Abstract：
OBJECTIVES:The determination of lesion boundaries on FDG PET is difficult due to the point-spread blurring and unknown uptake of activity within a lesion. Standard threshold-based methods for volumetric quantification on PET usually neglect any size dependence and are biased by dependence on the signal-to-background ratio (SBR). A novel, model-based method is hypothesized to provide threshold levels independent f the SBR and to allow accurate measurement of volumes down to the resolution of the PET scanner. METHODS:A background-subtracted relative-threshold level (RTL) method was derived, based on a convolution of the point-spread function and a sphere with diameter D. Validation of the RTL method was performed using PET imaging of a Jaszczak phantom with seven hollow spheres (D=10-60 mm). Activity concentrations for the background and spheres (signal) were varied to obtain SBRs of 1.5-10. An iterative procedure was introduced for volumetric quantification, as the optimal RTL depends on a priori knowledge of the volume. The feasibility of the RTL method was tested in two patients with liver metastases and compared to a standard method using a fixed percentage of the signal. RESULTS:Phantom data validated that the theoretically optimal RTL depends on the sphere size, but not on the SBR. Typically, RTL=40% (D=15-60 mm), and RTL>50% for small spheres (D<12 mm). The RTL method is better applicable to patient data than the standard method. CONCLUSIONS:Based on an iterative procedure, the RTL method has been shown to provide optimal threshold levels independent of the SBR and to be applicable in phantom and in patient studies. It is a promising tool for lesion delineation and volumetric quantification of PET lesions.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
van Dalen JA,Hoffmann AL,Dicken V,Vogel WV,Wiering B,Ruers TJ,Karssemeijer N,Oyen WJdoi
10.1097/MNM.0b013e328155d154subject
Has Abstractpub_date
2007-06-01 00:00:00pages
485-93issue
6eissn
0143-3636issn
1473-5628pii
00006231-200706000-00009journal_volume
28pub_type
临床试验,杂志文章abstract：BACKGROUND:The indication for sentinel node biopsy (SNB) has not been fully established yet for patients with ductal carcinoma in situ (DCIS). AIM:To relate the conversion rate to invasive carcinoma with sentinel node positivity in high risk DCIS, and to refine the clinical presentation analysis in order to better sel...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/01.mnm.0000230074.39071.bf
更新日期：2006-10-01 00:00:00
abstract：:Planar scintimammography with 99Tcm-sestamibi (99Tcm-MIBI) has been shown to be useful in diagnosing breast carcinoma. The aim of this study was to compare single photon emission tomography (SPET) and planar imaging for scintimammography with 99Tcm-MIBI in the detection of primary breast cancer and axillary lymph node...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：INTRODUCTION:Sentinel lymph node biopsy (SLNB) has progressively replaced complete axillary lymph node dissection in the evaluation of breast cancer patients with clinically node-negative disease. Our study investigates the rate of and risk factors involved in sentinel node identification failure. MATERIALS AND METHOD...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0b013e328361cd84
更新日期：2013-07-01 00:00:00
abstract：PURPOSE:The purpose of this study was to show the viability and performance of a shape-based pattern recognition technique applied to I-N-omega-fluoropropyl-2-beta-carbomethoxy-3beta-(4-iodophenyl) nortropane single-photon emission computed tomography (FP-CIT SPECT) in patients with parkinsonism. METHODS:A fully autom...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0b013e328314b863
更新日期：2009-03-01 00:00:00
abstract：:Although several hypotheses have been suggested regarding the accumulation of 99Tc(m)-sestamibi in tumours, the exact uptake mechanism is still a matter of discussion. We investigated ultrastructural cell type of thyroid tumours by electron microscopy (EM) and compared them with uptake of 99Tc(m)-sestamibi. Thyroid sc...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-200101000-00006
更新日期：2001-01-01 00:00:00
abstract：:Infants or children undergoing nuclear medicine investigations may subsequently come into close contact with nurses or parents responsible for their care. In order to estimate the radiation dose to these individuals, and to formulate appropriate recommendations, dose rates were measured at distances of 0.1, 0.5 and 1....
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：BACKGROUND:PET/computed tomography (CT) imaging with the sodium-(F)-fluoride/2-(F)-fluoro-2-deoxy-D-glucose (F-NaF/F-FDG) cocktail has been proposed for patients with osseous metastases. This work aimed to optimize the cocktail composition for patients with metastatic castration-resistant prostate cancer (mCRPC). MATE...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000383
更新日期：2015-12-01 00:00:00
abstract：:The Monte Carlo code SIMIND is used in nuclear medicine for research purposes, and also for testing the validity of various applications. Conversion of a SIMIND-generated interfile (header and image data file) is required to process the simulated image data on a Xeleris workstation. Currently there is no conversion pr...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000393
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to evaluate the incremental value of technetium-99m-methylene diphosphonate (99mTc-MDP) single-photon emission tomography/computed tomography (SPECT/CT) over planar bone scintigraphy (BS) and SPECT in the diagnosis of avascular necrosis (AVN) of the femoral head. MATERIALS AND METHOD...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000357
更新日期：2015-10-01 00:00:00
abstract：:To assess the precision of gated equilibrium radioventriculography in measuring changes in left ventricular stroke volume (LVSV), we studied five dogs each with a chronically implanted electromagnetic flowmeter on the ascending aorta. Per cent changes in left ventricular stroke counts (LVSC) were compared to those in ...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-198812000-00009
更新日期：1988-12-01 00:00:00
abstract：:A new radiopharmaceutical, 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HM-PAO) is described. This agent displays considerable promise for imaging cerebral blood flow. In studies in rats and one human volunteer, 99Tcm-HM-PAO demonstrates good brain uptake, prolonged retention of activity in the brain, and slow regional...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-198508000-00003
更新日期：1985-08-01 00:00:00
abstract：:The efficacy of wipe tests for assessing 99Tcm surface contamination was measured. Four types of surface were contaminated with four radiopharmaceuticals and wiped using four types of swab. The fraction of activity removed was measured by direct monitoring for each combination of surface, pharmaceutical and swab. The ...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-199102000-00005
更新日期：1991-02-01 00:00:00
abstract：OBJECTIVE:Large cell pulmonary neuroendocrine carcinoma (LCNEC) is a poorly differentiated and high-grade neoplasm. It is positioned between an atypical carcinoid and small cell neuroendocrine carcinoma of the lung in a distinct family of pulmonary neuroendocrine tumors. The aim of our study was to detect somatostatin ...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0b013e32834508b3
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:This radiotherapy planning study evaluated tumour delineation using both optimally respiratory gated and nongated fluorine-18 fluorodeoxyglucose-PET (F-FDG-PET). METHODS:For 22 non-small-cell lung tumours, both scans were used to create the nongated and gated (g) gross tumour volumes (GTVg) together with the...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000409
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to assess the relationship between fluorine-18 fluorodeoxyglucose (F-FDG) uptake and molecular biological markers in esophageal squamous cell carcinoma (ESCC) patients. METHODS:Our patient population included 51 patients who underwent F-FDG PET/computed tomography before surgery. Ex...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000550
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVE:To analyse the kinetic changes of uptake, washout and retention of Tc-sestamibi in order to evaluate the protective effects and possible mechanism of ischaemic preconditioning and adenosine preconditioning on myocardium injured by ischaemia/reperfusion. METHODS:Isolated ischaemia/reperfusion rabbit heart mod...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0b013e3282f1781b
更新日期：2007-11-01 00:00:00
abstract：:PET holds potential to provide additional information about tumour metabolic processes, which could aid brain tumour differential diagnosis, grading, molecular subtyping and/or the distinction of therapy effects from disease recurrence. This review discusses PET techniques currently in use for untreated and treated gl...
journal_title：Nuclear medicine communications
pub_type： 杂志文章,评审
doi：10.1097/MNM.0000000000000914
更新日期：2018-12-01 00:00:00
abstract：INTRODUCTION:The metabotropic glutamate receptor subtype 5 (mGluR5) is distributed throughout the central nervous system (CNS), and has been suggested to be a potential target for several CNS disorders suchas Parkinson's disease, pain, anxiety, depression, schizophrenia, and addiction. We report here on the rhesus monk...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0b013e3283060c72
更新日期：2008-10-01 00:00:00
abstract：:Dynamic penile scintigraphy was performed using 99Tcm-labelled autologous erythrocytes in five normally potent volunteers and 22 patients with erectile dysfunction including 11 patients with psychogenic and 11 patients with vasculogenic impotence (four arteriogenic, three venogenic, three arteriogenic and venogenic, o...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-199311000-00007
更新日期：1993-11-01 00:00:00
abstract：OBJECTIVE:Simulated data from the recent Institute of Physics and Engineering in Medicine audit of quantitative cerebral perfusion were used to optimize the parameters of eigenimage analysis, a method for computer-aided detection. METHODS:Twenty normal images provided by the audit were registered to the International ...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0b013e32832cc273
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVE:To verify the negative predictive value of pulmonary ventilation/perfusion scintigraphy with single photon emission computed tomography (V/Q SPECT) in ruling out pulmonary thromboembolism. METHODS:V/Q SPECT using 99mTc-Technegas was performed on 584 patients to rule out pulmonary thromboembolism between Octo...
journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
doi：10.1097/MNM.0b013e32827a8e99
更新日期：2007-08-01 00:00:00
abstract：:To clarify the biological significance of [18F]fluorodeoxyglucose (18F-FDG) accumulation in patients with cancer, we assessed the relationships between 18F-FDG uptake and glucose transporter-1 (GLUT-1) expression and proliferation rate in human glioma and lung cancer. We obtained FDG PET images and measured standardiz...
journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
doi：10.1097/00006231-200401000-00003
更新日期：2004-01-01 00:00:00
abstract：:The purpose of this study was to demonstrate the accumulation of 99Tcm-glutathione (GSH) in experimental abscesses. The biodistribution of 99Tcm-GSH was determined in mice with turpentine-induced abscesses in comparison with 99Tcm-human immunoglobulin (HIG) at 1, 3, 6 and 24 h. Arthritis was induced by intra-articular...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-199407000-00007
更新日期：1994-07-01 00:00:00
abstract：:The standard nuclear medicine textbooks describe the pyramidal lobe of the thyroid as arising from the upper part of the thyroid lobes. Anatomy and surgical texts however describe it as a thyroglossal tract remnant and state that it arises from the isthmus. Review of 150 thyroid scintigrams confirms that on scintigrap...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-198403000-00006
更新日期：1984-03-01 00:00:00
abstract：INTRODUCTION:The choice of metrics for defining active Takayasu arteritis (TAK) using fluorine-18-fluorodeoxyglucose (F-FDG)-PET remains controversial. OBJECTIVE:The aim of this study was to compare in the same patients the diagnostic performance for the detection of active TAK of different metrics applied for the qua...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000000867
更新日期：2018-08-01 00:00:00
abstract：:Marked changes in cardiac function have been noted in patients with hyperthyroidism or hypothyroidism due both to changes in sympathetic system function and to biochemical modifications of myocardial tissue. Metaiodobenzylguanidine (MIBG), an analogue of norepinephrine, can be used to evaluate myocardial sympathetic t...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-199908000-00006
更新日期：1999-08-01 00:00:00
abstract：:The presence of distant metastases is the main prognostic factor in patients with breast cancer and has a significant influence in the choice of therapy. Therefore, chest X-ray, bone scintigraphy and ultrasound of the abdomen are performed to detect distant metastases at diagnosis and follow-up. Fluorodeoxyglucose pos...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/00006231-200209000-00009
更新日期：2002-09-01 00:00:00
abstract：PURPOSE:Stunning of thyroid remnants after diagnostic scanning (Dx-WBS) using radioactive iodine- (¹³¹I) may limit the efficacy of I therapy. We aimed to evaluate this assumption in a prospectively designed study. METHODS:Forty patients who underwent thyroidectomy for differentiated thyroid carcinoma were studied and ...
journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
doi：10.1097/MNM.0b013e328362ad63
更新日期：2013-08-01 00:00:00
abstract：:Planar pulmonary scintigraphy is still regularly performed for the evaluation of pulmonary embolism (PE). However, only about 50-80% of cases can be resolved by this approach. This study evaluates the ability of tomographic acquisition (single photon emission computed tomography, SPECT) of the perfusion scan to improv...
journal_title：Nuclear medicine communications
pub_type： 临床试验,杂志文章
doi：10.1097/00006231-200211000-00011
更新日期：2002-11-01 00:00:00
abstract：PURPOSE:To investigate whether the number of fluorodeoxyglucose (FDG)-avid focal lesions and the presence of extramedullary disease (EMD) on F-FDG PET/computed tomography (PET/CT) can predict the outcomes of newly diagnosed symptomatic multiple myeloma patients. METHODS:We performed a meta-analysis to research the pro...
journal_title：Nuclear medicine communications
pub_type： 杂志文章
doi：10.1097/MNM.0000000000001242
更新日期：2020-06-23 00:00:00
