The "J curve" problem revisited: old and new findings.

abstract：PURPOSE OF REVIEW:This article introduces the haemodynamic principles that underpin the pathophysiology of hypertension and introduces a rational physiological approach to appropriate pharmacologic treatment. RECENT FINDINGS:Outdated understanding of haemodynamics based on previous measurement systems can no longer be...

journal_title：Current hypertension reports

authors： Smith BE,Madigan VM

更新日期：2018-04-10 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate recent developments in the management of hypertension in obese pregnant women. RECENT FINDINGS:The mainstay of management targets prevention of hypertension with preconception counselling, entering pregnancy with a lower BMI, limiting weight gain, and taking low-dose aspirin to prevent pr...

journal_title：Current hypertension reports

authors： Coroyannakis C,Khalil A

更新日期：2019-03-26 00:00:00

abstract：:The presence of renin production by the principal cells of the collecting duct has opened new perspectives for the regulation of intrarenal angiotensin II (Ang II). Angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) are present in the tubular fluid coming from the proximal tubule and collecting duct. All th...

journal_title：Current hypertension reports

authors： Gonzalez AA,Lara LS,Prieto MC

更新日期：2017-08-01 00:00:00

abstract：:The impaired capacity of the kidney to excrete sodium plays an essential role in the development of hypertension. Adrenal corticosteroids control renal handling of sodium by regulating tubular sodium reabsorption in the distal nephron where both mineralocorticoid receptors (MR) and glucocorticoid receptors are express...

journal_title：Current hypertension reports

authors： Ayuzawa N,Fujita T

更新日期：2015-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Mechanisms facilitating progression of hypertension via cross stimulation of the renin-angiotensin system (RAS) and inflammation have been proposed. Accordingly, we review and update evidence for regulation of RAS components by pro-inflammatory factors. RECENT FINDINGS:Angiotensin II (Ang II), which ...

journal_title：Current hypertension reports

authors： Satou R,Penrose H,Navar LG

更新日期：2018-10-05 00:00:00

abstract：PURPOSE OF REVIEW:To review the most recent literature on current strategies for the treatment of hypertension associated with pediatric obesity. RECENT FINDINGS:Over the last three decades, childhood and adolescent overweight and obesity prevalence in the USA has continued to rise. Unsurprisingly but rather disturbin...

journal_title：Current hypertension reports

authors： Binka E,Brady TM

更新日期：2019-02-12 00:00:00

abstract：:Hypertension is an established risk factor for stroke, premature coronary artery disease and heart failure. Control of elevated blood pressure has been shown to result in significant reduction of cardiovascular risk. Aldosterone, the final product of the renin-angiotensin-aldosterone system (RAAS), not only causes sal...

journal_title：Current hypertension reports

authors： Andersen K

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer's disease; however, associations between antihypertensive medications (AHMs) and dementia risk are less consistent. An increased interest in AHM has resulted in ex...

journal_title：Current hypertension reports

authors： Yasar S,Schuchman M,Peters J,Anstey KJ,Carlson MC,Peters R

更新日期：2016-08-01 00:00:00

abstract：:Obstructive sleep apnea (OSA) is a prevalent sleep disorder which is characterized by recurrent upper closure with oxygen desaturation and sleep disruption. OSA increases the risk of vascular disorders in the form of stroke, myocardial infarction, congestive heart failure, and hypertension. The mechanisms underlying t...

journal_title：Current hypertension reports

authors： Mohsenin V

更新日期：2014-10-01 00:00:00

abstract：:Essential hypertension is associated with impaired endothelium-dependent vasodilation and is caused mainly by production of oxygen free radicals that can destroy nitric oxide (NO), impairing its beneficial and protective effects on the vessel wall. Antihypertensive drugs can improve or restore endothelium-dependent va...

journal_title：Current hypertension reports

authors： Taddei S,Virdis A,Ghiadoni L,Sudano I,Salvetti A

更新日期：2000-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This meta-analysis and systematic review was conducted to evaluate the effect of probiotics on blood pressure, body mass index (BMI), and blood glucose changes in patients with hypertension. RECENT FINDINGS:We searched the PubMed, Cochrane, Embase, and ProQuest databases using a combination of MeSH a...

journal_title：Current hypertension reports

authors： Chi C,Li C,Wu D,Buys N,Wang W,Fan H,Sun J

更新日期：2020-03-21 00:00:00

abstract：:Masked hypertension refers to the phenomenon of having a non-elevated clinic blood pressure (BP) despite having an elevated out-of-clinic BP. Masked hypertension is a common phenotype with a cardiovascular risk profile similar to that of sustained hypertension, defined as elevated clinic and out-of-clinic BP. Current ...

journal_title：Current hypertension reports

authors： Anstey DE,Pugliese D,Abdalla M,Bello NA,Givens R,Shimbo D

更新日期：2017-10-25 00:00:00

abstract：PURPOSE OF REVIEW:To examine available clinical data on the differences between premenopausal and postmenopausal women with hypertension (HTN). Clinical conditions related to HTN and reproductive status differ in younger women compared with older women. Due to recent changes in the definition of HTN, the prevalence of ...

journal_title：Current hypertension reports

authors： Brahmbhatt Y,Gupta M,Hamrahian S

更新日期：2019-08-26 00:00:00

abstract：:The seventeenth century London neuroanatomical school headed by Thomas Willis published the first images of the sympathetic nervous system. Nineteenth century European physiologists characterised these as the "pressor nerves". Von Euler's demonstration that the sympathetic transmitter was norepinephrine brought the fi...

journal_title：Current hypertension reports

authors： Esler M

更新日期：2015-02-01 00:00:00

abstract：:Excess weight gain is a major cause of essential hypertension, and abnormal kidney function appears to be a cause as well as a consequence of obesity hypertension. Excess renal sodium reabsorption and a hypertensive shift of pressure natriuresis play a major role in mediating increased blood pressure associated with w...

journal_title：Current hypertension reports

authors： Hall JE

更新日期：2000-04-01 00:00:00

abstract：:Hypertension that complicates preeclampsia in pregnancy is a disorder that requires special consideration in both prevention and pharmacologic treatment. In recent years, few advances have been made regarding the pathophysiology and prevention of preeclampsia; however, there have been some promising results from studi...

journal_title：Current hypertension reports

authors： Frishman WH,Veresh M,Schlocker SJ,Tejani N

更新日期：2006-12-01 00:00:00

abstract：PURPOSE OF THE REVIEW:In our innate immune system, neutrophils are the first cells to sense signals of infection and to proceed to kill the invading pathogen. This is mediated by their production of neutrophil extracellular traps (NETS) to entrap pathogenic micro-organisms, preventing their amplification and disseminat...

journal_title：Current hypertension reports

authors： Moodley M,Moodley J,Naicker T

更新日期：2020-05-27 00:00:00

abstract：PURPOSE OF REVIEW:The pathophysiology of preeclampsia is complex and not entirely understood. A key feature in preeclampsia development is an immunological imbalance that shifts the maternal immune response from one of tolerance towards one promoting chronic inflammation and endothelial dysfunction. As a key regulator ...

journal_title：Current hypertension reports

authors： Cubro H,Kashyap S,Nath MC,Ackerman AW,Garovic VD

更新日期：2018-04-30 00:00:00

abstract：:The treatment of hypertension is proven to reduce cardiovascular and renal risk. Combination drug therapy is becoming recognized as a necessity in most patients with hypertension and kidney disease. Allegations about the safe use of calcium antagonists in patients with kidney disease have led to questions and confusio...

journal_title：Current hypertension reports

authors： Tobe S,Epstein M

更新日期：2002-06-01 00:00:00

abstract：:Essential hypertension is a very common health condition that is associated with an array of long-term end-organ diseases, including premature cardiovascular disease. Currently, there is no effective method to identify high-risk patients who may develop cardiovascular comorbidities in the future. Clinically, it would ...

journal_title：Current hypertension reports

authors： Xue Y,Iqbal N,Chan J,Maisel A

更新日期：2014-12-01 00:00:00

abstract：:Resistant hypertension is a common and growing clinical problem characterized by failure to achieve target blood pressure levels despite adequate use of at least three antihypertensive agents. Although numerous safe and effective pharmacologic therapies are available to treat elevated blood pressure, novel therapeutic...

journal_title：Current hypertension reports

authors： Schlaich MP,Krum H,Esler MD

更新日期：2010-08-01 00:00:00

abstract：:Aldosterone antagonists have been highly successful in treating congestive heart failure and resistant hypertension. Until recently, therapies targeting the mineralocorticoid receptor in chronic kidney disease (CKD) have received little attention, largely because of the risk of hyperkalemia and the incorrect assumptio...

journal_title：Current hypertension reports

authors： Volk MJ,Bomback AS,Klemmer PJ

更新日期：2011-08-01 00:00:00

abstract：:Circulating angiotensin II (Ang II) combined with high salt intake increases sympathetic nerve activity (SNA) in some forms of hypertension. Ang II-induced increases in SNA are modest, delayed, and specific to certain vascular beds. The brain targets for circulating Ang II are neurons in the area postrema (AP), subfor...

journal_title：Current hypertension reports

authors： Osborn JW,Fink GD,Sved AF,Toney GM,Raizada MK

更新日期：2007-06-01 00:00:00

abstract：:Hypertension contributes greatly to global disease burden and in many patients current treatments do not adequately control blood pressure (BP). Endothelin-1 (ET-1) is a potent vasoconstrictor that is implicated in the pathogenesis of hypertension, including the hypertension that is often associated with chronic kidne...

journal_title：Current hypertension reports

authors： Moorhouse RC,Webb DJ,Kluth DC,Dhaun N

更新日期：2013-10-01 00:00:00

abstract：:Hypertension and obesity are two closely related pathologies in clinical practice. Currently, about one billion adults worldwide are overweight, and it is estimated that, if no serious action is taken to effect profound change, that figure will continue to rise throughout this century. Hypertension is also a serious p...

journal_title：Current hypertension reports

authors： Díaz MG,Rusak EJ,Aguilar EA,Bellido CA

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This study aims to systematically review existing evidence on the effectiveness of mobile health technology (mHealth) interventions in addressing medication adherence among people with hypertension. RECENT FINDINGS:Twenty-one studies of mHealth interventions were included in the final review after sy...

journal_title：Current hypertension reports

authors： Xiong S,Berkhouse H,Schooler M,Pu W,Sun A,Gong E,Yan LL

更新日期：2018-08-07 00:00:00

abstract：:Albuminuria is an early marker for diabetic nephropathy in patients with diabetes, and has a clear place in patient care. It also predicts cardiovascular events and mortality in diabetic patients and in the general population, and is slowly becoming accepted in population screening for cardiovascular disease and chron...

journal_title：Current hypertension reports

authors： Bakker SJ,Gansevoort RT,de Zeeuw D

更新日期：2009-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The major health issue of being overweight or obese relates to the development of hypertension, insulin resistance and diabetic complications. One of the major underlying factors influencing the elevated blood pressure in obesity is increased activity of the sympathetic nerves to particular organs suc...

journal_title：Current hypertension reports

authors： Lim K,Jackson KL,Sata Y,Head GA

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The overactive renin-angiotensin-aldosterone system (RAAS) plays an important part in many pathologic conditions including hypertension, heart failure, and renal disease. Hyperkalemia, a potentially life-threatening side effect of RAAS inhibitors, limits their use. The recent introduction of new hyper...

journal_title：Current hypertension reports

authors： Rastogi A,Arman F,Alipourfetrati S

更新日期：2016-07-01 00:00:00

abstract：:High blood pressure in the setting of type 1 and type 2 diabetes is commonly associated with the earlier development of target-organ damage, including cardiovascular and cerebrovascular disease and progressive renal insufficiency. The major goal of treating high blood pressure in this population is to prevent or reduc...

journal_title：Current hypertension reports

authors： Lu WX,Lakkis J,Weir MR

更新日期：2003-06-01 00:00:00