3':5'-cyclic AMP and hormonal control of puparium formation in the fleshfly Sarcophaga bullata.

abstract：:Antiviral drugs targeting viral proteins often result in prompt selection for resistance. Moreover, the number of viral targets is limited. Novel antiviral targets are therefore needed. The unique characteristics of fusion between virion envelopes and cell membranes may provide such targets. Like all fusing bilayers, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： St Vincent MR,Colpitts CC,Ustinov AV,Muqadas M,Joyce MA,Barsby NL,Epand RF,Epand RM,Khramyshev SA,Valueva OA,Korshun VA,Tyrrell DL,Schang LM

更新日期：2010-10-05 00:00:00

abstract：:The HB-19 pseudopeptide 5[Kpsi(CH(2)N)PR]-TASP, psi(CH(2)N) for reduced peptide bond, is a specific inhibitor of HIV infection in different CD4(+) cell lines and in primary T-lymphocytes and macrophages. It blocks virus-particle attachment to permissive cells by binding and forming a stable complex with nucleolin expr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krust B,Vienet R,Cardona A,Rougeot C,Jacotot E,Callebaut C,Guichard G,Briand JP,Grognet JM,Hovanessian AG,Edelman L

更新日期：2001-11-20 00:00:00

abstract：:We have used a microfluidic mass sensor to measure the density of single living cells. By weighing each cell in two fluids of different densities, our technique measures the single-cell mass, volume, and density of approximately 500 cells per hour with a density precision of 0.001 g mL(-1). We observe that the intrins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grover WH,Bryan AK,Diez-Silva M,Suresh S,Higgins JM,Manalis SR

更新日期：2011-07-05 00:00:00

abstract：:A posttranslational protein O-mannosylation process resembling that found in fungi and animals has been reported in the major human pathogen Mycobacterium tuberculosis (Mtb) and related actinobacteria. However, the role and incidence of this process, which is essential in eukaryotes, have never been explored in Mtb. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu CF,Tonini L,Malaga W,Beau M,Stella A,Bouyssié D,Jackson MC,Nigou J,Puzo G,Guilhot C,Burlet-Schiltz O,Rivière M

更新日期：2013-04-16 00:00:00

abstract：:E-Cadherin, a cell adhesion molecule, which plays a key role in maintaining the epithelial phenotype, is regarded as an invasion-suppressor gene in light of accumulating evidence from in vitro experiments and clinical observations. In an attempt to clarify the mechanism responsible for inactivation of this gene in car...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoshiura K,Kanai Y,Ochiai A,Shimoyama Y,Sugimura T,Hirohashi S

更新日期：1995-08-01 00:00:00

abstract：:We have isolated, cloned, and expressed a male antennae-specific pheromone-degrading enzyme (PDE) [Antheraea polyphemus PDE (ApolPDE), formerly known as Sensillar Esterase] from the wild silkmoth, A. polyphemus, which seems essential for the rapid inactivation of pheromone during flight. The onset of enzymatic activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida Y,Leal WS

更新日期：2005-09-27 00:00:00

abstract：:Due to intrinsic aggressiveness and lack of effective therapies, prognosis of pancreatic cancer remains dismal. Because the only molecular targeted drug approved for pancreatic ductal adenocarcinoma is a kinase inhibitor specific to the epidermal growth factor receptor (EGFR), and this receptor collaborates with anoth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maron R,Schechter B,Mancini M,Mahlknecht G,Yarden Y,Sela M

更新日期：2013-09-17 00:00:00

abstract：:We examined the contributions of the human pulvinar to goal directed selection of visual targets in 3 patients with chronic, unilateral lesions involving topographic maps in the ventral pulvinar. Observers completed 2 psychophysical tasks in which they discriminated the orientation of a lateralized target grating in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Snow JC,Allen HA,Rafal RD,Humphreys GW

更新日期：2009-03-10 00:00:00

abstract：:To coordinate movements with events in a dynamic environment the brain has to anticipate when those events occur. A classic example is the estimation of time to contact (TTC), that is, when an object reaches a target. It is thought that TTC is estimated from kinematic variables. For example, a tennis player might use ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang CJ,Jazayeri M

更新日期：2018-03-20 00:00:00

abstract：:A yeast genetic system was developed to study how the basic regions of basic-helix-loop-helix (bHLH) proteins distinguish between related consensus bHLH binding sites, with nucleotide sequence CANNTG. The yeast bHLH protein CBF1 binds to the sequence CAC(A/G)TG found in the yeast centromere element CDE1 and in promote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dang CV,Dolde C,Gillison ML,Kato GJ

更新日期：1992-01-15 00:00:00

abstract：:Metastatic spread is the leading cause of cancer mortality. Breast cancer (BCa) metastatic recurrence can happen years after removal of the primary tumor. Here we show that Ubc13, an E2 enzyme that catalyzes K63-linked protein polyubiquitination, is largely dispensable for primary mammary tumor growth but is required ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu X,Zhang W,Font-Burgada J,Palmer T,Hamil AS,Biswas SK,Poidinger M,Borcherding N,Xie Q,Ellies LG,Lytle NK,Wu LW,Fox RG,Yang J,Dowdy SF,Reya T,Karin M

更新日期：2014-09-23 00:00:00

abstract：:To complete the set of synthetic analogs of the three recognized types of active sites in iron-sulfur redox proteins, the compound (Et4N)[Fe((SCH2)2C6H4)2], derived from o-xylyl-alpha,alpha'-dithiol, has been prepared and its structure has been determined by x-ray diffraction. The bischelate anion contains a near-tetr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lane RW,Ibers JA,Frankel RB,Holm RH

更新日期：1975-08-01 00:00:00

abstract：:The temporal dynamics of electrical activity in an olfactory organ, the procerebral lobe of the terrestrial mollusc Limax maximus, is studied. The lobe exhibits intrinsic oscillations in its field potential. Intracellular recordings show that the lobe contains two classes of neurons, both with activity phase-locked to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Delaney KR,Gelperin A,Fee MS,Flores JA,Gervais R,Tank DW,Kleinfeld D

更新日期：1994-01-18 00:00:00

abstract：:Using data from the Fragile Families and Child Wellbeing Study, this study examined the effects of the Great Recession on maternal harsh parenting. We found that changes in macroeconomic conditions, rather than current conditions, affected harsh parenting, that declines in macroeconomic conditions had a stronger impac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee D,Brooks-Gunn J,McLanahan SS,Notterman D,Garfinkel I

更新日期：2013-08-20 00:00:00

abstract：:Junctional Adhesion Molecule-A (JAM-A) is a transmembrane adhesive protein expressed at endothelial junctions and in leukocytes. Here we report that JAM-A is required for the correct infiltration of polymorphonuclear leukocytes (PMN) into an inflamed peritoneum or in the heart upon ischemia-reperfusion injury. The def...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corada M,Chimenti S,Cera MR,Vinci M,Salio M,Fiordaliso F,De Angelis N,Villa A,Bossi M,Staszewsky LI,Vecchi A,Parazzoli D,Motoike T,Latini R,Dejana E

更新日期：2005-07-26 00:00:00

abstract：:The trilaminate vascular architecture provides biochemical regulation and mechanical integrity. Yet regulatory control can be regained after injury without recapitulating tertiary structure. Tissue-engineered (TE) endothelium controls repair even when placed in the perivascular space of injured vessels. It remains unc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zani BG,Kojima K,Vacanti CA,Edelman ER

更新日期：2008-05-13 00:00:00

abstract：:N-Acetylaspartylglutamate, an endogenous brain peptide that binds with high affinity to a subpopulation of glutamate-binding sites in rat brain, is excitatory on rat piriform cortex pyramidal cells studied in a perfused brain slice. Both the monosynaptic excitation of the pyramidal cells elicited by stimulation of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ffrench-Mullen JM,Koller K,Zaczek R,Coyle JT,Hori N,Carpenter DO

更新日期：1985-06-01 00:00:00

abstract：:This article presents an agent-based computational model of civil violence. Two variants of the civil violence model are presented. In the first a central authority seeks to suppress decentralized rebellion. In the second a central authority seeks to suppress communal violence between two warring ethnic groups. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Epstein JM

更新日期：2002-05-14 00:00:00

abstract：:Targeting neuroendocrine tumors expressing somatostatin receptor subtypes (sst) with radiolabeled somatostatin agonists is an established diagnostic and therapeutic approach in oncology. While agonists readily internalize into tumor cells, permitting accumulation of radioactivity, radiolabeled antagonists do not, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ginj M,Zhang H,Waser B,Cescato R,Wild D,Wang X,Erchegyi J,Rivier J,Mäcke HR,Reubi JC

更新日期：2006-10-31 00:00:00

abstract：:Adeno-associated virus (AAV) is a small human Dependovirus whose low immunogenicity and capacity for long-term persistence have led to its widespread use as vector for gene therapy. Despite great recent successes in AAV-based gene therapy, further improvements in vector technology may be hindered by an inadequate unde...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith-Moore S,Neil SJD,Fraefel C,Linden RM,Bollen M,Rowe HM,Henckaerts E

更新日期：2018-04-10 00:00:00

abstract：:The medial preoptic area has been shown to be intricately involved in many behaviors, including locomotion, sexual behavior, maternal care, and aggression. The gene encoding estrogen receptor-α (ERα) protein is expressed in preoptic area neurons, and a very dense immunoreactive field of ERα is found in the preoptic re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ribeiro AC,Musatov S,Shteyler A,Simanduyev S,Arrieta-Cruz I,Ogawa S,Pfaff DW

更新日期：2012-10-02 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP) is an intermediate-filament (IF) protein that is highly specific for cells of astroglial lineage, although its tissue-specific role is speculative. Determination of the primary structure of this protein should be of importance for understanding the functional role it plays in ast...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeves SA,Helman LJ,Allison A,Israel MA

更新日期：1989-07-01 00:00:00

abstract：:Somatic LINE-1 (L1) retrotransposition has been detected in early embryos, adult brains, and the gastrointestinal (GI) tract, and many cancers, including epithelial GI tumors. We previously found numerous somatic L1 insertions in paired normal and GI cancerous tissues. Here, using a modified method of single-cell anal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamaguchi K,Soares AO,Goff LA,Talasila A,Choi JA,Ivenitsky D,Karma S,Brophy B,Devine SE,Meltzer SJ,Kazazian HH Jr

更新日期：2020-12-22 00:00:00

abstract：:In vitro recombination of cloned H-2 genes resulted in two allogeneically novel mouse transplantation antigens in which the C2 domains of H-2Ld and H-2Dd were exchanged. These genes were introduced into mouse L cells by DNA-mediated gene transfer. We have used these transformed fibroblast lines, expressing recombinant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ozato K,Evans GA,Shykind B,Margulies DH,Seidman JG

更新日期：1983-04-01 00:00:00

abstract：:Massively parallel signature sequencing (MPSS) generates millions of short sequence tags corresponding to transcripts from a single RNA preparation. Most MPSS tags can be unambiguously assigned to genes, thereby generating a comprehensive expression profile of the tissue of origin. From the comparison of MPSS data fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YT,Scanlan MJ,Venditti CA,Chua R,Theiler G,Stevenson BJ,Iseli C,Gure AO,Vasicek T,Strausberg RL,Jongeneel CV,Old LJ,Simpson AJ

更新日期：2005-05-31 00:00:00

abstract：:Although the F-specific ssRNA phage MS2 has long had paradigm status, little is known about penetration of the genomic RNA (gRNA) into the cell. The phage initially binds to the F-pilus using its maturation protein (Mat), and then the Mat-bound gRNA is released from the viral capsid and somehow crosses the bacterial e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harb L,Chamakura K,Khara P,Christie PJ,Young R,Zeng L

更新日期：2020-10-13 00:00:00

abstract：:Carbon nanotube (CNT) membranes were employed as the active element of a switchable transdermal drug delivery device that can facilitate more effective treatments of drug abuse and addiction. Due to the dramatically fast flow through CNT cores, high charge density, and small pore dimensions, highly efficient electroph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu J,Paudel KS,Strasinger C,Hammell D,Stinchcomb AL,Hinds BJ

更新日期：2010-06-29 00:00:00

abstract：:Acute myeloid leukemia subtype M4 with eosinophilia is associated with a chromosome 16 inversion that creates a fusion gene CBFB-MYH11. We have previously shown that CBFB-MYH11 is necessary but not sufficient for leukemogenesis. Here, we report the identification of genes that specifically cooperate with CBFB-MYH11 in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castilla LH,Perrat P,Martinez NJ,Landrette SF,Keys R,Oikemus S,Flanegan J,Heilman S,Garrett L,Dutra A,Anderson S,Pihan GA,Wolff L,Liu PP

更新日期：2004-04-06 00:00:00

abstract：:We construct a C*-algebra that has only one irreducible representation up to unitary equivalence but is not isomorphic to the algebra of compact operators on any Hilbert space. This answers an old question of Naimark. Our construction uses a combinatorial statement called the diamond principle, which is known to be co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akemann C,Weaver N

更新日期：2004-05-18 00:00:00

abstract：:Karrikins are a class of seed germination stimulants identified in smoke from wildfires. Microarray analysis of imbibed Arabidopsis thaliana seeds was performed to identify transcriptional responses to KAR(1) before germination. A small set of genes that are regulated by KAR(1), even when germination is prevented by t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nelson DC,Flematti GR,Riseborough JA,Ghisalberti EL,Dixon KW,Smith SM

更新日期：2010-04-13 00:00:00