Abstract：
OBJECTIVE:To evaluate whether soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) in CSF can serve as a biomarker for the presence of bacterial meningitis and outcome in patients with this disease. DESIGN:Retrospective study of diagnostic accuracy. SETTING AND PATIENTS:CSF was collected from 92 adults with community-acquired bacterial meningitis who participated in the prospective Dutch Meningitis Cohort Study; 8 patients with viral meningitis and 9 healthy control subjects. RESULTS:CSF sTREM-1 levels were higher in patients with bacterial meningitis (median 82 pg/ml, range 0-988) than in those with viral meningitis (0 pg/ml, 0-48) and controls (0 pg/ml, 0-36). The diagnostic accuracy of sTREM-1 in discriminating between patients with and without bacterial meningitis, expressed as the area under the receiver operating characteristic curve, was 0.82. At a cutoff level of 20 pg/ml the sensitivity was 0.73 and specificity 0.77. In patients with bacterial meningitis CSF sTREM-1 levels were associated with mortality (survivors, median 73 pg/ml, range 0-449 pg/ml; nonsurvivors, 15 pg/ml, 0-988). CONCLUSIONS:Measuring sTREM-1 in CSF may be a valuable new additional approach to accurately diagnose bacterial meningitis and identify patients at high risk for adverse outcome. Therefore a prospective study of sTREM-1 as a biomarker in bacterial meningitis is needed.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Determann RM,Weisfelt M,de Gans J,van der Ende A,Schultz MJ,van de Beek Ddoi
10.1007/s00134-006-0240-4subject
Has Abstractpub_date
2006-08-01 00:00:00pages
1243-7issue
8eissn
0342-4642issn
1432-1238journal_volume
32pub_type
杂志文章abstract：OBJECTIVES:Circulating levels of the proinflammatory mediator High Mobility Group Box Protein 1 (HMGB1) are increased in septic patients and may contribute to sepsis-induced organ dysfunction. Although HMGB1 has been shown to activate neutrophils from healthy volunteers, the responses of neutrophils from septic patient...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-007-0748-2
更新日期：2007-10-01 00:00:00
abstract：PURPOSE:Computerized clinical decision support systems (CDSS) for intensive insulin therapy (IIT) generate recommendations using blood glucose (BG) values manually transcribed from testing devices to computers, a potential source of error. We quantified the frequency and effect of blood glucose transcription mismatches...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-010-1868-7
更新日期：2010-09-01 00:00:00
abstract：:Conventional PEEP ventilation has been recently reported to be deleterious in some cases of ARF with unilateral pneumonia. In such respect, two cases of unilateral bacterial pneumonia were intubated with a Carlens tracheal tube. Measurement of tidal volume, static compliance, and functional residual capacity of each l...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01683935
更新日期：1979-11-01 00:00:00
abstract：OBJECTIVE:(1) To describe the pattern of intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in a group of severe head-injured patients, (2) to quantify complications of ICP monitoring, and (3) to describe a management protocol and its results. DESIGN:Prospective observational study. SETTING:General int...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050860
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVE:To assess the effect of partial liquid ventilation with perfluorocarbons on hemodynamics and gas exchange in large pigs with induced acute lung injury (ALI). DESIGN:Randomized, prospective, double-control, experimental study. Experimental intensive care unit of a university. MATERIALS:Eighteen large pigs (5...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01700657
更新日期：1995-12-01 00:00:00
abstract：OBJECTIVE:We describe a patient with a prolonged and severe hypercapnia occurring during an episode of status asthmaticus induced by ophthalmic instillation of carteolol. SETTING:Prehospital Emergency Medical Service and Pulmonary Intensive Care Unit in a university hospital. PATIENT:A 35-year-old female developed an...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050772
更新日期：1998-12-01 00:00:00
abstract：OBJECTIVE:To analyze the effects of polymyxin B-immobilized fiber (PMX-F) on bone resorption in septic patients. DESIGN AND SETTING:Observational prospective study in intensive care units of a general hospital. PATIENTS AND PARTICIPANTS:25 patients with severe sepsis and 20 healthy controls. MEASUREMENTS AND RESULTS...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00134-004-2357-7
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the use of antidotal therapy in patients with an elevated digitalis concentration following chronic or acute exposure. DESIGN AND SETTING:Retrospective review of patient records over 2 years in 20 city hospitals in France. PATIENTS:Overall 838 patients with an elevated serum digitalis concentrat...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-008-1092-x
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVE:To compare the effects of a cerebral perfusion pressure (CPP) intervention achieved with dopamine and norepinephrine after severe head injury. DESIGN:Prospective, controlled, trial. SETTING:Neurosciences critical care unit. PATIENTS:Eleven patients with a head injury, requiring dopamine or norepinephrine i...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00134-003-2155-7
更新日期：2004-05-01 00:00:00
abstract：PURPOSE:Previous observational studies have inconsistently associated early hyperoxia with worse outcomes after cardiac arrest, and have methodological limitations. We tested this association using a high-resolution database controlling for multiple disease-specific markers of severity of illness and care processes. M...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-014-3555-6
更新日期：2015-01-01 00:00:00
abstract：:Hemorrhagic complications from transection of cervical arteries in blunt traumas are rare. We report a case of potentially fatal hemorrhage from rupture of the left vertebral artery in a closed trauma, successfully treated by endovascular injection of glue. Endovascular embolization may be considered as an alternative...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051033
更新日期：1999-10-01 00:00:00
abstract：:In the past two years several guidelines for suggested components of emergency medical systems for children have been suggested, and for the first time, specific standards of pediatric trauma care have also been formulated. The American Academy of Pediatrics new Provisional Committee on Emergency Medicine has been cha...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00260888
更新日期：1989-01-01 00:00:00
abstract：:Nine patients hospitalized for tetanus were studied under the same protocol which included two haemodynamic studies with a preload trial (PLT). The first being made during therapy (diazepam barbiturate association), on the sixth day of hospitalisation, and the second one after recovery. The comparison of the results s...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01700252
更新日期：1978-07-01 00:00:00
abstract：OBJECTIVE:Nuclear factor-kappaB (NF-kappaB) is a transcription factor which plays a pivotal role in the induction of genes involved in the response to injury and inflammation. Calpain I inhibitor is a potent antioxidant which is an effective inhibitor of NF-kappaB. This study examined whether the postulate that calpain...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-004-2328-z
更新日期：2004-08-01 00:00:00
abstract：OBJECTIVE:The immediate overwhelming release of inflammatory mediators in septic shock is rapidly followed by strong anti-inflammatory responses inducing a state of immunosuppression. The patients who survive the initial hyper-inflammatory step of septic shock but subsequently die may be those who do not recover from i...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-006-0204-8
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVES:Controversy over the optimal intravenous fluid for volume resuscitation continues unabated. Our objectives were to characterize the demographics of physicians who prescribe intravenous colloids and determine factors that enter into their decision to choose a colloid. DESIGN:Questionnaire with 61 items. PAR...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1337-z
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVE:To investigate the theoretical interactions between ventilator settings, tracheal gas insufflation (TGI), and alveolar ventilation. DESIGN:We derived differential equations governing compartmental volume changes in a one-compartment model of TGI-assisted ventilation and equations governing gas dilution in th...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01699238
更新日期：1996-10-01 00:00:00
abstract：PURPOSE:To use the World Health Organisation's International Classification of Functioning to measure disability following critical illness using patient-reported outcomes. METHODS:A prospective, multicentre cohort study conducted in five metropolitan intensive care units (ICU). Participants were adults who had been a...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s00134-017-4830-0
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVE:To compare isoflurane with midazolam for prolonged sedation in ventilated patients. DESIGN:Randomised controlled study. SETTING:General intensive care unit in university teaching hospital. PATIENTS:Sixty patients aged 17-80 years who required mechanical ventilation for more than 24 h. INTERVENTIONS:Sedati...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01694344
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVE:To compare the ventilation achieved with chest compressions (CC) or ventilation plus compressions (VC) in a pediatric animal model of cardiac arrest. DESIGN:Randomized experimental study. SETTING:Experimental department of a University Hospital. METHODS:Twelve infant pigs with asphyxial cardiac arrest. Seq...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-010-1777-9
更新日期：2010-04-01 00:00:00
abstract：PURPOSE:Septic shock-induced disseminated intravascular coagulopathy (DIC) contributes to multiple organ failure. Mechanisms governing vascular responses to open occurrence of DIC have not yet been established. Circulating plasma microparticles (MPs), released upon cell stress, constitute a catalytic procoagulant surfa...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s00134-013-2993-x
更新日期：2013-10-01 00:00:00
abstract：: ...
journal_title：Intensive care medicine
pub_type： 评论,社论
doi：10.1007/s00134-018-5399-y
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:To examine the usefulness of preload indices obtained by transoesophageal echocardiography (TOE) for estimating stroke volume at various levels of cardiac index. DESIGN:Prospective clinical study. SETTING:Intensive care unit with surgical patients. PATIENTS:16 ventilated patients monitored via Swan-Ganz ca...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050349
更新日期：1997-04-01 00:00:00
abstract：: ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-018-5280-z
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:Caloric insufficiency during the first week of intensive care unit (ICU) stay was reported to be associated with increased infection rates, especially ICU-acquired bloodstream infection (ICU-BSI). However, the predisposition to ICU-BSI by a given pathogen remains not well known. We aimed to determine the impact...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-014-3502-6
更新日期：2014-12-01 00:00:00
abstract：:A randomized study of 30 patients undergoing uncomplicated surgery under spinal anesthesia was conducted to assess the influence of colloids on the kinetics of plasma fibronectin and complement. Both are opsonins of the reticuloendothelial system; moreover fibronectin is concerned with host resistance against septic c...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01691428
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVE:To determine the presence of tricuspid regurgitation (TR) in patients affected by acute lung injury (ALI) and the adult respiratory distress syndrome (ARDS) during mechanical ventilation with positive end-expiratory pressure (PEEP). DESIGN:A prospective clinical study. SETTING:10-bed general intensive care ...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s001340050419
更新日期：1997-08-01 00:00:00
abstract：OBJECTIVE:Atracurium besylate and laudanosine cause excitement and seizures when introduced into the central nervous system of laboratory animals. We examined the modulation of lipid-protein interaction in the lipid environment of rat brain synaptosomal plasma membrane (SPM)-bound enzymes as a possible mechanism leadin...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050605
更新日期：1998-05-01 00:00:00
abstract：OBJECTIVE:Angiopoietin-2 (Ang-2) is a potent regulator of vascular permeability and inflammation in acute lung injury and acute respiratory distress syndrome (ARDS). Genetic variants in the Ang-2 gene may lead to altered activities of Ang-2 (or ANGPT2) gene. The aim of this study was to assess if genetic variants of An...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-009-1413-8
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:Little evidence of increased thrombotic risk is available in COVID-19 patients. Our purpose was to assess thrombotic risk in severe forms of SARS-CoV-2 infection. METHODS:All patients referred to 4 intensive care units (ICUs) from two centers of a French tertiary hospital for acute respiratory distress syndrom...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s00134-020-06062-x
更新日期：2020-06-01 00:00:00
