Abstract:
:It is widely accepted that the pathophysiology of hypertension involves autonomic nervous system dysfunction, as well as a multitude of immune responses. However, the close interplay of these systems in the development and establishment of high blood pressure and its associated pathophysiology remains elusive and is the subject of extensive investigation. It has been proposed that an imbalance of the neuro-immune systems is a result of an enhancement of the "proinflammatory sympathetic" arm in conjunction with dampening of the "anti-inflammatory parasympathetic" arm of the autonomic nervous system. In addition to the neuronal modulation of the immune system, it is proposed that key inflammatory responses are relayed back to the central nervous system and alter the neuronal communication to the periphery. The overall objective of this review is to critically discuss recent advances in the understanding of autonomic immune modulation, and propose a unifying hypothesis underlying the mechanisms leading to the development and maintenance of hypertension, with particular emphasis on the bone marrow, as it is a crucial meeting point for neural, immune, and vascular networks.
journal_name
Curr Hypertens Repjournal_title
Current hypertension reportsauthors
Santisteban MM,Zubcevic J,Baekey DM,Raizada MKdoi
10.1007/s11906-013-0361-4subject
Has Abstractpub_date
2013-08-01 00:00:00pages
377-89issue
4eissn
1522-6417issn
1534-3111journal_volume
15pub_type
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journal_title:Current hypertension reports
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2005-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00
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更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2007-12-01 00:00:00
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journal_title:Current hypertension reports
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2004-06-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2014-06-01 00:00:00
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更新日期:2010-06-01 00:00:00
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