Improved method for detecting knee replacement infections based on extended combined 99mTc-white blood cell/bone imaging.

Abstract:

:The purpose of this study was to evaluate whether an extension of the imaging time to 24 h post-injection improves the diagnostic accuracy of technetium-99m-hexamethylpropyleneamine oxime (99mTc-HMPAO) leucocyte imaging in detecting knee replacement infections. Thirty patients were studied, with infection confirmed in eight (27%) and excluded in 22 on the basis of clinical and microbiological findings. Leucocyte imaging was carried out at 2-4 h (routine images) and at 24 h (late images) post-injection. For comparison, bone imaging with technetium-99m-hydroxydiphosphonate (99mTc-HDP) was carried out at arterial, soft tissue and metabolic phases. Late leucocyte imaging was found to be more sensitive (100% vs. 87.5%) and more specific (82% vs. 77%) than routine leucocyte imaging in detecting infections. All the bone imaging methods showed a sensitivity of 100%, whereas the specificity varied from only 5% to 23%. All procedures had high negative predictive values (NPVs) (94 to 100%) for excluding infection. However, the positive predictive value (PPV) was only 28 to 32% for bone imaging and 58% for routine leucocyte imaging, whereas late leucocyte imaging showed a PPV of 67% and a diagnostic accuracy of 87%. The data indicate that late leucocyte imaging may be superior to routine leucocyte imaging for examining patients with symptomatic knee replacements.

journal_name

Nucl Med Commun

authors

Larikka MJ,Ahonen AK,Junila JA,Niemelä O,Hämäläinen MM,Syrjälä HP

doi

10.1097/00006231-200110000-00015

keywords:

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

1145-50

issue

10

eissn

0143-3636

issn

1473-5628

journal_volume

22

pub_type

临床试验,杂志文章
  • Pulmonary perfusion assessment with respiratory gated 99mTc macroaggregated albumin SPECT: preliminary results.

    abstract:PURPOSE:Respiratory gated perfusion single photon emission computed tomography (SPECT) was applied to reduce respiratory lung motion effects and to reliably assess perfusion impairment in various lung diseases. METHODS:After injection of 259 MBq of 99mTc macroaggretated albumin (99mTc-MAA), gating was performed using ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200402000-00016

    authors: Suga K,Kawakami Y,Zaki M,Yamashita T,Matsumoto T,Matsunaga N

    更新日期:2004-02-01 00:00:00

  • A routine method for using sodium iodide to stabilize sodium pertechnetate [99Tcm] dispensed for the preparation of 99Tcm-exametazime.

    abstract::When preparing 99Tcm-exametazime, it is important to use sodium 99Tcm-pertechnetate that is less than 2 h old. The addition of sodium iodide (NaI) to 99Tcm-pertechnetate is known to extend this time to 6 h. This paper describes a technique for implementing this in routine practice. Sterile kits consisting of 440 micro...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199205000-00003

    authors: Millar AM

    更新日期:1992-05-01 00:00:00

  • Yttrium-90 dosimetry and implications on tumour response and survival after radioembolisation of chemo-refractory hepatic metastases from breast cancer.

    abstract:PURPOSE:The aim of the study was to evaluate the effects of tumour dose on tumour response and overall survival (OS) in patients with chemo-refractory metastatic breast cancer (MBC) to the liver undergoing yttrium-90 radioembolisation (Y90 RE). MATERIALS AND METHODS:In 20 consecutive patients with chemo-refractory MBC...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001345

    authors: Cheng B,Sethi I,Davisson N,Brandon D,Barron B,Galt J,Bercu Z,Schuster DM,Kokabi N

    更新日期:2020-12-09 00:00:00

  • Myocardial perfusion imaging versus biochemical markers in acute coronary syndromes.

    abstract::The assessment and appropriate clinical management of patients with acute chest pain and non-diagnostic electrocardiograms remain a continuing clinical problem. Accordingly, there is considerable interest in evaluating new strategies to improve early diagnostic accuracy in patients with possible acute myocardial ischa...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200310000-00004

    authors: Anand DV,Lahiri A

    更新日期:2003-10-01 00:00:00

  • Uptake in the pancreatic uncinate process on the 111In-octreotide scintigraphy: How to distinguish physiological from pathological uptake?

    abstract:BACKGROUND:The aim of this study was to assess the relevance of physiological In-octreotide uptake in the head of pancreas and to establish its imaging features in comparison with pathological uptake in patients with neuroendocrine tumors (NET). PATIENTS AND METHODS:We retrospectively reviewed all patients that underw...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000710

    authors: Ait Boudaoud A,Verges B,Petit JM,Tatulashvili S,Cochet A,Humbert O

    更新日期:2017-09-01 00:00:00

  • The role of nuclear medicine in orthopaedics.

    abstract::Patients with a wide variety of orthopaedic disorders can be usefully investigated by nuclear medicine techniques, mostly by bone scintigraphy. Overall this area of nuclear medicine activity is increasing which is a trend that can be expected to continue. The principal conditions that are imaged are fractures and thei...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/00006231-199405000-00006

    authors: Ryan PJ,Fogelman I

    更新日期:1994-05-01 00:00:00

  • Clinical competence in myocardial perfusion scintigraphic stress testing: general training guidelines and assessment.

    abstract::The suggestion by the National Institute for Clinical Excellence (NICE) to more than triple the number of myocardial perfusion scintigraphy (MPS) procedures carried out by the NHS each year is a challenge both in terms of numbers of gamma cameras available to carry out the scans and qualified staff to supervise stress...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,实务指引

    doi:10.1097/MNM.0b013e32818a6e72

    authors: Jones I,Latus K,Bartle L,Gardner M,Parkin V,Guideline Development and Writing Group, British Nuclear Medicine Society and British Nuclear Cardiac Society.

    更新日期:2007-07-01 00:00:00

  • Is computer-aided interpretation of 99Tcm-HMPAO leukocyte scans better than the naked eye?

    abstract::In order to compare visual interpretation of inflammation detected by leukocyte scintigraphy with that of different computer-aided quantification methods, 34 patients (25 with ulcerative colitis and 9 with endoscopically verified non-inflamed colonic mucosa), were investigated using 99Tcm-hexamethylpropyleneamine oxim...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199504000-00161

    authors: Almer S,Peters AM,Ekberg S,Franzén L,Granerus G,Ström M

    更新日期:1995-04-01 00:00:00

  • Different methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations: 99mTc-sestamibi in chemotherapy for breast tumours.

    abstract:AIM:This study was undertaken to evaluate different methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations in the same individual. No standard exists for making digital evaluations at single-photon examinations. For this purpose, we employed a patien...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/01.mnm.0000202866.97787.45

    authors: Jacobsson H,Wilczek B,Bergh J,von Schoultz E,Eriksson E,Larsson SA

    更新日期:2006-04-01 00:00:00

  • Predicting the response to cardiac resynchronization therapy using 99mTc-tetrofosmin myocardial scintigraphy in patients with drug-refractory heart failure: additional value of the washout of 99mTc-tetrofosmin.

    abstract:OBJECTIVE:A lack of response to cardiac resynchronization therapy (CRT) has been reported in 20-40% of heart failure patients with left ventricular (LV) dyssynchrony who underwent treatment based on the established guidelines. The study aimed to investigate the relationship between (99m)Tc-tetrofosmin ((99m)Tc-TF) myoc...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0000000000000150

    authors: Shigeru M,Fujiwara S,Takamine S,Yoshida A,Kawai H,Shiotani H,Hirata K

    更新日期:2014-09-01 00:00:00

  • Bone lesion detection with carrier-added 99mTc-EDTMP in comparison with 99mTc-DPD.

    abstract::An increased uptake of bone-seeking radiopharmaceuticals into malignant bone lesions could further improve the diagnostic accuracy of routine bone scanning. The tracers used in clinical routine for bone scanning are methylene-diphosphonate (MDP), dicarboxypropane-diphosphonate (DPD) and ethylenediaminetetramethylene-p...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200404000-00008

    authors: Fueger BJ,Mitterhauser M,Wadsak W,Ofluoglu S,Traub T,Karanikas G,Dudczak R,Pirich C

    更新日期:2004-04-01 00:00:00

  • 201Tl scintigraphy in the staging of lung cancer, breast cancer and lymphoma.

    abstract::To evaluate 201Tl in the detection of the primary tumour, lymph node involvement and mediastinal spread we have studied a total of 188 patients with histologically proven lung cancer, breast cancer or malignant lymphoma. Ten patients with benign lung disease were also examined. Static images were performed 20 min afte...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199004000-00002

    authors: Sehweil AM,McKillop JH,Milroy R,Sayed MA,Ziada G,Banham SW,Davidson KG,Ragib A,Omar YT,Abdel-Dayem HM

    更新日期:1990-04-01 00:00:00

  • 18F-Fluorodeoxyglucose PET/CT and dynamic contrast-enhanced MRI as imaging biomarkers in malignant pleural mesothelioma.

    abstract:PURPOSE:The purpose of this study was to compare the use of fluorine-18-fluorodeoxyglucose (F-FDG) PET with computed tomography (CT) and dynamic contrast-enhanced (DCE) MRI to predict prognosis and monitor treatment in malignant pleural mesothelioma. PATIENTS AND METHODS:F-FDG PET/CT and DCE-MRI studies carried out as...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0000000000000789

    authors: Hall DO,Hooper CE,Searle J,Darby M,White P,Harvey JE,Braybrooke JP,Maskell NA,Masani V,Lyburn ID

    更新日期:2018-02-01 00:00:00

  • Impact of fluorodeoxyglucose PET on the management of esophageal cancer.

    abstract::Esophageal cancer is the third most common malignancy of the alimentary tract. The incidence of esophageal cancer has steadily increased over the past three decades. Almost all therapeutic modalities for esophageal cancer are associated with a considerable mortality and morbidity. Consequently, there has been growing ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/MNM.0b013e32831af204

    authors: Salavati A,Basu S,Heidari P,Alavi A

    更新日期:2009-02-01 00:00:00

  • Isometric exercise testing and echocardiography at rest in aortic valve incompetence.

    abstract::Thirty patients with aortic valve incompetence and 21 control subjects were examined by M-mode echocardiography at rest and radionuclide ventriculography during submaximal handgrip exercise. The patients had greater left ventricular dimensions and end-systolic wall stress values but peak systolic wall stress values di...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199004000-00004

    authors: Groundstroem K,Huikuri H,Korhonen U,Ikäheimo M,Heikkilä J,Torniainen P,Linnaluoto M,Takkunen J

    更新日期:1990-04-01 00:00:00

  • Refillable point source for motion correction during first-pass radionuclide angiography.

    abstract::First-pass radionuclide angiography, for the evaluation of ventricular function during peak physiological stress, requires the use of a low-energy point source for correction of motion artifacts. A design for the construction of a refillable 125I point source is presented. ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199201000-00009

    authors: Hirsch JI,Fuhs BE,Tatum JL,Tatum TG

    更新日期:1992-01-01 00:00:00

  • Prevalence and risk factors of intraoperative identification failure of sentinel lymph nodes in patients affected by breast cancer.

    abstract:INTRODUCTION:Sentinel lymph node biopsy (SLNB) has progressively replaced complete axillary lymph node dissection in the evaluation of breast cancer patients with clinically node-negative disease. Our study investigates the rate of and risk factors involved in sentinel node identification failure. MATERIALS AND METHOD...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328361cd84

    authors: Bernardi S,Bertozzi S,Londero AP,Angione V,Petri R,Giacomuzzi F

    更新日期:2013-07-01 00:00:00

  • Utility of 18F-FDG PET/CT in the diagnosis and staging of extramammary Paget's disease.

    abstract:PURPOSE:Extramammary Paget's disease (EMPD) is rare, and limited data have been reported on the utilization of fluorine-18 fluorodeoxyglucose PET/computed tomography ((18)F-FDG PET/CT) in this disease. The aim of this study is to evaluate the role of (18)F-FDG PET/CT in the diagnosis and staging of EMPD. MATERIALS AND...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000340

    authors: Tian Y,Wu HB,Li DL,Li HS,Zhou WL,Wang QS

    更新日期:2015-09-01 00:00:00

  • Determination of left ventricular cardiac volume by simultaneous radionuclide angiography and measurement of oxygen consumption at rest and during maximal exercise: a comparison of two non-invasive isotopic procedures.

    abstract::The investigation of left ventricular contractile reserve usually requires the determination of left ventricular volume, but its measurement with radionuclide angiography is difficult. The aim of this study was to determine left ventricular volume directly during exercise by the simultaneous measurement of peak exerci...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199612000-00007

    authors: Faraggi M,Cohen-Solal A,Czitrom D,Sarda L,Lebtahi R,Daou D,Petegnief Y,Gourgon R,Guludec DL

    更新日期:1996-12-01 00:00:00

  • Quantifying the value of diagnostic tests.

    abstract::This paper considers the different statistics that can be derived from studies on the value of diagnostic tests. Well-accepted quantities, such as sensitivity and specificity, are reviewed and the value of the likelihood ratio in communicating particular test results is highlighted. A new quantity, the 'diagnostic val...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审

    doi:10.1097/00006231-199810000-00010

    authors: Lloyd JJ,Talbot PR,Lawson RS

    更新日期:1998-10-01 00:00:00

  • Validation set analysis to predict postoperative outcomes by technetium-99m galactosyl serum albumin scintigraphy for hepatectomy.

    abstract:BACKGROUND:The indocyanine green retention rate at 15 min (ICGR15) is a gold standard parameter of liver function when deciding on the extent of hepatectomy. However, ICGR15 is influenced by several hepatic conditions. To evaluate auxiliary preoperative liver functional reserve, we examined the clinical significance of...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001162

    authors: Nanashima A,Hiyoshi M,Imamura N,Yano K,Hamada T,Wada T,Nishimuta M,Shimizu I,Mizutani Y

    更新日期:2020-04-01 00:00:00

  • Acute effect of 3-(4-acetamido)-butyrril-lorazepam (DDS2700) on brain function assessed by PET at rest and during attentive tasks.

    abstract::The aim of this study was to assess, by positron emission tomography (PET), the effect on cerebral functional activity of a new lorazepam-gamma-aminobutyric acid (GABA) conjugate [3-(4-acetamido)-butyrril lorazepam (DDS2700)]. Ten healthy volunteers were studied by PET and [18F]fluoro-deoxy-D-glucose ([18F]FDG) under ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200104000-00008

    authors: Moresco RM,Tettamanti M,Gobbo C,Del Sole A,Ravasi L,Messa C,Paulesu E,Lucignani G,Perani D,Fazio F

    更新日期:2001-04-01 00:00:00

  • Significant reduction of 125 I-meta-iodobenzylguanidine accumulation directly caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine, a toxic agent for inducing experimental Parkinson's disease.

    abstract::A significant reduction of cardiac 123I-meta-iodobenzylguanidine (MIBG) accumulation has been reported in patients with idiopathic Parkinson's disease. However, it is unclear whether this reduction in cardiac sympathetic nerve is caused primarily or secondarily to the degeneration of sympathetic nerve centres which oc...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200202000-00008

    authors: Takatsu H,Wada H,Maekawa N,Takemura M,Saito K,Fujiwara H

    更新日期:2002-02-01 00:00:00

  • Diagnostic accuracy of combined 99mTc-sulesomab and 99mTc-nanocolloid bone marrow imaging in detecting prosthetic joint infection.

    abstract:OBJECTIVE(S):Autologous-labeled leukocytes combined with sulfur colloid bone marrow scan is the current nuclear medicine gold standard for the diagnosis of prosthetic joint infection. The goal of this study is to assess the diagnostic accuracy of a new nuclear medicine modality for detecting infection in this context. ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0b013e3283496695

    authors: Sousa R,Massada M,Pereira A,Fontes F,Amorim I,Oliveira A

    更新日期:2011-09-01 00:00:00

  • Image-derived input function in PET brain studies: blood-based methods are resistant to motion artifacts.

    abstract:BACKGROUND:Image-derived input function (IDIF) from carotid arteries is an elegant alternative to full arterial blood sampling for brain PET studies. However, a recent study using blood-free IDIFs found that this method is particularly vulnerable to patient motion. The present study used both simulated and clinical [11...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328356185c

    authors: Zanotti-Fregonara P,Liow JS,Comtat C,Zoghbi SS,Zhang Y,Pike VW,Fujita M,Innis RB

    更新日期:2012-09-01 00:00:00

  • Different fibrovascularization rate between coralline hydroxyapatite and high density porous polyethylene (Medpore) measured by 99mTc-MDP bone scintigraphy 6 months after intraorbital implantation.

    abstract::Many materials and types of implant have been used to achieve a cosmetic effect and prosthesis motility in the anophthalmic socket. Hydroxyapatite remains the implant material of choice for producing the most natural prosthesis motility while porous polyethylene shows promising characteristics as another useful materi...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200312000-00006

    authors: Pan MH,Wu YW,Yen RF,Tzen KY,Liao SL,Kao CH

    更新日期:2003-12-01 00:00:00

  • GFR measurement by simulating constant infusion with data acquired using a CdTe detector. A feasibility study.

    abstract::Conventional nuclear medicine methods for measuring glomerular filtration rate, GFR, are invalidated if the initial injection of radiopharmaceutical is tissued. An analytical method proposed by Veall and Gibbs in 1982 overcomes this difficulty but does require multiple blood samples. This paper investigates whether it...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198611000-00003

    authors: Casey M,Barker F,Duffy G

    更新日期:1986-11-01 00:00:00

  • Should the presence of other diseases exclude subjects as controls in studies of gallbladder response to cholecystokinin octapeptide (sincalide)? Scintigraphic results in patients with malignancies but no known gallbladder disease.

    abstract::Findings of hepatobiliary scintigraphy with intravenous cholecystokinin octapeptide (sincalide) were examined in 26 asymptomatic patients with various malignancies but no known pre-existing gallbladder disease, and normal hepatobiliary and gallbladder morphology on sonography. The maximum gallbladder ejection fraction...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199606000-00010

    authors: Jacobson AF,Teefey SA

    更新日期:1996-06-01 00:00:00

  • Occurrence of pulmonary thromboembolism immediately after arthroplasty.

    abstract:INTRODUCTION:Respiratory complications are common after arthroplasty, with pulmonary thromboembolic disease (PTE) and fat emboli being the most serious. A scintigraphic study was designed to assess the occurrence of both diseases. A prospective tomographic study of perfusion was performed within 24 h of arthroplasty. D...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200111000-00011

    authors: Bruce W,Van der Wall H,Peters M,Liaw Y,Morgan L,Storey G

    更新日期:2001-11-01 00:00:00

  • Optimizing an 18F-NaF and 18F-FDG cocktail for PET assessment of metastatic castration-resistant prostate cancer.

    abstract:BACKGROUND:PET/computed tomography (CT) imaging with the sodium-(F)-fluoride/2-(F)-fluoro-2-deoxy-D-glucose (F-NaF/F-FDG) cocktail has been proposed for patients with osseous metastases. This work aimed to optimize the cocktail composition for patients with metastatic castration-resistant prostate cancer (mCRPC). MATE...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000383

    authors: Simoncic U,Perlman S,Liu G,Jeraj R

    更新日期:2015-12-01 00:00:00