Abstract：
OBJECTIVE:We examined whether early diffusion-weighted magnetic resonance imaging (DW-MRI) abnormalities of the brain and variation of apparent diffusion coefficient (ADC) values can provide prognostic information on clinical outcome in children following cardiac arrest (CA). DESIGN:Retrospective study. SETTING:A 12-bed paediatric intensive care unit (PICU). PATIENTS:Children aged between 1 month and 18 years who had DW-MRI with ADC measurement within the first week following CA. Neurological outcomes were assessed using the Pediatric Cerebral Performance Category Scale (PCPC). Differences between the favourable (PCPC ≤3) and unfavourable (PCPC ≥4) groups were analysed with regard to clinical data, electrophysiological patterns as well as qualitative and quantitative DW-MRI abnormalities. RESULTS:Twenty children with a median age of 20 months (1.5-185) and a male/female sex ratio of 1.5 underwent DW-MRI after CA with a median delay of 3 days (1-7). Aetiologies of CA were (i) asphyxia (n = 10), (ii) haemodynamic (n = 5) or (iii) unknown (n = 5). With regard to DW-MRI findings, the unfavourable outcome group (n = 8) was associated with cerebral cortex (p = 0.02) and basal ganglia (p = 0.005) lesions, with a larger number of injured brain regions (p = 0.001) and a global decrease in measured ADC signal (p = 0.008). Normal DW-MRI (n = 5) was exclusively associated with the favourable outcome group (n = 12). CONCLUSION:Qualitative, topographic and quantitative analysis of early DW-MRI with ADC measurement in children following CA may provide valuable prognostic information on neurological outcomes.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Oualha M,Gatterre P,Boddaert N,Dupic L,De Saint Blanquat L,Hubert P,Lesage F,Desguerre Idoi
10.1007/s00134-013-2930-zsubject
Has Abstractpub_date
2013-07-01 00:00:00pages
1306-12issue
7eissn
0342-4642issn
1432-1238journal_volume
39pub_type
杂志文章abstract：OBJECTIVE:To investigate efficacy and safety of enoxaparin for catheter-related arterial thrombosis in infants with congenital heart disease. DESIGN:Prospective observational study. SETTING:Pediatric Intensive Care and Cardiology Unit at the University Children's Hospital of Zurich. PATIENTS:A cohort of 32[Symbol: s...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-007-0718-8
更新日期：2007-11-01 00:00:00
abstract：PURPOSE:To examine the association of intravenous iodinated contrast material administration with the subsequent development of post-contrast AKI (PC-AKI), emergent dialysis, and short-term mortality using a propensity score-adjusted analysis of a cohort of intensive care unit (ICU) patients who underwent CT examinatio...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-017-4699-y
更新日期：2017-06-01 00:00:00
abstract：:The pharmacokinetics of theophylline and ethylenediamine were examined in 6 patients with septicaemia and multiorgan failure (MOF). The patients received a bolus injection of 4 mg/kg aminophylline. Aminophylline is the ethylenediamine salt of theophylline. The clearance of theophylline was reduced in all our patients ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01690768
更新日期：1991-01-01 00:00:00
abstract：PURPOSE:To characterize the perceived utilization of physical restraint (PR) in mechanically ventilated intensive care unit (ICU) patients and to identify clinical and structural factors influencing PR use. METHODS:A questionnaire was personally handed to one intensivist in 130 ICUs in France then collected on-site 2 ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-012-2715-9
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:To measure water balance and changes in distribution, and the effect of giving supplementary albumin, early after a burn injury. DESIGN:Consecutive patients (matched groups) and healthy controls. SETTING:National burn unit in a Swedish university hospital. PATIENTS AND SUBJECTS:Eighteen patients with 18%-9...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340100935
更新日期：2001-05-01 00:00:00
abstract：OBJECTIVE:Aspiration of dead space (ASPIDS) improves carbon dioxide (CO2) elimination by replacing dead space air rich in CO2 with fresh gas during expiration. The hypothesis was that ASPIDS allows normocapnia to be maintained at low tidal volumes (VT). DESIGN:Prospective study. SETTING:Adult intensive care unit in a...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050929
更新日期：1999-07-01 00:00:00
abstract：OBJECTIVE:Angiopoietin-2 (Ang-2) is a potent regulator of vascular permeability and inflammation in acute lung injury and acute respiratory distress syndrome (ARDS). Genetic variants in the Ang-2 gene may lead to altered activities of Ang-2 (or ANGPT2) gene. The aim of this study was to assess if genetic variants of An...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-009-1413-8
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVE:To test the feasibility of the transcardiac conductance (TCC) method for continuous, on-line measurement of absolute left ventricular (LV) volume and to validate the method by comparison with biplane angiography. DESIGN AND SETTING:Prospective clinical feasibility and validation study in a cardiac catheteriz...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s00134-004-2300-y
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVE:To investigate the theoretical interactions between ventilator settings, tracheal gas insufflation (TGI), and alveolar ventilation. DESIGN:We derived differential equations governing compartmental volume changes in a one-compartment model of TGI-assisted ventilation and equations governing gas dilution in th...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01699238
更新日期：1996-10-01 00:00:00
abstract：PURPOSE:Optimal respiratory support for interhospital transport of critically ill children is challenging and has been scarcely investigated. High-flow nasal cannula (HFNC) therapy has emerged as a promising support mode in the paediatric intensive care unit (PICU), but no data are available on HFNC used during interho...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-014-3226-7
更新日期：2014-04-01 00:00:00
abstract：RATIONALE:Acute respiratory distress syndrome (ARDS) is frequently associated with hemodynamic instability which appears as the main factor associated with mortality. Shock is driven by pulmonary hypertension, deleterious effects of mechanical ventilation (MV) on right ventricular (RV) function, and associated-sepsis. ...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-016-4326-3
更新日期：2016-05-01 00:00:00
abstract：PURPOSE:To determine whether erythromycin is non-inferior to metoclopramide in facilitating post-pyloric placement of self-propelled spiral nasoenteric tubes (NETs) in critically ill patients. METHODS:A prospective, multicenter, open-label, parallel, and non-inferiority randomized controlled trial was conducted compar...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00134-018-5466-4
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:The aim of this prospective study was to evaluate the value of sinus echography results to directly indicate a transnasal puncture in intubated patients with suspicion of nosocomial maxillary sinusitis. DESIGN:prospective clinical investigation. SETTING:medical intensive care unit. PATIENTS:sixty patients ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-006-0152-3
更新日期：2006-06-01 00:00:00
abstract：OBJECTIVES:A range of children receive extra-corporeal life support (ECLS) for respiratory failure, but there is little published data on this group. Our aims were: (1) to analyse predictors of outcome and (2) comment on inclusion and exclusion criteria. DESIGN:Retrospective review. SETTING:Tertiary ECLS centre. PAT...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-008-1232-3
更新日期：2008-12-01 00:00:00
abstract：PURPOSE:The intravenous fluid 6% hydroxyethyl starch (130/0.4) (6% HES 130/0.4) is used widely for resuscitation but there is limited information on its efficacy and safety. A large-scale multi-centre randomised controlled trial (CHEST) in critically ill patients is currently underway comparing fluid resuscitation with...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00134-010-2117-9
更新日期：2011-05-01 00:00:00
abstract：:Physicians are increasingly involved in how their critically ill patients die [72]. The more this happens, the more physicians will have to understand not only how their own backgrounds and biases influence their medical management, but also the cultural and religious backgrounds of the patient and surrogate [72, 73]....
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s001340000641
更新日期：2000-10-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of respiratory physiotherapy on the prevention and treatment of ventilator-associated pneumonia (VAP) for adults in an intensive care unit (ICU) with an acquired brain injury (ABI). DESIGN AND SETTING:Two-part, prospective, randomised controlled trial. PATIENTS:A total of 144 subje...
journal_title：Intensive care medicine
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00134-008-1278-2
更新日期：2009-02-01 00:00:00
abstract：PURPOSE:To describe changes in hemodynamic variables, sedation, and pain score after discontinuation of prolonged infusions of dexmedetomidine in a pediatric population of critically ill cardiac patients. METHODS:Retrospective case series of patients who received continuous infusions of dexmedetomidine for longer than...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-011-2441-8
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVE:To assess the effect of partial liquid ventilation with perfluorocarbons on hemodynamics and gas exchange in large pigs with induced acute lung injury (ALI). DESIGN:Randomized, prospective, double-control, experimental study. Experimental intensive care unit of a university. MATERIALS:Eighteen large pigs (5...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01700657
更新日期：1995-12-01 00:00:00
abstract：PURPOSE:Hypoxia-ischemia (HI), as a major cause of fetal brain damage, has long-lasting neurological implications. Therefore, therapeutic interventions that attenuate the neuropathological outcome of HI while also improving the neurofunctional outcome are of paramount clinical importance. The aim of this study was to i...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-010-1913-6
更新日期：2010-09-01 00:00:00
abstract：:A 63-year-old man underwent distal oesophagectomy and proximal gastrectomy. Postoperatively, controlled ventilation was necessary for 53 days because of anastomotic leakage. Multiple sedative regimens proved to be inadequate. By contrast, a fentanyl-midazolam combination with continuous supplementation of clonidine 0....
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01705163
更新日期：1990-01-01 00:00:00
abstract：PURPOSE:Inflammatory markers may have a role in predicting severity of illness of intensive care unit (ICU) patients. The aim of this study is to determine whether low eosinophil count can predict 28-day mortality in medical ICU. METHODS:A prospective study over a 4-month period. To evaluate the prognosis information ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-011-2170-z
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:To analyze the actual cost of pediatric intensive care and its different components, particularly the differences between various patient groups, with special reference to the variable cost and the elements included in it. DESIGN:Prospective, observational study. SETTING:Multidisciplinary 12-bed pediatric i...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050320
更新日期：1997-02-01 00:00:00
abstract：PURPOSE:The use of heat and moisture exchangers (HME) during noninvasive ventilation (NIV) can increase the work of breathing, decrease alveolar ventilation, and deliver less humidity in comparison with heated humidifiers (HH). We tested the hypothesis that the use of HH during NIV with ICU ventilators for patients wit...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00134-013-3145-z
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVE:To compare the efficiency of non-invasive positive pressure ventilation (NPPV) in decompensated patients with either chronic obstructive pulmonary disease (COPD) or chronic restrictive pulmonary disease. DESIGN:Retrospective study. SETTING:A 17-bed intensive care unit in a university teaching hospital. SET...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-003-1654-x
更新日期：2003-04-01 00:00:00
abstract：:Central venous catheters (CVCs) are widely used in critically ill patients in intensive care units. However, infectious complications are common and may limit their utility. We critically review the literature to determine the impact of CVC design and composition, insertion site selection, insertion procedures, care a...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/BF01726542
更新日期：1995-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the nursing time required for difficult-to-wean patients in a dedicated weaning center (WC) and to examine the correlation of the nursing time with nursing workload (NW) scores and with clinical severity and dependency. SETTING:Four-bed WC of a pulmonary rehabilitation department. INTERVENTION:N...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051249
更新日期：2000-06-01 00:00:00
abstract：:Since the introduction of synchronized intermittent mandatory ventilation (SIMV) several advantages have been attributed to this ventilatory mode, one of them being a more homogeneous distribution of ventilation and perfusion than during controlled mechanical ventilation (CMV). Up to now no data are available to confi...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01704716
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that, during high-frequency oscillatory ventilation (HFOV) of pigs with acute lung injury, the oxygenation index (OI = Paw*FIO(2)*100/PaO(2)) is minimal at the lowest continuous distending pressure (Paw), where the physiological shunt fraction is below 0.1 (Paw(optimal)). DESIGN AND SE...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1368-5
更新日期：2002-08-01 00:00:00
abstract：:We examined the incidence, diagnosis and therapy of acute adrenal insufficiency, secondary to adrenal hemorrhage. This insufficiency resulted in temperature irregularities. hemodynamic instability, and a large volume resuscitation requirement post-operatively. The case illustrates that a high level of suspicion should...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01704704
更新日期：1994-01-01 00:00:00
