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Reliability of left ventricular ejection fraction calculated with gated myocardial perfusion single photon emission computed tomography in patients with extensive perfusion defect.

Abstract：

INTRODUCTION:Gated myocardial perfusion scintigraphy (g-MPS) provides functional information on the left ventricle (LV) apart from the perfusion status. Computer algorithm-based LV ejection fraction (EF) calculated from resting g-MPS has been found to be reliable in patients with normal perfusion. However, its role in patients with extensive perfusion defects is not clear. AIM:To find the reliability of LVEF calculated from resting g-MPS in patients with extensive perfusion defects (>25% of LV myocardium) and to correlate this with echocardiography and multigated radionuclide ventriculography (RNV). MATERIALS AND METHODS:Thirty patients with fixed perfusion defect of size greater than or equal to 25% of LV myocardium on rest g-MPS study were included. EF was calculated using three software packages: Emory Cardiac Toolbox, Myometrix, and quantitative gated single photon emission computed tomography (SPECT)/quantitative perfusion SPECT. The patients underwent RNV (gold standard) and echocardiography within a week of the g-MPS. Agreement among the EF values obtained by different methods was determined using Bland-Altman analysis. Correlation among the EF values was measured using Spearman's rank correlation. RESULTS:Thirty patients (23 male; seven female; mean age 51 years, range 32-70 years) were included prospectively. The average size of perfusion defect was 38% of the LV myocardium (range 25-56% of LV). The average ejection fraction values were 33% for Emory Cardiac Toolbox (range 11-50%), 31% for Myometrix (range 18-46%), and 33% for quantitative gated SPECT/quantitative perfusion SPECT (range 17-49%). The mean EF on echocardiography was 37% (range 22-60%), whereas that of RNV was 33% (range 10-50%). The data were normally distributed. There was statistically significant positive agreement between algorithm-based EF measurements to the gold standard RNV. CONCLUSION:This study suggests that EF calculations, from g-MPS SPECT data using different software, have high agreement with the gold standard RNV even in patients with extensive perfusion defects.

journal_name

Nucl Med Commun

journal_title

Nuclear medicine communications

authors

Harisankar CN,Mittal BR,Kamaleshwaran KK,Parmar M,Bhattacharya A,Singh B,Mahajan R

doi

10.1097/MNM.0b013e328342b97e

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

503-7

issue

eissn

0143-3636

issn

1473-5628

journal_volume

pub_type

临床试验,杂志文章

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Reliability of left ventricular ejection fraction calculated with gated myocardial perfusion single photon emission computed tomography in patients with extensive perfusion defect.