Abstract:
:Chronic exertional compartment syndrome (CECS) is currently diagnosed using invasive pressure measurements. We report the use of 99Tcm-methoxyisobutyl isonitrile (99Tcm-MIBI) scintigraphy as a new non-invasive method of diagnosis. Forty-six patients with suspected chronic compartment syndrome underwent graded treadmill exercise to reproduce the presenting symptoms. At peak exercise, 300 MBq of 99Tcm-MIBI were injected intravenously. Subsequent cross-sectional imaging provided by emission tomography demonstrated regional abnormalities in muscle perfusion in the calf. A repeat study was performed at rest the following day. All patients in whom there was a strong clinical suspicion of CECS were considered for invasive pressure measurements. Statistical analysis of the results for investigation of CECS using 99Tcm-MIBI versus pressure studies gave P = 0.06. A comparison of 99Tcm-MIBI versus outcome gave P < 0.0001. The sensitivity was 80% and the specificity 97% for 99Tcm-MIBI studies based on outcome. The positive predictive value was 89% and the negative predictive value 94%. Thus 99Tcm-MIBI can detect compartment syndromes with good positive and negative predictive values. It is relatively simple, cheap and less invasive than pressure measurements. This technique shows promise in the diagnosis of CECS.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Edwards PD,Miles KA,Owens SJ,Kemp PM,Jenner JRdoi
10.1097/00006231-199903000-00003keywords:
subject
Has Abstractpub_date
1999-03-01 00:00:00pages
215-8issue
3eissn
0143-3636issn
1473-5628journal_volume
20pub_type
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199311000-00007
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199508000-00009
更新日期:1995-08-01 00:00:00
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journal_title:Nuclear medicine communications
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journal_title:Nuclear medicine communications
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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journal_title:Nuclear medicine communications
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章
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