Abstract:
:Following injection for renography, 99Tcm-labelled diethylenetriamine-pentacetic acid (DTPA) rapidly enters the extravascular space. Background therefore comprises two components, a falling intravascular signal and an extravascular signal which initially rises. We estimated the relative magnitudes of these two components in terms of their impact on the calculation of differential renal function and individual kidney glomerular filtration rate (IKGFR) from the second phase of the 99Tcm-labelled DTPA renogram in 56 paediatric kidneys. We expressed each of the two background signals as a GFR equivalent. The GFR equivalent of the intravascular signal recorded from a peri-renal background region of interest (ROI), scaled by a factor equal to the ratio of the pixel numbers in the renal and background ROIs, was -39 (S.D. 14) ml min-1. The GFR equivalent of the extravascular signal was smaller than this and opposite to it at 23 (S.D. 10) ml min-1, giving a median ratio for the two equivalents of -1.68. Because of the opposing effects of the two background components on the second phase of the renogram, techniques recently described for the quantification of IKGFR from the renogram, and which eliminate the intravascular component, offer no theoretical advantage over a method of analysis which uses 'direct' subtraction of the total background signal. In practice, however, these new techniques are superior in their handling of 'noisy' data, consistently giving a lower coefficient of variation in their estimation of IKGFR.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Peters AM,Gordon I,Evans K,Todd-Pokropek Adoi
10.1097/00006231-198808000-00003subject
Has Abstractpub_date
1988-08-01 00:00:00pages
545-52issue
8eissn
0143-3636issn
1473-5628journal_volume
9pub_type
杂志文章abstract::Equilibrium radionuclide angiography (ERNA) is the 'gold standard' for assessing left ventricular ejection fraction (LVEF). The aim of the study was to determine whether the left ventricular cavity-to-myocardium count ratio (LVCMR) from 201Tl myocardial single photon emission computed tomography (SPECT) correlated wit...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200103000-00004
更新日期:2001-03-01 00:00:00
abstract::Single photon emission computed tomography (SPECT) using N-isopropyl-p-(123I)iodoamphetamine (123I-IMP) and 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HMPAO) was performed in 25 patients with different clinical stages of AIDS encephalopathy. The average interval between the two examinations was 7 days. In 15 of the 2...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract::The aim of this study was to look for regional cerebral blood flow (rCBF) abnormalities in patients with a recent diagnosis of pseudotumour cerebri (PTC) and to compare 99Tcm-hexamethylpropylene amine oxime (99Tcm-HMPAO) cerebral single photon emission tomographic (SPET) findings with those of X-ray computed tomograph...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199608000-00009
更新日期:1996-08-01 00:00:00
abstract::One hundred and twenty-eight patients had a stress test with sestamibi injection and a coronarography within 2 months of the sestamibi study. Sestamibi studies were reconstructed using Hanning 0.65 and Wiener 1.0 filters; the latter improved the results significantly (P < 0.05). Significant correlations were found bet...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199301000-00006
更新日期:1993-01-01 00:00:00
abstract::We performed a prospective study to establish the optimal background correction algorithm for the determination of differential renal function (DRF), using 99Tc(m)-diethylenetriamine pentaacetate (99Tc(m)-DTPA) in the presence of unilateral hydronephrosis, with 24 h 99Tc(m)-dimercaptosuccinic acid (99Tc(m)-DMSA) uptak...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199803000-00009
更新日期:1998-03-01 00:00:00
abstract::Good working practice and legal obligation impose a duty on nuclear medicine departments to check syringe activities before administration to a patient. If syringe guards are used to reduce staff exposure while drawing up injections, the guard has to be removed to measure the activity in a conventional reentrant ioniz...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199708000-00013
更新日期:1997-08-01 00:00:00
abstract::Cystic fibrosis patients require pancreatic enzyme supplements to aid food digestion. It is suspected that incorrect delivery of this enzyme may result in both significant malabsorption and the development of strictures in the proximal colon caused by the high-dose supplement reaching this region before the food. Inve...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199808000-00006
更新日期:1998-08-01 00:00:00
abstract::This paper considers the different statistics that can be derived from studies on the value of diagnostic tests. Well-accepted quantities, such as sensitivity and specificity, are reviewed and the value of the likelihood ratio in communicating particular test results is highlighted. A new quantity, the 'diagnostic val...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/00006231-199810000-00010
更新日期:1998-10-01 00:00:00
abstract::The aim of this study was to assess, by positron emission tomography (PET), the effect on cerebral functional activity of a new lorazepam-gamma-aminobutyric acid (GABA) conjugate [3-(4-acetamido)-butyrril lorazepam (DDS2700)]. Ten healthy volunteers were studied by PET and [18F]fluoro-deoxy-D-glucose ([18F]FDG) under ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200104000-00008
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:To assess the ability of Ga DOTA-NOC PET/computed tomography (CT) to differentiate dural metastases from meningioma. PATIENTS AND METHODS:Patients who underwent a Ga DOTA-NOC PET/CT for differentiating meningiomas from dural metastases were included in the study. A visual score was assigned to the dural lesi...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001155
更新日期:2020-04-01 00:00:00
abstract::Since the appearance of superficial tissue is often an unreliable indicator of deep tissue viability in cases of frostbite, radionuclide scintigraphy with 99Tcm-disodium oxidronate (HDP) was used to assess changes in tissue viability after experimental freezing and thawing of the rabbit ear. One shaved ear, left or ri...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199207000-00010
更新日期:1992-07-01 00:00:00
abstract::Single photon emission computed tomography (SPECT) and positron emission tomography (PET) have advanced our understanding of the biological underpinnings of depression. There is, however, considerable variability in the literature. Depression is a complex disorder with marked heterogeneity in diagnosis and treatment. ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/00006231-200503000-00004
更新日期:2005-03-01 00:00:00
abstract::The Monte Carlo code SIMIND is used in nuclear medicine for research purposes, and also for testing the validity of various applications. Conversion of a SIMIND-generated interfile (header and image data file) is required to process the simulated image data on a Xeleris workstation. Currently there is no conversion pr...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000393
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:This study aimed to assess the efficacy of fluorine-18 fluorodeoxyglucose (F-FDG)-PET for predicting overall survival (OS) and disease-free survival (DFS) in oesophageal cancer patients after definitive chemoradiotherapy (CRT) and prognostic importance of metabolic response detected by post-treatment PET at ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000594
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:To determine whether any patient or hepatic tumor characteristics are predictive of hepatopulmonary shunt fraction when performed before radioembolization. MATERIALS AND METHODS:A retrospective review was performed on 190 patients who underwent preradioembolization hepatic arteriography with calculation of h...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000528
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:A lack of response to cardiac resynchronization therapy (CRT) has been reported in 20-40% of heart failure patients with left ventricular (LV) dyssynchrony who underwent treatment based on the established guidelines. The study aimed to investigate the relationship between (99m)Tc-tetrofosmin ((99m)Tc-TF) myoc...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000000150
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND AND AIM:To evaluate the diagnostic value of integrated 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) to discriminate malignant from benign ovarian tumors. METHODS:One hundred and eight women suspected of having ovarian cancer underwent preoperative FDG-PET/CT sca...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e328345b339
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVES:As PET has become a standard of treatment in patients with cancer, publications of oncologic PET have grown sharply. We aimed to organize the data of meta-analyses of oncologic PET and assess the quality of studies. MATERIALS AND METHODS:The inclusion criteria were studies that meta-analyzed to combine the ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,meta分析
doi:10.1097/MNM.0000000000000908
更新日期:2018-12-01 00:00:00
abstract::Measurements were made of the concentration of radioactivity in the breast milk of two patients: one following 100 MBq (2.7 mCi) 99Tcm-pertechnetate administration, and the other following administration of 550 MBq (15 mCi) 99Tcm-glucoheptonate. The fractional activity concentrations in the former case were about two ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198710000-00011
更新日期:1987-10-01 00:00:00
abstract::A gamma extremity monitoring system (GEMS) has been used to measure finger doses during radio-nuclide dispensing procedures. GEMS uses a small semi-conductor probe that can be attached to a finger from which a continuous read-out can be obtained that is related to dose rate. The pattern of dose accumulation can be ana...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199902000-00013
更新日期:1999-02-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001031
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The widely applied F-FDG is known for its disadvantage in brain tumour PET imaging because of its high background uptake. C-choline can achieve high contrast of brain tumour imaging and was expected to have higher sensitivity and specificity. We analysed the misdiagnoses in C-choline PET imagin...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3282f4a21e
更新日期:2008-04-01 00:00:00
abstract::Tumour uptake of the inert, neutral complex 67Ga-9N3 and the tumour:blood concentration ratio (1,4,7,triazacyclononane-1,4,7, triacetic acid) were measured in mice bearing xenografts of the human melanotic melanoma HX118. Between 1 and 4 h after the injection the tumour:blood ratio increased from 3.5 to 21 and the con...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199209000-00006
更新日期:1992-09-01 00:00:00
abstract::To assess the precision of gated equilibrium radioventriculography in measuring changes in left ventricular stroke volume (LVSV), we studied five dogs each with a chronically implanted electromagnetic flowmeter on the ascending aorta. Per cent changes in left ventricular stroke counts (LVSC) were compared to those in ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198812000-00009
更新日期:1988-12-01 00:00:00
abstract:PURPOSE:Upon diagnosis, distant metastases are encountered in 21-50% of neuroendocrine tumours (NETs). However, few systemic treatment options are available for the well-differentiated NETs in the metastatic stage. Lu-DOTATATE is one of the most effective treatments in this limited patient group. We retrospectively inv...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000874
更新日期:2018-08-01 00:00:00
abstract::A number of authors have indicated a more sensitive detection of renal cortical defects using single photon emission tomography (SPET) compared with planar imaging when performing 99Tcm-dimer-captosuccinic acid (99Tcm-DMSA) renal scintigraphy. The place of SPET in the evaluation of kidneys in adults suspected of acute...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::Venous thromboembolism (VTE) can present as deep vein thrombosis (DVT) and/or acute pulmonary embolism (PE). In fluorine-18 fluorodeoxyglucose (18F-FDG) PET/CT, 18F-FDG activity along the deep veins of the lower extremities (LE) is often observed and, unless it is associated with focal intense activity, is not conside...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000442
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:The liver is the most frequent metastatic site from colorectal cancer and about 20% of these patients are treated by surgical resection. However, the 5-year disease-free survival (DFS) following resection is only about 25% and 5-year overall survival (OS) about 38%. The aim of the study was to evaluate the ab...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001235
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:Ga-PSMA-11 is a novel PET tracer suggested to be used for imaging of advanced prostate cancer. In this study, we aimed to present a detailed biodistribution of Ga-PSMA-11, including physiological and benign variants of prostate-specific membrane antigen (PSMA) imaging. MATERIALS AND METHODS:We carried out a re...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000566
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:In this study, primary tumors' fluorine-18-fluorodeoxyglucose (F-FDG) uptake in luminal A, luminal B, triple-negative, and human epidermal growth factor receptor type-2 subtypes of breast cancer was evaluated. In addition, the relationship between the primary tumor maximum standardized uptake value (SUVmax) v...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000856
更新日期:2018-07-01 00:00:00