Abstract:
OBJECTIVE:To determine whether any patient or hepatic tumor characteristics are predictive of hepatopulmonary shunt fraction when performed before radioembolization. MATERIALS AND METHODS:A retrospective review was performed on 190 patients who underwent preradioembolization hepatic arteriography with calculation of hepatopulmonary shunt fraction using technetium-99m-labeled macroaggregated albumin perfusion scintigraphy. Patient and tumor characteristics including imaging features were reviewed for correlation with absolute shunt fraction, shunt fraction greater than 10%, and shunt fraction greater than 20%. RESULTS:Most tumor types showed some cases of elevated shunt fraction greater than 10%. Six patients had a shunt fraction greater than 20%: four were hepatocellular carcinoma and two were neuroendocrine tumor metastases. Univariate analysis showed that dominant tumor diameter, hepatic tumor burden, vascular invasion, hepatic venous invasion, and hypervascularity on angiography were associated with a shunt fraction greater than 10%. Only dominant tumor diameter and vascular invasion were associated with a shunt fraction greater than 20%. On multivariate analysis, only tumor diameter (odds ratio 1.2) and hepatic venous invasion (odds ratio 23.0) were associated independently with an increased shunt fraction greater than 10%. CONCLUSION:Multiple patient and tumor-related characteristics were significantly correlated with the hepatopulmonary shunt fraction on univariate analysis. However, on multivariate analysis, only the dominant tumor diameter and presence of hepatic venous invasion were associated independently with a greater than 10% shunt fraction.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Yerubandi V,Ronald J,Howard BA,Suhocki PV,James OG,Wong TZ,Kim CYdoi
10.1097/MNM.0000000000000528subject
Has Abstractpub_date
2016-09-01 00:00:00pages
939-46issue
9eissn
0143-3636issn
1473-5628journal_volume
37pub_type
杂志文章abstract:AIM:To perform a detailed analysis of the performance of mobile intraoperative imaging systems and gamma probes in a phantom set-up, and compare this with a conventional gamma camera. METHODS:Two separate experiments were performed. In the first, a modified Jaszczak phantom equipped with five (99m)Tc-filled hot sphere...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3283508577
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:Paragangliomas are rare tumours of neural crest origin that express high levels of somatostatin receptor. Ga-68 DOTATATE PET/CT is a widely accepted method for imaging of neuroendocrine tumours. This study was performed to review a Ga-68 DOTATATE PET/CT patient database and to establish the impact of the moda...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001130
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:Sickle cell disease (SCD) is a common hematologic hereditary disorder characterized by vaso-occlusive episodes affecting multiple organs, and substantially alters renal structure and function. We aimed to evaluate the utility of renal scintigraphy and single photon emission computed tomography/computed tomograp...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000001086
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Single photon emission tomography (SPECT) of the lung is a well-established non-invasive technique for quantitative assessment of regional lung ventilation and perfusion distribution in children and in adults. However, its application in neonates as well as infants has been scarce because of several practica...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3282f25905
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to investigate the diagnostic value of fluorodeoxyglucose-18 (FDG)-PET/computed tomography (CT) and MRI parameters in determining the molecular subtypes of invasive breast cancer. METHODS:Data from 55 primary invasive breast cancer masses in 51 female patients who underwent pre-treat...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001220
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:The standard imaging used for delineation of dominant intraprostatic lesion (DIL) is multiparametric MRI (mpMRI). The use of biologic imaging such as Ga-68 prostate-specific membrane antigen (PSMA) PET-computed tomography (PET-CT) for this purpose is being explored in view of increased sensitivity of this modal...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001283
更新日期:2020-12-01 00:00:00
abstract::In a search for a rapid and accurate imaging agent for scintigraphic detection of infection and inflammation, an LTB4 receptor antagonist, 99Tcm-RP517, which contains the hydrazino nicotinamide moiety, has been developed recently. To study the in vivo behaviour of 99Tcm-RP517, rabbits with Escherichia coli infection w...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200011000-00010
更新日期:2000-11-01 00:00:00
abstract::Esophageal cancer is the third most common malignancy of the alimentary tract. The incidence of esophageal cancer has steadily increased over the past three decades. Almost all therapeutic modalities for esophageal cancer are associated with a considerable mortality and morbidity. Consequently, there has been growing ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/MNM.0b013e32831af204
更新日期:2009-02-01 00:00:00
abstract::Fluorine-18-sodium fluoride (F-NaF) PET/CT is a relatively new and high-resolution bone imaging modality. Since the use of F-NaF PET/CT has been increasing, it is important to accurately assess the images and be aware of normal distribution and major artifacts. In this pictorial review article, we will describe the no...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/MNM.0000000000000720
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare the sensitivity of single-photon emission computed tomography/computed tomography (SPECT/CT) using 99mTc-sestamibi (MIBI) with that of PET/CT using 11C-methionine (MET) for localization of parathyroid adenomas/hyperplasia in primary hyperparathyroidism. MATERIALS AND ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000216
更新日期:2015-01-01 00:00:00
abstract::Increasingly, dual-detector gamma cameras are being purchased as replacements for single-headed cameras. The improvement in sensitivity offered by a dual-detector device can be used in several ways: to shorten acquisition times, to improve signal-to-noise ratios, or to reduce administered doses. This paper focuses on ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/00006231-199507000-00003
更新日期:1995-07-01 00:00:00
abstract::A significant number of patients with primary hyperparathyroidism have negative preoperative 201Tl/99Tcm subtraction localization scans. In this study an attempt was made to improve scan localization by creating a period of relative hypocalcaemia and increased parathyroid hormone (PTH) secretion before scanning. Six p...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199109000-00005
更新日期:1991-09-01 00:00:00
abstract::Technetium-99m-sestamibi (99mTc-MIBI) imaging is a well-established modality in oncologic investigations. The current study aimed to investigate whether any relationship could be found between 99mTc-MIBI uptake and local perfusion in malignant bone and soft-tissue tumours. It also aimed to compare 99mTc-MIBI images wi...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200106000-00012
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:Simulated data from the recent Institute of Physics and Engineering in Medicine audit of quantitative cerebral perfusion were used to optimize the parameters of eigenimage analysis, a method for computer-aided detection. METHODS:Twenty normal images provided by the audit were registered to the International ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32832cc273
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:To measure and describe patterns of interobserver variation in visual interpretation of 18-FDG PET in malignant lymphoma. METHODS:Eleven nuclear medicine physicians with different levels of PET experience independently reviewed 37 18F-FDG PET scans of lymphoma patients (10 obtained at presentation, 27 during...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3282eff2d5
更新日期:2007-10-01 00:00:00
abstract::This paper considers the different statistics that can be derived from studies on the value of diagnostic tests. Well-accepted quantities, such as sensitivity and specificity, are reviewed and the value of the likelihood ratio in communicating particular test results is highlighted. A new quantity, the 'diagnostic val...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/00006231-199810000-00010
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:Gated blood-pool single-photon emission computed tomography (GBPS) was compared with cardiac magnetic resonance (CMR) for the measurement of left ventricular (LV) and right ventricular (RV) ejection fractions (EF) and volumes [end-diastolic volume (EDV) or end-systolic volume (ESV)] in a mixed population. ME...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0b013e32834155f1
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:Patients with normal stress perfusion have an excellent prognosis. Prospective studies on the diagnostic accuracy of stress-only scans with contemporary, independent examinations as gold standards are lacking. PATIENTS AND METHODS:A total of 109 patients with typical angina and no previous coronary artery di...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000000739
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:PET/computed tomography (CT) imaging with the sodium-(F)-fluoride/2-(F)-fluoro-2-deoxy-D-glucose (F-NaF/F-FDG) cocktail has been proposed for patients with osseous metastases. This work aimed to optimize the cocktail composition for patients with metastatic castration-resistant prostate cancer (mCRPC). MATE...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000383
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:The herpes simplex virus thymidine kinase (HSVtk) gene has frequently been applied as a reporter gene for monitoring transgene expression in animal models. In clinical gene therapy protocols, however, extremely low expression levels of the transferred gene are generally observed. Consequently, sensitive and s...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/01.mnm.0000186609.12895.20
更新日期:2006-01-01 00:00:00
abstract::Quantification of the number of receptors per cell (NRPC) is important when assessing whether a tumor surface biomarker is suitable for medical imaging. One common method for NPRC quantification is to use a binding saturation assay, which is time consuming and requires large amounts of reagents. The aim of this study ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3283483e1c
更新日期:2011-09-01 00:00:00
abstract::To clarify the biological significance of [18F]fluorodeoxyglucose (18F-FDG) accumulation in patients with cancer, we assessed the relationships between 18F-FDG uptake and glucose transporter-1 (GLUT-1) expression and proliferation rate in human glioma and lung cancer. We obtained FDG PET images and measured standardiz...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200401000-00003
更新日期:2004-01-01 00:00:00
abstract::Thallium-201 (201Tl) stress-redistribution/reinjection imaging provides a reliable diagnostic approach in patients evaluated for myocardial ischaemia. Immediate reinjection of 201Tl after completing the stress images followed by imaging 1 h later shortens the investigation time to 2.5 h and may provide a novel approac...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::Orofacial granulomatosis is a granulomatous inflammatory disorder, affecting the soft tissues of the face and mouth. The predominant feature is disfiguring lip swelling. Patients with this condition may be exhibiting a Type IV hypersensitivity reaction to dietary or environmental allergens, or these may be the orofaci...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200002000-00006
更新日期:2000-02-01 00:00:00
abstract::In addition to imaging, radionuclide venography can be used for studying haemodynamic changes in superior vena cava syndrome (SVCS) by using the indices of transit time (TT), time of half peak count (TH) and peak count ratio (PC ratio). The objective of this study was to examine the utility of applying these indices, ...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-199805000-00003
更新日期:1998-05-01 00:00:00
abstract:AIMS:Peptide receptor radionuclide therapy (PRRT) has been shown to be useful in inoperable/metastatic medullary thyroid carcinoma (MTC). However, the role of concomitant PRRT and low-dose capecitabine therapy has not yet been studied in these patients. This study was conducted to evaluate the efficacy and safety of th...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001205
更新日期:2020-07-01 00:00:00
abstract::While 18F-FDG labelling of monocytes would allow in vivo trafficking with positron emission tomography (PET), present methods suffer from poor retention of radioactivity. We investigated the feasibility of utilizing insulin for improved [18F]fluorodeoxyglucose (18F-FDG) labelling. Separated human monocytes and lymphoc...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200206000-00007
更新日期:2002-06-01 00:00:00
abstract::The effect of the dual window scatter subtraction method was tested for first-pass radiocardiography using 99Tcm. The photopeak window of 126-154 keV (20%) and Compton window of 93-125 keV (30%) were used. The set of scattered images was multiplied by a factor of 0.4 and subtracted from the primary images. The size of...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199611000-00009
更新日期:1996-11-01 00:00:00
abstract:PURPOSE:Despite the growing use of fluorine-18-fluorodeoxyglucose (F-FDG) PET texture analysis to measure intratumoural heterogeneity in cancer research, the biologic basis of F-FDG PET-derived texture variables is poorly understood. We aimed to assess correlations between F-FDG PET-derived texture variables and whole-...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000000925
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:Determine the prevalence of benign indium-111 (In) pentetreotide uptake in the pancreatic head and determine if a semi-quantitative method can be used to differentiate physiologic from pathologic uptake. PATIENTS AND METHODS:Institutional Review Board-approved, HIPAA-compliant retrospective review of 197 som...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001022
更新日期:2019-07-01 00:00:00