Abstract:
:Although several hypotheses have been suggested regarding the accumulation of 99Tc(m)-sestamibi in tumours, the exact uptake mechanism is still a matter of discussion. We investigated ultrastructural cell type of thyroid tumours by electron microscopy (EM) and compared them with uptake of 99Tc(m)-sestamibi. Thyroid scintigraphy with 99Tc(m)-sestamibi was performed on 25 patients who displayed a cold nodule on previous pertechnetate scintigraphy. Tumour-to-thyroid (T/N) uptake ratio was measured semiquantitatively. Surgery was performed in all patients and cytological evaluations were done by EM. Histopathology revealed six papillary carcinomas, 16 follicular adenomas and three Hurthle cell tumours. Thyroid cells were classified as A and B cells using EM. The cytoplasm of an A cell has the normal amount of mitochondria, whereas cytoplasm of a B cell (mitochondria-rich oxyphilic cell) contains abundant mitochondria. The median T/N ratio on the early scan for an A-cell tumour was 1.21 (range, 0.74-3.2), late T/N ratio was 1.25 (range, 0.72-3.85). The T/N ratio for the B-cell tumours was 1.42 (range, 0.6-3.6) on the early scan and 1.18 (range, 0.64-5.58) on the late scan. There was no statistically significant difference between T/N ratios of A- and B-cell tumour groups. A significant difference was also not seen between early and late T/N ratios. According to our findings, 99Tc(m)-sestamibi accumulates in thyroid tumours with both A and B cells, therefore these results suggest that the mitochondrial content of tumours is not only responsible for sestamibi uptake and retention.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Sarikaya A,Huseyinova G,Irfanoğlu ME,Erkmen N,Cermik TF,Berkarda Sdoi
10.1097/00006231-200101000-00006keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
39-44issue
1eissn
0143-3636issn
1473-5628journal_volume
22pub_type
杂志文章abstract::Venous thromboembolism (VTE) can present as deep vein thrombosis (DVT) and/or acute pulmonary embolism (PE). In fluorine-18 fluorodeoxyglucose (18F-FDG) PET/CT, 18F-FDG activity along the deep veins of the lower extremities (LE) is often observed and, unless it is associated with focal intense activity, is not conside...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000442
更新日期:2016-03-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200504000-00003
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001349
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journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200110000-00015
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3282f3d03e
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199608000-00009
更新日期:1996-08-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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更新日期:1992-05-01 00:00:00
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更新日期:2011-11-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198510000-00007
更新日期:1985-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00006231-198710000-00005
更新日期:1987-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00006231-199402000-00002
更新日期:1994-02-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3282f5d291
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e328360d8ec
更新日期:2013-06-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0b013e32835afe62
更新日期:2013-02-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199802000-00010
更新日期:1998-02-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32835587f8
更新日期:2012-08-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199504000-00161
更新日期:1995-04-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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更新日期:1986-08-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200409000-00012
更新日期:2004-09-01 00:00:00
abstract:INTRODUCTION:The metabotropic glutamate receptor subtype 5 (mGluR5) is distributed throughout the central nervous system (CNS), and has been suggested to be a potential target for several CNS disorders suchas Parkinson's disease, pain, anxiety, depression, schizophrenia, and addiction. We report here on the rhesus monk...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3283060c72
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journal_title:Nuclear medicine communications
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00