Stunning phenomenon after a radioactive iodine- ¹³¹I diagnostic whole-body scan: Is it really a point of clinical consideration?

Abstract:

PURPOSE:Stunning of thyroid remnants after diagnostic scanning (Dx-WBS) using radioactive iodine- (¹³¹I) may limit the efficacy of I therapy. We aimed to evaluate this assumption in a prospectively designed study. METHODS:Forty patients who underwent thyroidectomy for differentiated thyroid carcinoma were studied and divided into two identical groups: G1 and G2. In the G1 group, no Dx-WBS was performed and the ablation dose was given directly on the basis of the risk stratification; in the G2 group, Dx-WBS was performed with 185 MBq (5 mCi) of ¹³¹I, and ablation was given for a mean number of 11 ± 1.1 days; stunning was found on a semiquantitative basis in all patients. At a mean of 6.5 ± 0.3 months, the ablation success rate (ASR) was evaluated on the basis of Dx-WBS, thyroglobulin levels, and neck sonography. Complete ASR was considered when no ¹³¹I uptake could be seen in the neck or elsewhere, thyroglobulin was less than 2 ng/ml, and neck sonography was negative for any disease-related abnormalities. RESULTS:G1 and G2 groups were completely identical as no significant differences were found between their different characteristics, including the mean ablative dose. ASR was 81.7 and 78.3% in G1 and G2 groups, respectively (P=0.6). Multivariate Cox regression analysis showed the mean ablation dose to be the most influential factor in ASR (odds ratio 1.045; 95% confidence interval 0.936-1.1189; P=0.01). CONCLUSION:Our data suggest that stunning had no influence on ASR and is not a point of clinical consideration with respect to this aspect.

journal_name

Nucl Med Commun

authors

Amin A,Amin M,Badwey A

doi

10.1097/MNM.0b013e328362ad63

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

771-6

issue

8

eissn

0143-3636

issn

1473-5628

journal_volume

34

pub_type

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