Abstract：
:Our understanding of Na(+) transport defects has exploded in the past several years, and has provided unique insights into epithelial transport processes, and unusual clinical syndromes resulting from mutations of specific ion transporters. These genetic disorders affect Na(+) balance, with both Na(+) retaining and Na(+) wasting conditions being the consequence. A major focus of these studies has been the epithelial sodium channel (ENaC), which can be directly affected by mutations (eg, Liddle syndrome, autosomal recessive pseudohypoaldosteronism, type I) or by changes in the response to (autosomal recessive pseudohypoaldosteronism, type I), or production of mineralocorticoids (apparent mineralocorticoid excess syndrome, glucocorticoid-remediable aldosteronism). As a result, we now have clearly defined syndromes in which ENaC activity is dysregulated with subsequent development of disorders of systemic blood pressure that can be attributed to a primary renal mechanism.
journal_name
Curr Hypertens Repjournal_title
Current hypertension reportsauthors
Warnock DGdoi
10.1007/s11906-999-0013-xkeywords:
subject
Has Abstractpub_date
1999-04-01 00:00:00pages
158-63issue
2eissn
1522-6417issn
1534-3111journal_volume
1pub_type
杂志文章,评审abstract：:The fact that cardiovascular risk factors cluster among individuals with the insulin resistance syndrome strongly suggests a common pathogenetic denominator. For many years, abnormalities of nonesterified fatty acid metabolism have been implicated in the disturbances of carbohydrate and lipid metabolism that character...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-001-0021-y
更新日期：2001-04-01 00:00:00
abstract：:Diabetes mellitus is one of the leading causes of end-stage renal disease. The pathogenesis of diabetic nephropathy is still poorly understood, but glomerular injury has been ascribed, at least in part, to glomerular hyperfiltration, which occurs early in the course of diabetes mellitus. Therefore, a better understand...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-005-0089-x
更新日期：2005-04-01 00:00:00
abstract：:Essential hypertension is characterized by endothelial dysfunction due to reduced availability of nitric oxide (NO) secondary to increased generation of oxygen-free radicals. Some antihypertensive drugs may improve or restore endothelial function independently of their blood pressure lowering effect. The newer generat...
journal_title：Current hypertension reports
pub_type： 杂志文章
doi：10.1007/s11906-011-0207-x
更新日期：2011-08-01 00:00:00
abstract：:Essential hypertension is a very common health condition that is associated with an array of long-term end-organ diseases, including premature cardiovascular disease. Currently, there is no effective method to identify high-risk patients who may develop cardiovascular comorbidities in the future. Clinically, it would ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0502-4
更新日期：2014-12-01 00:00:00
abstract：:Primary aldosteronism (PA) is a common cause of arterial hypertension: in the PA Prevalence in Hypertensives (PAPY) Study, the prevalence of PA was 11.2% in consecutive referred hypertensive patients. When adrenal vein sampling (AVS) is available, two thirds of the cases can be attributed to a tumor and one third of c...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-010-0134-2
更新日期：2010-10-01 00:00:00
abstract：:Peak-systolic blood pressure (SBP) and end-diastolic blood pressure (DBP) have been considered the exclusive mechanical factors predicting cardiovascular (CV) risk in populations of normotensive and hypertensive subjects. The purpose of this review is to show that in addition to SBP and DBP, other hemodynamic indices ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-004-0068-7
更新日期：2004-06-01 00:00:00
abstract：:The World Health Organization's annual report World Health Statistics 2012 was recently published. In addition to annually published indicators of health, this year's report contains a highlighted new section on non-communicable diseases and their impact on world health. The section gives particular attention to hyper...
journal_title：Current hypertension reports
pub_type： 杂志文章
doi：10.1007/s11906-012-0303-6
更新日期：2012-12-01 00:00:00
abstract：PURPOSE OF REVIEW:This review provides a comprehensive insight into the angiogenic profile of hypertensive and normotensive pregnancies compromised by HIV infection. Furthermore, we evaluate the economic implementation of the sFlt-1/PlGF ratio and review the reports on therapeutic apheresis in limiting sFlt-1 productio...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-019-0970-7
更新日期：2019-07-24 00:00:00
abstract：:Recent studies have identified key gender differences in cardiovascular function, renal hemodynamics, and the renin-angiotensin system. Extensive epidemiologic evidence has shown a clear gender difference in cardiovascular and renal disease progression, whereby female sex appears to be protective. The mechanisms under...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-002-0039-9
更新日期：2002-04-01 00:00:00
abstract：:Hypertension is present in three of four patients with coronary artery disease (CAD) but remains largely uncontrolled in most patients. Treating hypertension in these patients is complicated by the concern of precipitating coronary ischemia when diastolic blood pressure (DBP) is reduced excessively. However, an emergi...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-008-0066-2
更新日期：2008-10-01 00:00:00
abstract：:Hypertension and obesity are two closely related pathologies in clinical practice. Currently, about one billion adults worldwide are overweight, and it is estimated that, if no serious action is taken to effect profound change, that figure will continue to rise throughout this century. Hypertension is also a serious p...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0438-8
更新日期：2014-07-01 00:00:00
abstract：:Hypertension (HTN) is the most common modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality worldwide. Lower- and middle-income countries (LMICs) are projected to bear the vast majority of this disease burden, but local and regional health care delivery systems in these countries are ill equi...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-017-0707-4
更新日期：2017-01-01 00:00:00
abstract：:The research on molecular genetics of human hypertension aims to identify the loci involved in the regulation of blood pressure, detect gene variants within the identified loci, associate them with intermediate phenotypes, and ultimately estimate their quantitative effects on blood pressure level and their interaction...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-999-0071-0
更新日期：1999-02-01 00:00:00
abstract：:Hypertension is a preventable condition, and the outcomes of clinical trials have established that its treatment reduces cardiovascular morbidity and mortality. Although awareness about the disease has improved in the past two decades, the reality is that many people remain untreated or not adequately controlled. The ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-001-0007-9
更新日期：2001-12-01 00:00:00
abstract：PURPOSE OF REVIEW:To estimate the impact of the 2017 American College of Cardiology/American Heart Association (ACC/AHA) guidelines for high blood pressure (BP) on the next hypertension guidelines in Asia. RECENT FINDINGS:The 2017 ACC/AHA guidelines for high BP in adults changed the diagnostic threshold and the manage...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-019-0906-2
更新日期：2019-01-10 00:00:00
abstract：:The treatment of hypertension is proven to reduce cardiovascular and renal risk. Combination drug therapy is becoming recognized as a necessity in most patients with hypertension and kidney disease. Allegations about the safe use of calcium antagonists in patients with kidney disease have led to questions and confusio...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-002-0006-5
更新日期：2002-06-01 00:00:00
abstract：:The ubiquitin-proteasome system (UPS) is a major proteolytic system that regulates the degradation of intracellular proteins in the heart. The UPS regulates the turnover of misfolded and damaged proteins, in addition to numerous cellular processes, by affecting the stability of short-lived proteins such as transcripti...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-009-0069-7
更新日期：2009-12-01 00:00:00
abstract：:High blood pressure in the setting of type 1 and type 2 diabetes is commonly associated with the earlier development of target-organ damage, including cardiovascular and cerebrovascular disease and progressive renal insufficiency. The major goal of treating high blood pressure in this population is to prevent or reduc...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-003-0020-2
更新日期：2003-06-01 00:00:00
abstract：:Primary aldosteronism is commonly regarded as largely sporadic, but both germline and somatic mutations are increasingly recognized as underlying the condition. Three germline mutations causing familial hyperaldosteronism have been described, dubbed FH I (due to a CYP11B1/CYP11B2 chimera), FH II (localized to chromoso...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-012-0255-x
更新日期：2012-04-01 00:00:00
abstract：PURPOSE OF REVIEW:The intrarenal renin-angiotensin-aldosterone system (RAS) is an independent paracrine hormonal system with an increasingly prominent role in hypertension and renal disease. Two enzyme components of this system are angiotensin-converting enzyme (ACE) and more recently discovered ACE2. The purpose of th...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-017-0778-2
更新日期：2017-09-19 00:00:00
abstract：:We are used to thinking of angiotensin (Ang) II as a regulatory hormone that stimulates constriction of vascular smooth muscle cells, aldosterone release from the adrenal gland, and sodium reabsorption in the renal tubule. We have also become accustomed to understanding that Ang II may be formed and may act locally as...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-001-0082-y
更新日期：2001-02-01 00:00:00
abstract：:Resistant hypertension is defined as blood pressure that remains uncontrolled despite using at least three antihypertensive medications in effective doses, ideally including a diuretic. Stricter blood pressure goals, higher obesity rates, older age, and increased use of certain exogenous substances are related to an i...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-007-0066-7
更新日期：2007-11-01 00:00:00
abstract：PURPOSE OF REVIEW:Review the renal nerve anatomy and physiology basics and explore the concept of global vs. selective renal denervation (RDN) to uncover some of the fundamental limitations of non-targeted renal nerve ablation and the potential superiority of selective RDN. RECENT FINDINGS:Recent trials testing the ef...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-018-0838-2
更新日期：2018-05-01 00:00:00
abstract：:Individuals with hypertension need to stay on therapy with antihypertensive medication to obtain the full benefits of blood pressure reduction. There are important differences in tolerability across antihypertensive drug classes, and these differences influence the extent to which patients are willing to continue taki...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-002-0021-6
更新日期：2002-12-01 00:00:00
abstract：:Albuminuria is an early marker for diabetic nephropathy in patients with diabetes, and has a clear place in patient care. It also predicts cardiovascular events and mortality in diabetic patients and in the general population, and is slowly becoming accepted in population screening for cardiovascular disease and chron...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-009-0021-x
更新日期：2009-04-01 00:00:00
abstract：:It is widely accepted that the pathophysiology of hypertension involves autonomic nervous system dysfunction, as well as a multitude of immune responses. However, the close interplay of these systems in the development and establishment of high blood pressure and its associated pathophysiology remains elusive and is t...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-013-0361-4
更新日期：2013-08-01 00:00:00
abstract：:Inflammation plays an important role in the pathogenesis of hypertension. Innate and adaptive immune response may contribute to this process. The mechanisms implicating immune response in hypertension are still elusive. To date, the evidence originates in three major areas of data: cytokine production, central nervous...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-011-0224-9
更新日期：2011-12-01 00:00:00
abstract：:The metabolic syndrome associates metabolic abnormalities such as insulin resistance and dyslipidemia with increased waist circumference and hypertension. It is a major public health concern, as its prevalence could soon reach 30% to 50% in developed countries. Aldosterone, a mineralocorticoid hormone classically invo...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-011-0182-2
更新日期：2011-04-01 00:00:00
abstract：:Nycthemeral changes in renal function have been known for a long time, but our knowledge about the underlying mechanisms is still far from complete. From a theoretical point of view, many physiological systems could be involved in turning the kidney from a sodium-excretory organ during daytime into a sodium-conserving...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-011-0183-1
更新日期：2011-04-01 00:00:00
abstract：:Hypertension and high serum cholesterol levels are two of the most relevant risk factors for cardiovascular diseases. A combined increase in both risk factors has been reported in a significant proportion of patients with coronary artery disease. Statins are the most widely used drugs to treat hypercholesterolemia, an...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-001-0090-y
更新日期：2001-08-01 00:00:00
