Resistant hypertension and the Birmingham Hypertension Square.

abstract：PURPOSE OF REVIEW:Use of antihypertensives in older adults can be complicated by the potential for undesired effects on comorbidities, adverse effects of the drugs, and overall medication burden. The purpose of this two-part review is to discuss contemporary issues encountered in the management of hypertension in aged ...

journal_title：Current hypertension reports

authors： Ernst ME,MacLaughlin EJ

更新日期：2019-10-10 00:00:00

abstract：:Excess weight gain is a major cause of essential hypertension, and abnormal kidney function appears to be a cause as well as a consequence of obesity hypertension. Excess renal sodium reabsorption and a hypertensive shift of pressure natriuresis play a major role in mediating increased blood pressure associated with w...

journal_title：Current hypertension reports

authors： Hall JE

更新日期：2000-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of the study is to perform a critical assessment of in vitro models of pre-eclampsia using complementary human and cell line-based studies. Molecular mechanisms involved in spiral uterine artery (SUA) remodelling and trophoblast functionality will also be discussed. RECENT FINDINGS:A number o...

journal_title：Current hypertension reports

authors： McNally R,Alqudah A,Obradovic D,McClements L

更新日期：2017-10-23 00:00:00

abstract：:Resistant hypertension is a common and growing clinical problem characterized by failure to achieve target blood pressure levels despite adequate use of at least three antihypertensive agents. Although numerous safe and effective pharmacologic therapies are available to treat elevated blood pressure, novel therapeutic...

journal_title：Current hypertension reports

authors： Schlaich MP,Krum H,Esler MD

更新日期：2010-08-01 00:00:00

abstract：:This paper reviews findings on the relationship between blood pressure control and the progression of renal disease. Experimental studies demonstrate a correlation between systemic blood pressure and histologic glomerular injury and the delay in progression of renal disease with antihypertensive therapy, particularly ...

journal_title：Current hypertension reports

authors： Dworkin LD,Shemin DG

更新日期：1999-10-01 00:00:00

abstract：:The post-macula densa segments of the renal tubule--that is, the distal convoluted tubule, connecting tubule, and collecting duct--play a central role in determining final urine sodium excretion. The major regulated sodium transporters and channels in these cell types include the thiazide-sensitive (Na-Cl) cotransport...

journal_title：Current hypertension reports

authors： Ecelbarger CA,Tiwari S

更新日期：2006-05-01 00:00:00

abstract：:Hypertension is very common in patients with chronic renal failure and contributes to cardiovascular morbidity and mortality. Several mechanisms may contribute to hypertension in these patients, but recently a large body of evidence supports the notion that activation of the sympathetic nervous system (SNS) may play a...

journal_title：Current hypertension reports

authors： Campese VM,Krol E

更新日期：2002-06-01 00:00:00

abstract：:The treatment of hypertension is proven to reduce cardiovascular and renal risk. Combination drug therapy is becoming recognized as a necessity in most patients with hypertension and kidney disease. Allegations about the safe use of calcium antagonists in patients with kidney disease have led to questions and confusio...

journal_title：Current hypertension reports

authors： Tobe S,Epstein M

更新日期：2002-06-01 00:00:00

abstract：:Vascular changes associated with elevated blood pressure may precede the clinical diagnosis of hypertension. Even after the diagnosis is made, associated coronary heart disease and renal disease continue to progress, despite adequate blood pressure control. Early treatment of blood pressure may reduce the incidence of...

journal_title：Current hypertension reports

authors： Nesbitt SD,Julius S

更新日期：2000-08-01 00:00:00

abstract：:Nycthemeral changes in renal function have been known for a long time, but our knowledge about the underlying mechanisms is still far from complete. From a theoretical point of view, many physiological systems could be involved in turning the kidney from a sodium-excretory organ during daytime into a sodium-conserving...

journal_title：Current hypertension reports

authors： de Leeuw PW

更新日期：2011-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide insight into the mechanisms underlying cerebral pathophysiology and to highlight possible methods for evaluation, screening, and surveillance of cerebral complications in preeclampsia. RECENT FINDINGS:The pathophysiology of eclampsia remains enigmatic. Animal studies show that the cerebral...

journal_title：Current hypertension reports

authors： Bergman L,Torres-Vergara P,Penny J,Wikström J,Nelander M,Leon J,Tolcher M,Roberts JM,Wikström AK,Escudero C

更新日期：2019-08-02 00:00:00

abstract：:The central nervous system plays a key role in the regulation of cardiovascular function, and alterations in the central neural mechanisms that control blood pressure may underlie the vast majority of cases of primary hypertension. The well-studied baroreceptor reflex powerfully regulates arterial pressure, though its...

journal_title：Current hypertension reports

authors： Sved AF,Ito S,Sved JC

更新日期：2003-06-01 00:00:00

abstract：:Hypertension is present in three of four patients with coronary artery disease (CAD) but remains largely uncontrolled in most patients. Treating hypertension in these patients is complicated by the concern of precipitating coronary ischemia when diastolic blood pressure (DBP) is reduced excessively. However, an emergi...

journal_title：Current hypertension reports

authors： Vongpatanasin W

更新日期：2008-10-01 00:00:00

abstract：:Na+,K+-ATPase distributes ions between the intracellular and extracellular space and is responsible for total-body sodium homeostasis. The activity of this ion pump is regulated by catecholamines and peptide hormones; by the ligand of Na+,K+-ATPase, ouabain; and by direct interaction with cytoskeleton proteins. This r...

journal_title：Current hypertension reports

authors： Aperia A

更新日期：2001-04-01 00:00:00

abstract：:The discovery of beneficial neuroprotective effects of the angiotensin converting enzyme 2-angiotensin-(1-7)-Mas axis [ACE2-Ang-(1-7)-Mas] in ischemic and hemorrhagic stroke has spurred interest in a more complete characterization of its mechanisms of action. Here, we summarize findings that describe the protective ro...

journal_title：Current hypertension reports

authors： Bennion DM,Haltigan E,Regenhardt RW,Steckelings UM,Sumners C

更新日期：2015-02-01 00:00:00

abstract：:The epithelial sodium channel (ENaC) is a membrane protein made of three different but homologous subunits (a, b, and g) present in the apical membrane of epithelial cells of, for example, the distal nephron. This channel is responsible for salt reabsorption in the kidney and can cause human diseases by increasing cha...

journal_title：Current hypertension reports

authors： Hummler E

更新日期：2003-02-01 00:00:00

abstract：:The inhibition of angiotensin II through angiotensin converting enzyme inhibitors or angiotensin receptor blockers has become the foundation of medical treatment of progressive chronic renal disease. Although these drugs provide a significant improvement over earlier treatments, they only slow the progression of renal...

journal_title：Current hypertension reports

authors： Gaedeke J,Noble NA,Border WA

更新日期：2002-10-01 00:00:00

abstract：:Heart failure has emerged as one of the most important diseases of the past century. The understanding and treatment of heart failure has evolved significantly over the years. As we move further into the era of device therapy, attention has turned to the idea of sympathetic nervous system modulation through renal dene...

journal_title：Current hypertension reports

authors： Fong MW,Shavelle D,Weaver FA,Nadim MK

更新日期：2015-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the most recent literature on current strategies for the treatment of hypertension associated with pediatric obesity. RECENT FINDINGS:Over the last three decades, childhood and adolescent overweight and obesity prevalence in the USA has continued to rise. Unsurprisingly but rather disturbin...

journal_title：Current hypertension reports

authors： Binka E,Brady TM

更新日期：2019-02-12 00:00:00

abstract：PURPOSE OF REVIEW:Do dietary fats lower blood pressure? This review covers total fats, individual fatty acids and foods that provide specific fats. RECENT FINDINGS:Evidence for blood pressure lowering is stronger for supplements providing individual marine fatty acids than for fish intake since data on fish consumptio...

journal_title：Current hypertension reports

authors： Nestel PJ

更新日期：2019-02-12 00:00:00

abstract：:Interpretation of some recent trials in hypertension opened a debate on the clinical value of new-onset diabetes in treated hypertensive patients. It is not completely clear whether certain antihypertensive drug classes are associated with a higher risk for developing type 2 diabetes when compared with other classes. ...

journal_title：Current hypertension reports

authors： Verdecchia P,Angeli F,Reboldi GP,Gattobigio R

更新日期：2005-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Mechanisms facilitating progression of hypertension via cross stimulation of the renin-angiotensin system (RAS) and inflammation have been proposed. Accordingly, we review and update evidence for regulation of RAS components by pro-inflammatory factors. RECENT FINDINGS:Angiotensin II (Ang II), which ...

journal_title：Current hypertension reports

authors： Satou R,Penrose H,Navar LG

更新日期：2018-10-05 00:00:00

abstract：:Atherosclerotic cardiovascular disease (CVD) is the most common cause of death worldwide. Usually atherosclerosis is caused by the combined effects of multiple risk factors. For this reason, most guidelines on the prevention of CVD stress the assessment of total CVD risk. The most intensive risk factor modification ca...

journal_title：Current hypertension reports

authors： Cooney MT,Cooney HC,Dudina A,Graham IM

更新日期：2010-10-01 00:00:00

abstract：:Essential hypertension is a very common health condition that is associated with an array of long-term end-organ diseases, including premature cardiovascular disease. Currently, there is no effective method to identify high-risk patients who may develop cardiovascular comorbidities in the future. Clinically, it would ...

journal_title：Current hypertension reports

authors： Xue Y,Iqbal N,Chan J,Maisel A

更新日期：2014-12-01 00:00:00

abstract：:Diastolic pressure, systolic pressure, and pulse pressure have all been assigned the role of the best predictor of cardiovascular events during the 20th century. At the dawn of the new millennium, concepts that draw attention to vascular mechanics reconcile the seemingly conflicting results of epidemiologic studies, b...

journal_title：Current hypertension reports

authors： Vlachopoulos C,O'Rourke M

更新日期：2000-06-01 00:00:00

abstract：:It is widely accepted that the pathophysiology of hypertension involves autonomic nervous system dysfunction, as well as a multitude of immune responses. However, the close interplay of these systems in the development and establishment of high blood pressure and its associated pathophysiology remains elusive and is t...

journal_title：Current hypertension reports

authors： Santisteban MM,Zubcevic J,Baekey DM,Raizada MK

更新日期：2013-08-01 00:00:00

abstract：:Primary aldosteronism is commonly regarded as largely sporadic, but both germline and somatic mutations are increasingly recognized as underlying the condition. Three germline mutations causing familial hyperaldosteronism have been described, dubbed FH I (due to a CYP11B1/CYP11B2 chimera), FH II (localized to chromoso...

journal_title：Current hypertension reports

authors： Funder JW

更新日期：2012-04-01 00:00:00

abstract：:There is increasing concern that sugar consumption may be linked to the development of metabolic and cardiovascular diseases. There is indeed strong evidence that consumption of energy-dense sugary beverages and foods is associated with increased energy intake and body weight gain over time. It is further proposed tha...

journal_title：Current hypertension reports

authors： Rosset R,Surowska A,Tappy L

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the current literature on use of telehealth at different stages of the hypertension control cascade in sub-Saharan Africa (SSA) and to discuss opportunities to harness technology infrastructure in SSA to improve population-level blood pressure control. RECENT FINDINGS:Despite the high burde...

journal_title：Current hypertension reports

authors： Muiruri C,Manavalan P,Jazowski SA,Knettel BA,Vilme H,Zullig LL

更新日期：2019-08-26 00:00:00

abstract：:The research on molecular genetics of human hypertension aims to identify the loci involved in the regulation of blood pressure, detect gene variants within the identified loci, associate them with intermediate phenotypes, and ultimately estimate their quantitative effects on blood pressure level and their interaction...

journal_title：Current hypertension reports

authors： Jeunemaitre X,Gimenez-Roqueplo AP,Célérier J,Corvol P

更新日期：1999-02-01 00:00:00