Abstract:
:Cerebral blood flow (CBF) can be quantified non-invasively using the brain perfusion index (BPI) determined from radionuclide angiographic data generated with 99mTc-hexamethylpropylene amine oxime (99mTc-HMPAO). When measuring the BPI, manual drawing of regions of interest (ROIs) (manual ROI method) for the extraction of the arterial input function (AIF) can lead to serious individual differences. The purpose of this study was to apply the fuzzy c-means (FCM) clustering method to determine AIF, and to investigate its usefulness in comparison with the manual ROI method. Radionuclide angiography was performed using a bolus injection of about 555 MBq of 99mTc-HMPAO, followed by sequential imaging (1 sec/frame x 120 s) using a solid-state gamma camera, and the BPI values were calculated using spectral analysis. To investigate the dependence of BPI on the ROI size, we drew five ROIs with different sizes over the aortic arch, and calculated the BPI using the manual ROI method [BPI(manual)] and the FCM clustering method [BPI(FCM)]. Furthermore, we asked 10 individuals to draw ROIs to investigate the inter-operator variability of the two methods. The mean and standard deviation (SD) of BPI(manual) increased with increasing ROI size, whereas the mean of BPI(FCM) was almost constant regardless of the ROI size; the SD of BPI(FCM) was smaller than that of BPI(manual). The inter-operator variability of the FCM clustering method was smaller than that of the manual ROI method. These results suggest that the FCM clustering method appears to be useful for the measurement of BPI, because it allows a reliable and objective determination of AIF.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Murase K,Nagayoshi M,Uenishi Y,Kawamata M,Yamazaki Y,Takasawa M,Oku N,Hatazawa Jdoi
10.1097/00006231-200403000-00014keywords:
subject
Has Abstractpub_date
2004-03-01 00:00:00pages
299-303issue
3eissn
0143-3636issn
1473-5628pii
00006231-200403000-00014journal_volume
25pub_type
临床试验,杂志文章abstract:OBJECTIVES:The aim of this prospective study was to assess the influence of different normalization procedures on relative changes in standardized uptake values (SUV) of F-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for the assessment of chemotherapy response in patients with colorectal carcinoma ...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0b013e32832bdc80
更新日期:2009-07-01 00:00:00
abstract::Technetium-99m-galactosyl human serum albumin (99mTc-GSA) is a radiopharmaceutical that binds to asialoglycoprotein receptors in the hepatocyte membrane; the level of 99mTc-GSA accumulation in the liver correlates well with the parameters of hepatic function tests. We hypothesized that the early blood kinetics of 99mT...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200107000-00008
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to compare quantitative ECG-gated single-photon emission computed tomography (SPECT) (QGS) and model-based ECG-gated single-photon emission computed tomography (MBGS) for determination of end-diastolic cardiac volume (EDV), end-systolic cardiac volume (ESV), and left ventricular...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3283294d19
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Follow-up of 131I whole-body scanning after 131I ablation is associated with potential stunning. Previous studies have suggested that, for scanning, 123I is more sensitive than 131I in identifying thyroid tissue, but its specificity when positive is less certain. AIM:The use of 123I as an imaging agent in p...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/01.mnm.0000194397.20067.b6
更新日期:2006-02-01 00:00:00
abstract::The aims of this study were to develop an objective method for assessing rCBF deficits using a statistical image analysis protocol and to validate its effective use in clinical practice. 99Tcm-HMPAO brain SPET images were acquired for 40 normal subjects, 10 patients with Alzheimer's disease and 10 patients with depres...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199901000-00006
更新日期:1999-01-01 00:00:00
abstract::The purpose of this study was to validate different scintigraphic approaches for assessing acute myocardial infarctions. 201Tl, 99Tcm pyrophosphate (PPi) and combined 201Tl/99Tcm PPi tomograms were evaluated in 115 consecutive patients, in 85 of whom clinical examination revealed acute myocardial infarction. The overa...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199009000-00005
更新日期:1990-09-01 00:00:00
abstract::The purpose of this study was to compare six methods of measuring the left ventricular (LV) transient ischaemic dilation (TID) ratio during stress-rest myocardial perfusion single-photon emission tomography (SPET). The TID ratio was defined as the mean LV short-axis area at stress divided by the mean LV area of simila...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200010000-00013
更新日期:2000-10-01 00:00:00
abstract::(99m)Tc dimercaptosuccinic acid (DMSA) renal scans can provide accurate diagnosis of acute pyelonephritis, its sequelae (renal scars) and differential renal function (DRF). The purposes of this retrospective study were (1) to assess the relationship between DRF obtained during acute pyelonephritis and at follow-up, an...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200210000-00011
更新日期:2002-10-01 00:00:00
abstract:INTRODUCTION:PET/computed tomography (CT) using fluorine-18 fluorodeoxyglucose (F-FDG) has been used in the diagnosis of recurrence and metastases of differentiated thyroid cancer (DTC) in cases of negative whole-body scan (WBS) despite elevated concentrations of stimulated thyroglobulin (Tg). AIM:To assess the utilit...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000563
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:Lymphoid hyperplasia is not uncommon in the midline roof of the nasopharynx. Most nasopharyngeal carcinoma patients present with primary tumors in the midline of the nasopharynx. The aim of this study was to evaluate the efficacy of 2-[fluorine-18] fluoro-2-deoxy-D-glucose ((18)F-FDG) PET/computed tomography (C...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000000141
更新日期:2014-09-01 00:00:00
abstract::We evaluated the clinical usefulness of 99Tcm-N,N-ethylenedicysteine (99Tcm-EC), a new renal tubular agent, in normal children and in children with various renal disorders and compared it with 99Tcm-mercaptoacetyltriglycine (99Tcm-MAG3). In a first group of children (Group 1), which included 15 patients and 4 normal c...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199701000-00009
更新日期:1997-01-01 00:00:00
abstract::A significant number of patients with primary hyperparathyroidism have negative preoperative 201Tl/99Tcm subtraction localization scans. In this study an attempt was made to improve scan localization by creating a period of relative hypocalcaemia and increased parathyroid hormone (PTH) secretion before scanning. Six p...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199109000-00005
更新日期:1991-09-01 00:00:00
abstract::Single photon emission computed tomography (SPECT) imaging of dopamine transporters by using the cocaine derivative [123I]-(1R)-2-beta-carbomethoxy-3-beta-(4-iodophenyl)-tropane ([123I]-beta-CIT) has been shown to be useful in patients with Parkinsonism. The aim of this study was to compare beta-CIT imaging with singl...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200102000-00005
更新日期:2001-02-01 00:00:00
abstract::The technique of 99Tcm-labelled red cell scintigraphy as a means of detecting rebleeding was investigated in 33 patients with bleeding peptic ulcers. Scintigrams were performed twice during the 24 h period succeeding diagnostic endoscopy. There was scintigraphic evidence of rebleeding in 23 patients but this was clini...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198509000-00003
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND:Clinical studies in women using technetium-99m (Tc)-Bombesin have shown successful radionuclide imaging of breast tumours overexpressing gastrin-releasing peptide receptors (GRPRs). Recent studies have demonstrated that most breast tumours overexpress folate receptors (FRα). AIM:The aim of this work was to ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000460
更新日期:2016-04-01 00:00:00
abstract::The aims of this study were (1) to compare N-isopropyl-p-[I-123]-iodoamphetamine (123I-IMP) SPET with computed tomography (CT) in chronic-stage head trauma patients with neurological abnormalities and (2) to quantify regional cerebral blood flow (rCBF) in patients with chronic-stage head trauma. 123I-IMP SPET and CT w...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199501000-00006
更新日期:1995-01-01 00:00:00
abstract::The results of scintigraphy in 29 patients with Cushing's syndrome were evaluated. It was possible to separate bilateral hyperplasia from unilateral abnormality. In cases of unilateral abnormality correct localization of the tumour was accomplished and it was possible to visualize adrenocortical carcinoma. The many ad...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198501000-00005
更新日期:1985-01-01 00:00:00
abstract:AIM:The objective of this study was to assess the relevance of physiological (68)Ga-DOTATATE PET/CT findings in the pancreas guided by morphological imaging (MI) in comparison with pathological tumour uptake in patients with neuroendocrine tumours (NETs). METHODS:A total of 138 patients with pancreatic NET (pNET; n=38...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000106
更新日期:2014-06-01 00:00:00
abstract::A non-invasive technique for the assessment of hepatic haemodynamics using radiocolloid imaging with a computer, in which absolute values of hepatic, mesenteric and splenic arterial effective blood flows were assessed, is described. The technique was carried out on ten volunteers, before and after a standard meal. Aft...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198708000-00002
更新日期:1987-08-01 00:00:00
abstract::Comparisons of gastric emptying between different centres are difficult because of wide variations in methods. Reproducibility of a method is very important before it is used to compare different subjects or to assess the effect of treatment. The aim of this study was to measure the reproducibility of gastric emptying...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199801000-00011
更新日期:1998-01-01 00:00:00
abstract::Following injection for renography, 99Tcm-labelled diethylenetriamine-pentacetic acid (DTPA) rapidly enters the extravascular space. Background therefore comprises two components, a falling intravascular signal and an extravascular signal which initially rises. We estimated the relative magnitudes of these two compone...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198808000-00003
更新日期:1988-08-01 00:00:00
abstract:OBJECTIVE:Patients with normal stress perfusion have an excellent prognosis. Prospective studies on the diagnostic accuracy of stress-only scans with contemporary, independent examinations as gold standards are lacking. PATIENTS AND METHODS:A total of 109 patients with typical angina and no previous coronary artery di...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000000739
更新日期:2017-11-01 00:00:00
abstract::We have developed a new method to replace the conventional method of quantitatively measuring cerebral blood flow (CBF), in which octanol-extracted radioactivity counts are measured in continuous arterial blood samples. With the new method, the whole-brain time-activity curves early after the intravenous injection of ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199806000-00008
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate myocardial findings of F-fluorodeoxyglucose PET/computed tomography (F-FDG PET/CT) after thoracic radiotherapy. METHODS:F-Fluorodeoxyglucose PET/CT examination was performed in 38 patients at least 4 months after radiotherapy. Patients with known cardiac diseases,...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e328362f824
更新日期:2013-09-01 00:00:00
abstract::Conventional nuclear medicine methods for measuring glomerular filtration rate, GFR, are invalidated if the initial injection of radiopharmaceutical is tissued. An analytical method proposed by Veall and Gibbs in 1982 overcomes this difficulty but does require multiple blood samples. This paper investigates whether it...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198611000-00003
更新日期:1986-11-01 00:00:00
abstract::The aims of this study were to establish the percentage of metastatic renal cell carcinoma (RCC) lesions detected by radioimmunoscintigraphy (RIS) with the chimeric monoclonal antibody 131I-cG250 versus positron emission tomography (PET) with 18F-labelled deoxyglucose ([18F]FDG), and to evaluate the use of these radio...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200203000-00005
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVES:This survey was designed to assess the trends in the frequencies of nuclear medicine procedures in the UK and to determine their contributions to the annual collective effective dose to the UK population. The average activities administered by nuclear medicine departments were compared with guidance on diagn...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/01.mnm.0000184939.28994.f9
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is known that fluorine-18 fluorodeoxyglucose PET/computed tomography (CT) segmentation algorithms have an impact on the metabolic tumor volume (MTV). This leads to some uncertainties in PET/CT guidance of tumor radiotherapy. The aim of this study was to investigate the effect of segmentation a...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000641
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:Computed tomography (CT) automatic exposure control (AEC) systems are now used in all modern PET-CT scanners. A collaborative study was undertaken to compare AEC techniques of the three major PET-CT manufacturers for fluorine-18 fluorodeoxyglucose half-body oncology imaging. MATERIALS AND METHODS:An audit o...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000064
更新日期:2014-04-01 00:00:00
abstract::LL1, a monoclonal antibody (MAb) to HLA Class-II-like antigen (li determinant) on the surface of B-lymphocytes, monocytes and histiocytes, was evaluated as an agent for bone marrow imaging. Six patients with diverse diseases (non-Hodgkin's lymphoma, n = 2; multiple myeloma, n = 1; polycythaemia vera, n = 1; lung cance...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00