Dual isotope brain SPECT imaging for monitoring cognitive activation: physical considerations.

Abstract:

:The physical considerations of using dual isotope brain SPECT imaging to monitor blood flow changes during cognitive activation studies were investigated. These factors included field uniformity, spatial resolution and crosstalk. Serial dual isotope single photon emission computed tomographic (SPECT) studies of a test tube phantom and an anthropomorphic brain phantom filled with 99Tcm and 123I were made over a 10 h period. The reconstructed counts in the 99Tcm and 123I windows were corrected for crosstalk and were plotted as a function of time. The plotted data from each window decreased over time with a half-life characteristic of each radionuclide. The relative difference between true 123I and 99Tcm region counts has to be of the order of 10% to be statistically significant at the P < 0.05 level.

journal_name

Nucl Med Commun

authors

Madsen MT,O'Leary DS,Andreasen NC,Kirchner PT

doi

10.1097/00006231-199305000-00008

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

391-6

issue

5

eissn

0143-3636

issn

1473-5628

journal_volume

14

pub_type

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