Abstract:
AIM:99mTc-HL91 is a new hypoxia agent and can identify acutely ischaemic viable myocardium in a canine model using a standard gamma camera. The purpose of the study was to determine whether this tracer could be used to detect regional ischaemia in chronic ischaemic myocardium in a swine model. METHOD:Using a porcine model of chronic myocardial ischaemia, five mini-pigs with proximal left anterior descending artery (LAD) stenoses were studied. Injection of 462.5 MBq (12.5 mCi) 99mTc-HL91 was followed by imaging over 2 h. Coronary angiography and dipyridamole stress-re-injection 201Tl single photon emission computed tomography (SPECT) were performed within 1 day of each other. RESULTS:None of the five pigs demonstrated positive hot 99mTc-HL91 uptake throughout the 2 h imaging, whereas four of the five animals showed significant myocardial ischaemia on 201Tl SPECT. The region of interest analysis of LAD/left circumflex artery count ratios at 1 and 2 h demonstrated similar 99mTc-HL91 uptake and retention in chronic ischaemic as well as non-ischaemic myocardium. CONCLUSION:99mTc-HL91 is inferior to 201Tl in scintigraphic detection of chronic myocardial ischaemia.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Wu YW,Lee CM,Huang YH,Chou NK,Yen RF,Tzen KY,Huang PJdoi
10.1097/00006231-200512000-00012keywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
1119-23issue
12eissn
0143-3636issn
1473-5628pii
00006231-200512000-00012journal_volume
26pub_type
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000300
更新日期:2015-06-01 00:00:00
abstract::Radioiodine therapy using oral administration of Iodine-131 (I) is a widespread employed strategy for the treatment of hyperthyroidism and thyroid cancer. Such a therapy requires well-trained staff, equipment and procedures regarding radiation safety. The aims of this work are to report an incidental experience of rad...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
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journal_title:Nuclear medicine communications
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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更新日期:1998-06-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2017-12-01 00:00:00
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更新日期:2008-11-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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更新日期:1995-12-01 00:00:00
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更新日期:2014-04-01 00:00:00