99mTc-HL91 is inferior to 201Tl in scintigraphic detection of chronic myocardial ischaemia.

Abstract:

AIM:99mTc-HL91 is a new hypoxia agent and can identify acutely ischaemic viable myocardium in a canine model using a standard gamma camera. The purpose of the study was to determine whether this tracer could be used to detect regional ischaemia in chronic ischaemic myocardium in a swine model. METHOD:Using a porcine model of chronic myocardial ischaemia, five mini-pigs with proximal left anterior descending artery (LAD) stenoses were studied. Injection of 462.5 MBq (12.5 mCi) 99mTc-HL91 was followed by imaging over 2 h. Coronary angiography and dipyridamole stress-re-injection 201Tl single photon emission computed tomography (SPECT) were performed within 1 day of each other. RESULTS:None of the five pigs demonstrated positive hot 99mTc-HL91 uptake throughout the 2 h imaging, whereas four of the five animals showed significant myocardial ischaemia on 201Tl SPECT. The region of interest analysis of LAD/left circumflex artery count ratios at 1 and 2 h demonstrated similar 99mTc-HL91 uptake and retention in chronic ischaemic as well as non-ischaemic myocardium. CONCLUSION:99mTc-HL91 is inferior to 201Tl in scintigraphic detection of chronic myocardial ischaemia.

journal_name

Nucl Med Commun

authors

Wu YW,Lee CM,Huang YH,Chou NK,Yen RF,Tzen KY,Huang PJ

doi

10.1097/00006231-200512000-00012

keywords:

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

1119-23

issue

12

eissn

0143-3636

issn

1473-5628

pii

00006231-200512000-00012

journal_volume

26

pub_type

杂志文章
  • The predictive value of C-reactive protein and erythrocyte sedimentation rate for 18F-FDG PET/CT outcome in patients with fever and inflammation of unknown origin.

    abstract:OBJECTIVES:The objective of this study was to determine the predictive value of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) to a positive fluorine-18 fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (CT) result in patients with inflammation of unknown origin and fever of unknown origin. PAT...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000300

    authors: Balink H,Veeger NJ,Bennink RJ,Slart RH,Holleman F,van Eck-Smit BL,Verberne HJ

    更新日期:2015-06-01 00:00:00

  • Management and evaluation of sodium [131I] iodide contamination after oral administration.

    abstract::Radioiodine therapy using oral administration of Iodine-131 (I) is a widespread employed strategy for the treatment of hyperthyroidism and thyroid cancer. Such a therapy requires well-trained staff, equipment and procedures regarding radiation safety. The aims of this work are to report an incidental experience of rad...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001276

    authors: Labbe E,Peyronnet D,Desmonts C,Vigne J

    更新日期:2020-11-01 00:00:00

  • Multidose use of exametazine for leukocyte labelling: a new approach using tin enhancement.

    abstract::Reconstituted exametazime is inherently unstable due to the rapid oxidation of the small amount (7.6 micrograms) of stannous chloride present in the kit. A novel approach has been used to improve the shelf-life of reconstituted exametazime based on the premise that tin lost through oxidation should be replaced by furt...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199311000-00016

    authors: Solanki C,Li DJ,Wong A,Miles KA,Sampson CB

    更新日期:1993-11-01 00:00:00

  • Assessment of left ventricular volume and ejection fraction: comparison of QGS and MBGS analyses of ECG-gated myocardial perfusion SPECT imaging.

    abstract:OBJECTIVES:The purpose of this study was to compare quantitative ECG-gated single-photon emission computed tomography (SPECT) (QGS) and model-based ECG-gated single-photon emission computed tomography (MBGS) for determination of end-diastolic cardiac volume (EDV), end-systolic cardiac volume (ESV), and left ventricular...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3283294d19

    authors: Khorsand A,Gyöngyösi M,Graf S,Zamini S,Schuster E,Sochor H,Porenta G

    更新日期:2009-04-01 00:00:00

  • Depression and anxiety during isolation and radionuclide therapy.

    abstract::The combination of a diagnosis of malignancy and hospitalization, isolation and radioactivity of a radionuclide therapy may have an important effect on the psychological equilibrium of patients and may hamper compliance and acceptability. We performed a psychiatric evaluation in order to study psycho-pathological mani...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.mnm.0000084586.29433.83

    authors: Brans B,van den Eynde F,Audenaert K,Vervaet M,van Daele K,van Heeringen C,Dierckx RA

    更新日期:2003-08-01 00:00:00

  • Risk factors for extensive skeletal muscle uptake in oncologic FDG-PET/CT for patients undergoing a 4-h fast.

    abstract:OBJECTIVES:Postprandial insulin secretion causes extensive skeletal muscle accumulation (ESMA) of fluorine-18 fluorodeoxyglucose (FDG), which adversely affects visual interpretation of FDG-PET/CT. We investigated factors related to ESMA despite a fast of at least 4 h. METHODS:A total of 3595 patients underwent FDG-PET...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328352290f

    authors: Nakatani K,Nakamoto Y,Togashi K

    更新日期:2012-06-01 00:00:00

  • Interpretation, accuracy and management implications of FDG PET/CT in cutaneous malignant melanoma.

    abstract:PURPOSE:To investigate the accuracy of different interpretative approaches and to evaluate the management implications of fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in cutaneous malignant melanoma. METHODS:We retrospectively identified 60 consecutive patients who underwent 76 PET/...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e3280708ecf

    authors: Falk MS,Truitt AK,Coakley FV,Kashani-Sabet M,Hawkins RA,Franc B

    更新日期:2007-04-01 00:00:00

  • Formulation and characterization of lutetium-177-labeled stannous (tin) colloid for radiosynovectomy.

    abstract:OBJECTIVE:Easy large-scale production, easy availability, cost-effectiveness, long half-life, and favorable radiation characteristics have made lutetium-177 (Lu) a preferred radionuclide for use in therapy. Lutetium-177-labeled stannous (Lu-Sn) colloid particles were formulated for application in radiosynovectomy, foll...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000684

    authors: Arora G,Singh M,Jha P,Tripathy S,Bal C,Mukherjee A,Shamim SA

    更新日期:2017-07-01 00:00:00

  • PET-CT imaging features that differentiate between positive and negative EWSR1 translocation in Ewing sarcoma.

    abstract:OBJECTIVES:Ewing sarcoma breakpoint region 1 (EWSR1) translocation-negative tumors represent a minor portion of small round cell tumors consistent with Ewing sarcoma morphology. The purpose of this study was to differentiate EWSR1 translocation-positive tumors from EWSR1 translocation-negative tumors using PET-computed...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001031

    authors: Soffer S,Amitai MM,Weizen R,Retter A,Barshack I,Shimon O,Davidson T,Klang E

    更新日期:2019-08-01 00:00:00

  • False-positive F-18 FDG uptake in PET/CT studies in pediatric patients with abdominal Burkitt's lymphoma.

    abstract:INTRODUCTION:In pediatric patients with abdominal Burkitt's lymphoma, the involvement of the gastrointestinal tract and abdominal lymph nodes are the main presenting feature of the disease. Chemotherapy is the main treatment modality and could be preceded by surgical excision of the abdominal masses. To achieve cure or...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328334fc14

    authors: Riad R,Omar W,Sidhom I,Zamzam M,Zaky I,Hafez M,Abdel-Dayem HM

    更新日期:2010-03-01 00:00:00

  • Intraperitoneal 131I- and 111In-791T/36 monoclonal antibody in recurrent ovarian cancer: imaging and biodistribution.

    abstract::An examination of the biokinetics and biodistribution of i.p. administered 131I- or 111In-labelled 791T/36 antibody (1 mg) has been carried out in five patients with stage III/IV ovarian cancer. Blood kinetics and urinary excretion of the radiolabels were assayed. Scintigraphy was performed immediately following admin...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198908010-00006

    authors: Perkins AC,Pimm MV,Gie C,Marksman RA,Symonds EM,Baldwin RW

    更新日期:1989-08-01 00:00:00

  • Pre-surgical identification of epileptogenic areas in temporal lobe epilepsy by 123I-iomazenil SPECT: a comparison with IMP SPECT and FDG PET.

    abstract:OBJECTIVES:The aim of this study was to evaluate the usefulness of (123)I-iomazenil (IMZ) single photon emission computed tomography (SPECT) for the pre-surgical identification of epileptogenic areas in patients with temporal lobe epilepsy and to compare the results with those of (123)I-IMP SPECT and (18)Fluorodeoxyglu...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/01.mnm.0000243380.79872.32

    authors: Kaneko K,Sasaki M,Morioka T,Koga H,Abe K,Sawamoto H,Ohya N,Yoshiura T,Mihara F,Honda H

    更新日期:2006-11-01 00:00:00

  • Correlation of 99mTc-sestamibi uptake with blood-pool and osseous phase 99mTc-MDP uptake in malignant bone and soft-tissue tumours.

    abstract::Technetium-99m-sestamibi (99mTc-MIBI) imaging is a well-established modality in oncologic investigations. The current study aimed to investigate whether any relationship could be found between 99mTc-MIBI uptake and local perfusion in malignant bone and soft-tissue tumours. It also aimed to compare 99mTc-MIBI images wi...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200106000-00012

    authors: Ozcan Z,Burak Z,Erinç R,Dirlik A,Başdemir G,Sabah D,Ozkiliç H

    更新日期:2001-06-01 00:00:00

  • The impact of PET/CT imaging performed in the early postoperative period on the management of breast cancer patients.

    abstract:OBJECTIVES:The aim of the study was to evaluate the role of F-fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (CT) in the early postoperative staging of breast cancer and to document (18)F-FDG PET/CT-based stage alterations and any subsequent impact on management. MATERIALS AND METHODS:Between January 2009 and ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328360d8ec

    authors: Sen F,Akpinar AT,Ogur U,Duman G,Tamgac F,Alper E

    更新日期:2013-06-01 00:00:00

  • Clinical implications of the differences between diagnostic 123I and post-therapy 131I scans.

    abstract:BACKGROUND:123I has been promoted for diagnostic imaging as a means of avoiding 'stunning'. It has also been suggested that the more favourable physical characteristics and consequent enhanced imaging resolution provided by 123I offers a more accurate diagnostic assessment of the extent of disease prior to therapy. Thi...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200402000-00006

    authors: Cohen JB,Kalinyak JE,McDougall IR

    更新日期:2004-02-01 00:00:00

  • Predictive approaches for post-therapy PET/CT in patients with extranodal natural killer/T-cell lymphoma: a retrospective study.

    abstract:PURPOSE:The aim of this study was to assess the prognostic capacity of three methods of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT analysis carried out after therapy in patients with extranodal natural killer/T-cell lymphoma (ENKTL). The three methods of PET/CT analysis included the International Harmonization Proje...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000731

    authors: Jiang C,Liu J,Li L,Kosik RO,Su M,Zou L,Tian R

    更新日期:2017-11-01 00:00:00

  • Pentavalent 99Tcm-DMSA imaging in patients with bone metastases.

    abstract::Pentavalent 99Tcm-dimercaptosuccinic acid (99Tcm-(V)DMSA) has an established role in imaging medullary thyroid carcinoma. There have been case reports of uptake in bone metastases. Our aims were to compare 99Tcm-(V)DMSA with 99Tcm-hydroxymethylene diphosphonate (99Tcm-HDP) in bone metastases, to assess its value in im...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199710000-00003

    authors: Lam AS,Kettle AG,O'Doherty MJ,Coakley AJ,Barrington SF,Blower PJ

    更新日期:1997-10-01 00:00:00

  • A new non-invasive test for the detection of compartment syndromes.

    abstract::Chronic exertional compartment syndrome (CECS) is currently diagnosed using invasive pressure measurements. We report the use of 99Tcm-methoxyisobutyl isonitrile (99Tcm-MIBI) scintigraphy as a new non-invasive method of diagnosis. Forty-six patients with suspected chronic compartment syndrome underwent graded treadmil...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199903000-00003

    authors: Edwards PD,Miles KA,Owens SJ,Kemp PM,Jenner JR

    更新日期:1999-03-01 00:00:00

  • Can administration of metoclopramide reduce artefacts related to abdominal activity in myocardial perfusion SPECT?

    abstract:OBJECTIVES:Myocardial perfusion SPECT is frequently affected by artefacts related to abdominal activity. Metoclopramide has been suggested to relieve this, but two previous studies have shown conflicting results. METHODS:Ninety-five patients received 10 mg metoclopramide orally after injection of 99mTc-tetrofosmin for...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.mnm.0000243368.73141.61

    authors: Grüning T,Brogsitter C,Khonsari M,Jones IW,Nevin SM,Burchert W

    更新日期:2006-12-01 00:00:00

  • Appropriate utilization of semi-quantitative analysis in salivary scintigraphy.

    abstract:AIM:The purpose of this case-control study was to determine whether semi-quantitative indices derived from salivary time-activity curves (TACs) are useful in the diagnosis and management of xerostomia. METHODS:Twenty-six healthy volunteers and 83 consecutive patients with xerostomia, including a subset of 40 patients ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200412000-00009

    authors: Booker J,Howarth D,Taylor L,Voutnis D,Sutherland D

    更新日期:2004-12-01 00:00:00

  • The early plasma concentration of 51Cr-EDTA in patients with cirrhosis and ascites: a comparison of three models.

    abstract:OBJECTIVES:The aim of the study was to determine which of three two-parameter fitting functions (exponential, linear-log, and negative-power function of time) most accurately models early chromium-51-EDTA (51Cr-EDTA) plasma concentration data prior to 120 min in patients with cirrhosis and ascites and understand how th...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000255

    authors: Wanasundara SN,Wesolowski MJ,Puetter RC,Burniston MT,Xirouchakis E,Giamalis IG,Babyn PS,Wesolowski CA

    更新日期:2015-04-01 00:00:00

  • Optimization of the radiosynthesis of [68Ga]Ga-PSMA-11 using a Trasis MiniAiO synthesizer: do we need to heat and purify?.

    abstract::INTRODUTION:: [Ga]Ga-prostate specific membrane antigen (PSMA)-11 showed a clear gain in sensitivity for lesion detection in the biological recurrence of prostate cancer as compared to the standard [F]fluorocholine radiopharmaceutical. To meet the strong demand for [Ga]Ga-PSMA-11, we aimed to optimize an automated rad...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001233

    authors: Reverchon J,Khayi F,Roger M,Moreau A,Kryza D

    更新日期:2020-06-18 00:00:00

  • Influence of early (F+0) intravenous furosemide injection on the split renal function using 99mTc-DTPA renography.

    abstract::In busy nuclear medicine departments, the F+0 protocol for diuretic renography is routinely used to shorten the acquisition time. The aim of this study was to evaluate the influence of the F+0 protocol on the split renal function (SRF) during a dynamic renal scan using technetium-99m diethylene triamine pentaacetic ac...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e32835e7437

    authors: Kandeel AA,Elhossainy SA,Elsayed ND

    更新日期:2013-04-01 00:00:00

  • A method for estimating the integral of the input function for the quantification of cerebral blood flow with 123I-IMP using one-point arterial blood sampling.

    abstract::We have developed a new method to replace the conventional method of quantitatively measuring cerebral blood flow (CBF), in which octanol-extracted radioactivity counts are measured in continuous arterial blood samples. With the new method, the whole-brain time-activity curves early after the intravenous injection of ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199806000-00008

    authors: Fujioka H,Murase K,Inoue T,Ishimaru Y,Akamune A,Yamamoto Y,Ikezoe J

    更新日期:1998-06-01 00:00:00

  • Reliability of left ventricular ejection fraction calculated with gated myocardial perfusion single photon emission computed tomography in patients with extensive perfusion defect.

    abstract:INTRODUCTION:Gated myocardial perfusion scintigraphy (g-MPS) provides functional information on the left ventricle (LV) apart from the perfusion status. Computer algorithm-based LV ejection fraction (EF) calculated from resting g-MPS has been found to be reliable in patients with normal perfusion. However, its role in ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e328342b97e

    authors: Harisankar CN,Mittal BR,Kamaleshwaran KK,Parmar M,Bhattacharya A,Singh B,Mahajan R

    更新日期:2011-06-01 00:00:00

  • The efficacy of the available peptide receptor radionuclide therapy for neuroendocrine tumors: a meta-analysis.

    abstract:AIM:This study was carried out to compare the efficacy of Y, Lu, and combination of both radiotracers (tandem) peptide receptor radionuclide therapy (PRRT) in patients with inoperable and metastatic neuroendocrine tumors. MATERIALS AND METHODS:Systematic searches of PubMed and SciVerse Scopus databases were performed ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,meta分析

    doi:10.1097/MNM.0000000000000758

    authors: Dannoon SF,Alenezi SA,Elgazzar AH

    更新日期:2017-12-01 00:00:00

  • Differential renal function estimation by dynamic renal scintigraphy: influence of background definition and radiopharmaceutical.

    abstract:OBJECTIVES:Differential renal function (DRF) calculation with 99mTc-diethylenetriamine-pentaacetic acid (DTPA) or mercaptoacetyltriglycine (MAG3) is gaining clinical importance in the evaluation of patients with ureteropelvic junction obstruction with hydronephrosis (HN). Although many decisions regarding surgery are b...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e32830978af

    authors: Caglar M,Gedik GK,Karabulut E

    更新日期:2008-11-01 00:00:00

  • Morphine-augmented hepatobiliary scintigraphy: a meta-analysis.

    abstract::The aim of this study was to compare the sensitivity and specificity of morphine-augmented hepatobiliary scintigraphy (MA-HBS) with that of conventional hepatobiliary scintigraphy (C-HBS) for acute cholecystitis. The results of most MA-HBS studies cannot be compared with C-HBS estimates, since articles describing C-HB...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199512000-00013

    authors: Cabana MD,Alavi A,Berlin JA,Shea JA,Kim CK,Williams SV

    更新日期:1995-12-01 00:00:00

  • Background in 99Tcm DTPA renography evaluated by the impact of its components on individual kidney glomerular filtration rate.

    abstract::Following injection for renography, 99Tcm-labelled diethylenetriamine-pentacetic acid (DTPA) rapidly enters the extravascular space. Background therefore comprises two components, a falling intravascular signal and an extravascular signal which initially rises. We estimated the relative magnitudes of these two compone...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198808000-00003

    authors: Peters AM,Gordon I,Evans K,Todd-Pokropek A

    更新日期:1988-08-01 00:00:00

  • The effectiveness of low-dose versus high-dose 99mTc MIBI protocols for radioguided surgery in patients with primary hyperparathyroidism.

    abstract:OBJECTIVE:The aim of this study was to compare the efficacy of low-dose and high-dose (99m)Tc methoxy isobutyl isonitrile (MIBI) protocols in intraoperative localization of parathyroid adenomas by means of a gamma probe in patients with primary hyperparathyroidism (PHPT). PATIENTS AND METHODS:The study included 62 pat...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000056

    authors: Gencoglu EA,Aras M,Moray G,Aktas A

    更新日期:2014-04-01 00:00:00