test using indigenously produced (14)C-urea capsules and a modified technique for trapping exhaled breath: a pilot study.

    abstract::The carbon urea breath test ((14)C-UBT) is a noninvasive technique used to detect Helicobacter pylori infection in patients presenting with dyspeptic symptoms. The present study was undertaken to determine the efficacy of indigenously produced (14)C-UBT capsules by the Board of Radiation and Isotope Technology, India....

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Tiwari BP,Nistala S,Patil SP,Kalgutkar DP,Jaychandran N,Chander H,Basu S

    更新日期:2014-03-01 00:00:00

  • Incremental value of 99mTc-MDP hybrid SPECT/CT over planar scintigraphy and SPECT in avascular necrosis of the femoral head.

    abstract:OBJECTIVE:The aim of the study was to evaluate the incremental value of technetium-99m-methylene diphosphonate (99mTc-MDP) single-photon emission tomography/computed tomography (SPECT/CT) over planar bone scintigraphy (BS) and SPECT in the diagnosis of avascular necrosis (AVN) of the femoral head. MATERIALS AND METHOD...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Agarwal KK,Mukherjee A,Sharma P,Bal C,Kumar R

    更新日期:2015-10-01 00:00:00

  • Effect of different segmentation algorithms on metabolic tumor volume measured on 18F-FDG PET/CT of cervical primary squamous cell carcinoma.

    abstract:BACKGROUND AND PURPOSE:It is known that fluorine-18 fluorodeoxyglucose PET/computed tomography (CT) segmentation algorithms have an impact on the metabolic tumor volume (MTV). This leads to some uncertainties in PET/CT guidance of tumor radiotherapy. The aim of this study was to investigate the effect of segmentation a...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Xu W,Yu S,Ma Y,Liu C,Xin J

    更新日期:2017-03-01 00:00:00

  • The gamma camera as an absolute measurement device: determination of glomerular filtration rate in 99mTc-DTPA renography using a dual head gamma camera.

    abstract:AIM:The aim of this study was to design a general nuclear medicine method for fast, accurate and direct determination of the clearance of a radioactive indicator provided that all uptake compartments of the radioactive indicator could be included in the field of view of the gamma camera. METHODS:The data material for ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章


    authors: Carlsen O

    更新日期:2004-10-01 00:00:00

  • Does lymph node localization affect prostate-specific membrane antigen uptake?

    abstract:OBJECTIVE:To investigate the relationship between lymph node (LN) size and localization and prostate-specific membrane antigen (PSMA) uptake in patients with prostate cancer. PATIENTS AND METHODS:Between February 2015 and February 2017, a total of 178 patients diagnosed with prostate adenocarcinoma by gallium-68 PSMA ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Sönmezer B,Acar E,Erkoyun E,Capa Kaya G

    更新日期:2019-08-01 00:00:00

  • 99mTc-exendin(9-39)/octreotide: biokinetics and radiation dosimetry in healthy individuals.

    abstract:AIM:About 90% of insulinomas are benign and 5-15% are malignant. Benign insulinomas express the glucagon-like peptide-1 receptor (GLP-1R, which recognizes exendin-4 and low levels of the somatostatin receptor (SSTR, which recognizes octreotide), whereas malignant insulinomas overexpress SSTR and low levels of GLP-1R. R...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Ocampo-García BE,Santos-Cuevas CL,Luna-Gutiérrez MA,Ignacio-Alvarez E,Pedraza-López M,Manzano-Mayoral C

    更新日期:2017-11-01 00:00:00

  • Synthesis and preclinical evaluation of the 177Lu-DOTA-PSMA(inhibitor)-Lys3-bombesin heterodimer designed as a radiotheranostic probe for prostate cancer.

    abstract:BACKROUND:Human tumors show intrinsic heterogeneity and changes in phenotype during disease progression, which implies different expression levels of cell surface receptors. The research on new heterodimeric lutetium-177 (Lu)-radiopharmaceuticals interacting with two different targets on tumor cells is a strategy for i...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Escudero-Castellanos A,Ocampo-García B,Ferro-Flores G,Santos-Cuevas C,Morales-Ávila E,Luna-Gutiérrez M,Isaac-Olivé K

    更新日期:2019-03-01 00:00:00

  • Significant reduction of 125 I-meta-iodobenzylguanidine accumulation directly caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine, a toxic agent for inducing experimental Parkinson's disease.

    abstract::A significant reduction of cardiac 123I-meta-iodobenzylguanidine (MIBG) accumulation has been reported in patients with idiopathic Parkinson's disease. However, it is unclear whether this reduction in cardiac sympathetic nerve is caused primarily or secondarily to the degeneration of sympathetic nerve centres which oc...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Takatsu H,Wada H,Maekawa N,Takemura M,Saito K,Fujiwara H

    更新日期:2002-02-01 00:00:00

  • Predictive approaches for post-therapy PET/CT in patients with extranodal natural killer/T-cell lymphoma: a retrospective study.

    abstract:PURPOSE:The aim of this study was to assess the prognostic capacity of three methods of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT analysis carried out after therapy in patients with extranodal natural killer/T-cell lymphoma (ENKTL). The three methods of PET/CT analysis included the International Harmonization Proje...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Jiang C,Liu J,Li L,Kosik RO,Su M,Zou L,Tian R

    更新日期:2017-11-01 00:00:00

  • Non-invasive assessment of absolute values of hepatic haemodynamics using radiocolloid scintigraphy.

    abstract::A non-invasive technique for the assessment of hepatic haemodynamics using radiocolloid imaging with a computer, in which absolute values of hepatic, mesenteric and splenic arterial effective blood flows were assessed, is described. The technique was carried out on ten volunteers, before and after a standard meal. Aft...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Walmsley BH,Fleming JS,Ackery DM,Karran SJ

    更新日期:1987-08-01 00:00:00

  • Investigating the histopathologic correlates of 18F-FDG PET heterogeneity in non-small-cell lung cancer.

    abstract:PURPOSE:Despite the growing use of fluorine-18-fluorodeoxyglucose (F-FDG) PET texture analysis to measure intratumoural heterogeneity in cancer research, the biologic basis of F-FDG PET-derived texture variables is poorly understood. We aimed to assess correlations between F-FDG PET-derived texture variables and whole-...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章


    authors: Bashir U,Foot O,Wise O,Siddique MM,Mclean E,Bille A,Goh V,Cook GJ

    更新日期:2018-12-01 00:00:00

  • Quantitative assessment of cardiac mechanical dyssynchrony and prediction of response to cardiac resynchronization therapy in patients with nonischaemic dilated cardiomyopathy using gated myocardial perfusion SPECT.

    abstract:OBJECTIVE:The aim of the study was to evaluate gated myocardial perfusion SPECT (GMPS) in the prediction of response to cardiac resynchronization therapy (CRT) in nonischaemic dilated cardiomyopathy patients. PATIENTS AND METHODS:Thirty-two patients (23 men, mean age 57.5±12.1 years) with severe heart failure, who wer...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章


    authors: Mukherjee A,Patel CD,Naik N,Sharma G,Roy A

    更新日期:2015-05-01 00:00:00

  • 99mTc galactosyl human serum albumin liver dynamic SPET for pre-operative assessment of hepatectomy in relation to percutaneous transhepatic portal embolization.

    abstract::We have devised an original predictive residual index (PRI) using 99mTc diethylenetriaminepentaacetic acid galactosyl human serum albumin (99mTc-GSA) liver dynamic SPET for the pre-operative assessment of hepatectomy, including the prediction of residual liver function before hepatectomy. The aim of this study was to ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章


    authors: Nishiyama Y,Yamamoto Y,Hino I,Satoh K,Wakabayashi H,Ohkawa M

    更新日期:2003-07-01 00:00:00

  • Detection of CBF deficits in neuropsychiatric disorders by an expert system: a 99Tcm-HMPAO brain SPET study using automated image registration.

    abstract::The aims of this study were to develop an objective method for assessing rCBF deficits using a statistical image analysis protocol and to validate its effective use in clinical practice. 99Tcm-HMPAO brain SPET images were acquired for 40 normal subjects, 10 patients with Alzheimer's disease and 10 patients with depres...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Imran MB,Kawashima R,Sato K,Kinomura S,Ono S,Qureshy A,Fukuda H

    更新日期:1999-01-01 00:00:00

  • Reproducibility of gastric emptying of a pancake and milkshake meal in normal subjects.

    abstract::Comparisons of gastric emptying between different centres are difficult because of wide variations in methods. Reproducibility of a method is very important before it is used to compare different subjects or to assess the effect of treatment. The aim of this study was to measure the reproducibility of gastric emptying...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Kong MF,Perkins AC,King P,Blackshaw PE,Macdonald IA

    更新日期:1998-01-01 00:00:00

  • 177Lu-DOTATATE therapy in patients with neuroendocrine tumours including high-grade (WHO G3) neuroendocrine tumours: response to treatment and long-term survival update.

    abstract:PURPOSE:Upon diagnosis, distant metastases are encountered in 21-50% of neuroendocrine tumours (NETs). However, few systemic treatment options are available for the well-differentiated NETs in the metastatic stage. Lu-DOTATATE is one of the most effective treatments in this limited patient group. We retrospectively inv...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Demirci E,Kabasakal L,Toklu T,Ocak M,Şahin OE,Alan-Selcuk N,Araman A

    更新日期:2018-08-01 00:00:00

  • Scintigraphic evaluation of renoprotective effects of coenzyme Q10 in a rat renal ischemia-reperfusion injury.

    abstract:PURPOSE:Renal ischemia-reperfusion injury (RIRI) may occur secondary to several reasons leading to renal failure. Coenzyme-Q10 (CoQ10) is a well-known antioxidant. However, the effects CoQ10 against RIRI have not been evaluated. Our aim was to evaluate protective effects of CoQ10 to renal ischemia-reperfusion by bioche...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Akbulut A,Keseroglu BB,Koca G,Yuceturk CN,Ozgur BC,Surer H,Ogus E,Yumuşak N,Karakaya J,Korkmaz M

    更新日期:2019-10-01 00:00:00

  • Comparison of treatment efficacy 1 and 2 years after thyroid remnant ablation with 1110 versus 5550 MBq of iodine-131 in patients with intermediate-risk differentiated thyroid cancer.

    abstract:BACKGROUND:Radioiodine ablation may be associated with improved survival in patients with intermediate-risk follicular cell differentiated thyroid cancer (FCDTC). The aim of this study was to compare ablation efficacy of 1110 versus 5500 MBq of iodine-131 (I) in FCDTC patients with intermediate risk. METHODS:Thirty-ni...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Aghaei A,Ayati N,Shafiei S,Abbasi B,Zakavi SR

    更新日期:2017-11-01 00:00:00

  • Mobile PET in the UK: legislative, regulatory and cost-effectiveness considerations.

    abstract::Mobile PET/CT or mobile stand alone PET, is becoming more widely available throughout the developed world, allowing many small and medium-sized hospitals that do not have the scale or financial resources to purchase the static diagnostic equipment, to benefit from this imaging technology. Before embarking on such a se...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审


    authors: Chua SC,Perkins AC,Pearson D,Ganatra RH

    更新日期:2008-02-01 00:00:00

  • New possibilities in erythrocyte survival studies with the application of a Well-type germanium semiconductor detector.

    abstract::The application of a Well-type germanium semiconductor detector creates new possibilities in erythrocyte survival studies. Using 51Cr, the effective dose equivalent in a standard procedure can be reduced from approximately 780 to 2 microSv. The properties of the detector, namely, high efficiency and high energy resolu...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: De Vries RA,Oldenburg SJ,Thelosen T,De Bruin M,Poortman J,Van de Wiel A

    更新日期:1991-05-01 00:00:00

  • Estimation of ascitic fluid volume using 99Tcm labelled macroaggregated albumin.

    abstract::We have assessed the usefulness of a radionuclide dilution method for estimation of ascitic fluid volume. 99Tc(m) macroaggregated albumin (10 MBq) was injected into the peritoneal fluid. Multiple samples were taken using a trocath peritoneal dialysis catheter over a 4-h period. Blood samples were taken at the same tim...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章


    authors: Notghi A,Williams NR,Kehoe S,Smith NB,Harding LK

    更新日期:2000-12-01 00:00:00