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Early organ dysfunction course, cooling time and outcome in classic heatstroke.

Abstract：

PURPOSE:To describe the course of early organ dysfunction in a cohort of patients admitted in ICU suffering classic heatstroke. METHODS:Prospective observational single-centre cohort study with a 1-year follow-up. INTERVENTIONS:None. MEASUREMENTS AND MAIN RESULTS:Clinical and biological data of 22 patients were analysed. Median body temperature on admission was 41.1 degrees C. Respiratory, circulatory, haematological, hepatic and renal function all deteriorated within the first 24 h of admission. ICU-mortality was 63.6%. Cooling time, serum lactate, serum cardiac troponin I and creatinine were significantly higher in non-survivors. Early ICU-mortality (within 7 days of ICU stay) was due to multiple organ failure. Late ICU-mortality was due to neurological disability. CONCLUSIONS:Classic heat stroke may demonstrate a rapidly worsening organ dysfunction course leading to death even though cooling procedures and intensive care management are promptly started.

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Pease S,Bouadma L,Kermarrec N,Schortgen F,Régnier B,Wolff M

doi

10.1007/s00134-009-1500-x

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

1454-8

issue

8

eissn

0342-4642

issn

1432-1238

journal_volume

35

pub_type

杂志文章

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