Pathogenesis of Cardiovascular and Metabolic Diseases: Are Fructose-Containing Sugars More Involved Than Other Dietary Calories?

abstract：PURPOSE OF REVIEW:Hypertension remains to be a major contributor to global morbidity and mortality. Despite a plethora of pharmacological options available, an abundance of patients have uncontrolled blood pressure thus creating the need for additional strategies, including non-pharmacologic approaches. In this review,...

journal_title：Current hypertension reports

authors： Cernes R,Zimlichman R

更新日期：2017-06-01 00:00:00

abstract：:Blood pressure is typically lower in premenopausal women than in men. However, after menopause, the prevalence of hypertension in women is higher than it is in men. Hypertension is a major risk factor for cardiovascular disease in women and men, but cardiovascular disease is the leading cause of death in women. Furthe...

journal_title：Current hypertension reports

authors： Lima R,Wofford M,Reckelhoff JF

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To review data supporting the use of home blood pressure monitoring (HBPM) and provide practical guidance to clinicians wishing to incorporate HBPM into their practice. RECENT FINDINGS:HBPM more accurately reflects the risk of cardiovascular events than office blood pressure measurement. In addition,...

journal_title：Current hypertension reports

authors： Liyanage-Don N,Fung D,Phillips E,Kronish IM

更新日期：2019-02-12 00:00:00

abstract：:High-quality medical care requires implementing evidence-based best practices, with continued monitoring to improve performance. Implementation science is beginning to identify approaches to developing, implementing, and evaluating quality improvement strategies across health care systems that lead to good outcomes fo...

journal_title：Current hypertension reports

authors： Goldstein MK

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This article introduces the haemodynamic principles that underpin the pathophysiology of hypertension and introduces a rational physiological approach to appropriate pharmacologic treatment. RECENT FINDINGS:Outdated understanding of haemodynamics based on previous measurement systems can no longer be...

journal_title：Current hypertension reports

authors： Smith BE,Madigan VM

更新日期：2018-04-10 00:00:00

abstract：:High blood pressure in the setting of type 1 and type 2 diabetes is commonly associated with the earlier development of target-organ damage, including cardiovascular and cerebrovascular disease and progressive renal insufficiency. The major goal of treating high blood pressure in this population is to prevent or reduc...

journal_title：Current hypertension reports

authors： Lu WX,Lakkis J,Weir MR

更新日期：2003-06-01 00:00:00

abstract：:The incidence and prevalence of obesity and the metabolic syndrome have risen markedly in the past decade, representing a serious cardiovascular health hazard with significant morbidity and mortality. The etiology of the metabolic syndrome and its various pathogenic mechanisms are incompletely defined and under intens...

journal_title：Current hypertension reports

authors： Patel SB,Reams GP,Spear RM,Freeman RH,Villarreal D

更新日期：2008-04-01 00:00:00

abstract：:Diabetes and hypertension are common coexistent conditions, the combination of which results in an increased risk for cardiovascular and renal disease. Clinical trials have convincingly demonstrated the benefit of tight blood pressure control among patients with diabetes in reducing these risks. Furthermore, the choic...

journal_title：Current hypertension reports

authors： Borzecki AM,Berlowitz DR

更新日期：2005-12-01 00:00:00

abstract：:The sodium pump, an ancestral enzyme with conserved ability to bind ouabain, plays a key role in salt conservation and is regulated by aldosterone and endogenous ouabain (EO). Plasma EO is elevated in about 45% of patients with essential hypertension and correlates with blood pressure. The relationship of EO with Na(+...

journal_title：Current hypertension reports

authors： Hamlyn JM,Manunta P

更新日期：2011-02-01 00:00:00

abstract：:Heart failure has emerged as one of the most important diseases of the past century. The understanding and treatment of heart failure has evolved significantly over the years. As we move further into the era of device therapy, attention has turned to the idea of sympathetic nervous system modulation through renal dene...

journal_title：Current hypertension reports

authors： Fong MW,Shavelle D,Weaver FA,Nadim MK

更新日期：2015-03-01 00:00:00

abstract：:The underlying pathophysiologic concept of diverse invasive devices to treat resistant hypertension (e.g., sympathetic denervation, carotid sinus nerve stimulation) is known for a long time. Since the pioneering work in the 1940s in humans, innovative techniques have been developed resulting in less invasive treatment...

journal_title：Current hypertension reports

authors： Ott C,Schmieder RE

更新日期：2014-11-01 00:00:00

abstract：:How chlorthalidone (CTDN) reduces risk for cardiovascular events (CVEs) can be considered in light of its ability to lower blood pressure (BP) and its non-BP related, pleiotropic effects. The mechanism by which CTDN lowers BP is unclear but may include alterations in whole body regulation and vasodilatory actions on v...

journal_title：Current hypertension reports

authors： Roush GC,Buddharaju V,Ernst ME,Holford TR

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To review latest reports of the food products which might increase blood pressure and therefore might participate in the pathogenesis of hypertension. RECENT FINDINGS:Results of clinical study suggest that consumption of high-sodium food leads to transient increase in plasma sodium concentration. Thi...

journal_title：Current hypertension reports

authors： Adamczak M,Wiecek A

更新日期：2020-01-08 00:00:00

abstract：:Inflammation plays an important role in the pathogenesis of hypertension. Innate and adaptive immune response may contribute to this process. The mechanisms implicating immune response in hypertension are still elusive. To date, the evidence originates in three major areas of data: cytokine production, central nervous...

journal_title：Current hypertension reports

authors： Leibowitz A,Schiffrin EL

更新日期：2011-12-01 00:00:00

abstract：:With current immunosuppression, elevated blood pressure is found in almost 90% of renal graft recipients. Major causes of this are impairment of renal function (secondary to chronic allograft nephropathy or less frequently recurrence of primary renal disease), the use of calcineurin inhibitors as immunosuppressants, u...

journal_title：Current hypertension reports

authors： Schwenger V,Zeier M,Ritz E

更新日期：2001-10-01 00:00:00

abstract：:When a large multicenter research trial is abruptly terminated, it is usually a consequence of significant adverse events. In contrast, when the Randomized Aldactone Evaluation Study (RALES) mortality trial was discontinued 18 months early, it was because of the prominent salutary effect of spironolactone, added to st...

journal_title：Current hypertension reports

authors： Soberman JE,Weber KT

更新日期：2000-10-01 00:00:00

abstract：:Excess weight gain is a major cause of essential hypertension, and abnormal kidney function appears to be a cause as well as a consequence of obesity hypertension. Excess renal sodium reabsorption and a hypertensive shift of pressure natriuresis play a major role in mediating increased blood pressure associated with w...

journal_title：Current hypertension reports

authors： Hall JE

更新日期：2000-04-01 00:00:00

abstract：:Obesity is recognized as a major health problem throughout the world. Excess weight is a major cause of increased blood pressure in most patients with essential hypertension and greatly increases the risk for diabetes, cardiovascular diseases, and end-stage renal disease. Although the mechanisms by which obesity raise...

journal_title：Current hypertension reports

authors： da Silva AA,do Carmo J,Dubinion J,Hall JE

更新日期：2009-06-01 00:00:00

abstract：:The fact that cardiovascular risk factors cluster among individuals with the insulin resistance syndrome strongly suggests a common pathogenetic denominator. For many years, abnormalities of nonesterified fatty acid metabolism have been implicated in the disturbances of carbohydrate and lipid metabolism that character...

journal_title：Current hypertension reports

authors： Egan BM,Greene EL,Goodfriend TL

更新日期：2001-04-01 00:00:00

abstract：:Nitric oxide is involved in the regulation of resting vascular tone, adaptation of blood flow to metabolic demand of tissue, and adaptation of vessel diameter to volume of inflow, ie, flow-mediated dilation. Arterial hypertension is associated with an increased vascular tone of resistance vessels, a reduced compliance...

journal_title：Current hypertension reports

authors： Kelm M

更新日期：2003-02-01 00:00:00

abstract：:The concept of "perioperative hypertensive emergency" must be defined differently from that of ambulatory hypertensive emergency in view of its unique clinical considerations in an atypical setting. It should be noted that moderately high normal blood pressure (BP) values in the perioperative setting often trigger sit...

journal_title：Current hypertension reports

authors： Aronson S

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this meta-analysis is to compare the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on blood pressure of hypertensive individuals. RECENT FINDINGS:Continuous aerobic training programs are successful in health promotion and are effec...

journal_title：Current hypertension reports

authors： Leal JM,Galliano LM,Del Vecchio FB

更新日期：2020-03-03 00:00:00

abstract：:We are used to thinking of angiotensin (Ang) II as a regulatory hormone that stimulates constriction of vascular smooth muscle cells, aldosterone release from the adrenal gland, and sodium reabsorption in the renal tubule. We have also become accustomed to understanding that Ang II may be formed and may act locally as...

journal_title：Current hypertension reports

authors： Luft FC

更新日期：2001-02-01 00:00:00

abstract：:Hypertension contributes greatly to global disease burden and in many patients current treatments do not adequately control blood pressure (BP). Endothelin-1 (ET-1) is a potent vasoconstrictor that is implicated in the pathogenesis of hypertension, including the hypertension that is often associated with chronic kidne...

journal_title：Current hypertension reports

authors： Moorhouse RC,Webb DJ,Kluth DC,Dhaun N

更新日期：2013-10-01 00:00:00

abstract：:Salt-sensitive hypertension is closely related with natriuretic capacity of the kidney. Besides several genome-wide research reported candidate gene or gene polymorphism responsible for salt-sensitive hypertension, recently, several new factors for acquired salt-sensitive hypertension are reported. Among them, we have...

journal_title：Current hypertension reports

authors： Shimosawa T,Mu S,Shibata S,Fujita T

更新日期：2012-10-01 00:00:00

abstract：:Primary aldosteronism (PA) is a common cause of arterial hypertension: in the PA Prevalence in Hypertensives (PAPY) Study, the prevalence of PA was 11.2% in consecutive referred hypertensive patients. When adrenal vein sampling (AVS) is available, two thirds of the cases can be attributed to a tumor and one third of c...

journal_title：Current hypertension reports

authors： Rossi GP

更新日期：2010-10-01 00:00:00

abstract：:The discovery of beneficial neuroprotective effects of the angiotensin converting enzyme 2-angiotensin-(1-7)-Mas axis [ACE2-Ang-(1-7)-Mas] in ischemic and hemorrhagic stroke has spurred interest in a more complete characterization of its mechanisms of action. Here, we summarize findings that describe the protective ro...

journal_title：Current hypertension reports

authors： Bennion DM,Haltigan E,Regenhardt RW,Steckelings UM,Sumners C

更新日期：2015-02-01 00:00:00

abstract：:Diabetes mellitus is one of the leading causes of end-stage renal disease. The pathogenesis of diabetic nephropathy is still poorly understood, but glomerular injury has been ascribed, at least in part, to glomerular hyperfiltration, which occurs early in the course of diabetes mellitus. Therefore, a better understand...

journal_title：Current hypertension reports

authors： Vallon V,Blantz R,Thomson S

更新日期：2005-04-01 00:00:00

abstract：:The research on molecular genetics of human hypertension aims to identify the loci involved in the regulation of blood pressure, detect gene variants within the identified loci, associate them with intermediate phenotypes, and ultimately estimate their quantitative effects on blood pressure level and their interaction...

journal_title：Current hypertension reports

authors： Jeunemaitre X,Gimenez-Roqueplo AP,Célérier J,Corvol P

更新日期：1999-02-01 00:00:00

abstract：PURPOSE OF REVIEW:There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer's disease; however, associations between antihypertensive medications (AHMs) and dementia risk are less consistent. An increased interest in AHM has resulted in ex...

journal_title：Current hypertension reports

authors： Yasar S,Schuchman M,Peters J,Anstey KJ,Carlson MC,Peters R

更新日期：2016-08-01 00:00:00