The relationship between 99Tc(m)-sestamibi uptake and ultrastructural cell types of thyroid tumours.

Abstract:

:Although several hypotheses have been suggested regarding the accumulation of 99Tc(m)-sestamibi in tumours, the exact uptake mechanism is still a matter of discussion. We investigated ultrastructural cell type of thyroid tumours by electron microscopy (EM) and compared them with uptake of 99Tc(m)-sestamibi. Thyroid scintigraphy with 99Tc(m)-sestamibi was performed on 25 patients who displayed a cold nodule on previous pertechnetate scintigraphy. Tumour-to-thyroid (T/N) uptake ratio was measured semiquantitatively. Surgery was performed in all patients and cytological evaluations were done by EM. Histopathology revealed six papillary carcinomas, 16 follicular adenomas and three Hurthle cell tumours. Thyroid cells were classified as A and B cells using EM. The cytoplasm of an A cell has the normal amount of mitochondria, whereas cytoplasm of a B cell (mitochondria-rich oxyphilic cell) contains abundant mitochondria. The median T/N ratio on the early scan for an A-cell tumour was 1.21 (range, 0.74-3.2), late T/N ratio was 1.25 (range, 0.72-3.85). The T/N ratio for the B-cell tumours was 1.42 (range, 0.6-3.6) on the early scan and 1.18 (range, 0.64-5.58) on the late scan. There was no statistically significant difference between T/N ratios of A- and B-cell tumour groups. A significant difference was also not seen between early and late T/N ratios. According to our findings, 99Tc(m)-sestamibi accumulates in thyroid tumours with both A and B cells, therefore these results suggest that the mitochondrial content of tumours is not only responsible for sestamibi uptake and retention.

journal_name

Nucl Med Commun

authors

Sarikaya A,Huseyinova G,Irfanoğlu ME,Erkmen N,Cermik TF,Berkarda S

doi

10.1097/00006231-200101000-00006

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

39-44

issue

1

eissn

0143-3636

issn

1473-5628

journal_volume

22

pub_type

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