Abstract:
:Prorenin and renin bind to a 350-amino acid protein called the (pro)renin receptor, which is present on the surface and functions intracellularly. When the receptor's N terminus binds either prorenin or renin, intracellular signaling occurs via extracellular-regulated kinases, which can result in plasminogen activator inhibitor and transforming growth factor-beta production. Investigators have developed a novel decoy peptide, called the handle-region peptide (HRP), which obviates binding of prorenin to the receptor. HRP has successfully inhibited diabetic nephropathy in rats and in angiotensin receptor-deleted mice, and has blocked fibrosis in the hearts of spontaneously hypertensive rats. The same researchers developed a transgenic (pro)renin receptor-expressing rat with glomerulosclerosis that responded dramatically to HRP treatment. However, groups in Paris, Rotterdam, and Berlin have not been able to confirm the findings, and the precise role of the (pro)renin receptor remains imperfectly defined.
journal_name
Curr Hypertens Repjournal_title
Current hypertension reportsauthors
Müller DN,Luft FCdoi
10.1007/s11906-008-0075-1subject
Has Abstractpub_date
2008-10-01 00:00:00pages
405-9issue
5eissn
1522-6417issn
1534-3111journal_volume
10pub_type
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更新日期:2007-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-02-12 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-07-26 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2006-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2007-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2019-02-07 00:00:00