Technetium-99m-dimercaptosuccinic acid renal scintigraphy and single photon emission computed tomography/computed tomography in patients with sickle cell disease.

Abstract:

PURPOSE:Sickle cell disease (SCD) is a common hematologic hereditary disorder characterized by vaso-occlusive episodes affecting multiple organs, and substantially alters renal structure and function. We aimed to evaluate the utility of renal scintigraphy and single photon emission computed tomography/computed tomography (SPECT/CT) with technetium-99m-dimercaptosuccinic acid (Tc-DMSA) in adult patients with SCD and no clinical evidence of renal insufficiency. MATERIALS AND METHODS:Twenty-six patients (16 female) aged 23-58 years with SCD and no clinical evidence of renal insufficiency were prospectively studied. Planar and SPECT/CT images were, respectively, obtained after 3 and 4 hours of the injection of 110-180 MBq of Tc-DMSA. The relative radiopharmaceutical uptake and renal length were, respectively, determined using SPECT and CT images. Planar and SPECT/CT images were visually analyzed to identify focal areas of Tc-DMSA reduced uptake and anatomical deformities of the kidneys. RESULTS:Focal areas of reduced Tc-DMSA uptake with an image aspect of renal scars or inflammation were present in 21/26 patients (81%). In 11/21 (52%) of these patients, the cortical lesions were clearly identified only on SPECT images. Prominent renal columns were observed in 17/26 (65%) patients. The left kidney tended to be more affected than the right kidney. Most patients had enlarged kidneys. CONCLUSION:Tc-DMSA scintigraphy and SPECT/CT identify renal lesions possible related to renal infarcts or infections in most adult patients with SCD and no clinical evidence of renal insufficiency. Prominent renal columns and increased renal size tend to occur in most of these patients.

journal_name

Nucl Med Commun

authors

Ramos CD,Onusic DM,Brunetto SQ,Amorim BJ,Souza TF,Saad STO,Lima MDCL

doi

10.1097/MNM.0000000000001086

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

1158-1165

issue

11

eissn

0143-3636

issn

1473-5628

journal_volume

40

pub_type

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