Abstract:
:At present, it is difficult to distinguish between bacterial infections and sterile inflammatory processes using radiopharmaceuticals. This is so for a variety of reasons, including binding to bacteria with low affinity (e.g. infection) and binding to a specific micro-organism (e.g. radiolabelled monoclonal antibodies or F(ab)2 fragments thereof against micro-organisms). In this review, we propose that radiolabelled antimicrobial peptides should be the first choice in the development of new radiopharmaceuticals for imaging of bacterial infections. Antimicrobial peptides are a recently discovered component of the innate defence system of plants, animals and humans. These peptides, which now number more than 100, with proven microbicidal activity against a variety of micro-organisms, share certain properties, such as their small size and cationic charge. The latter allows them to bind preferentially to a broad spectrum of micro-organisms. We have recently demonstrated that radiolabelled human defensins allow the rapid visualization of bacterial infections in mice. Furthermore, binding of this antimicrobial peptide to bacteria is the major factor contributing to the accumulation of this tracer in bacterial infections. Based on these considerations, we believe that radiolabelled antimicrobial peptides will be an important asset in the imaging of infections in patients.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Nibbering PH,Welling MM,van den Broek PJ,van Wyngaarden KE,Pauwels EK,Calame Wdoi
10.1097/00006231-199812000-00002subject
Has Abstractpub_date
1998-12-01 00:00:00pages
1117-21issue
12eissn
0143-3636issn
1473-5628journal_volume
19pub_type
杂志文章,评审abstract:OBJECTIVE:The aim of this study was to investigate the capability of F-FDG PET/computed tomography (CT)-related metabolic parameters to predict lymph node metastasis (LNM) and occult lymph node metastasis (OLNM) in patients with esophageal squamous cell carcinoma (ESCC). METHODS:Totally 84 patients undergoing curative...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001050
更新日期:2019-09-01 00:00:00
abstract::Medullary thyroid cancer (MTC) originates from parafollicular C cells of the thyroid and accounts for 3-12% of all thyroid cancers. As opposed to other types of dedifferentiated thyroid tumours, MTC cells are highly functional, producing and secreting high amounts of calcitonin and carcinoembryonic antigen. As parafol...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/MNM.0b013e32830f4af2
更新日期:2008-11-01 00:00:00
abstract::The radiation dose to the pulp of both index fingers has been measured in a radiopharmacy supplying 11 000 patient doses a year, in a hospital dispensary (4500 doses a year) and in its injection area. Tungsten syringe shields were used for one week and not used during the other week. In the radiopharmacy and the dispe...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198508000-00004
更新日期:1985-08-01 00:00:00
abstract:AIM:This study was carried out to compare the efficacy of Y, Lu, and combination of both radiotracers (tandem) peptide receptor radionuclide therapy (PRRT) in patients with inoperable and metastatic neuroendocrine tumors. MATERIALS AND METHODS:Systematic searches of PubMed and SciVerse Scopus databases were performed ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,meta分析
doi:10.1097/MNM.0000000000000758
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To analyse the kinetic changes of uptake, washout and retention of Tc-sestamibi in order to evaluate the protective effects and possible mechanism of ischaemic preconditioning and adenosine preconditioning on myocardium injured by ischaemia/reperfusion. METHODS:Isolated ischaemia/reperfusion rabbit heart mod...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3282f1781b
更新日期:2007-11-01 00:00:00
abstract::We evaluated the clinical usefulness of 99Tcm-N,N-ethylenedicysteine (99Tcm-EC), a new renal tubular agent, in normal children and in children with various renal disorders and compared it with 99Tcm-mercaptoacetyltriglycine (99Tcm-MAG3). In a first group of children (Group 1), which included 15 patients and 4 normal c...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199701000-00009
更新日期:1997-01-01 00:00:00
abstract::Uterine leiomyomas, benign tumours of the human uterus, are the most common uterine neoplasm and are composed of smooth muscle with varying amounts of fibrous connective tissue. As a functional imaging modality, 2-[F]fluoro-2-deoxy-D-glucose (F-FDG) positron emission tomography can be used to obtain information about ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200409000-00012
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:Large cell pulmonary neuroendocrine carcinoma (LCNEC) is a poorly differentiated and high-grade neoplasm. It is positioned between an atypical carcinoid and small cell neuroendocrine carcinoma of the lung in a distinct family of pulmonary neuroendocrine tumors. The aim of our study was to detect somatostatin ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32834508b3
更新日期:2011-06-01 00:00:00
abstract::Following injection for renography, 99Tcm-labelled diethylenetriamine-pentacetic acid (DTPA) rapidly enters the extravascular space. Background therefore comprises two components, a falling intravascular signal and an extravascular signal which initially rises. We estimated the relative magnitudes of these two compone...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198808000-00003
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:The indication for sentinel node biopsy (SNB) has not been fully established yet for patients with ductal carcinoma in situ (DCIS). AIM:To relate the conversion rate to invasive carcinoma with sentinel node positivity in high risk DCIS, and to refine the clinical presentation analysis in order to better sel...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/01.mnm.0000230074.39071.bf
更新日期:2006-10-01 00:00:00
abstract::Fractionation of 99Tcm-exametazime enables several patients doses to be prepared from one vial. To overcome the disadvantages of storage at -70 degrees C, storage at higher temperatures was investigated with replacement of stannous ions before use. Kits were fractionated using a nitrogen-purged 0.9% w/v sodium chlorid...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199903000-00013
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:Attempts have been made to improve the positivity of the radionuclide detection of gastroesophageal reflux (GER). The aim of this study was to examine the possible contribution of coughing as a provoking maneuver in GER scintigraphy. METHODS:One hundred and twenty-five patients (mean age: 9.2+/-3.2 years) w...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3283298f90
更新日期:2009-06-01 00:00:00
abstract::Should one correct for extrathyroidal neck radioactivity ('neck background') when interpreting perchlorate discharge test results? A new background correction method was developed using a linear probe. 123I produces photon peaks at two energy levels: 159 keV (gamma-rays) and 28 keV (X-rays), with an attenuation of 15 ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199211000-00013
更新日期:1992-11-01 00:00:00
abstract::We have devised an original predictive residual index (PRI) using 99mTc diethylenetriaminepentaacetic acid galactosyl human serum albumin (99mTc-GSA) liver dynamic SPET for the pre-operative assessment of hepatectomy, including the prediction of residual liver function before hepatectomy. The aim of this study was to ...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200307000-00011
更新日期:2003-07-01 00:00:00
abstract::Radioimmunoscintigraphy (RIS) and radioimmunoguided surgery (RIGS) were assessed for their usefulness in patients with colorectal carcinoma. Twenty-nine patients (18 primary tumours, 10 with a suspicion of recurrence and one colonic diverticulitis) were studied. Radioimmunoscintigraphy was performed 48 and 72 h after ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199902000-00003
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Radium-223 was a treatment approved for patients with metastatic castrate-resistant prostate cancer, symptomatic bone metastases and no-visceral metastases, in progression after at least two prior lines of systemic therapy, or ineligible for any available systemic treatment. The aim of this study was to prov...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001164
更新日期:2020-04-01 00:00:00
abstract::The aims of this study were to establish the percentage of metastatic renal cell carcinoma (RCC) lesions detected by radioimmunoscintigraphy (RIS) with the chimeric monoclonal antibody 131I-cG250 versus positron emission tomography (PET) with 18F-labelled deoxyglucose ([18F]FDG), and to evaluate the use of these radio...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200203000-00005
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:In studies of the distribution of lung function, the image quality of lung single photon emission computed tomography (SPECT) is important and one factor influencing it is the reconstruction algorithm. AIM:To systematically evaluate ordered subsets expectation maximization (OSEM) and compare it with filtere...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3282f1acac
更新日期:2007-12-01 00:00:00
abstract::To evaluate right ventricular overload in paediatric patients with congenital cardiac disease (n = 25), the uptakes of 201Tl and 99Tcm-sestamibi (99Tcm-MIBI) were compared. 99Tcm-MIBI showed a clearer myocardial border and better contrast between the myocardium and ventricular cavity. Although hepatic activity may inf...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199511000-00010
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:A dedicated breast PET scanner with C-shaped detectors (C scanner) has been newly developed. The purpose of this study was to re-evaluate the diagnostic performance of high-resolution PET images with the new reconstruction conditions, obtained using this C scanner in breast cancer patients, and to compare th...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000661
更新日期:2017-05-01 00:00:00
abstract::Single kidney clearance can be obtained using the 99Tcm-DTPA complex and the scintillation camera. In order to evaluate the influence of statistical noise on the determination of the clearance, several non-noisy curves were constructed, simulating renal, background and precordial curves. Poisson noise was added to the...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198508000-00008
更新日期:1985-08-01 00:00:00
abstract::The standard nuclear medicine textbooks describe the pyramidal lobe of the thyroid as arising from the upper part of the thyroid lobes. Anatomy and surgical texts however describe it as a thyroglossal tract remnant and state that it arises from the isthmus. Review of 150 thyroid scintigrams confirms that on scintigrap...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198403000-00006
更新日期:1984-03-01 00:00:00
abstract::Technetium-99m (99Tcm)(V) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to evaluate squamous carcinoma (SCC) of the head and neck. This study evaluated the pharmacokinetics and biodistribution of 99Tcm(V)DMSA in patients with SCC and calculated the bone mass of a New Zealand White (N...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199005000-00002
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between lymph node (LN) size and localization and prostate-specific membrane antigen (PSMA) uptake in patients with prostate cancer. PATIENTS AND METHODS:Between February 2015 and February 2017, a total of 178 patients diagnosed with prostate adenocarcinoma by gallium-68 PSMA ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001032
更新日期:2019-08-01 00:00:00
abstract::This work was designed to compare sentinel lymph node (SLN) uptake of 99mTc-labelled human serum albumin colloid (99mTc-HSAC), 99mTc-labelled antimony sulphur colloid (99mTc-SC) and a 99mTc-labelled dextran 70 solution (99mTc-Dx) and their selectivity in the identification of this node in the right rear footpad (RRF) ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200105000-00006
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:The indocyanine green retention rate at 15 min (ICGR15) is a gold standard parameter of liver function when deciding on the extent of hepatectomy. However, ICGR15 is influenced by several hepatic conditions. To evaluate auxiliary preoperative liver functional reserve, we examined the clinical significance of...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001162
更新日期:2020-04-01 00:00:00
abstract:AIM:To develop a strategy for checking the reliability of slope intercept measurement of glomerular filtration rate (GFR). METHODS:Six blood samples, obtained bilaterally 20-240 min after the injection of Cr-ethylenediaminetetraacetic acid (EDTA) and iohexol into opposite arms, were assayed for indicator injected cont...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e328310b378
更新日期:2008-12-01 00:00:00
abstract::The efficacy of wipe tests for assessing 99Tcm surface contamination was measured. Four types of surface were contaminated with four radiopharmaceuticals and wiped using four types of swab. The fraction of activity removed was measured by direct monitoring for each combination of surface, pharmaceutical and swab. The ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199102000-00005
更新日期:1991-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the diagnostic value of 2-(fluorine-18)-fluoro-2-deoxy-D-glucose ((18)F-FDG) PET/CT in comparison with MRI for the detection of recurrent ovarian cancer. METHODS:Forty-seven patients with suspected ovarian cancer recurrence after total ablative or cytoreductive surgery, ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32834fc5bf
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:In-vivo quantitative cerebral blood flow (CBF) measurement using positron emission tomography (PET) has typically employed invasive arterial blood sampling procedure to determine the arterial input function (AIF). The present study was performed to provide a non-invasive quantitative CBF measurement technique...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200510000-00009
更新日期:2005-10-01 00:00:00