Abstract：
:Obesity is recognized as a major health problem throughout the world. Excess weight is a major cause of increased blood pressure in most patients with essential hypertension and greatly increases the risk for diabetes, cardiovascular diseases, and end-stage renal disease. Although the mechanisms by which obesity raises blood pressure are not completely understood, increased renal sodium reabsorption, impaired pressure natriuresis, and volume expansion appear to play important roles. Several potential mechanisms have been suggested to contribute to altered kidney function and hypertension in obesity, including activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system, as well as physical compression of the kidneys, especially when visceral obesity is present. Activation of the sympathetic nervous system in obesity may be due, in part, to hyperleptinemia and other factors secreted by adipocytes and the gastrointestinal tract, activation of the central nervous system melanocortin pathway, and baroreceptor dysfunction.
journal_name
Curr Hypertens Repjournal_title
Current hypertension reportsauthors
da Silva AA,do Carmo J,Dubinion J,Hall JEdoi
10.1007/s11906-009-0036-3subject
Has Abstractpub_date
2009-06-01 00:00:00pages
206-11issue
3eissn
1522-6417issn
1534-3111journal_volume
11pub_type
杂志文章,评审abstract：PURPOSE OF THE REVIEW:In our innate immune system, neutrophils are the first cells to sense signals of infection and to proceed to kill the invading pathogen. This is mediated by their production of neutrophil extracellular traps (NETS) to entrap pathogenic micro-organisms, preventing their amplification and disseminat...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-020-01047-z
更新日期：2020-05-27 00:00:00
abstract：:The seventeenth century London neuroanatomical school headed by Thomas Willis published the first images of the sympathetic nervous system. Nineteenth century European physiologists characterised these as the "pressor nerves". Von Euler's demonstration that the sympathetic transmitter was norepinephrine brought the fi...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0519-8
更新日期：2015-02-01 00:00:00
abstract：:Individuals with hypertension need to stay on therapy with antihypertensive medication to obtain the full benefits of blood pressure reduction. There are important differences in tolerability across antihypertensive drug classes, and these differences influence the extent to which patients are willing to continue taki...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-002-0021-6
更新日期：2002-12-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-015-0620-7
更新日期：2016-02-01 00:00:00
abstract：PURPOSE OF REVIEW:The renin-angiotensin system (RAS) plays an important role in modulating cardiovascular function and fluid homeostasis. While the systemic actions of the RAS are widely accepted, the role of the RAS in the brain, its regulation of cardiovascular function, and sympathetic outflow remain controversial. ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-018-0810-1
更新日期：2018-02-26 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-013-0371-2
更新日期：2013-10-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-011-0231-x
更新日期：2011-12-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-006-0089-5
更新日期：2006-10-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-017-0763-9
更新日期：2017-08-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-002-0006-5
更新日期：2002-06-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-001-0101-z
更新日期：2001-12-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-004-0091-8
更新日期：2004-04-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章
doi：10.1007/s11906-011-0207-x
更新日期：2011-08-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-013-0416-6
更新日期：2014-02-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-019-0981-4
更新日期：2019-09-04 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-017-0712-7
更新日期：2017-02-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-004-0020-x
更新日期：2004-08-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,meta分析
doi：10.1007/s11906-020-01042-4
更新日期：2020-03-21 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-008-0014-1
更新日期：2008-02-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-005-0019-y
更新日期：2005-08-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
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更新日期：2015-02-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
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更新日期：2005-04-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
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更新日期：2021-01-15 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-015-0548-y
更新日期：2015-05-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-001-0007-9
更新日期：2001-12-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-008-0038-6
更新日期：2008-06-01 00:00:00
abstract：:Our understanding of Na(+) transport defects has exploded in the past several years, and has provided unique insights into epithelial transport processes, and unusual clinical syndromes resulting from mutations of specific ion transporters. These genetic disorders affect Na(+) balance, with both Na(+) retaining and Na...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-999-0013-x
更新日期：1999-04-01 00:00:00
abstract：:Inflammation plays an important role in the pathogenesis of hypertension. Innate and adaptive immune response may contribute to this process. The mechanisms implicating immune response in hypertension are still elusive. To date, the evidence originates in three major areas of data: cytokine production, central nervous...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-011-0224-9
更新日期：2011-12-01 00:00:00
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journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-003-0083-0
更新日期：2003-10-01 00:00:00
abstract：:Resistant hypertension is a common and growing clinical problem characterized by failure to achieve target blood pressure levels despite adequate use of at least three antihypertensive agents. Although numerous safe and effective pharmacologic therapies are available to treat elevated blood pressure, novel therapeutic...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-010-0119-1
更新日期：2010-08-01 00:00:00
