Abstract:
:Circulating angiotensin II (Ang II) combined with high salt intake increases sympathetic nerve activity (SNA) in some forms of hypertension. Ang II-induced increases in SNA are modest, delayed, and specific to certain vascular beds. The brain targets for circulating Ang II are neurons in the area postrema (AP), subfornical organ (SFO), and possibly other circumventricular organs. Ang II signaling is integrated with sodium-sensitive neurons in the SFO and/or organum vasculosum of the lamina terminalis (OVLT) and drives sympathetic premotor neurons in the rostral ventrolateral medulla (RVLM) via the paraventricular nucleus (PVN). It is likely that, over time, new patterns of gene expression emerge within neurons of the SFO-PVN-RVLM pathway that transform their signaling properties. This transformation is critical in maintaining increased SNA. Identification of a novel gene supporting this process may provide new targets for treatment of neurogenic hypertension.
journal_name
Curr Hypertens Repjournal_title
Current hypertension reportsauthors
Osborn JW,Fink GD,Sved AF,Toney GM,Raizada MKdoi
10.1007/s11906-007-0041-3subject
Has Abstractpub_date
2007-06-01 00:00:00pages
228-35issue
3eissn
1522-6417issn
1534-3111journal_volume
9pub_type
杂志文章,评审abstract::Individuals with hypertension need to stay on therapy with antihypertensive medication to obtain the full benefits of blood pressure reduction. There are important differences in tolerability across antihypertensive drug classes, and these differences influence the extent to which patients are willing to continue taki...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-002-0021-6
更新日期:2002-12-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-017-0707-4
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-017-0788-0
更新日期:2017-10-18 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-005-0019-y
更新日期:2005-08-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-002-0039-9
更新日期:2002-04-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-014-0508-y
更新日期:2015-01-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-017-0786-2
更新日期:2017-10-23 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-015-0620-7
更新日期:2016-02-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-011-0202-2
更新日期:2011-08-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章
doi:10.1007/s11906-012-0320-5
更新日期:2013-02-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-020-01045-1
更新日期:2020-05-13 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-019-0977-0
更新日期:2019-08-02 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-020-01118-1
更新日期:2021-01-15 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-006-0030-y
更新日期:2006-12-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-999-0071-0
更新日期:1999-02-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-999-0036-3
更新日期:1999-08-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-999-0025-6
更新日期:1999-06-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-014-0502-4
更新日期:2014-12-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-005-0058-4
更新日期:2005-02-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-011-0221-z
更新日期:2011-12-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2001-04-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-008-0038-6
更新日期:2008-06-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章
doi:10.1007/s11906-018-0886-7
更新日期:2018-08-07 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-017-0792-4
更新日期:2017-10-25 00:00:00
abstract::The kidneys play a central role in the long-term regulation of blood pressure and in the pathogenesis of hypertension. A common defect that has been found in all forms of hypertension examined to date is a hypertensive shift in the pressure-natriuresis relationship. A major objective of this brief review is to highlig...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-006-0068-x
更新日期:2006-08-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11906-019-0929-8
更新日期:2019-02-07 00:00:00
abstract::Hypertension is an established risk factor for stroke, premature coronary artery disease and heart failure. Control of elevated blood pressure has been shown to result in significant reduction of cardiovascular risk. Aldosterone, the final product of the renin-angiotensin-aldosterone system (RAAS), not only causes sal...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-013-0379-7
更新日期:2013-10-01 00:00:00
abstract::Hypertension contributes greatly to global disease burden and in many patients current treatments do not adequately control blood pressure (BP). Endothelin-1 (ET-1) is a potent vasoconstrictor that is implicated in the pathogenesis of hypertension, including the hypertension that is often associated with chronic kidne...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-013-0380-1
更新日期:2013-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Use of antihypertensives in older adults can be complicated by the potential for undesired effects on comorbidities, adverse effects of the drugs, and overall medication burden. The purpose of this two-part review is to discuss contemporary issues encountered in the management of hypertension in aged ...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-019-0988-x
更新日期:2019-10-10 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章
doi:10.1007/s11906-999-0046-1
更新日期:1999-08-01 00:00:00