Reproducibility and repeatability of differential renal function in 4-week-old piglets.

Abstract:

BACKGROUND:Congenital obstructive renal disease often requires a decision early in the child's life on whether or not surgery is required. Differential renal function (DRF) calculated from the renogram provides important information for the correct decision in this process. A recent publication cast doubt as to the reliability of the renogram in providing DRF in the young child. AIM:To describe the day-to-day variation and reproducibility of the two commonly used agents for estimating DRF. METHODS:Within 1 week, 4-week-old pigs each underwent three examinations with both 99mTc-DTPA and 99mTc-DMSA. DRF values from the 99mTc-DTPA renograms were calculated using both the area under the curve (AUC) and the Rutland-Patlak equation. Day-to-day variations in the results using different background subtraction methods were analysed using the coefficient of variation for each case and the repeatability coefficient for each type of background subtraction. RESULTS:DRF calculated from the 99mTc-DMSA studies showed little variation, with a coefficient of variation of 3.9% in the worst case. The repeatability coefficient calculated from the 99mTc-DTPA studies using the AUC technique combined with the background subtraction method giving the least variation was 14.9% while using the Rutland-Patlak technique with its best background subtraction showed an RC of 9.4%. CONCLUSIONS:The study demonstrates that DRF calculated from 99mTc-DMSA studies have low variability and the results are highly reproducible in immature pigs. The DRF calculated from 99mTc-DTPA renograms failed to show acceptable reproducibility when analysed using either the AUC method or the Rutland-Patlak equation.

journal_name

Nucl Med Commun

authors

Dissing TH,Eskild-Jensen A,Pedersen M,Anderson PJ,Rittig N,Frøkiaer J,Gordon I

doi

10.1097/MNM.0b013e3282f20e1f

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

76-82

issue

1

eissn

0143-3636

issn

1473-5628

pii

00006231-200801000-00011

journal_volume

29

pub_type

杂志文章
  • InfuShield: a shielded enclosure for administering therapeutic radioisotope treatments using standard syringe pumps.

    abstract::The administration of radionuclide therapies presents significant radiation protection challenges. The aim of this work was to develop a delivery system for intravenous radioisotope therapies to substantially moderate radiation exposures to staff and operators. A novel device (InfuShield) was designed and tested befor...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000634

    authors: Rushforth DP,Pratt BE,Chittenden SJ,Murray IS,Causer L,Grey MJ,Gear JI,Du Y,Flux GD

    更新日期:2017-03-01 00:00:00

  • Clinical significance of decreased myocardial uptake of 123I-BMIPP in patients with stable effort angina pectoris.

    abstract::The aim of this study was to assess the feasibility of resting myocardial fatty acid metabolic imaging with 123I-beta-methyliodophenyl-pentadecanoic acid (123I-BMIPP) for the detection of patients with stable effort angina pectoris and to clarify the clinical significance of abnormal 123I-BMIPP images. Myocardial imag...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199512000-00003

    authors: Takeishi Y,Sukekawa H,Saito H,Nishimura S,Shibu T,Sasaki Y,Tomoike H

    更新日期:1995-12-01 00:00:00

  • A phantom assessment of portable imaging and radio-guided surgery systems with technetium-99m and fluorine-18.

    abstract:AIM:To perform a detailed analysis of the performance of mobile intraoperative imaging systems and gamma probes in a phantom set-up, and compare this with a conventional gamma camera. METHODS:Two separate experiments were performed. In the first, a modified Jaszczak phantom equipped with five (99m)Tc-filled hot sphere...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3283508577

    authors: Krohn T,Verburg FA,Brockmann H,Winz OH,Mottaghy FM,Behrendt FF

    更新日期:2012-05-01 00:00:00

  • Osteomyelitis.

    abstract::The use of 111In-labelled granulocyte scintigraphy is recognized as a reliable method for detecting osteomyelitis and has similar sensitivity and significantly increased specificity compared to bone scintigraphy and 67Ga studies. Recent published work using pure granulocytes labelled with 111In tropolonate to detect o...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198810000-00007

    authors: Roddie ME,Peters AM,Osman S,Danpure HJ,Lavender JP,Neirinckx RD

    更新日期:1988-10-01 00:00:00

  • Extraction of arterial input function for measurement of brain perfusion index with 99mTc compounds using fuzzy clustering.

    abstract::Cerebral blood flow (CBF) can be quantified non-invasively using the brain perfusion index (BPI) determined from radionuclide angiographic data generated with 99mTc-hexamethylpropylene amine oxime (99mTc-HMPAO). When measuring the BPI, manual drawing of regions of interest (ROIs) (manual ROI method) for the extraction...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200403000-00014

    authors: Murase K,Nagayoshi M,Uenishi Y,Kawamata M,Yamazaki Y,Takasawa M,Oku N,Hatazawa J

    更新日期:2004-03-01 00:00:00

  • A new non-invasive test for the detection of compartment syndromes.

    abstract::Chronic exertional compartment syndrome (CECS) is currently diagnosed using invasive pressure measurements. We report the use of 99Tcm-methoxyisobutyl isonitrile (99Tcm-MIBI) scintigraphy as a new non-invasive method of diagnosis. Forty-six patients with suspected chronic compartment syndrome underwent graded treadmil...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199903000-00003

    authors: Edwards PD,Miles KA,Owens SJ,Kemp PM,Jenner JR

    更新日期:1999-03-01 00:00:00

  • Removal of the internal mammary sentinel node in breast cancer.

    abstract:OBJECTIVE:The aim of the study was to determine the evolution of patients with internal mammary chain (IMC) drainage whether the IMC-sentinel lymph node (IMC-SLN) was biopsied or not, as well as to determine the clinical implications of the biopsy of the IMC-SLN (IMC-SLNB) in patients with breast cancer and IMC drainag...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328330addf

    authors: Domènech-Vilardell A,Bajén MT,Benítez AM,Ricart Y,Mora J,Rodríguez-Bel L,García-Tejedor A,Climent J,López-Ojeda A,Urruticoechea A,Martín-Comín J

    更新日期:2009-12-01 00:00:00

  • Detection of CBF deficits in neuropsychiatric disorders by an expert system: a 99Tcm-HMPAO brain SPET study using automated image registration.

    abstract::The aims of this study were to develop an objective method for assessing rCBF deficits using a statistical image analysis protocol and to validate its effective use in clinical practice. 99Tcm-HMPAO brain SPET images were acquired for 40 normal subjects, 10 patients with Alzheimer's disease and 10 patients with depres...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199901000-00006

    authors: Imran MB,Kawashima R,Sato K,Kinomura S,Ono S,Qureshy A,Fukuda H

    更新日期:1999-01-01 00:00:00

  • Comparison of [18F]fluorodeoxyglucose uptake with glucose transporter-1 expression and proliferation rate in human glioma and non-small-cell lung cancer.

    abstract::To clarify the biological significance of [18F]fluorodeoxyglucose (18F-FDG) accumulation in patients with cancer, we assessed the relationships between 18F-FDG uptake and glucose transporter-1 (GLUT-1) expression and proliferation rate in human glioma and lung cancer. We obtained FDG PET images and measured standardiz...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200401000-00003

    authors: Chung JK,Lee YJ,Kim SK,Jeong JM,Lee DS,Lee MC

    更新日期:2004-01-01 00:00:00

  • Stunning phenomenon after a radioactive iodine- ¹³¹I diagnostic whole-body scan: Is it really a point of clinical consideration?

    abstract:PURPOSE:Stunning of thyroid remnants after diagnostic scanning (Dx-WBS) using radioactive iodine- (¹³¹I) may limit the efficacy of I therapy. We aimed to evaluate this assumption in a prospectively designed study. METHODS:Forty patients who underwent thyroidectomy for differentiated thyroid carcinoma were studied and ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e328362ad63

    authors: Amin A,Amin M,Badwey A

    更新日期:2013-08-01 00:00:00

  • 18F-Flourodeoxy glucose PET-computed tomography in testicular carcinoma: diagnostic and prognostic value.

    abstract:AIM:This study aims to assess the diagnostic role of F-FDG PET/computed tomography in primary staging and restaging of testicular cancer in comparison with contrast-enhanced diagnostic thoracic-abdominopelvic computed tomography. MATERIAL AND METHOD:Thirty-two consecutive male patients with testicular carcinoma (media...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001093

    authors: Soydal C,Araz M,Urun Y,Gulpinar B,Nak D,Ozkan E,Kucuk NO

    更新日期:2019-12-01 00:00:00

  • Time sensitivity-corrected retention index: an enhanced metabolic index from 18F-FDG PET to differentiate between benign and malignant pulmonary nodules.

    abstract::The aim of the study was to evaluate pulmonary nodules (PNs) by incorporating time sensitivity (S) factor in the retention index (RI) and compare with the traditional fixed interval method. After obtaining approval from the Human Investigations Committee, 97 PNs from 81 patients (age=70±11) referred for dual-time fluo...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000190

    authors: Wong CY,Al-faham Z,Jolepalem P,Wong WW,Thie J

    更新日期:2014-12-01 00:00:00

  • Osteoblastic and hyperostotic craniofacial lesion detected by 99mTc-labeled methylene diphosphonate bone scintigraphy and single-photon emission computed tomography/computed tomography: a pictorial essay.

    abstract::99mTc-bisphophonates bone scan, planar and single-photon emission computed tomography/computed tomography (SPECT/CT) modalities, is a commonly used technique that provides high sensitivity and specificity for detection of osseous metastases. However, besides bone metastases, SPECT/CT provides an accurate evaluation of...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001318

    authors: Ju H,Paycha F

    更新日期:2021-02-01 00:00:00

  • False-positive F-18 FDG uptake in PET/CT studies in pediatric patients with abdominal Burkitt's lymphoma.

    abstract:INTRODUCTION:In pediatric patients with abdominal Burkitt's lymphoma, the involvement of the gastrointestinal tract and abdominal lymph nodes are the main presenting feature of the disease. Chemotherapy is the main treatment modality and could be preceded by surgical excision of the abdominal masses. To achieve cure or...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328334fc14

    authors: Riad R,Omar W,Sidhom I,Zamzam M,Zaky I,Hafez M,Abdel-Dayem HM

    更新日期:2010-03-01 00:00:00

  • One year's clinical experience of 18F-FDG PET with a modified SPET camera using molecular coincidence detection.

    abstract::High-quality positron emission tomographic (PET) cameras are expensive and, therefore, not available in many centres. To allow access to clinical 18F-fluorodeoxyglucose (18F-FDG) PET, we began working with an ADAC Vertex camera equipped with a molecular coincidence detection (MCD) module in February 1997. Here we give...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199911000-00005

    authors: Erler H,Zaknun J,Donnemiller E,Bacher-Stier C,Oberladstätter M,Riccabona G,Moncayo R

    更新日期:1999-11-01 00:00:00

  • Left ventricular function and the distribution of pulmonary and total blood volume in hypertensive and normotensive man.

    abstract::Using radionuclide methods the relationship between total and central blood volume and left ventricular function was studied in 12 patients with untreated essential hypertension and contrasted with the findings in eight normotensive subjects. The principal findings were of an increased stroke volume and end-diastolic ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198410000-00002

    authors: Mackay I,Nath K,Watson ML,Hannan WJ,Muir AL

    更新日期:1984-10-01 00:00:00

  • Patient and tumor characteristics predictive of an elevated hepatopulmonary shunt fraction before radioembolization of hepatic tumors.

    abstract:OBJECTIVE:To determine whether any patient or hepatic tumor characteristics are predictive of hepatopulmonary shunt fraction when performed before radioembolization. MATERIALS AND METHODS:A retrospective review was performed on 190 patients who underwent preradioembolization hepatic arteriography with calculation of h...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000528

    authors: Yerubandi V,Ronald J,Howard BA,Suhocki PV,James OG,Wong TZ,Kim CY

    更新日期:2016-09-01 00:00:00

  • Evaluation of reconstruction techniques for lung single photon emission tomography: a Monte Carlo study.

    abstract:BACKGROUND:In studies of the distribution of lung function, the image quality of lung single photon emission computed tomography (SPECT) is important and one factor influencing it is the reconstruction algorithm. AIM:To systematically evaluate ordered subsets expectation maximization (OSEM) and compare it with filtere...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3282f1acac

    authors: Norberg P,Bake B,Jacobsson L,Carlsson GA,Gustafsson A

    更新日期:2007-12-01 00:00:00

  • A review of PET normalization: striving for count rate uniformity.

    abstract::The advent of PET instrumentation signaled the beginning of a new perspective in nuclear medicine diagnostic imaging. PET systems rely on several corrections that must be applied in order to establish accurate and reliable quantification. The inherent properties of PET detector architecture and the crystals themselves...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/MNM.0b013e328365ac1e

    authors: Theodorakis L,Loudos G,Prassopoulos V,Kappas C,Tsougos I,Georgoulias P

    更新日期:2013-11-01 00:00:00

  • A study of the behaviour of cobalt chloride during the labelling of leukocytes with 99Tcm-HMPAO stabilised in vitro by the addition of cobalt chloride solution.

    abstract::The method described by Weisner et al. for stabilizing 99Tcm-hexamethylpropylene amine oxime (99Tcm-HMPAO) with cobalt chloride hexahydrate solution is the most promising developed to date. The aim of our work was to study the behaviour of cobalt during the labelling of leukocytes with 99Tcm-HMPAO stabilized in vitro ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199703000-00010

    authors: Prangere T,Bowden AD,Beauchat V,Caulier MT,Ziegels P,Huglo D,Pickett RD,Steinling M

    更新日期:1997-03-01 00:00:00

  • Could the skewness and kurtosis texture parameters of lesions obtained from pretreatment Ga-68 DOTA-TATE PET/CT images predict receptor radionuclide therapy response in patients with gastroenteropancreatic neuroendocrine tumors?

    abstract:PURPOSE:In our study, tumor heterogeneity was evaluated using the parameters skewness and kurtosis on pretreatment Ga-68 DOTA-TATE PET/CT to assess therapy responses of lesions in patients with gastroenteropancreatic neuroendocrine tumors (GEP NETs) treated with peptide receptor radionuclide therapy (PRRT). METHOD:We ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001231

    authors: Önner H,Abdülrezzak Ü,Tutuş A

    更新日期:2020-10-01 00:00:00

  • Intraperitoneal 131I- and 111In-791T/36 monoclonal antibody in recurrent ovarian cancer: imaging and biodistribution.

    abstract::An examination of the biokinetics and biodistribution of i.p. administered 131I- or 111In-labelled 791T/36 antibody (1 mg) has been carried out in five patients with stage III/IV ovarian cancer. Blood kinetics and urinary excretion of the radiolabels were assayed. Scintigraphy was performed immediately following admin...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198908010-00006

    authors: Perkins AC,Pimm MV,Gie C,Marksman RA,Symonds EM,Baldwin RW

    更新日期:1989-08-01 00:00:00

  • Bone marrow scintigraphy in small cell carcinoma of the lung.

    abstract::A comparative study of bone marrow scintigraphy using 99Tcm-nanocolloid, conventional bone scintigraphy and bone marrow biopsy were performed in 35 patients with histologically proven small cell carcinoma of the lung to determine whether bone marrow scintigraphy has a role in the early detection of bone marrow metasta...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199401000-00006

    authors: Li DJ,Maughan TS,Miles KA,Wraight EP

    更新日期:1994-01-01 00:00:00

  • Imatinib mesylate for the treatment of gastrointestinal stromal tumours: best monitored with FDG PET.

    abstract:BACKGROUND:The new anti-cancer drug imatinib mesylate inhibits the tyrosine kinase growth factor receptor, c-KIT, and has shown spectacular activity in patients with gastrointestinal stromal tumours (GISTs). OBJECTIVE:To assess whether fluorodeoxyglucose positron emission tomography (FDG PET) is suitable for response ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200405000-00002

    authors: Jager PL,Gietema JA,van der Graaf WT

    更新日期:2004-05-01 00:00:00

  • 99mTc-exendin(9-39)/octreotide: biokinetics and radiation dosimetry in healthy individuals.

    abstract:AIM:About 90% of insulinomas are benign and 5-15% are malignant. Benign insulinomas express the glucagon-like peptide-1 receptor (GLP-1R, which recognizes exendin-4 and low levels of the somatostatin receptor (SSTR, which recognizes octreotide), whereas malignant insulinomas overexpress SSTR and low levels of GLP-1R. R...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000736

    authors: Ocampo-García BE,Santos-Cuevas CL,Luna-Gutiérrez MA,Ignacio-Alvarez E,Pedraza-López M,Manzano-Mayoral C

    更新日期:2017-11-01 00:00:00

  • Normal bone and soft tissue distribution of fluorine-18-sodium fluoride and artifacts on 18F-NaF PET/CT bone scan: a pictorial review.

    abstract::Fluorine-18-sodium fluoride (F-NaF) PET/CT is a relatively new and high-resolution bone imaging modality. Since the use of F-NaF PET/CT has been increasing, it is important to accurately assess the images and be aware of normal distribution and major artifacts. In this pictorial review article, we will describe the no...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/MNM.0000000000000720

    authors: Sarikaya I,Elgazzar AH,Sarikaya A,Alfeeli M

    更新日期:2017-10-01 00:00:00

  • Gender differences in brown adipose tissue-related brain functional networks: an 18F-FDG-PET study.

    abstract:PURPOSE:Thermogenesis of brown adipose tissue (BAT) is controlled by central modulating mechanisms, although changes in brain metabolism of BAT-positive subjects with different genders are still unclear. We hypothesized that changes in regional cerebral glucose metabolic activity were associated with BAT activities, an...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001190

    authors: Shao X,Chen Y,Shao X,Wang S,Wang S,Wang Y

    更新日期:2020-06-01 00:00:00

  • Relationship between various parameters derived from 123I-labelled beta-methyl-branched fatty acid whole-body scintigraphy and left ventricular ejection fraction in patients with ischaemic heart disease.

    abstract::Heart uptake and clearance of 123I-15-(p-iodophenyl)-3(R,S)-methyl- pentadecanoic acid (BMIPP) by whole-body scintigraphy in relation to left ventricular ejection fraction (LVEF) was evaluated in 34 patients with ischaemic heart disease. At 45 and 210 min after injection, anterior whole-body images were obtained. In e...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199409000-00004

    authors: Matsunari I,Saga T,Taki J,Akashi Y,Wakasugi T,Hirai JI,Aoyama T,Matoba M,Nishikawa T,Ichiyanagi K

    更新日期:1994-09-01 00:00:00

  • A review of pediatric neuroendocrine tumors, their detection, and treatment by radioisotopes.

    abstract::Neuroendocrine tumors (NETs) are rare in childhood. Neuroblastoma is the most common pediatric extracranial solid tumor, occurring >90% in children younger than 5 years of age. Pheochromocytoma and paraganglioma are rare NETs, causing hypertension in 0.5-2% of hypertensive children. Gastroenteropancreatic NETs can occ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001305

    authors: Haddad T,Fard-Esfahani A,Vali R

    更新日期:2021-01-01 00:00:00

  • Assessment of left ventricular function by 201Tl SPECT using left ventricular cavity-to-myocardium count ratio.

    abstract::Equilibrium radionuclide angiography (ERNA) is the 'gold standard' for assessing left ventricular ejection fraction (LVEF). The aim of the study was to determine whether the left ventricular cavity-to-myocardium count ratio (LVCMR) from 201Tl myocardial single photon emission computed tomography (SPECT) correlated wit...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200103000-00004

    authors: Maunoury C,Antonietti T,Sebahoun S,Barritault L

    更新日期:2001-03-01 00:00:00