Abstract：
OBJECTIVE:To characterize hemodynamic changes during experimental aspiration pneumonitis, paying special attention to echocardiographic assessment. DESIGN AND SETTING:Animal study in a university-based research laboratory. SUBJECTS:Fourteen mechanically ventilated New Zealand white rabbits INTERVENTIONS:We instilled 1 ml/kg human gastric juice (mean pH: 4.1+0.2) intratracheally. Hemodynamic and respiratory parameters were measured every hour for 4 h, associated with a transthoracic echocardiography. MEASUREMENTS AND RESULTS:Lung injury occurred within 1 hour with a marked decrease in PaO(2)/FIO(2) and an increase in plateau pressure; after this initial drop the ratio remained stable throughout the experiment. Seven rabbits experienced only a mild to moderate alteration in lung oxygenation function as defined by a PaO(2)/FIO(2) ratio above 200 (group A), while the other seven developed a severe alteration with a ratio below 200 (group B). At the end of the experiment pH and cardiac output were lower in group B than in group A. Using a PaO(2)/FIO(2) threshold value of 150, pH, mean arterial pressure, and cardiac output were lower in the animals with the more severe hypoxemia. Neither left nor right ventricular dysfunction occurred during the experiment, and no animal experienced circulatory failure CONCLUSION:Experimental aspiration pneumonitis after intratracheal infusion of human gastric juice is characterized by a stable fall in PaO(2)/FIO(2). Animals with the most severe lung injury experienced a lower systemic arterial pressure, cardiac output, and metabolic acidosis without circulatory failure or cardiac dysfunction.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Fraisse A,Bregeon F,Delpierre S,Gaudart J,Payan MJ,Pugin J,Papazian Ldoi
10.1007/s00134-006-0457-2subject
Has Abstractpub_date
2007-02-01 00:00:00pages
300-7issue
2eissn
0342-4642issn
1432-1238journal_volume
33pub_type
杂志文章abstract：PURPOSE:The clinical significance of septic myocardial dysfunction is controversial, a fact that may be explained by the influence of loading conditions. Many indices may be useful to characterize cardiac function during septic shock, but their feasibility and physiological coherence in the clinical setting are unknown...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-017-4698-z
更新日期：2017-05-01 00:00:00
abstract：PURPOSE:This prospective observational study aimed at describing prescription patterns of tigecycline and patient outcomes in 26 French intensive care units (ICU). METHODS:Data of consecutive cases of adult patients treated with tigecycline were collected from the initiation until 7 days after the end of treatment. Re...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s00134-014-3323-7
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:To identify and reduce medication-prescribing errors by introducing systematic physician education and post-cardiac surgery admission prescription forms. DESIGN:Errors were defined as: incomplete prescriptions; potential adverse drug events (ADEs), i.e. either intercepted or non-intercepted incorrect prescri...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-008-1054-3
更新日期：2008-06-01 00:00:00
abstract：PURPOSE:To evaluate the diagnostic accuracy of ultrasonography of optic nerve sheath diameter (ONSD) for assessment of intracranial hypertension. METHODS:Systematic review without language restriction based on electronic databases, with manual review of literature and conference proceedings until July 2010. Studies we...
journal_title：Intensive care medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00134-011-2224-2
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:To document the costs and outcomes of the various forms of the septic syndromes [systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock), particularly those associated with infection acquired in an intensive care unit (ICU). DESIGN:Prospective data collection for all septic patie...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-003-1877-x
更新日期：2003-09-01 00:00:00
abstract：:Pneumonia caused by herpes simplex virus type 1 (HSV1) is rare and occurs in severely immunosuppressed patients. HSV1 can be detected in bronchoalveolar lavage (BAL) from patients presenting with respiratory failure, but its direct effect on disease is difficult to prove. We demonstrate the causative role of HSV1 in t...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050339
更新日期：1997-03-01 00:00:00
abstract：OBJECTIVE:Measurement of functional residual capacity (FRC) during controlled and especially during assisted ventilation remains a challenge in the physiological evaluation of ventilated patients. To validate a bag-in-box closed helium dilution technique allowing measurements both during pressure-controlled (PCV) and p...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-007-0833-6
更新日期：2007-12-01 00:00:00
abstract：:Extracorporeal life support (ECLS) can support gas exchange in patients with the acute respiratory distress syndrome (ARDS). During ECLS, venous blood is drained from a central vein via a cannula, pumped through a semipermeable membrane that permits diffusion of oxygen and carbon dioxide, and returned via a cannula to...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-020-06290-1
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:Candida spp. airway colonization could promote development of ventilator-associated pneumonia (VAP) caused by Pseudomonas aeruginosa, a potentially multidrug-resistant (MDR) bacteria, and worsen the outcome of VAP regardless of pathogen. We therefore address the question of the risk of MDR bacteria isolation ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-012-2584-2
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVE:a) to describe a non-barotraumatic ventilatory setting for independent lung ventilation (ILV); b) to determine the utility of single lung end-tidal CO(2) (EtCO(2)) monitoring to evaluate the ventilation to perfusion (V/Q) matching in each lung during ILV and for ILV weaning. DESIGN:prospective study. SETTIN...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s00134-001-1149-6
更新日期：2001-12-01 00:00:00
abstract：:One hundred and eighteen 20-g radial artery catheters were prospectively evaluated in 109 cardiovascular surgical patients. 0.024% papaverine in saline was used as a continuous flushing solution. Using the Doppler method, obstruction of the radial artery with the catheter in situ was found in 11 (9.8%) patients. Decan...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00254675
更新日期：1986-01-01 00:00:00
abstract：:A case of metabolic acidosis, acute renal failure and hepatic failure following paracetamol ingestion is presented. The diagnostic difficulty at presentation is highlighted. Continuous arteriovenous haemofiltration proved a valuable means of maintaining fluid and electrolyte balance. The patient recovered. ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00262905
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVE:We undertook this study to evaluate the influence of the inspiration:expiration (I:E) ratio on intracranial pressure and cerebral perfusion in patients with acute stroke. DESIGN:Ventilated patients with acute stroke were examined under a protocol involving variations of I:E ratio from 1:2 to 1:1 to 1:2 under...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1351-1
更新日期：2002-08-01 00:00:00
abstract：PURPOSE:To examine the association of intravenous iodinated contrast material administration with the subsequent development of post-contrast AKI (PC-AKI), emergent dialysis, and short-term mortality using a propensity score-adjusted analysis of a cohort of intensive care unit (ICU) patients who underwent CT examinatio...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-017-4699-y
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:To define the mechanisms of the stable and prolonged post-operative plasma volume expansion observed with Hydroxyethyl Starches (HES) and to determine whether a partial intravascular hydrolysis of large molecules contribute to reinforce the colloid-osmotic effect. DESIGN:Prospective, pharmacologic study usin...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/BF01700163
更新日期：1995-07-01 00:00:00
abstract：: ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-018-5280-z
更新日期：2018-12-01 00:00:00
abstract：:The article "Accumulation of hydroxyethyl starch in human and animal tissues: a systematic review", written by Christian J. Wiedermann and Michael Joannidis, was originally published Online First without Open Access. ...
journal_title：Intensive care medicine
pub_type： 已发布勘误
doi：10.1007/s00134-020-06269-y
更新日期：2020-10-14 00:00:00
abstract：OBJECTIVE:We examined whether early diffusion-weighted magnetic resonance imaging (DW-MRI) abnormalities of the brain and variation of apparent diffusion coefficient (ADC) values can provide prognostic information on clinical outcome in children following cardiac arrest (CA). DESIGN:Retrospective study. SETTING:A 12-...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-013-2930-z
更新日期：2013-07-01 00:00:00
abstract：PURPOSE:To provide recommendations and standard operating procedures for intensive care units and hospital preparedness for an influenza pandemic. METHODS:Based on a literature review and expert opinion, a Delphi process was used to define the essential topics. RESULTS:Key recommendations include: Hospitals should in...
journal_title：Intensive care medicine
pub_type： 指南,杂志文章,评审
doi：10.1007/s00134-010-1759-y
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:The Sonoclot analyser provides global measurement of haemostasis, including plasma coagulation, platelet function and fibrinolysis. Benefits of its use in cardiovascular and hepatic surgery are well-documented and it may be useful in managing obstetric complications. The aim of this study was to determine ran...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050047
更新日期：2000-02-01 00:00:00
abstract：OBJECTIVE:To assess the effects of the association of positive end-expiratory pressure (PEEP) with different inflation volumes (V(T)'s) on passive lung deflation and alveolar recruitment in ARDS patients. DESIGN:Clinical study using PEEP with two different V(T)'s and analyzing whether passive lung deflation and alveol...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051275
更新日期：2000-07-01 00:00:00
abstract：OBJECTIVE:Transcapillary heat transfer after injections of cold saline into the right atrium generates bronchial thermodilution curves resembling those observed in the aorta. Under the assumption that no indicator is lost or gained within the pulmonary capillary bed and changes in blood temperature are instantaneously ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050818
更新日期：1999-02-01 00:00:00
abstract：:Paediatric admissions to a general ITU are briefly reviewed. Although it may not be an ideal arrangement it is suggested that children can be safely cared for in such a unit. The problems created by the child with acute upper airway obstruction are discussed to demonstrate the way in which the unit is organized to rec...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00260356
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVE:To derive recommendations for the dosing of commonly used medications in the morbidly obese patient in the ICU. DATA SOURCES:Articles were obtained through computerized searches involving MEDLINE. The bibliographies of retrieved publications and textbooks were reviewed for additional references. STUDY SELEC...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-003-2059-6
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:Sepsis-evoked myocardial dysfunction is possibly due to decreased myofilament calcium sensitivity, and a calcium sensitizer may thus specifically improve contractility in sepsis by enhancing myofilament calcium sensitivity. We examined whether the calcium sensitizer levosimendan mitigates myocardial dysfuncti...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-003-1879-8
更新日期：2003-10-01 00:00:00
abstract：PURPOSE:A retrieval program was developed in New South Wales (NSW), Australia to provide extracorporeal membrane oxygenation support (ECMO) for the safe transport of adults with severe, acute respiratory or cardiac failure. We describe the development and results of this program and the impact of the 2009 H1N1 epidemic...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-011-2158-8
更新日期：2011-05-01 00:00:00
abstract：:The World Health Organization defines overweight and obesity as the condition where excess or abnormal fat accumulation increases risks to health. The prevalence of obesity is increasing worldwide and is around 20% in ICU patients. Adipose tissue is highly metabolically active, and especially visceral adipose tissue h...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-019-05594-1
更新日期：2019-06-01 00:00:00
abstract：:As part of a nationwide evaluation of intensive care, we examined patient- and hospital-related factors which could influence the patterns of utilization of arterial cannulae and central venous and pulmonary artery catheters. We also studied the possible impact of these interventions on the short-term outcome among 14...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01713935
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVE:Endotracheal suctioning can cause alveolar collapse and impede ventilation. One reason is the gas flow through a single-lumen endotracheal tube (ETT) provoking a gradient between airway opening and tracheal (P(tr)) pressures. Separately extending the patient tubing limbs of a suitable ventilator into the trac...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-004-2537-5
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVE:Antithrombin exerts direct effects on neutrophils by inhibiting chemokine-induced migration. This study examined the potency of different pharmaceutical antithrombin preparations in inhibiting neutrophil chemotaxis toward interleukin 8. METHODS:Cell migration was tested by the leading front assay in modified...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1432-1
更新日期：2002-10-01 00:00:00
