Investigating Maternal Brain Alterations in Preeclampsia: the Need for a Multidisciplinary Effort.

abstract：:Epinephrine is the prototypical stress hormone. Its stimulation of all α and β adrenergic receptors elicits short-term systolic hypertension, hyperglycemia, and other aspects of the metabolic syndrome. Acute epinephrine infusion increases cardiac output and induces insulin resistance, but removal of the adrenal medull...

journal_title：Current hypertension reports

authors： Ziegler MG,Elayan H,Milic M,Sun P,Gharaibeh M

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The intrarenal renin-angiotensin-aldosterone system (RAS) is an independent paracrine hormonal system with an increasingly prominent role in hypertension and renal disease. Two enzyme components of this system are angiotensin-converting enzyme (ACE) and more recently discovered ACE2. The purpose of th...

journal_title：Current hypertension reports

authors： Culver S,Li C,Siragy HM

更新日期：2017-09-19 00:00:00

abstract：PURPOSE OF REVIEW:The aim of the study is to perform a critical assessment of in vitro models of pre-eclampsia using complementary human and cell line-based studies. Molecular mechanisms involved in spiral uterine artery (SUA) remodelling and trophoblast functionality will also be discussed. RECENT FINDINGS:A number o...

journal_title：Current hypertension reports

authors： McNally R,Alqudah A,Obradovic D,McClements L

更新日期：2017-10-23 00:00:00

abstract：:Hypertension is an important public health problem, and increasingly children are being diagnosed with primary hypertension. As the list of secondary causes of hypertension is extensive, pediatric practitioners increasingly need to decide on investigations needed for evaluating children presenting with high blood pres...

journal_title：Current hypertension reports

authors： Kapur G,Baracco R

更新日期：2013-10-01 00:00:00

abstract：:The epidemiology of pulmonary arterial hypertension (PAH) has changed over the last decade. Remarkable advances in understanding the pathobiology and clinical care required in PAH have resulted in improved quality of life and survival. Despite such important progress, the long-term rate of survival is still unacceptab...

journal_title：Current hypertension reports

authors： Jiang X,Jing ZC

更新日期：2013-12-01 00:00:00

abstract：:To further understand chronic heart disease, such as heart failure and cardiomyopathy, we must fully define signaling pathways within the myocardium. Recent studies suggest that some forms of heart disease are associated with a chronic low-grade inflammation that promotes adverse ventricular remodeling and correlates ...

journal_title：Current hypertension reports

authors： Ahn J,Kim J

更新日期：2012-12-01 00:00:00

abstract：:Diabetes and hypertension are common coexistent conditions, the combination of which results in an increased risk for cardiovascular and renal disease. Clinical trials have convincingly demonstrated the benefit of tight blood pressure control among patients with diabetes in reducing these risks. Furthermore, the choic...

journal_title：Current hypertension reports

authors： Borzecki AM,Berlowitz DR

更新日期：2005-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Renal sympathetic denervation (RDN) as treatment option for hypertension has a strong rationale; however, variable effects on blood pressure (BP) have been reported ranging from non-response to marked reductions in BP. The absence of a procedural end point for RDN is one of the potential factors assoc...

journal_title：Current hypertension reports

authors： Hoogerwaard AF,de Jong MR,Elvan A

更新日期：2018-03-19 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate recent developments in the management of hypertension in obese pregnant women. RECENT FINDINGS:The mainstay of management targets prevention of hypertension with preconception counselling, entering pregnancy with a lower BMI, limiting weight gain, and taking low-dose aspirin to prevent pr...

journal_title：Current hypertension reports

authors： Coroyannakis C,Khalil A

更新日期：2019-03-26 00:00:00

abstract：:Diabetes mellitus is well recognized as a potent and prevalent risk factor for accelerated atherosclerosis and ischemic heart disease. However, there is also evidence of cardiac dysfunction in diabetes in the absence of coronary atherosclerosis, termed diabetic cardiomyopathy. Changes in ventricular structure and left...

journal_title：Current hypertension reports

authors： Karnik AA,Fields AV,Shannon RP

更新日期：2007-12-01 00:00:00

abstract：:Lipodystrophy (LD) associated with HIV infection is a syndrome of abnormal fat distribution observed in HIV-infected patients treated with various antiretroviral agents. In addition, insulin resistance and dyslipidemia can occur in HIV-infected patients with or without LD. The demonstration of the latter metabolic dis...

journal_title：Current hypertension reports

authors： Mikhail N

更新日期：2003-04-01 00:00:00

abstract：:The renin-angiotensin system (RAS) plays an important role in the initiation and progression of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. In the past t...

journal_title：Current hypertension reports

authors： Namsolleck P,Recarti C,Foulquier S,Steckelings UM,Unger T

更新日期：2014-02-01 00:00:00

abstract：:Hypertension (especially systolic hypertension) is very common in older persons. Systolic hypertension occurs because large conduit arteries become stiffer with age. Strong evidence from randomized trials suggests that treating systolic blood pressures initially higher than 160 mm Hg is extremely beneficial, and a rec...

journal_title：Current hypertension reports

authors： Hyman DJ,Taffet GE

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review is intended to briefly describe the primary mechanistic pathways by which several common drugs can increase blood pressure. We also propose potential management strategies based on the underlying mechanisms responsible for the blood pressure elevation. RECENT FINDINGS:As hypertension is a...

journal_title：Current hypertension reports

authors： Lovell AR,Ernst ME

更新日期：2017-05-01 00:00:00

abstract：:Endothelin receptor antagonists (ERAs) have the potential to be a new paradigm in the treatment of chronic kidney disease (CKD). ERAs inhibit the effects of endothelin-1 (ET-1), which is known to promote CKD by causing renal cellular injury, proteinuria, inflammation, fibrosis, and hypertrophy. ERAs have been extensiv...

journal_title：Current hypertension reports

authors： Tobe S,Kohan DE,Singarayer R

更新日期：2015-07-01 00:00:00

abstract：:The discovery of beneficial neuroprotective effects of the angiotensin converting enzyme 2-angiotensin-(1-7)-Mas axis [ACE2-Ang-(1-7)-Mas] in ischemic and hemorrhagic stroke has spurred interest in a more complete characterization of its mechanisms of action. Here, we summarize findings that describe the protective ro...

journal_title：Current hypertension reports

authors： Bennion DM,Haltigan E,Regenhardt RW,Steckelings UM,Sumners C

更新日期：2015-02-01 00:00:00

abstract：:Essential hypertension is associated with impaired endothelium-dependent vasodilation and is caused mainly by production of oxygen free radicals that can destroy nitric oxide (NO), impairing its beneficial and protective effects on the vessel wall. Antihypertensive drugs can improve or restore endothelium-dependent va...

journal_title：Current hypertension reports

authors： Taddei S,Virdis A,Ghiadoni L,Sudano I,Salvetti A

更新日期：2000-02-01 00:00:00

abstract：PURPOSE OF THE REVIEW:The purpose of this review is to highlight the clinical significance of increased renal risk that has its origins in fetal life. This review will also discuss the critical need to identify therapeutic interventions for use in a pregnancy complicated by placental dysfunction and intrauterine growth...

journal_title：Current hypertension reports

authors： Coats LE,Davis GK,Newsome AD,Ojeda NB,Alexander BT

更新日期：2019-06-21 00:00:00

abstract：:Hypertension is the leading risk factor for the global burden of disease, yet more than 20% of adults with hypertension are unaware of their condition. Underlying hypertension affects over 25% emergency department attendees, and the condition is more commonly encountered in emergency departments than in primary care s...

journal_title：Current hypertension reports

authors： Chan SS,Graham CA,Rainer TH

更新日期：2016-04-01 00:00:00

abstract：:Essential hypertension is characterized by endothelial dysfunction due to reduced availability of nitric oxide (NO) secondary to increased generation of oxygen-free radicals. Some antihypertensive drugs may improve or restore endothelial function independently of their blood pressure lowering effect. The newer generat...

journal_title：Current hypertension reports

authors： Virdis A,Ghiadoni L,Taddei S

更新日期：2011-08-01 00:00:00

abstract：:Insulin resistance (IR) is present in pathologies such as diabetes, obesity, metabolic syndrome, impaired glucose tolerance, hypertension, inflammation, cardiac disease, and dyslipidemias. Population studies show that IR is multifactorial and has genetic components, such as defects in the insulin-signaling pathway (as...

journal_title：Current hypertension reports

authors： Molina MN,Ferder L,Manucha W

更新日期：2016-01-01 00:00:00

abstract：:The inhibition of angiotensin II through angiotensin converting enzyme inhibitors or angiotensin receptor blockers has become the foundation of medical treatment of progressive chronic renal disease. Although these drugs provide a significant improvement over earlier treatments, they only slow the progression of renal...

journal_title：Current hypertension reports

authors： Gaedeke J,Noble NA,Border WA

更新日期：2002-10-01 00:00:00

abstract：PURPOSE OF REVIEW:We focus on the current understanding of preeclampsia (PE) in order to examine how it mediates glomerular injury and affects the course of glomerulonephritis (GNs). In addition, this review discusses the role of GNs on the development of PE. RECENT FINDINGS:In PE, the dysfunctional utero-placental pe...

journal_title：Current hypertension reports

authors： Di Leo V,Capaccio F,Gesualdo L

更新日期：2020-03-21 00:00:00

abstract：:Dual blockade of the renin angiotensin system is based on a principle of obtaining the broadest and most efficient blockade of the effects of angiotensin II, by using the combination of an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin II-receptor blocker (ARB). By combining two, different pharmacolo...

journal_title：Current hypertension reports

authors： Andersen NH,Mogensen CE

更新日期：2004-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The pathophysiology of preeclampsia is complex and not entirely understood. A key feature in preeclampsia development is an immunological imbalance that shifts the maternal immune response from one of tolerance towards one promoting chronic inflammation and endothelial dysfunction. As a key regulator ...

journal_title：Current hypertension reports

authors： Cubro H,Kashyap S,Nath MC,Ackerman AW,Garovic VD

更新日期：2018-04-30 00:00:00

abstract：:The presence of renin production by the principal cells of the collecting duct has opened new perspectives for the regulation of intrarenal angiotensin II (Ang II). Angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) are present in the tubular fluid coming from the proximal tubule and collecting duct. All th...

journal_title：Current hypertension reports

authors： Gonzalez AA,Lara LS,Prieto MC

更新日期：2017-08-01 00:00:00

abstract：:The fact that cardiovascular risk factors cluster among individuals with the insulin resistance syndrome strongly suggests a common pathogenetic denominator. For many years, abnormalities of nonesterified fatty acid metabolism have been implicated in the disturbances of carbohydrate and lipid metabolism that character...

journal_title：Current hypertension reports

authors： Egan BM,Greene EL,Goodfriend TL

更新日期：2001-04-01 00:00:00

abstract：:This review attempts to highlight the potential of calcium-channel blockers in the prevention of sequelae of diabetes mellitus and hypertension in patients who have both disorders. Evidence-based medicine is driven by the results of randomized, clinical trials. Major contributions were therefore derived from post hoc ...

journal_title：Current hypertension reports

authors： Birkenhäger WH,Staessen JA

更新日期：1999-06-01 00:00:00

abstract：:The adverse cardiovascular consequences of high blood pressure (BP) not only depend on absolute BP values, but also on BP variability (BPV). Evidence has been provided that independently of mean BP levels, BP variations in the short- and long-term are associated with the development, progression and severity of cardia...

journal_title：Current hypertension reports

authors： Parati G,Ochoa JE,Bilo G

更新日期：2012-10-01 00:00:00

abstract：:Oxidative stress is known to be implicated in the pathogenesis of essential hypertension. Glutathione-S-transferase (GST) enzymes are key components of cellular defense against oxidative stress. The present study aimed to clarify the association between polymorphisms in GST and risk of essential hypertension using a m...

journal_title：Current hypertension reports

authors： Eslami S,Sahebkar A

更新日期：2014-06-01 00:00:00