Abstract:
INTRODUCTION:Diagnosis of focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) using conventional imaging techniques can be difficult; however, it is important to differentiate between them as these benign liver tumors require different therapeutic strategies. The aim of our study was to prospectively evaluate the use of PET/computed tomography (CT) with F-fluoromethylcholine (F-FCH) as a novel diagnostic approach in the differentiation between HCA and FNH. MATERIALS AND METHODS:Fifty-six consecutive patients with a suspicion of one or multiple HCAs or FNHs larger than 2 cm were prospectively included after written informed consent was obtained from them. All the patients underwent a PET/CT with F-FCH. Histopathology of the lesions was the standard of reference. The ratio of the standardized uptake value (SUV) of the lesions compared with normal liver uptake within the same patient was calculated. Statistical tests were evaluated at the 95% confidence interval. RESULTS:Forty-nine patients with 60 lesions and histopathological diagnosis of FNH or HCA completed the study and were analyzed. The mean SUV ratio for FNH was 1.67±0.31 (mean±SD, n=28), resulting in a positive likelihood ratio of 32.3 for PET-positive FNH. The mean SUV ratio for HCA was 0.82±0.17 (n=32), with a likelihood ratio of ∼100 for PET-negative HCA. Receiver operating characteristic curve analysis revealed an optimal SUV ratio cutoff value of 1.13, which reached 100% sensitivity and 97% specificity in differentiating FNH from HCA. CONCLUSION:This prospective study shows that PET/CT with F-FCH can accurately differentiate FNH from HCA and may become a valuable diagnostic tool when conventional imaging techniques fail to do so.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Bieze M,Bennink RJ,El-Massoudi Y,Phoa SS,Verheij J,Beuers U,van Gulik TMdoi
10.1097/MNM.0b013e32835afe62subject
Has Abstractpub_date
2013-02-01 00:00:00pages
146-54issue
2eissn
0143-3636issn
1473-5628journal_volume
34pub_type
临床试验,杂志文章abstract::It is possible to obtain an estimate of the bone uptake of diphosphonates after 3 h (BU) on the basis of the difference between the dose administered and the sum of the component eliminated in the urine plus the component present in the extra-osseous volume of distribution. The results of this simple method have been ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199509000-00008
更新日期:1995-09-01 00:00:00
abstract:PURPOSE:Sickle cell disease (SCD) is a common hematologic hereditary disorder characterized by vaso-occlusive episodes affecting multiple organs, and substantially alters renal structure and function. We aimed to evaluate the utility of renal scintigraphy and single photon emission computed tomography/computed tomograp...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000001086
更新日期:2019-11-01 00:00:00
abstract::The biodistribution of 131I-6 beta-iodomethyl-19-norcholesterol (NP-59) was assessed in hypercholesterolaemic patients and in a rabbit model of HC to examine the alterations in the relative distribution of NP-59 and its metabolites and to explain the changes in the patterns of adrenal cortical imaging in patients with...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198608000-00010
更新日期:1986-08-01 00:00:00
abstract::The aims of this study were to develop an objective method for assessing rCBF deficits using a statistical image analysis protocol and to validate its effective use in clinical practice. 99Tcm-HMPAO brain SPET images were acquired for 40 normal subjects, 10 patients with Alzheimer's disease and 10 patients with depres...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199901000-00006
更新日期:1999-01-01 00:00:00
abstract::The aim of the study was to measure the actual dose at 1 m from the patients per unit activity with the aim of providing a more accurate prediction of the dose levels around radioiodine patients in the hospital, as well as to compare our results with the literature. In this work the demonstration of a patient body tis...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000223
更新日期:2015-02-01 00:00:00
abstract::The main aim of this study was to investigate the role of N-(2,4,6 trimethyl-3-bromophenylcarbamoylmethyl) iminodiacetic acid (IDA; Mebrofenin) scintigraphy in follow-up assessments of the biliary system in patients with cystic fibrosis associated liver disease. Fourteen patients from a study published in 1996 were re...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200207000-00012
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVES:Concurrent inflammation or anemia at the time of PET/computed tomography (CT) could be one of several causes of diffuse splenic (18)F-fluorodeoxyglucose ((18)F-FDG) uptake. In this study, we focused on cytokines to investigate interactions during this phenomenon and clarify the significance of splenic (18)F-...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0b013e3283595cac
更新日期:2013-01-01 00:00:00
abstract::The standard nuclear medicine textbooks describe the pyramidal lobe of the thyroid as arising from the upper part of the thyroid lobes. Anatomy and surgical texts however describe it as a thyroglossal tract remnant and state that it arises from the isthmus. Review of 150 thyroid scintigrams confirms that on scintigrap...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198403000-00006
更新日期:1984-03-01 00:00:00
abstract:AIM:To develop a strategy for checking the reliability of slope intercept measurement of glomerular filtration rate (GFR). METHODS:Six blood samples, obtained bilaterally 20-240 min after the injection of Cr-ethylenediaminetetraacetic acid (EDTA) and iohexol into opposite arms, were assayed for indicator injected cont...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e328310b378
更新日期:2008-12-01 00:00:00
abstract:PURPOSE:Despite the growing use of fluorine-18-fluorodeoxyglucose (F-FDG) PET texture analysis to measure intratumoural heterogeneity in cancer research, the biologic basis of F-FDG PET-derived texture variables is poorly understood. We aimed to assess correlations between F-FDG PET-derived texture variables and whole-...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000000925
更新日期:2018-12-01 00:00:00
abstract::The purpose of this study was to evaluate whether an extension of the imaging time to 24 h post-injection improves the diagnostic accuracy of technetium-99m-hexamethylpropyleneamine oxime (99mTc-HMPAO) leucocyte imaging in detecting knee replacement infections. Thirty patients were studied, with infection confirmed in...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200110000-00015
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to compare quantitative ECG-gated single-photon emission computed tomography (SPECT) (QGS) and model-based ECG-gated single-photon emission computed tomography (MBGS) for determination of end-diastolic cardiac volume (EDV), end-systolic cardiac volume (ESV), and left ventricular...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3283294d19
更新日期:2009-04-01 00:00:00
abstract::Four methods of calculating the activity of 99Tcm-hexamethylpropyleneamine oxime to be administered in cerebral blood flow investigations of children were evaluated in patient studies. Three of the methods were based on the size of the child. We also constructed a theoretical dosage model based on physiological data a...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199605000-00012
更新日期:1996-05-01 00:00:00
abstract::Radioactive tracer techniques using 131I- and 125I-insulin have been applied to study insulin metabolism. A simple method to label human insulin with 123I to a high specific activity is described. We have used this radiotracer to study insulin kinetics in vivo in normal subjects and in two groups of diabetic patients....
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198710000-00003
更新日期:1987-10-01 00:00:00
abstract::Fluorine-18-sodium fluoride (F-NaF) PET/CT is a relatively new and high-resolution bone imaging modality. Since the use of F-NaF PET/CT has been increasing, it is important to accurately assess the images and be aware of normal distribution and major artifacts. In this pictorial review article, we will describe the no...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/MNM.0000000000000720
更新日期:2017-10-01 00:00:00
abstract::Many materials and types of implant have been used to achieve a cosmetic effect and prosthesis motility in the anophthalmic socket. Hydroxyapatite remains the implant material of choice for producing the most natural prosthesis motility while porous polyethylene shows promising characteristics as another useful materi...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200312000-00006
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:Radium-223 was a treatment approved for patients with metastatic castrate-resistant prostate cancer, symptomatic bone metastases and no-visceral metastases, in progression after at least two prior lines of systemic therapy, or ineligible for any available systemic treatment. The aim of this study was to prov...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001164
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:In our study, tumor heterogeneity was evaluated using the parameters skewness and kurtosis on pretreatment Ga-68 DOTA-TATE PET/CT to assess therapy responses of lesions in patients with gastroenteropancreatic neuroendocrine tumors (GEP NETs) treated with peptide receptor radionuclide therapy (PRRT). METHOD:We ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001231
更新日期:2020-10-01 00:00:00
abstract::The study of the kinetics of labelled platelets makes sense only when the platelets preserve their viability after separation and labelling. The separation and labelling procedures described in the manual of two producers of 111In-oxinate (Amersham, Mallinckrodt) have been evaluated by in vitro aggregation tests. The ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract:AIM:To perform a detailed analysis of the performance of mobile intraoperative imaging systems and gamma probes in a phantom set-up, and compare this with a conventional gamma camera. METHODS:Two separate experiments were performed. In the first, a modified Jaszczak phantom equipped with five (99m)Tc-filled hot sphere...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3283508577
更新日期:2012-05-01 00:00:00
abstract::Positron emission tomography (PET) is increasingly used clinically to provide functional information on disease processes, especially in oncology using the glucose analogue 2-[18F]fluoro-2-deoxy-D-glucose (F-FDG). In the clinical setting it has become standard practice to use simplified imaging protocols compared to t...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/01.mnm.0000134327.85170.6b
更新日期:2004-07-01 00:00:00
abstract::We studied two different methods for the evaluation of differential renal function in a group of 100 patients with various kidney disorders whose effective renal plasma flow (ERPF) had been calculated previously by single 125I-orthoiodohippurate (OIH) injection and multiple blood sampling. Patients were divided into t...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198910000-00008
更新日期:1989-10-01 00:00:00
abstract::The effect of the dual window scatter subtraction method was tested for first-pass radiocardiography using 99Tcm. The photopeak window of 126-154 keV (20%) and Compton window of 93-125 keV (30%) were used. The set of scattered images was multiplied by a factor of 0.4 and subtracted from the primary images. The size of...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199611000-00009
更新日期:1996-11-01 00:00:00
abstract::Morphine sulfate has been used by several investigators in the cholescintigraphic diagnosis of acute cholecystitis. A review of the available literature indicates that morphine sulfate significantly reduces the total time required for the hepatobiliary examination, while retaining both high sensitivity (98.8%) and spe...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/00006231-198803000-00005
更新日期:1988-03-01 00:00:00
abstract::This study surveyed practice in nuclear cardiology in the UK in 1994. A questionnaire was sent to 219 centres performing nuclear imaging asking for details of current practice in nuclear cardiology. Replies were received from 192 centres (88%). Activity in performance of myocardial perfusion imaging (MPI) and radionuc...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199804000-00004
更新日期:1998-04-01 00:00:00
abstract::Planar scintimammography with 99Tcm-sestamibi (99Tcm-MIBI) has been shown to be useful in diagnosing breast carcinoma. The aim of this study was to compare single photon emission tomography (SPET) and planar imaging for scintimammography with 99Tcm-MIBI in the detection of primary breast cancer and axillary lymph node...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Attempts have been made to improve the positivity of the radionuclide detection of gastroesophageal reflux (GER). The aim of this study was to examine the possible contribution of coughing as a provoking maneuver in GER scintigraphy. METHODS:One hundred and twenty-five patients (mean age: 9.2+/-3.2 years) w...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3283298f90
更新日期:2009-06-01 00:00:00
abstract::Reticuloendothelial system (RES) phagocytic function or capacity can be measured by clearance studies with test substances. This study in the rat examines three commercially available 99Tcm-labelled test substances, and different methods of calculating RES capacity. Albures size 500 nm and sulphur colloid size 600 nm ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198705000-00004
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVE:To determine whether any patient or hepatic tumor characteristics are predictive of hepatopulmonary shunt fraction when performed before radioembolization. MATERIALS AND METHODS:A retrospective review was performed on 190 patients who underwent preradioembolization hepatic arteriography with calculation of h...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000528
更新日期:2016-09-01 00:00:00
abstract::Scintigraphically, Warthin's tumour usually demonstrates increased tracer uptake compared to normal adjacent salivary tissue. A case is presented in which tumour uptake is no greater than the normal adjacent gland. Gustatory stimulation results in failure of tumour tracer washout, and this finding rather than 'hot' sa...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198806000-00007
更新日期:1988-06-01 00:00:00