Abstract：
:Interpretation of some recent trials in hypertension opened a debate on the clinical value of new-onset diabetes in treated hypertensive patients. It is not completely clear whether certain antihypertensive drug classes are associated with a higher risk for developing type 2 diabetes when compared with other classes. Some longitudinal studies suggest that new-onset diabetes in treated hypertensive subjects carries a risk for subsequent cardiovascular disease similar to that of previously known diabetes. In a study, plasma glucose before treatment and diuretic treatment were independent predictors of new-onset diabetes in hypertensive patients, independent of confounding factors. We estimated that one cardiovascular event associated with new-onset diabetes might be prevented for every 385 to 449 patients treated with "new," rather than "old," antihypertensive drugs for approximately 4 years. These observations suggest that concern about the risk for new-onset diabetes should prompt a more judicious use of diuretics and beta-blockers in the treatment of hypertension. These drugs should be given cautiously in subjects who are at increased risk for new-onset diabetes, owing to impaired fasting glucose or obesity. The lowest effective dose should be used, and plasma glucose should be carefully monitored.
journal_name
Curr Hypertens Repjournal_title
Current hypertension reportsauthors
Verdecchia P,Angeli F,Reboldi GP,Gattobigio Rdoi
10.1007/s11906-005-0006-3keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
174-9issue
3eissn
1522-6417issn
1534-3111journal_volume
7pub_type
杂志文章,评审abstract：:The epidemiology of pulmonary arterial hypertension (PAH) has changed over the last decade. Remarkable advances in understanding the pathobiology and clinical care required in PAH have resulted in improved quality of life and survival. Despite such important progress, the long-term rate of survival is still unacceptab...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-013-0397-5
更新日期：2013-12-01 00:00:00
abstract：:The central nervous system plays a key role in the regulation of cardiovascular function, and alterations in the central neural mechanisms that control blood pressure may underlie the vast majority of cases of primary hypertension. The well-studied baroreceptor reflex powerfully regulates arterial pressure, though its...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-003-0030-0
更新日期：2003-06-01 00:00:00
abstract：:Heart failure has emerged as one of the most important diseases of the past century. The understanding and treatment of heart failure has evolved significantly over the years. As we move further into the era of device therapy, attention has turned to the idea of sympathetic nervous system modulation through renal dene...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0528-7
更新日期：2015-03-01 00:00:00
abstract：:Hypertension is an established risk factor for stroke, premature coronary artery disease and heart failure. Control of elevated blood pressure has been shown to result in significant reduction of cardiovascular risk. Aldosterone, the final product of the renin-angiotensin-aldosterone system (RAAS), not only causes sal...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-013-0379-7
更新日期：2013-10-01 00:00:00
abstract：:The World Health Organization's annual report World Health Statistics 2012 was recently published. In addition to annually published indicators of health, this year's report contains a highlighted new section on non-communicable diseases and their impact on world health. The section gives particular attention to hyper...
journal_title：Current hypertension reports
pub_type： 杂志文章
doi：10.1007/s11906-012-0303-6
更新日期：2012-12-01 00:00:00
abstract：:With the cut-off point between "normal" and "high" blood pressure (BP) being pushed increasingly downward, especially for patients with multiple cardiovascular risk factors, most hypertensives need more than one antihypertensive agent to reach their target BP. In this article, we examine the rationale for combining dr...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-004-0020-x
更新日期：2004-08-01 00:00:00
abstract：:Diabetes and hypertension are common coexistent conditions, the combination of which results in an increased risk for cardiovascular and renal disease. Clinical trials have convincingly demonstrated the benefit of tight blood pressure control among patients with diabetes in reducing these risks. Furthermore, the choic...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-005-0039-7
更新日期：2005-12-01 00:00:00
abstract：:Dual blockade of the renin angiotensin system is based on a principle of obtaining the broadest and most efficient blockade of the effects of angiotensin II, by using the combination of an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin II-receptor blocker (ARB). By combining two, different pharmacolo...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-004-0056-y
更新日期：2004-10-01 00:00:00
abstract：:Masked hypertension refers to the phenomenon of having a non-elevated clinic blood pressure (BP) despite having an elevated out-of-clinic BP. Masked hypertension is a common phenotype with a cardiovascular risk profile similar to that of sustained hypertension, defined as elevated clinic and out-of-clinic BP. Current ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-017-0792-4
更新日期：2017-10-25 00:00:00
abstract：:Essential hypertension is a very common health condition that is associated with an array of long-term end-organ diseases, including premature cardiovascular disease. Currently, there is no effective method to identify high-risk patients who may develop cardiovascular comorbidities in the future. Clinically, it would ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0502-4
更新日期：2014-12-01 00:00:00
abstract：:Diagnosis of resistant hypertension (RH) is currently based upon awake-time office blood pressure (BP). An increasing number of studies have documented abnormally elevated sleep-time BP in most RH patients, indicating that diagnosis of true RH cannot be determined solely by comparison of office BP with either patient ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0445-9
更新日期：2014-07-01 00:00:00
abstract：PURPOSE OF REVIEW:To review the current literature on use of telehealth at different stages of the hypertension control cascade in sub-Saharan Africa (SSA) and to discuss opportunities to harness technology infrastructure in SSA to improve population-level blood pressure control. RECENT FINDINGS:Despite the high burde...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-019-0983-2
更新日期：2019-08-26 00:00:00
abstract：:Young hypertensive adults demonstrate decreased performance on neurocognitive testing compared with that of normotensive controls. There is emerging, preliminary evidence that children with hypertension also manifest cognitive differences when compared to normotensive controls. These preliminary studies consist mostly...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0508-y
更新日期：2015-01-01 00:00:00
abstract：:The underlying pathophysiologic concept of diverse invasive devices to treat resistant hypertension (e.g., sympathetic denervation, carotid sinus nerve stimulation) is known for a long time. Since the pioneering work in the 1940s in humans, innovative techniques have been developed resulting in less invasive treatment...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0488-y
更新日期：2014-11-01 00:00:00
abstract：PURPOSE OF REVIEW:The major health issue of being overweight or obese relates to the development of hypertension, insulin resistance and diabetic complications. One of the major underlying factors influencing the elevated blood pressure in obesity is increased activity of the sympathetic nerves to particular organs suc...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-017-0750-1
更新日期：2017-07-01 00:00:00
abstract：:Endothelin receptor antagonists (ERAs) have the potential to be a new paradigm in the treatment of chronic kidney disease (CKD). ERAs inhibit the effects of endothelin-1 (ET-1), which is known to promote CKD by causing renal cellular injury, proteinuria, inflammation, fibrosis, and hypertrophy. ERAs have been extensiv...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-015-0568-7
更新日期：2015-07-01 00:00:00
abstract：PURPOSE OF REVIEW:The renin-angiotensin system (RAS) plays an important role in modulating cardiovascular function and fluid homeostasis. While the systemic actions of the RAS are widely accepted, the role of the RAS in the brain, its regulation of cardiovascular function, and sympathetic outflow remain controversial. ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-018-0810-1
更新日期：2018-02-26 00:00:00
abstract：:Diabetic nephropathy and hypertension are the major causes of chronic kidney disease. The renin system plays a key role in the control of blood pressure (BP), as well as in the regulation of renal and adrenal function. Chronic activation of the renin system can lead to organ damage, particularly renal damage; increasi...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-007-0076-5
更新日期：2007-11-01 00:00:00
abstract：:Although it is clear that hypertension is a primary cause of stroke, there has been controversy concerning blood pressure management after stroke. Recent studies indicate that lowering systemic blood pressure after stroke reduces the risk for recurrent stroke or vascular events, but other studies provide evidence that...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-005-0058-4
更新日期：2005-02-01 00:00:00
abstract：:Hypertension and obesity are two closely related pathologies in clinical practice. Currently, about one billion adults worldwide are overweight, and it is estimated that, if no serious action is taken to effect profound change, that figure will continue to rise throughout this century. Hypertension is also a serious p...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0438-8
更新日期：2014-07-01 00:00:00
abstract：:Hypertension is very common in patients with chronic renal failure and contributes to cardiovascular morbidity and mortality. Several mechanisms may contribute to hypertension in these patients, but recently a large body of evidence supports the notion that activation of the sympathetic nervous system (SNS) may play a...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-002-0016-3
更新日期：2002-06-01 00:00:00
abstract：PURPOSE OF REVIEW:To evaluate recent developments in the management of hypertension in obese pregnant women. RECENT FINDINGS:The mainstay of management targets prevention of hypertension with preconception counselling, entering pregnancy with a lower BMI, limiting weight gain, and taking low-dose aspirin to prevent pr...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-019-0927-x
更新日期：2019-03-26 00:00:00
abstract：:The nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling system is a well-characterized modulator of cardiovascular function, in general, and blood pressure, in particular. The availability of mice mutant for key enzymes in the NO-cGMP signaling system facilitated the identification of interactions with o...
journal_title：Current hypertension reports
pub_type： 杂志文章
doi：10.1007/s11906-012-0320-5
更新日期：2013-02-01 00:00:00
abstract：:This paper critically addresses the issue of the "J-curve" paradox--the finding described in studies performed about 30 years ago indicating that treatment-induced systolic blood pressure values below 120 or 125 mm Hg and diastolic blood pressure values below 75 mm Hg are characterized by an increase, rather than a re...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-010-0121-7
更新日期：2010-08-01 00:00:00
abstract：:Resistant hypertension is defined as blood pressure that remains uncontrolled despite using at least three antihypertensive medications in effective doses, ideally including a diuretic. Stricter blood pressure goals, higher obesity rates, older age, and increased use of certain exogenous substances are related to an i...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-007-0066-7
更新日期：2007-11-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this meta-analysis is to compare the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on blood pressure of hypertensive individuals. RECENT FINDINGS:Continuous aerobic training programs are successful in health promotion and are effec...
journal_title：Current hypertension reports
pub_type： 杂志文章,meta分析
doi：10.1007/s11906-020-1030-z
更新日期：2020-03-03 00:00:00
abstract：:The inhibition of angiotensin II through angiotensin converting enzyme inhibitors or angiotensin receptor blockers has become the foundation of medical treatment of progressive chronic renal disease. Although these drugs provide a significant improvement over earlier treatments, they only slow the progression of renal...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-002-0071-9
更新日期：2002-10-01 00:00:00
abstract：:The discovery of beneficial neuroprotective effects of the angiotensin converting enzyme 2-angiotensin-(1-7)-Mas axis [ACE2-Ang-(1-7)-Mas] in ischemic and hemorrhagic stroke has spurred interest in a more complete characterization of its mechanisms of action. Here, we summarize findings that describe the protective ro...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0512-2
更新日期：2015-02-01 00:00:00
abstract：:The incidence and prevalence of obesity and the metabolic syndrome have risen markedly in the past decade, representing a serious cardiovascular health hazard with significant morbidity and mortality. The etiology of the metabolic syndrome and its various pathogenic mechanisms are incompletely defined and under intens...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-008-0025-y
更新日期：2008-04-01 00:00:00
abstract：:The adverse cardiovascular consequences of high blood pressure (BP) not only depend on absolute BP values, but also on BP variability (BPV). Evidence has been provided that independently of mean BP levels, BP variations in the short- and long-term are associated with the development, progression and severity of cardia...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-012-0290-7
更新日期：2012-10-01 00:00:00
