Evaluating the use of optimally respiratory gated 18F-FDG-PET in target volume delineation and its influence on radiation doses to the organs at risk in non-small-cell lung cancer patients.

Abstract:

OBJECTIVE:This radiotherapy planning study evaluated tumour delineation using both optimally respiratory gated and nongated fluorine-18 fluorodeoxyglucose-PET (F-FDG-PET). METHODS:For 22 non-small-cell lung tumours, both scans were used to create the nongated and gated (g) gross tumour volumes (GTVg) together with the accompanying clinical target volumes (CTV) and planning target volumes (PTV). The size of the target volumes (TV) was evaluated and the accompanying radiotherapy plans were created to study the radiation doses to the organs at risk (OAR). RESULTS:The median volumes of GTVg, CTVg and PTVg were statistically significantly smaller compared with the corresponding nongated volumes, resulting in a median TV reduction of 0.5 cm (interquartile range 0.1-1.2), 1.5 cm (-0.2 to 7.0) and 2.3 cm (-0.5 to 11.3) for the GTVg, CTVg and PTVg, respectively. For the OAR, only the percentage of lung (GTV included) receiving at least 35 Gy was significantly smaller after gating, with a median difference in lung volume receiving at least 35 Gy of 5.7 cm (interquartile range -0.8 to 30.50). CONCLUSION:Compared with nongated F-FDG-PET, the TVs obtained with optimally respiratory gated F-FDG-PET were significantly smaller, however, without a clinically relevant difference in radiation dose to the OAR.

journal_name

Nucl Med Commun

authors

Wijsman R,Grootjans W,Troost EG,van der Heijden EH,Visser EP,de Geus-Oei LF,Bussink J

doi

10.1097/MNM.0000000000000409

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

66-73

issue

1

eissn

0143-3636

issn

1473-5628

journal_volume

37

pub_type

杂志文章
  • Clinical evaluation of hypertrophic cardiomyopathy by myocardial scintigraphy using 123I-labelled 15-(p-iodophenyl)-3-R, S-methylpentadecanoic acid (123I-BMIPP).

    abstract::To evaluate the clinical utility of 123I-labelled 15-(p-iodophenyl)-3-R, S-methylpentadecanoic acid (123I-BMIPP), myocardial scintigraphy using 123I-BMIPP was performed in 13 patients with hypertrophic cardiomyopathy (HCM), and the findings were compared with those of 201Tl. The uptake of each tracer was scored visual...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199406000-00008

    authors: Ohtsuki K,Sugihara H,Umamoto I,Nakamura T,Nakagawa T,Nakagawa M

    更新日期:1994-06-01 00:00:00

  • A novel liver function evaluation system using radiopharmacokinetic modeling of technetium-99m-DTPA-galactosyl human serum albumin.

    abstract:BACKGROUND:A new kinetic model of technetium-99m-labeled diethylenetriaminepentaacetic acid-galactosyl human serum albumin (Tc-GSA) was developed to show the speed of asialoglycoprotein receptor-mediated endocytosis. MATERIALS AND METHODS:Ten healthy volunteers and 17 patients with liver cirrhosis were intravenously i...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e328362e7c7

    authors: Du S,Mao Y,Tong J,Li F,Che L,Li S,Yang H,Ba J,Hu N,Xing H,Lu X,Sang X,Zhang X,Wang X,Zhong S

    更新日期:2013-09-01 00:00:00

  • Imatinib mesylate for the treatment of gastrointestinal stromal tumours: best monitored with FDG PET.

    abstract:BACKGROUND:The new anti-cancer drug imatinib mesylate inhibits the tyrosine kinase growth factor receptor, c-KIT, and has shown spectacular activity in patients with gastrointestinal stromal tumours (GISTs). OBJECTIVE:To assess whether fluorodeoxyglucose positron emission tomography (FDG PET) is suitable for response ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200405000-00002

    authors: Jager PL,Gietema JA,van der Graaf WT

    更新日期:2004-05-01 00:00:00

  • Incidental detection of apical hypertrophic cardiomyopathy by myocardial perfusion imaging.

    abstract:BACKGROUND:Echocardiography plays a central role in the diagnosis of hypertrophic cardiomyopathy (HCM). However, apical involvement of HCM may be missed because of foreshortening and inadequate clinical suspicion. These patients may be referred for single-photon emission computed tomography imaging. METHODS:We present...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328334fc41

    authors: Irwin RB,Arumugam P,Khattar RS

    更新日期:2010-04-01 00:00:00

  • Radiolytic breakdown of sodium iodide (131I) in sodium iodide (131I) capsules.

    abstract::Sodium iodide (131I) capsules are widely used for both diagnosis and therapy. The radiochemical purity of both diagnostic and therapeutic capsules in use in Australia was studied by gel chromatography, high voltage electrophoresis and paper chromatography. It was found that in two of the three bands of therapeutic cap...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198611000-00007

    authors: Bonnyman J,Van Every B

    更新日期:1986-11-01 00:00:00

  • Effective dose to children and adolescents from radiopharmaceuticals.

    abstract::Published values of tissue weighting factors for adolescents and children derived from the life-span study of the atomic bomb survivors have been used to calculate the effective dose to patients aged 1, 5, 10 and 15 years undergoing a common paediatric procedure requiring one of the following radiopharmaceuticals: 99T...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199906000-00012

    authors: Gadd R,Mountford PJ,Oxtoby JW

    更新日期:1999-06-01 00:00:00

  • Evaluation of somatostatin receptors in large cell pulmonary neuroendocrine carcinoma with 99mTc-EDDA/HYNIC-TOC scintigraphy.

    abstract:OBJECTIVE:Large cell pulmonary neuroendocrine carcinoma (LCNEC) is a poorly differentiated and high-grade neoplasm. It is positioned between an atypical carcinoid and small cell neuroendocrine carcinoma of the lung in a distinct family of pulmonary neuroendocrine tumors. The aim of our study was to detect somatostatin ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e32834508b3

    authors: Nocuń A,Chrapko B,Gołębiewska R,Stefaniak B,Czekajska-Chehab E

    更新日期:2011-06-01 00:00:00

  • Biodistribution and radiation dosimetry of [18F]F-PEB in nonhuman primates.

    abstract:INTRODUCTION:The metabotropic glutamate receptor subtype 5 (mGluR5) is distributed throughout the central nervous system (CNS), and has been suggested to be a potential target for several CNS disorders suchas Parkinson's disease, pain, anxiety, depression, schizophrenia, and addiction. We report here on the rhesus monk...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3283060c72

    authors: Bélanger MJ,Krause SM,Ryan C,Sanabria-Bohorquez S,Li W,Hamill TG,Burns HD

    更新日期:2008-10-01 00:00:00

  • Significant correlation between cerebral hypoperfusion and neuropsychological assessment scores of patients with mild cognitive impairment.

    abstract:PURPOSE:The regions of significant correlation between cerebral hypoperfusion and neuropsychological assessment scores were evaluated using (99m)Tc-HMPAO SPECT in patients with mild cognitive impairment (MCI) on the basis of its three subtypes, namely, single-domain amnestic MCI (aMCI-s), multiple-domain amnestic MCI (...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e32835587f8

    authors: Yoon HJ,Park KW,Jeong YJ,Kang DY

    更新日期:2012-08-01 00:00:00

  • Radiation doses from nuclear medicine patients to an imaging technologist: relation to ICRP recommendations for pregnant workers.

    abstract::The ICRP has now recommended that the dose limit to the surface of the mother's abdomen during the declared term of pregnancy is reduced to 2 mSv. Direct measurements of the radiation dose to technologists carrying out a variety of imaging studies were made. The average dose ranged from 0.3 micro Sv for a liver scan t...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199211000-00004

    authors: Clarke EA,Thomson WH,Notghi A,Harding LK

    更新日期:1992-11-01 00:00:00

  • Reliability of left ventricular ejection fraction calculated with gated myocardial perfusion single photon emission computed tomography in patients with extensive perfusion defect.

    abstract:INTRODUCTION:Gated myocardial perfusion scintigraphy (g-MPS) provides functional information on the left ventricle (LV) apart from the perfusion status. Computer algorithm-based LV ejection fraction (EF) calculated from resting g-MPS has been found to be reliable in patients with normal perfusion. However, its role in ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e328342b97e

    authors: Harisankar CN,Mittal BR,Kamaleshwaran KK,Parmar M,Bhattacharya A,Singh B,Mahajan R

    更新日期:2011-06-01 00:00:00

  • An assessment of wall motion, perfusion and glucose metabolism in recent myocardial infarction: a comparison in patients with and without revascularization.

    abstract::The aim of this study was to compare the extent and severity of wall motion abnormalities, perfusion and glucose metabolism, in recent myocardial infarction in patients with and without revascularization. Forty-nine patients were studied (82% men; mean age 58 years) by using echocardiography, 201Tl single photon emiss...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200311000-00006

    authors: González P,Massardo T,Coll C,Redondo F,Yovanovich J,Jofré J,Chamorro H,Humeres P,Sierralta P,Ramírez A,Kunstmann S,López H,Aramburú I,Brugère S

    更新日期:2003-11-01 00:00:00

  • A technique for the absolute quantification of 131I radiopharmaceuticals using SPECT.

    abstract::A technique is described for the quantification of the three-dimensional distribution of 131I radiopharmaceuticals using single photon emission computed tomography (SPECT). A theoretical discussion of the problems of scatter and septal penetration in 131I SPECT is presented. The correction of these effects using the g...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199306000-00014

    authors: Fleming JS,Alaamer AA,Perring S

    更新日期:1993-06-01 00:00:00

  • The feasibility of 225Ac as a source of alpha-particles in radioimmunotherapy.

    abstract::This paper proposes the utilization of 225Ac for the alpha-radioimmunotherapy of cancer. The isotope decays with a radioactive half-life of 10 days into a cascade of short-lived alpha- and beta-emitting isotopes. In addition, when indicated by the pharmacokinetic requirements of particular clinical applications, 213Bi...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199302000-00009

    authors: Geerlings MW,Kaspersen FM,Apostolidis C,van der Hout R

    更新日期:1993-02-01 00:00:00

  • Uptake of 77Br-spiperone in the striata of schizophrenic patients and controls.

    abstract::Twelve patients with a diagnosis of schizophrenia and thirteen control subjects were injected with 77Br-bromospiperone and scanned using single photon emission tomography after 16 h. Although a statistically significant increase in patients by comparison with controls could be demonstrated, wide variations in specific...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198608000-00006

    authors: Crawley JC,Crow TJ,Johnstone EC,Oldland SR,Owen F,Owens DG,Smith T,Veall N,Zanelli GD

    更新日期:1986-08-01 00:00:00

  • InfuShield: a shielded enclosure for administering therapeutic radioisotope treatments using standard syringe pumps.

    abstract::The administration of radionuclide therapies presents significant radiation protection challenges. The aim of this work was to develop a delivery system for intravenous radioisotope therapies to substantially moderate radiation exposures to staff and operators. A novel device (InfuShield) was designed and tested befor...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000634

    authors: Rushforth DP,Pratt BE,Chittenden SJ,Murray IS,Causer L,Grey MJ,Gear JI,Du Y,Flux GD

    更新日期:2017-03-01 00:00:00

  • Improvement of the amplitude image through statistical filtering.

    abstract::In order to perform automatically the thresholding of the amplitude image obtained by phase analysis, a filter based on the probability density of the amplitude is proposed. It generates the image of the significant amplitude by setting to zero the amplitude if its square is lower than 4a0 log(1/alpha)/N where a0 is t...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198710000-00005

    authors: Liehn JC,Valeyre J

    更新日期:1987-10-01 00:00:00

  • Pancreatic cancer detected by positron emission tomography with 18F-labelled deoxyglucose: method and first results.

    abstract::In order to evaluate the utility of positron emission tomography (PET) with 18F-labelled deoxyglucose (FDG) for detection of pancreatic cancer 15 patients with pancreatic masses shown by computed tomography were investigated. Static PET scans covering an axial field of view of 15 cm were obtained 45 min after intraven...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199307000-00013

    authors: Bares R,Klever P,Hellwig D,Hauptmann S,Fass J,Hambuechen U,Zopp L,Mueller B,Buell U,Schumpelick V

    更新日期:1993-07-01 00:00:00

  • Performance of a single crystal digital gamma camera for first pass cardiac studies.

    abstract::First pass radionuclide angiocardiography (FPRNA) has gained increasing interest because of the development of new 99Tcm-labelled perfusion agents and of new 191Os/191Irm generator systems. The aim of the study was to evaluate the performance capacities of a small field of view single crystal digital gamma camera for ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199101000-00004

    authors: Dobbeleir A,Franken PR,Ham HR,Brihaye C,Guillaume M,Knapp FF,Vandevivere J

    更新日期:1991-01-01 00:00:00

  • Fluorine-18 fluorodeoxyglucose avid thyroid incidentalomas on PET/CT scan in cancer patients: how sinister are they?

    abstract:OBJECTIVE:To evaluate the prevalence of malignancy in incidental thyroidal uptake on PET with fluorine-18 deoxyglucose integrated with computed tomography (F-FDG PET/CT) in Pakistani cancer patients and to assess the role of standardized uptake value (SUV) in deciding which lesions to investigate further. METHOD:We re...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000557

    authors: Hassan A,Riaz S,Zafar W

    更新日期:2016-10-01 00:00:00

  • Pulmonary perfusion assessment with respiratory gated 99mTc macroaggregated albumin SPECT: preliminary results.

    abstract:PURPOSE:Respiratory gated perfusion single photon emission computed tomography (SPECT) was applied to reduce respiratory lung motion effects and to reliably assess perfusion impairment in various lung diseases. METHODS:After injection of 259 MBq of 99mTc macroaggretated albumin (99mTc-MAA), gating was performed using ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200402000-00016

    authors: Suga K,Kawakami Y,Zaki M,Yamashita T,Matsumoto T,Matsunaga N

    更新日期:2004-02-01 00:00:00

  • Pentavalent 99Tcm-DMSA imaging in patients with bone metastases.

    abstract::Pentavalent 99Tcm-dimercaptosuccinic acid (99Tcm-(V)DMSA) has an established role in imaging medullary thyroid carcinoma. There have been case reports of uptake in bone metastases. Our aims were to compare 99Tcm-(V)DMSA with 99Tcm-hydroxymethylene diphosphonate (99Tcm-HDP) in bone metastases, to assess its value in im...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199710000-00003

    authors: Lam AS,Kettle AG,O'Doherty MJ,Coakley AJ,Barrington SF,Blower PJ

    更新日期:1997-10-01 00:00:00

  • Depression and anxiety during isolation and radionuclide therapy.

    abstract::The combination of a diagnosis of malignancy and hospitalization, isolation and radioactivity of a radionuclide therapy may have an important effect on the psychological equilibrium of patients and may hamper compliance and acceptability. We performed a psychiatric evaluation in order to study psycho-pathological mani...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.mnm.0000084586.29433.83

    authors: Brans B,van den Eynde F,Audenaert K,Vervaet M,van Daele K,van Heeringen C,Dierckx RA

    更新日期:2003-08-01 00:00:00

  • Scintigraphic imaging of breast cancer: a review.

    abstract::Scintimammography is a recently verified technique that will expand the use of nuclear medicine to a new group of patients in whom scintigraphic imaging has not been widely used. If performed correctly, and in certain groups of patients, it delivers a sensitivity as high as X-ray mammography or magnetic resonance imag...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/00006231-199708000-00003

    authors: Buscombe JR,Cwikla JB,Thakrar DS,Hilson AJ

    更新日期:1997-08-01 00:00:00

  • Removal of the internal mammary sentinel node in breast cancer.

    abstract:OBJECTIVE:The aim of the study was to determine the evolution of patients with internal mammary chain (IMC) drainage whether the IMC-sentinel lymph node (IMC-SLN) was biopsied or not, as well as to determine the clinical implications of the biopsy of the IMC-SLN (IMC-SLNB) in patients with breast cancer and IMC drainag...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328330addf

    authors: Domènech-Vilardell A,Bajén MT,Benítez AM,Ricart Y,Mora J,Rodríguez-Bel L,García-Tejedor A,Climent J,López-Ojeda A,Urruticoechea A,Martín-Comín J

    更新日期:2009-12-01 00:00:00

  • The usefulness of fluorine-18 fluorodeoxyglucose PET in the detection of recurrence in patients with differentiated thyroid cancer with elevated thyroglobulin and negative radioiodine whole-body scan.

    abstract:INTRODUCTION:PET/computed tomography (CT) using fluorine-18 fluorodeoxyglucose (F-FDG) has been used in the diagnosis of recurrence and metastases of differentiated thyroid cancer (DTC) in cases of negative whole-body scan (WBS) despite elevated concentrations of stimulated thyroglobulin (Tg). AIM:To assess the utilit...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000563

    authors: Stangierski A,Kaznowski J,Wolinski K,Jodlowska E,Michaliszyn P,Kubiak K,Czepczynski R,Ruchala M

    更新日期:2016-09-01 00:00:00

  • Bone scan index as metastatic bone disease quantifier and predictor of radium-223-dichloride biochemical response.

    abstract:OBJECTIVES:This work aims to assess whether the biochemical response of radium-223-dichloride treatment can be predicted based on the pretherapy bone scan, and consequently if bone scan index (BSI) and maximum lesion intensity have a place as alternatives or as complements to extent of bone disease (EOBD) scoring in pr...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001005

    authors: Roque V,Jessop M,Pereira L,Gape P,Dizdarevic S,Sousa E,Carolino E

    更新日期:2019-06-01 00:00:00

  • Preparation and properties of 99Tcm-exametazime using stannous ion augmentation of fractionated cold kits.

    abstract::Fractionation of 99Tcm-exametazime enables several patients doses to be prepared from one vial. To overcome the disadvantages of storage at -70 degrees C, storage at higher temperatures was investigated with replacement of stannous ions before use. Kits were fractionated using a nitrogen-purged 0.9% w/v sodium chlorid...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199903000-00013

    authors: Baker RJ

    更新日期:1999-03-01 00:00:00

  • Prognostic value of metabolic response measured by 18F-FDG-PET in oesophageal cancer patients treated with definitive chemoradiotherapy.

    abstract:BACKGROUND:This study aimed to assess the efficacy of fluorine-18 fluorodeoxyglucose (F-FDG)-PET for predicting overall survival (OS) and disease-free survival (DFS) in oesophageal cancer patients after definitive chemoradiotherapy (CRT) and prognostic importance of metabolic response detected by post-treatment PET at ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000594

    authors: Onal C,Torun N,Guler OC,Yildirim BA

    更新日期:2016-12-01 00:00:00

  • Role of 18F-FDG PET/CT in evaluating molecular subtypes and clinicopathological features of primary breast cancer.

    abstract:OBJECTIVE:In this study, primary tumors' fluorine-18-fluorodeoxyglucose (F-FDG) uptake in luminal A, luminal B, triple-negative, and human epidermal growth factor receptor type-2 subtypes of breast cancer was evaluated. In addition, the relationship between the primary tumor maximum standardized uptake value (SUVmax) v...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000856

    authors: Arslan E,Çermik TF,Trabulus FDC,Talu ECK,Başaran Ş

    更新日期:2018-07-01 00:00:00