Abstract:
:To evaluate the clinical utility of 123I-labelled 15-(p-iodophenyl)-3-R, S-methylpentadecanoic acid (123I-BMIPP), myocardial scintigraphy using 123I-BMIPP was performed in 13 patients with hypertrophic cardiomyopathy (HCM), and the findings were compared with those of 201Tl. The uptake of each tracer was scored visually from 4 (increased) to 0 (severely decreased) in a total of 13 segments in the apical and basal short axial images, and the long axial images of myocardial single photon emission tomography (SPET). In the comparison of the early images with 123I-BMIPP (taken 15 min after injection) and the 201Tl perfusion images, 70% of the segments showed uncoupled uptake, with the uptake of 123I-BMIPP more often being less. In the hypertrophic regions, 123I-BMIPP demonstrated significantly less uptake than 201Tl, especially in the delayed images (taken 3 h after injection). In the nonhypertrophic regions, there was no significant difference in uptake between the 123I-BMIPP early images and the 201Tl images; the 123I-BMIPP delayed images, however, demonstrated significantly less uptake than the 201Tl images. These results suggest that the uncoupling between the 123I-BMIPP and 201Tl uptakes and the washout (the relative decrease in activity from early to delayed images of 123I-BMIPP) reflect abnormal myocardial fatty acid metabolism in HCM.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Ohtsuki K,Sugihara H,Umamoto I,Nakamura T,Nakagawa T,Nakagawa Mdoi
10.1097/00006231-199406000-00008subject
Has Abstractpub_date
1994-06-01 00:00:00pages
441-7issue
6eissn
0143-3636issn
1473-5628journal_volume
15pub_type
杂志文章abstract::To evaluate right ventricular overload in paediatric patients with congenital cardiac disease (n = 25), the uptakes of 201Tl and 99Tcm-sestamibi (99Tcm-MIBI) were compared. 99Tcm-MIBI showed a clearer myocardial border and better contrast between the myocardium and ventricular cavity. Although hepatic activity may inf...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199511000-00010
更新日期:1995-11-01 00:00:00
abstract:INTRODUCTION:Respiratory complications are common after arthroplasty, with pulmonary thromboembolic disease (PTE) and fat emboli being the most serious. A scintigraphic study was designed to assess the occurrence of both diseases. A prospective tomographic study of perfusion was performed within 24 h of arthroplasty. D...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200111000-00011
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVES:This survey was designed to assess the trends in the frequencies of nuclear medicine procedures in the UK and to determine their contributions to the annual collective effective dose to the UK population. The average activities administered by nuclear medicine departments were compared with guidance on diagn...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/01.mnm.0000184939.28994.f9
更新日期:2005-11-01 00:00:00
abstract::Medullary thyroid cancer (MTC) originates from parafollicular C cells of the thyroid and accounts for 3-12% of all thyroid cancers. As opposed to other types of dedifferentiated thyroid tumours, MTC cells are highly functional, producing and secreting high amounts of calcitonin and carcinoembryonic antigen. As parafol...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/MNM.0b013e32830f4af2
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the usefulness of (123)I-iomazenil (IMZ) single photon emission computed tomography (SPECT) for the pre-surgical identification of epileptogenic areas in patients with temporal lobe epilepsy and to compare the results with those of (123)I-IMP SPECT and (18)Fluorodeoxyglu...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/01.mnm.0000243380.79872.32
更新日期:2006-11-01 00:00:00
abstract::Thirty patients with aortic valve incompetence and 21 control subjects were examined by M-mode echocardiography at rest and radionuclide ventriculography during submaximal handgrip exercise. The patients had greater left ventricular dimensions and end-systolic wall stress values but peak systolic wall stress values di...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199004000-00004
更新日期:1990-04-01 00:00:00
abstract::Since 99Tcm-DTPA is diffusible and not significantly protein bound in plasma, it rapidly enters the extravascular space following injection. Therefore, during the first few minutes of the DTPA renogram, the period on which the measurements of individual kidney glomerular filtration rate and differential function are b...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198812000-00006
更新日期:1988-12-01 00:00:00
abstract:OBJECTIVE:Paragangliomas are rare tumours of neural crest origin that express high levels of somatostatin receptor. Ga-68 DOTATATE PET/CT is a widely accepted method for imaging of neuroendocrine tumours. This study was performed to review a Ga-68 DOTATATE PET/CT patient database and to establish the impact of the moda...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001130
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:Increasing evidence, primarily from animal studies and patients with compromised neurotransmitter systems, indicates a possibly important role for dopamine in modulating sleep. We therefore conducted this study to explore the relation between sleep and dopamine in healthy adults. METHODS:We used the Pittsburgh...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3280bad8b6
更新日期:2007-05-01 00:00:00
abstract::Single photon emission computed tomography (SPECT) and positron emission tomography (PET) have advanced our understanding of the biological underpinnings of depression. There is, however, considerable variability in the literature. Depression is a complex disorder with marked heterogeneity in diagnosis and treatment. ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/00006231-200503000-00004
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:18F-Fluorodeoxyglucose-positron emission tomography (18F-FDG-PET) is a very useful imaging technique and is the best modality for the evaluation of many kinds of tumour. However, in the evaluation of hepatocellular carcinoma (HCC), the diagnostic accuracy of routine 60 min static imaging is not satisfactory....
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200504000-00003
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the diagnostic accuracy of PET/computed tomography (CT) in detecting marrow infiltration in indolent non-Hodgkin lymphoma (NHL) with histopathological correlation. METHODS:All treatment-naive newly diagnosed indolent NHL with staging PET/CT were retrospectively evaluated for marrow infiltration a...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000361
更新日期:2015-10-01 00:00:00
abstract::We performed a prospective study to establish the optimal background correction algorithm for the determination of differential renal function (DRF), using 99Tc(m)-diethylenetriamine pentaacetate (99Tc(m)-DTPA) in the presence of unilateral hydronephrosis, with 24 h 99Tc(m)-dimercaptosuccinic acid (99Tc(m)-DMSA) uptak...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199803000-00009
更新日期:1998-03-01 00:00:00
abstract::Esophageal cancer is the third most common malignancy of the alimentary tract. The incidence of esophageal cancer has steadily increased over the past three decades. Almost all therapeutic modalities for esophageal cancer are associated with a considerable mortality and morbidity. Consequently, there has been growing ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/MNM.0b013e32831af204
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to identify deficiencies in product labelling instructions for reconstitution and in the quality control directions detailed in the technical leaflets (TLs) or summary product characteristic (SPC) sheets of commonly used technetium labelling cold kits. MATERIALS AND METHODS:The recon...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000030
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the diagnostic value of 2-(fluorine-18)-fluoro-2-deoxy-D-glucose ((18)F-FDG) PET/CT in comparison with MRI for the detection of recurrent ovarian cancer. METHODS:Forty-seven patients with suspected ovarian cancer recurrence after total ablative or cytoreductive surgery, ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32834fc5bf
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:The recent development of mixed ligand complexes using a 99mTc tricarbonyl synthon has prompted us to revisit the first generation product, 99mTc-t-butyl isonitrile (TBI), for possible myocardial imaging after modification of the 99mTc core to a mixed ligand core of carbonyl and t-butyl isonitrile. The easy a...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200502000-00013
更新日期:2005-02-01 00:00:00
abstract::Using platelet scintigraphy to evaluate early thrombogenicity, we examined 39 new vascular accesses 4 weeks and 3 months after surgery. We found a significant association between platelet deposition and Doppler flow (P < 0.01) and blood pressure (P < 0.01). Compared with arteriovenous fistulae, prosthetic grafts showe...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199905000-00008
更新日期:1999-05-01 00:00:00
abstract::The ICRP has now recommended that the dose limit to the surface of the mother's abdomen during the declared term of pregnancy is reduced to 2 mSv. Direct measurements of the radiation dose to technologists carrying out a variety of imaging studies were made. The average dose ranged from 0.3 micro Sv for a liver scan t...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199211000-00004
更新日期:1992-11-01 00:00:00
abstract::A patient satisfaction survey was carried out in a nuclear medicine department of a large acute hospital. Surveys were initially carried out by interview and postal techniques, with approximately 100 responders in each category. The responses to each question were not significantly different for the two types of surve...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199404000-00158
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to evaluate the accuracy of the sequential multiphase and dual-tracer (SMADT) technique utilizing technetium-99m pertechnetate (99mTcO4) and dynamic technetium-99m-2-methoxyisobutylisonitrile (99mTc-MIBI) with single-photon emission computed tomography/computed tomography (SPECT/CT) f...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000215
更新日期:2015-01-01 00:00:00
abstract::Conventional nuclear medicine methods for measuring glomerular filtration rate, GFR, are invalidated if the initial injection of radiopharmaceutical is tissued. An analytical method proposed by Veall and Gibbs in 1982 overcomes this difficulty but does require multiple blood samples. This paper investigates whether it...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198611000-00003
更新日期:1986-11-01 00:00:00
abstract::Planar pulmonary scintigraphy is still regularly performed for the evaluation of pulmonary embolism (PE). However, only about 50-80% of cases can be resolved by this approach. This study evaluates the ability of tomographic acquisition (single photon emission computed tomography, SPECT) of the perfusion scan to improv...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200211000-00011
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the changes in early and late washout rates of 99mTc-methoxyisobutylisonitrile (MIBI) in hypertrophic cardiomyopathy (HCM), and to analyze the relationships between early and late washout rates and the hypertrophic thickness of left ventricular (LV) wall. METHODS:The ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3283009f36
更新日期:2008-08-01 00:00:00
abstract::Radiolabeled sucralfate has been utilized by several investigators to evaluate peptic ulcer, active inflammatory bowel disease, esophageal ulcer, and gastric cancer. A review of the available literature indicates that radiolabeled sucralfate has been used to evaluate peptic ulcer and active inflammatory bowel diseases...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:
更新日期:1987-05-01 00:00:00
abstract::High-grade astrocytoma represents the most common primary malignant brain tumour in the adult, and is associated with high morbidity and mortality rates. The aim of this study was to investigate the prognostic value of 99Tcm-hexamethylpropyleneamine oxime (HMPAO) brain single photon emission computed tomography (SPECT...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199312000-00002
更新日期:1993-12-01 00:00:00
abstract::Single photon emission computed tomography (SPECT) using N-isopropyl-p-(123I)iodoamphetamine (123I-IMP) and 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HMPAO) was performed in 25 patients with different clinical stages of AIDS encephalopathy. The average interval between the two examinations was 7 days. In 15 of the 2...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract::The time course of thyroglobulin (Tg) was monitored in patients with differentiated thyroid carcinoma after ablative therapy (thyroidectomy + 131I-treatment) with particular respect to endogeneous antibodies (Tg-ABs). In 232 patients (196 without Tg-ABs, 36 with Tg-ABs at the time of treatment) a sensitivity of 88% (a...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198405000-00003
更新日期:1984-05-01 00:00:00
abstract::A significant reduction of cardiac 123I-meta-iodobenzylguanidine (MIBG) accumulation has been reported in patients with idiopathic Parkinson's disease. However, it is unclear whether this reduction in cardiac sympathetic nerve is caused primarily or secondarily to the degeneration of sympathetic nerve centres which oc...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200202000-00008
更新日期:2002-02-01 00:00:00
abstract::The use of 111In-labelled granulocyte scintigraphy is recognized as a reliable method for detecting osteomyelitis and has similar sensitivity and significantly increased specificity compared to bone scintigraphy and 67Ga studies. Recent published work using pure granulocytes labelled with 111In tropolonate to detect o...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198810000-00007
更新日期:1988-10-01 00:00:00