Abstract:
OBJECTIVES:The aim of the study was to investigate the combined effects of serum lipids, BMI, and fatty liver on the liver uptake of fluorine-18 fluorodeoxyglucose ((18)F-FDG). METHODS:A total of 676 individuals were retrospectively studied. The mean standardized uptake value (SUV) was used to quantify liver (18)F-FDG uptake. Univariate analyses and multivariate regression models identified variables that predicted the mean liver SUV before and after dichotomizing participants into low and high BMI groups. RESULTS:The mean liver SUV (1.831 ± 0.417) differed significantly among nutritional categories (P = 0.005) and degrees of fatty liver (P < 0.001). An increase in mean liver SUV was noted in individuals with mild and moderate fatty liver compared with normal individuals and in overweight individuals compared with underweight individuals, whereas a downward trend was identified in both individuals with severe fatty liver and those who were obese. BMI had the strongest association with severity of fatty liver (r = 0.443, P < 0.001). Triglyceride, HDL, apolipoprotein-A, age, and BMI were independent variables predicting liver SUV mean in the whole population, whereas fatty liver severity presented as an independent variable only in the low BMI population (P = 0.031). CONCLUSION:BMI, age, triglyceride, HDL, and apolipoprotein-A were independent variables predicting liver (18)F-FDG uptake. Mild and moderate degree of fatty liver had a positive effect on liver (18)F-FDG uptake, whereas a severe degree of fatty liver negatively affected (18)F-FDG uptake. Attention should be paid to liver metabolism in patients with fatty liver before using liver as the comparator in determining focal (18)F-FDG uptake elsewhere within the abdomen.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Liu G,Li Y,Hu P,Cheng D,Shi Hdoi
10.1097/MNM.0000000000000301subject
Has Abstractpub_date
2015-07-01 00:00:00pages
709-16issue
7eissn
0143-3636issn
1473-5628journal_volume
36pub_type
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