Abstract：
:Stratification by age at onset has been useful for genetic studies across all of medicine. For the past 20 years, the National Institute of Mental Health has been systematically recruiting patients with onset of schizophrenia before age 13 years. Examination of familial transmission of known candidate risk genes was carried out, and a 10% rate of cytogenetic abnormalities was found. Most recently, high-density, array-based scans for submicroscopic rare copy number variations (CNVs) have suggested that this kind of genetic variation occurs more frequently than expected by chance in childhood-onset schizophrenia (COS) and at a higher rate than observed in adult-onset disorder. Several CNVs and cytogenetic abnormalities associated with COS are also seen in autism and mental retardation. Populations with COS may have more salient genetic influence than adult-onset cases. The relationship of rare CNVs to prepsychotic development is being studied further.
journal_name
Curr Psychiatry Repjournal_title
Current psychiatry reportsauthors
Addington AM,Rapoport JLdoi
10.1007/s11920-009-0024-ysubject
Has Abstractpub_date
2009-04-01 00:00:00pages
156-61issue
2eissn
1523-3812issn
1535-1645journal_volume
11pub_type
杂志文章,评审abstract：:Animal models may be useful in investigating the fundamental mechanisms underlying psychiatric disorders, and may contribute to the development of new medications. A computerized literature search was used to collect studies on recently developed animal models for anxiety disorders. Particular cognitive-affective proc...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-003-0056-7
更新日期：2003-08-01 00:00:00
abstract：PURPOSE OF REVIEW:We review topical evidence on ethical issues in conducting disaster research with children and families affected by natural disasters, with an emphasis on analyzing specific vulnerabilities associated with children and families affected by disasters, identifying significant findings and trends of ethi...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-018-0902-2
更新日期：2018-05-18 00:00:00
abstract：:Although initial reports of genetic contributions to personality dimensions were promising, continued empirical support remains controversial. The focus has largely revolved around polymorphisms of the serotonin transporter gene-linked polymorphic region and the D4 dopamine receptor subtype. Equivocal findings likely ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-005-0028-1
更新日期：2005-03-01 00:00:00
abstract：:Alzheimer's disease (AD) is associated with neuropsychologic and neuropsychiatric dysfunction and is a leading cause of disability among the elderly. Impairments in activities of daily living (ADL) contribute significantly to the disability reported among patients with AD and diminish quality of life for patients and ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-004-0033-9
更新日期：2004-02-01 00:00:00
abstract：:The existence of a group of psychoses that are symptomatologically and prognostically different from schizophrenia and affective psychotic disorders is supported by clinical and epidemiologic evidence. Although such "atypical" psychoses account for up to 10% of all psychotic disorders, their aetiology, pathophysiology...
journal_title：Current psychiatry reports
pub_type： 历史文章,杂志文章
doi：10.1007/s11920-001-0029-7
更新日期：2001-08-01 00:00:00
abstract：PURPOSE OF REVIEW:We review recent and growing evidence that provides support for a novel parasomnia, trauma associated sleep disorder (TASD). Based on these findings, we further develop the clinical and polysomnographic (PSG) characteristics of TASD. We also address factors that precipitate TASD, develop a differentia...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1066-4
更新日期：2019-08-13 00:00:00
abstract：:This paper aims to critically review currently available data on kleptomania and to analyze the possible future evolution of clinical research and therapeutic strategies. ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-003-0007-3
更新日期：2003-05-01 00:00:00
abstract：PURPOSE OF REVIEW:To highlight an emerging understanding of burnout and physician mental health. This review will provide a discussion of conceptual and diagnostic issues of the burnout syndrome with its relevance to psychiatry, and how psychiatry may interface with other medical disciplines to provide support in creat...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1100-6
更新日期：2019-10-15 00:00:00
abstract：:The purposes of this paper are to provide an overview of the state of the science of sleep in children with autism spectrum disorder (ASD), present hypotheses for the high prevalence of insomnia in children with ASD, and present a practice pathway for promoting optimal sleep. Approximately two thirds of children with ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-017-0782-x
更新日期：2017-06-01 00:00:00
abstract：:The importance of an adequate and satisfying level of functioning for the course and outcome of schizophrenia has been increasingly emphasized by researchers in recent years. Employment status is a major component of the patient's functioning and is generally believed to be essential for well-being, satisfaction in li...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-012-0261-3
更新日期：2012-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Sex differences in cognitive function are well documented yet few studies had adequate numbers of women and men living with HIV (WLWH; MLWH) to identify sex differences in neurocognitive impairment (NCI) and the factors contributing to NCI. Here, we review evidence that WLWH may be at greater risk for...
journal_title：Current psychiatry reports
pub_type： 杂志文章
doi：10.1007/s11920-019-1089-x
更新日期：2019-09-14 00:00:00
abstract：PURPOSE OF REVIEW:The aim of the present review is to systematically examine published data regarding ecological momentary assessment (EMA) in children and adolescents with mood disorders. RECENT FINDINGS:EMA is increasingly used to collect participant's information in their real environment and in real time. There ar...
journal_title：Current psychiatry reports
pub_type： 杂志文章
doi：10.1007/s11920-018-0913-z
更新日期：2018-08-01 00:00:00
abstract：:In May 2013 the APA will release DSM-5, which will restructure the diagnostic classification for autism spectrum disorders (ASDs) into a single category. The proposed changes in DSM-5 aim to better reflect the current state of research by consistently identifying the core features in social/communication and restricti...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-012-0327-2
更新日期：2012-12-01 00:00:00
abstract：:Acute mania is frequently a medical emergency requiring hospitalization for behavioral control, rapid resolution of irritability, agitation, de-escalation of mood, and decreasing of risk-taking behavior. Lithium efficacy in the management of acute mania was reported in 1949 and approved by the US Food and Drug Adminis...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-006-0058-3
更新日期：2006-12-01 00:00:00
abstract：:Relapse is a highly prevalent phenomenon in addiction. This paper examines the new research on identifying biological factors that contribute to addiction relapse risk. Prospective studies examining relapse risk are reviewed, and clinical, biological, and neural factors that predict relapse risk are identified. Clinic...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-011-0224-0
更新日期：2011-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Artificial intelligence (AI) technology holds both great promise to transform mental healthcare and potential pitfalls. This article provides an overview of AI and current applications in healthcare, a review of recent original research on AI specific to mental health, and a discussion of how AI can s...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1094-0
更新日期：2019-11-07 00:00:00
abstract：:The effects of overt hypothyroidism (HO) on cognition and mood are well established, and HO is considered a common cause of reversible dementia. There is now increasing evidence to suggest that subclinical hypothyroidism (ie, elevated thyroid stimulating hormone in the presence of normal thyroxine concentrations) may ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-003-0073-6
更新日期：2003-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Greater racial discrimination is associated with poorer mental health among Black Americans; yet, there remains an incomplete understanding of sex differences in exposure to racial discrimination, and further, of how sex differences in coping with racial discrimination may heighten or diminish risk fo...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1098-9
更新日期：2019-11-04 00:00:00
abstract：:A recent publication focused on biomarkers of future suicidal behaviors identifies several genes expressed in high-risk states among four samples. We discuss the implications of this study as well as the current state of research regarding biomarkers of suicidal behavior. ...
journal_title：Current psychiatry reports
pub_type： 评论,杂志文章
doi：10.1007/s11920-013-0424-x
更新日期：2013-12-01 00:00:00
abstract：:Anxiety symptoms and disorders have long been described in schizophrenia. This article reviews the epidemiology, phenomenology, and neurobiologic underpinnings of comorbid anxiety symptoms and disorders in schizophrenia. Recent literature was obtained by Medline searches using key words relating to schizophrenia and a...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-004-0074-0
更新日期：2004-08-01 00:00:00
abstract：:An "Alternative DSM-5 Model for Personality Disorders" was published in Sect. III of DSM-5, while the identical categories and criteria from DSM-IV for the personality disorders (PDs) are in Sect. II. Given strong shifts from categorical diagnoses toward dimensional representations in psychiatry, how did the PDs end u...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-014-0480-x
更新日期：2014-10-01 00:00:00
abstract：:Bipolar depression is considered the most difficult-to-treat phase of bipolar disorder, in relation to its pervasiveness and efficacy and/or tolerability limitations of available treatments. Indeed, most mood stabilizers and atypical antipsychotics are not as effective in ameliorating depressive compared with manic sy...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-013-0378-z
更新日期：2013-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Phenibut (β-phenyl-γ-aminobutyric acid) is a psychoactive GABA analogue currently being marketed online as an anxiolytic and nootropic dietary supplement. Its use is growing in popularity, but its pharmacological activity is well beyond that of a conventional nutritional supplement, and similar to tha...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1009-0
更新日期：2019-03-09 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this study was to review the literature on perinatal intimate partner violence, focusing on recent knowledge to guide mental health professionals on the best approaches to identify and treat women exposed to perinatal intimate partner violence. RECENT FINDINGS:Risk factors have been br...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-017-0778-6
更新日期：2017-05-01 00:00:00
abstract：:This paper reviews recent evidence on the value of phallometric (i.e., erectile) measures of sex offenders plus earlier crucial papers. Distinctions are made between types of measuring devices with the volumetric instrument appearing to be the most sensitive. Considering the meaning of responses it is concluded that a...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-013-0428-6
更新日期：2014-01-01 00:00:00
abstract：:Effective treatments for co-occurring schizophrenia and substance abuse have emerged over the past 15 years. They involve integration and melding of mental health and substance abuse treatments, helping people to acquire the skills and supports they need to manage both illnesses and to pursue functional goals, and a c...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-996-0037-8
更新日期：2001-10-01 00:00:00
abstract：:A growing body of evidence suggests that depressive disorders and anxiety disorders are much more prevalent among medically ill children and adolescents when compared with the general population, and that the presence of comorbidity may adversely affect medical outcomes and quality of life. Whereas the prevalence and ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-007-0080-0
更新日期：2007-04-01 00:00:00
abstract：:HIV, the cause of AIDS, has infected more than 65 million people worldwide, including 1 million children. An estimated 39.5 million people are living with HIV. As of 2006, 4.3 million were newly infected, with 2.8 million occurring in sub-Saharan Africa. Rates of infection have risen more than 50% in Eastern Europe an...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-008-0020-7
更新日期：2008-04-01 00:00:00
abstract：:Manic symptoms frequently occur in patients with comorbid medical disorders and present a diagnostic and treatment challenge. Manic symptoms may be due to an independent psychiatric illness, may be induced or precipitated by a medical condition, or may result from medication or substance use. The presence of manic sym...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-007-0024-8
更新日期：2007-06-01 00:00:00
abstract：:Children's and adolescent's use of computer games and videogames is becoming highly popular and has increased dramatically over the last decade. There is growing evidence of high prevalence of addiction to computer games and videogames among children, which is causing concern because of its harmful consequences. There...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-012-0311-x
更新日期：2012-10-01 00:00:00
