Abstract:
:Recent studies have identified key gender differences in cardiovascular function, renal hemodynamics, and the renin-angiotensin system. Extensive epidemiologic evidence has shown a clear gender difference in cardiovascular and renal disease progression, whereby female sex appears to be protective. The mechanisms underlying this phenomenon are unknown, but likely reflect the aforementioned sex differences in common pathophysiologic pathways. This review focuses on studies examining sex differences in these underlying pathways, which together may provide a plausible mechanism for the gender disparity in clinical outcomes.
journal_name
Curr Hypertens Repjournal_title
Current hypertension reportsauthors
Kang AK,Miller JAdoi
10.1007/s11906-002-0039-9keywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
143-51issue
2eissn
1522-6417issn
1534-3111journal_volume
4pub_type
杂志文章,评审abstract::The presence of renin production by the principal cells of the collecting duct has opened new perspectives for the regulation of intrarenal angiotensin II (Ang II). Angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) are present in the tubular fluid coming from the proximal tubule and collecting duct. All th...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-017-0763-9
更新日期:2017-08-01 00:00:00
abstract::The epithelial sodium channel (ENaC) is a membrane protein made of three different but homologous subunits (a, b, and g) present in the apical membrane of epithelial cells of, for example, the distal nephron. This channel is responsible for salt reabsorption in the kidney and can cause human diseases by increasing cha...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-003-0005-1
更新日期:2003-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this meta-analysis is to compare the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on blood pressure of hypertensive individuals. RECENT FINDINGS:Continuous aerobic training programs are successful in health promotion and are effec...
journal_title:Current hypertension reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11906-020-1030-z
更新日期:2020-03-03 00:00:00
abstract:PURPOSE OF REVIEW:This review is intended to briefly describe the primary mechanistic pathways by which several common drugs can increase blood pressure. We also propose potential management strategies based on the underlying mechanisms responsible for the blood pressure elevation. RECENT FINDINGS:As hypertension is a...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-017-0736-z
更新日期:2017-05-01 00:00:00
abstract::Diabetes mellitus is one of the leading causes of end-stage renal disease. The pathogenesis of diabetic nephropathy is still poorly understood, but glomerular injury has been ascribed, at least in part, to glomerular hyperfiltration, which occurs early in the course of diabetes mellitus. Therefore, a better understand...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-005-0089-x
更新日期:2005-04-01 00:00:00
abstract::Patients with hypertension have a high prevalence of concurrent metabolic abnormalities (eg, obesity, dyslipidemia, and hyperglycemia). Clustering of these risk factors, defined as the metabolic syndrome, is associated with a high cardiovascular risk profile. This review summarizes current knowledge about the prevalen...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-007-0019-1
更新日期:2007-04-01 00:00:00
abstract::Recent guidelines for the treatment of hypertension place great emphasis on tighter blood pressure control, especially in the presence of hypertensive target organ damage and diabetes. In order to achieve these treatment targets, more patients will require a combination of antihypertensive medications. However, resist...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-001-0039-1
更新日期:2001-06-01 00:00:00
abstract::Excess weight gain is a major cause of essential hypertension, and abnormal kidney function appears to be a cause as well as a consequence of obesity hypertension. Excess renal sodium reabsorption and a hypertensive shift of pressure natriuresis play a major role in mediating increased blood pressure associated with w...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-000-0073-4
更新日期:2000-04-01 00:00:00
abstract::When a large multicenter research trial is abruptly terminated, it is usually a consequence of significant adverse events. In contrast, when the Randomized Aldactone Evaluation Study (RALES) mortality trial was discontinued 18 months early, it was because of the prominent salutary effect of spironolactone, added to st...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-000-0027-x
更新日期:2000-10-01 00:00:00
abstract:PURPOSE OF REVIEW:This review provides a comprehensive insight into the angiogenic profile of hypertensive and normotensive pregnancies compromised by HIV infection. Furthermore, we evaluate the economic implementation of the sFlt-1/PlGF ratio and review the reports on therapeutic apheresis in limiting sFlt-1 productio...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-019-0970-7
更新日期:2019-07-24 00:00:00
abstract::Masked hypertension refers to the phenomenon of having a non-elevated clinic blood pressure (BP) despite having an elevated out-of-clinic BP. Masked hypertension is a common phenotype with a cardiovascular risk profile similar to that of sustained hypertension, defined as elevated clinic and out-of-clinic BP. Current ...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-017-0792-4
更新日期:2017-10-25 00:00:00
abstract::The metabolic syndrome associates metabolic abnormalities such as insulin resistance and dyslipidemia with increased waist circumference and hypertension. It is a major public health concern, as its prevalence could soon reach 30% to 50% in developed countries. Aldosterone, a mineralocorticoid hormone classically invo...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-011-0182-2
更新日期:2011-04-01 00:00:00
abstract::Levels of urinary albumin excretion that are below the usual limit of detection by qualitative testing, but are above normal levels (microalbuminuria; MA), can be readily identified by simple measures, such as the urinary albumin to creatinine ratio in untimed urine samples. Such measurements, particularly when combin...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-010-0133-3
更新日期:2010-10-01 00:00:00
abstract::The post-macula densa segments of the renal tubule--that is, the distal convoluted tubule, connecting tubule, and collecting duct--play a central role in determining final urine sodium excretion. The major regulated sodium transporters and channels in these cell types include the thiazide-sensitive (Na-Cl) cotransport...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-006-0013-z
更新日期:2006-05-01 00:00:00
abstract::Sympathetic nerve activity is involved in the pathogenesis of salt-sensitive hypertension. The central nervous system, which regulates sympathetic nerve activity and blood pressure, plays a pivotal role. Central sympathoexcitation is deeply involved in the pathogenesis of salt-sensitive hypertension, although the prec...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-015-0620-7
更新日期:2016-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this meta-analysis was to compare the magnitude of systematic bias (mean difference) and random error (standard deviation of mean difference) between the cuff method of indirect blood pressure and directly measured intra-arterial pressure. RECENT FINDINGS:Blood pressure is almost exclu...
journal_title:Current hypertension reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11906-019-0929-8
更新日期:2019-02-07 00:00:00
abstract::Hypertension that complicates preeclampsia in pregnancy is a disorder that requires special consideration in both prevention and pharmacologic treatment. In recent years, few advances have been made regarding the pathophysiology and prevention of preeclampsia; however, there have been some promising results from studi...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-006-0030-y
更新日期:2006-12-01 00:00:00
abstract:PURPOSE OF REVIEW:To evaluate recent developments in the management of hypertension in obese pregnant women. RECENT FINDINGS:The mainstay of management targets prevention of hypertension with preconception counselling, entering pregnancy with a lower BMI, limiting weight gain, and taking low-dose aspirin to prevent pr...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-019-0927-x
更新日期:2019-03-26 00:00:00
abstract::The incidence and prevalence of obesity and the metabolic syndrome have risen markedly in the past decade, representing a serious cardiovascular health hazard with significant morbidity and mortality. The etiology of the metabolic syndrome and its various pathogenic mechanisms are incompletely defined and under intens...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-008-0025-y
更新日期:2008-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This meta-analysis and systematic review was conducted to evaluate the effect of probiotics on blood pressure, body mass index (BMI), and blood glucose changes in patients with hypertension. RECENT FINDINGS:We searched the PubMed, Cochrane, Embase, and ProQuest databases using a combination of MeSH a...
journal_title:Current hypertension reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11906-020-01042-4
更新日期:2020-03-21 00:00:00
abstract:PURPOSE OF REVIEW:Mechanisms facilitating progression of hypertension via cross stimulation of the renin-angiotensin system (RAS) and inflammation have been proposed. Accordingly, we review and update evidence for regulation of RAS components by pro-inflammatory factors. RECENT FINDINGS:Angiotensin II (Ang II), which ...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-018-0900-0
更新日期:2018-10-05 00:00:00
abstract::This paper reviews findings on the relationship between blood pressure control and the progression of renal disease. Experimental studies demonstrate a correlation between systemic blood pressure and histologic glomerular injury and the delay in progression of renal disease with antihypertensive therapy, particularly ...
journal_title:Current hypertension reports
pub_type: 杂志文章
doi:10.1007/s11906-999-0058-x
更新日期:1999-10-01 00:00:00
abstract::Women with chronic hypertension and pregnancy-induced hypertension are at substantial risk for developing pre-eclampsia/eclampsia, a disease with high fetomaternal morbidity and mortality. However, the etiology of this disease is still unknown. In this article, recent concepts on the pathophysiology of pre-eclampsia, ...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-003-0057-2
更新日期:2003-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The overactive renin-angiotensin-aldosterone system (RAAS) plays an important part in many pathologic conditions including hypertension, heart failure, and renal disease. Hyperkalemia, a potentially life-threatening side effect of RAAS inhibitors, limits their use. The recent introduction of new hyper...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-016-0663-4
更新日期:2016-07-01 00:00:00
abstract::This review is focused on the interplay between two major factors affecting the vascular tree in diabetes, insulin resistance, and hyperglycemia. The implications for vascular function, structure, and the interaction between vascular cells and other tissues by which they are affected under these conditions are reviewe...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-004-0082-9
更新日期:2004-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Use of antihypertensives in older adults can be complicated by the potential for undesired effects on comorbidities, adverse effects of the drugs, and overall medication burden. The purpose of this two-part review is to discuss contemporary issues encountered in the management of hypertension in aged ...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-019-0988-x
更新日期:2019-10-10 00:00:00
abstract::Resistant hypertension is defined as blood pressure that remains uncontrolled despite using at least three antihypertensive medications in effective doses, ideally including a diuretic. Stricter blood pressure goals, higher obesity rates, older age, and increased use of certain exogenous substances are related to an i...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-007-0066-7
更新日期:2007-11-01 00:00:00
abstract::How chlorthalidone (CTDN) reduces risk for cardiovascular events (CVEs) can be considered in light of its ability to lower blood pressure (BP) and its non-BP related, pleiotropic effects. The mechanism by which CTDN lowers BP is unclear but may include alterations in whole body regulation and vasodilatory actions on v...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-013-0372-1
更新日期:2013-10-01 00:00:00
abstract::Obstructive sleep apnea is a common disorder that is often unrecognized and underappreciated. Emerging evidence suggests that there is a causal link between obstructive sleep apnea and hypertension. This relationship appears to be independent of other comorbidities that have been previously linked to hypertension, suc...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-003-0083-0
更新日期:2003-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Here, we review the known relations between hypertension and obesity to inflammation and postulate the endogenous protective effect of melatonin and its potential as a therapeutic agent. We will describe the multiple effects of melatonin on blood pressure, adiposity, body weight, and focus on mitochon...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-018-0842-6
更新日期:2018-05-09 00:00:00