Three years' clinical practice of Radium-223 therapy in patients with symptomatic bone metastases from metastatic castrate-resistant prostate cancer: a single-centre experience.


BACKGROUND:Radium-223 was a treatment approved for patients with metastatic castrate-resistant prostate cancer, symptomatic bone metastases and no-visceral metastases, in progression after at least two prior lines of systemic therapy, or ineligible for any available systemic treatment. The aim of this study was to provide further characterization and sub-selection of patients who would benefit most with Radium-223 treatment. METHODS:We retrospectively analysed 38 patients treated with Radium-223 between 2015 and 2018. All patients underwent a baseline visit and a bone scintigraphy. Bone scan, ALP and PSA levels were repeated after third and after the end of therapy. All patients were re-evaluated after 2 months from the end of therapy. Survival curves were plotted according to the Kaplan-Meier method and differences between groups were analysed by using a two-tailed log-rank test. RESULTS:The response to the treatment in term of change in pain was reduction in 16 patients; no change in 14 and increased in eight. We arbitrarily established a cut-off 10 bone lesions to evaluate the response: patients with less than 10 metastasis had significant differences in PFS (P < 0.001) compared to patients with more than 10, no statistical significance was found considering the OS (P = 0.23) between the two groups. The same results were founded in patients with baseline ALP <220 U/L with a PFS (P < 0.001) and OS (P = 0.027). CONCLUSION:The most important finding was the correlation between the number of bone metastasis and ALP with outcome survival and efficacy of Radium-223 treatment.


Nucl Med Commun


Gazzilli M,Durmo R,Cossalter E,Cerudelli E,Panarotto MB,Albano D,Bertagna F,Giubbini R




Has Abstract


2020-04-01 00:00:00












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    abstract:BACKGROUND:Image-derived input function (IDIF) from carotid arteries is an elegant alternative to full arterial blood sampling for brain PET studies. However, a recent study using blood-free IDIFs found that this method is particularly vulnerable to patient motion. The present study used both simulated and clinical [11...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Zanotti-Fregonara P,Liow JS,Comtat C,Zoghbi SS,Zhang Y,Pike VW,Fujita M,Innis RB

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  • Audit of nuclear medicine scientific and technical standards.

    abstract::The British Nuclear Medicine Society has developed a process for the service-specific organizational audit of nuclear medicine departments. This process identified the need for a scheme suitable for the audit of the scientific and technical standards of a department providing such a service. This document has evolved ...

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    pub_type: 指南,杂志文章,实务指引


    authors: Jarritt PH,Perkins AC,Woods SD,British Nuclear Medicine Society.

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  • The use of single photon emission computed tomography in depressive disorders.

    abstract::Single photon emission computed tomography (SPECT) and positron emission tomography (PET) have advanced our understanding of the biological underpinnings of depression. There is, however, considerable variability in the literature. Depression is a complex disorder with marked heterogeneity in diagnosis and treatment. ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审


    authors: Smith DJ,Cavanagh JT

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  • 131 I-cG250 monoclonal antibody immunoscintigraphy versus [18 F]FDG-PET imaging in patients with metastatic renal cell carcinoma: a comparative study.

    abstract::The aims of this study were to establish the percentage of metastatic renal cell carcinoma (RCC) lesions detected by radioimmunoscintigraphy (RIS) with the chimeric monoclonal antibody 131I-cG250 versus positron emission tomography (PET) with 18F-labelled deoxyglucose ([18F]FDG), and to evaluate the use of these radio...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章


    authors: Brouwers AH,Dorr U,Lang O,Boerman OC,Oyen WJ,Steffens MG,Oosterwijk E,Mergenthaler HG,Bihl H,Corstens FH

    更新日期:2002-03-01 00:00:00

  • Stunning phenomenon after a radioactive iodine- ¹³¹I diagnostic whole-body scan: Is it really a point of clinical consideration?

    abstract:PURPOSE:Stunning of thyroid remnants after diagnostic scanning (Dx-WBS) using radioactive iodine- (¹³¹I) may limit the efficacy of I therapy. We aimed to evaluate this assumption in a prospectively designed study. METHODS:Forty patients who underwent thyroidectomy for differentiated thyroid carcinoma were studied and ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章


    authors: Amin A,Amin M,Badwey A

    更新日期:2013-08-01 00:00:00

  • Negative 18F-FDG-PET-CT may exclude residual or recurrent disease in anal cancer.

    abstract:OBJECTIVES:The incidence of anal cancer is increasing in Western countries. Fluorine-18 fluorodeoxyglucose (F-FDG) PET-computed tomography (CT) is used in the assessment of anal cancer, but its routine use is not established. The aim of this study was to assess the value of F-FDG-PET-CT in staging and post-treatment as...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Teagle AR,Gilbert DC,Jones JR,Burkill GJ,McKinna F,Dizdarevic S

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    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Lee EY,Gill H,Wang Y,Kwong YL,Khong PL

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  • Yttrium-90 dosimetry and implications on tumour response and survival after radioembolisation of chemo-refractory hepatic metastases from breast cancer.

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    authors: Cheng B,Sethi I,Davisson N,Brandon D,Barron B,Galt J,Bercu Z,Schuster DM,Kokabi N

    更新日期:2020-12-09 00:00:00

  • Long-lived radiopharmaceuticals: dispensing from multidose vials.

    abstract::We report the use of broth simulation as a means of validating the practice of sub-dispensing from stock vials of long-lived sterile radiopharmaceuticals. 'Matched' vials of nutrient broth accompanied the stock vials of long-lived sterile radiopharmaceuticals during their time in use and were subject to the same handl...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Murray T,Elliott AT,Hilditch TE

    更新日期:2005-06-01 00:00:00

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    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Clarke SE,McKillop JH,Prescott MC,Williams ED

    更新日期:1992-04-01 00:00:00

  • Myocardial fatty acid imaging with 123I-labelled 9-methyl-branched pentadecanoic acid (9MPA) using SPET.

    abstract::123I-labelled 15-(p-iodophenyl)-9-(R,S)-methylpentadecanoic acid (9MPA) is a modified long-chain fatty acid that shows some beta-oxidation. Some basic aspects of this fatty acid, including myocardial uptake, distribution, clearance and differences from 201Tl myocardial perfusion, have yet to be evaluated. An average o...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Nakajima K,Taki J,Yamamoto W,Takata S,Shimizu M,Tonami N

    更新日期:1998-09-01 00:00:00

  • Prospective evaluation of qualitative and quantitative ¹⁸F-FDG PET-CT parameters for predicting survival in recurrent carcinoma of the cervix.

    abstract:OBJECTIVE:The aim of this study was to evaluate the prognostic significance of qualitative and quantitative F-fluorodeoxyglucose (F-FDG) PET-computed tomography (PET-CT) parameters in patients with recurrent cervical carcinoma. METHODS:Twenty-six patients (age: 44 ± 10.1 years) with histologically proven recurrent car...

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    pub_type: 临床试验,杂志文章


    authors: Maharjan S,Sharma P,Patel CD,Sharma DN,Dhull VS,Jain SK,Thulkar S,Malhotra A,Kumar R

    更新日期:2013-08-01 00:00:00

  • Efficacy and safety of concomitant 177Lu-DOTATATE and low-dose capecitabine in advanced medullary thyroid carcinoma: a single-centre experience.

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    pub_type: 杂志文章


    authors: Satapathy S,Mittal BR,Sood A,Verma R,Panda N

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    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Dobbeleir A,Franken PR,Ham HR,Brihaye C,Guillaume M,Knapp FF,Vandevivere J

    更新日期:1991-01-01 00:00:00

  • 99Tcm-MAG3: a sensitive indicator for evaluating perfusion and rejection of renal transplants.

    abstract::Radionuclide renography has a role in evaluating perfusion of transplanted kidneys. In the course of rejection, cortical perfusion decreases before urinary excretion changes. Based on the facts that 99Tcm-MAG3 has different pharmacokinetics and shows a higher kidney-to-background count ratio than 99Tcm-DTPA, we postul...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Oriuchi N,Miyamoto K,Hoshino K,Imai J,Takahashi Y,Sakai S,Shimada A,Endo K

    更新日期:1997-05-01 00:00:00

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    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,meta分析,评审


    authors: Cascini GL,De Palma D,Matteucci F,Biggi A,Rambaldi PF,Signore A,Mansi L

    更新日期:2006-03-01 00:00:00

  • Changes in septal regional ejection fraction early and late following coronary artery bypass grafting in patients without postoperative myocardial infarction.

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    authors: Jacobson AF,Tow DE,Lapsley D,Khuri S

    更新日期:1992-10-01 00:00:00

  • Evaluation of relative renal function for patients who had undergone simultaneous liver-kidney transplants using Tc-99m-MAG3 scintigraphy with attenuation correction from anatomical images and SPECT/CT.

    abstract:OBJECTIVE:Assessing the relative function of each of the three kidneys using nuclear scintigraphy with standard planar imaging in patients having undergone kidney transplant is problematic because of the different photon-attenuation factors associated with native versus transplanted kidneys. To address this, we applied...

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    authors: Palmer MR,Donohoe KJ,Francis JM,A Mandelbrot D

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  • Enhanced uptake of 99Tcm-MDP in skeletal metastases from prostate cancer following initiation of hormone treatment: potential for increasing delivery of therapeutic agents.

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    authors: Bushnell DL,Madsen M,Kahn D,Nathan M,Williams RD

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    pub_type: 杂志文章


    authors: Bauwens M,Chekol R,Vanbilloen H,Bormans G,Verbruggen A

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  • Differentiating dural metastases from meningioma: role of 68Ga DOTA-NOC PET/CT.

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    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Purandare NC,Puranik A,Shah S,Agrawal A,Gupta T,Moiyadi A,Shetty P,Shridhar E,Patil V,Rangarajan V

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  • Left ventricular function and the distribution of pulmonary and total blood volume in hypertensive and normotensive man.

    abstract::Using radionuclide methods the relationship between total and central blood volume and left ventricular function was studied in 12 patients with untreated essential hypertension and contrasted with the findings in eight normotensive subjects. The principal findings were of an increased stroke volume and end-diastolic ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Mackay I,Nath K,Watson ML,Hannan WJ,Muir AL

    更新日期:1984-10-01 00:00:00

  • Propagation of measurement errors in glomerular filtration rate determination: a comparison of slope-intercept, single-sample and slope-only methods.

    abstract:BACKGROUND:Measurement errors occurring during glomerular filtration rate (GFR) studies propagate to an error in the calculated GFR. Previous work has modelled measurement errors for slope-intercept (SI-GFR), single-sample (SS-GFR) and slope-only (SO-GFR) methods. In this study, we have extended these models. The prima...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Holness JL,Fleming JS,Chirehwa MT,Warwick JM

    更新日期:2019-04-01 00:00:00

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    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Hirsch JI,Fuhs BE,Tatum JL,Tatum TG

    更新日期:1992-01-01 00:00:00

  • Phagocytosis and dynamic RES scintigraphy: an evaluation of commercial colloids in rats.

    abstract::Reticuloendothelial system (RES) phagocytic function or capacity can be measured by clearance studies with test substances. This study in the rat examines three commercially available 99Tcm-labelled test substances, and different methods of calculating RES capacity. Albures size 500 nm and sulphur colloid size 600 nm ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Holmberg SB,Hafström L,Jacobsson L

    更新日期:1987-05-01 00:00:00

  • Indium-111 platelet kinetics in patients with diabetes mellitus.

    abstract::We performed in vitro aggregation and indium-111 labeled platelet kinetic and biodistribution studies in seven patients with diabetes mellitus and in five control subjects. All subjects were male. All diabetic patients were poorly controlled at the time of study with blood glucose greater than 140 mg % and hemoglobin ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Luikens B,Forstrom LA,Johnson T,Johnson G

    更新日期:1988-03-01 00:00:00

  • Intravenous administration of morphine sulfate in hepatobiliary imaging for acute cholecystitis: a review of clinical efficacy.

    abstract::Morphine sulfate has been used by several investigators in the cholescintigraphic diagnosis of acute cholecystitis. A review of the available literature indicates that morphine sulfate significantly reduces the total time required for the hepatobiliary examination, while retaining both high sensitivity (98.8%) and spe...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,评审


    authors: Vasquez TE,Rimkus DS,Pretorius HT,Greenspan G

    更新日期:1988-03-01 00:00:00

  • 99Tcm-N,N-ethylenedicysteine scintigraphy in children with various renal disorders: a comparative study with 99Tcm-MAG3.

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    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Kibar M,Noyan A,Anarat A

    更新日期:1997-01-01 00:00:00

  • The use of dual-isotope imaging to compare the gastrointestinal transit of food and pancreatic enzyme pellets in cystic fibrosis patients.

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    journal_title:Nuclear medicine communications

    pub_type: 杂志文章


    authors: Hillel PG,Tindale WB,Taylor CJ,Frier M,Senior S,Ghosal S

    更新日期:1998-08-01 00:00:00

  • Usefulness of meta-[123I]iodobenzylguanidine myocardial scintigraphy for predicting cardiac events in patients with dilated cardiomyopathy who receive long-term beta blocker treatment.

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    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章


    authors: Fujimoto S,Inoue A,Hisatake S,Yamashina S,Yamashina H,Nakano H,Yamazaki J

    更新日期:2005-02-01 00:00:00