Abstract:
PURPOSE:Sickle cell disease (SCD) is a common hematologic hereditary disorder characterized by vaso-occlusive episodes affecting multiple organs, and substantially alters renal structure and function. We aimed to evaluate the utility of renal scintigraphy and single photon emission computed tomography/computed tomography (SPECT/CT) with technetium-99m-dimercaptosuccinic acid (Tc-DMSA) in adult patients with SCD and no clinical evidence of renal insufficiency. MATERIALS AND METHODS:Twenty-six patients (16 female) aged 23-58 years with SCD and no clinical evidence of renal insufficiency were prospectively studied. Planar and SPECT/CT images were, respectively, obtained after 3 and 4 hours of the injection of 110-180 MBq of Tc-DMSA. The relative radiopharmaceutical uptake and renal length were, respectively, determined using SPECT and CT images. Planar and SPECT/CT images were visually analyzed to identify focal areas of Tc-DMSA reduced uptake and anatomical deformities of the kidneys. RESULTS:Focal areas of reduced Tc-DMSA uptake with an image aspect of renal scars or inflammation were present in 21/26 patients (81%). In 11/21 (52%) of these patients, the cortical lesions were clearly identified only on SPECT images. Prominent renal columns were observed in 17/26 (65%) patients. The left kidney tended to be more affected than the right kidney. Most patients had enlarged kidneys. CONCLUSION:Tc-DMSA scintigraphy and SPECT/CT identify renal lesions possible related to renal infarcts or infections in most adult patients with SCD and no clinical evidence of renal insufficiency. Prominent renal columns and increased renal size tend to occur in most of these patients.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Ramos CD,Onusic DM,Brunetto SQ,Amorim BJ,Souza TF,Saad STO,Lima MDCLdoi
10.1097/MNM.0000000000001086subject
Has Abstractpub_date
2019-11-01 00:00:00pages
1158-1165issue
11eissn
0143-3636issn
1473-5628journal_volume
40pub_type
临床试验,杂志文章abstract::Using radionuclide methods the relationship between total and central blood volume and left ventricular function was studied in 12 patients with untreated essential hypertension and contrasted with the findings in eight normotensive subjects. The principal findings were of an increased stroke volume and end-diastolic ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198410000-00002
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journal_title:Nuclear medicine communications
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199105000-00010
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pub_type: 杂志文章
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doi:10.1097/00006231-199307000-00013
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
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更新日期:1995-02-01 00:00:00
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journal_title:Nuclear medicine communications
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journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
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journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
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更新日期:2017-05-01 00:00:00
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更新日期:2011-07-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
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更新日期:2004-02-01 00:00:00
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更新日期:2006-04-01 00:00:00