Abstract：
:LCZ696 is a single molecule which combines the angiotensin receptor blocker valsartan with the neprilysn inhibitor sacubitril (AHU377). In the recently published PARADIGM-HF trial, LCZ696 proved superior to enalapril in reducing overall mortality, heart failure hospitalizations, and other endpoints in patients with systolic dysfunction heart failure. Increases in counter-regulatory natriuretic peptides which oppose sodium retention, vasoconstriction, and the deleterious structural changes which follow neurohormonal activation are thought to account for these improved outcomes. In two large hypertension studies, LCZ696 has proved to be a potent, effective antihypertensive agent with tolerability similar to valsartan and placebo and potency comparable to amlodipine. Although several have occurred in the heart failure population, there have been no cases of angioedema noted in the hypertension trials, although few black patients-a group at high risk for its occurrence-have been studied. Whether LCZ696 will displace angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers (ARBs) as preferred renin-angiotensin system (RAS) blocking agents in hypertension will require demonstration of improved long-term outcomes compared with currently preferred first-line drugs. In this regard, experience has shown that it is difficult to extrapolate results achieved in heart failure to the treatment of hypertension, a condition in which neurohormonal activation is less critical in determining long-term prognosis. It will be particularly important to demonstrate renal protection with LCZ696 in patients with diabetes, proteinuria, and hypertension-the only therapeutic area other than heart failure in which RAS blockade has proved essential for optimal endpoint reduction. Superiority over available RAS blockers in terms of 'vascular protection' in high-risk populations represents another path to acceptance of LCZ696 as a preferred agent in cardiovascular medicine.
journal_name
Curr Hypertens Repjournal_title
Current hypertension reportsauthors
Gradman AHdoi
10.1007/s11906-015-0548-ysubject
Has Abstractpub_date
2015-05-01 00:00:00pages
37issue
5eissn
1522-6417issn
1534-3111journal_volume
17pub_type
杂志文章,评审abstract：:Diabetes mellitus is one of the leading causes of end-stage renal disease. The pathogenesis of diabetic nephropathy is still poorly understood, but glomerular injury has been ascribed, at least in part, to glomerular hyperfiltration, which occurs early in the course of diabetes mellitus. Therefore, a better understand...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-005-0089-x
更新日期：2005-04-01 00:00:00
abstract：:In the quest for "evidence-based" medicine, an accepted hierarchy of evidence has been proposed. This hierarchy places in vitro studies and animal data at the base, and puts systematic reviews, meta-analyses, and randomized controlled trials at the pinnacle. However, when clinical medicine faces questions that have no...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-006-0054-3
更新日期：2006-06-01 00:00:00
abstract：:Excess weight gain is a major cause of essential hypertension, and abnormal kidney function appears to be a cause as well as a consequence of obesity hypertension. Excess renal sodium reabsorption and a hypertensive shift of pressure natriuresis play a major role in mediating increased blood pressure associated with w...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-000-0073-4
更新日期：2000-04-01 00:00:00
abstract：:Hypertension is very common in patients with chronic renal failure and contributes to cardiovascular morbidity and mortality. Several mechanisms may contribute to hypertension in these patients, but recently a large body of evidence supports the notion that activation of the sympathetic nervous system (SNS) may play a...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-002-0016-3
更新日期：2002-06-01 00:00:00
abstract：:Decreased endothelial nitric oxide (NO) bioavailability as it relates to endothelial dysfunction plays an important role in various cardiovascular disorders, including athero-sclerosis. Recent research has provided evidence that endothelial dysfunction in atherosclerosis is not primarily caused by decreased endothelia...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-006-0041-8
更新日期：2006-04-01 00:00:00
abstract：:Nycthemeral changes in renal function have been known for a long time, but our knowledge about the underlying mechanisms is still far from complete. From a theoretical point of view, many physiological systems could be involved in turning the kidney from a sodium-excretory organ during daytime into a sodium-conserving...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-011-0183-1
更新日期：2011-04-01 00:00:00
abstract：:There are many drug studies for the treatment of hypertension. Most studies compare one drug with another to determine if a drug or class of drugs have unique benefits. In evaluating drug trials, separation of hypertension as compared with atherosclerotic events is important. Trials that focus on prevention of hyperte...
journal_title：Current hypertension reports
pub_type： 杂志文章
doi：10.1007/s11906-999-0046-1
更新日期：1999-08-01 00:00:00
abstract：:With current immunosuppression, elevated blood pressure is found in almost 90% of renal graft recipients. Major causes of this are impairment of renal function (secondary to chronic allograft nephropathy or less frequently recurrence of primary renal disease), the use of calcineurin inhibitors as immunosuppressants, u...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-001-0063-1
更新日期：2001-10-01 00:00:00
abstract：:Peak-systolic blood pressure (SBP) and end-diastolic blood pressure (DBP) have been considered the exclusive mechanical factors predicting cardiovascular (CV) risk in populations of normotensive and hypertensive subjects. The purpose of this review is to show that in addition to SBP and DBP, other hemodynamic indices ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-004-0068-7
更新日期：2004-06-01 00:00:00
abstract：PURPOSE OF REVIEW:To review studies evaluating renal outcomes based on patient adherence to the Mediterranean diet or to the Dietary Approaches to Stop Hypertension (DASH) diet and to determine which diet is most effective in preventing and managing renal disease. RECENT FINDINGS:Both the DASH and Mediterranean diets ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-020-01054-0
更新日期：2020-07-15 00:00:00
abstract：:Primary aldosteronism (PA) is a common cause of arterial hypertension: in the PA Prevalence in Hypertensives (PAPY) Study, the prevalence of PA was 11.2% in consecutive referred hypertensive patients. When adrenal vein sampling (AVS) is available, two thirds of the cases can be attributed to a tumor and one third of c...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-010-0134-2
更新日期：2010-10-01 00:00:00
abstract：:The epidemiology of pulmonary arterial hypertension (PAH) has changed over the last decade. Remarkable advances in understanding the pathobiology and clinical care required in PAH have resulted in improved quality of life and survival. Despite such important progress, the long-term rate of survival is still unacceptab...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-013-0397-5
更新日期：2013-12-01 00:00:00
abstract：:Essential hypertension is characterized by endothelial dysfunction due to reduced availability of nitric oxide (NO) secondary to increased generation of oxygen-free radicals. Some antihypertensive drugs may improve or restore endothelial function independently of their blood pressure lowering effect. The newer generat...
journal_title：Current hypertension reports
pub_type： 杂志文章
doi：10.1007/s11906-011-0207-x
更新日期：2011-08-01 00:00:00
abstract：:The publication of the Antihypertensive and Lipid-lowering Treatment to Prevent Heart Attack Trial (ALLHAT) results, when used in conjunction with a new meta-analysis, provides hypertension research with a watershed. Data demonstrate clearly that lowering blood pressure is the most important aspect of hypertension man...
journal_title：Current hypertension reports
pub_type： 杂志文章,meta分析
doi：10.1007/s11906-003-0044-7
更新日期：2003-08-01 00:00:00
abstract：:Na+,K+-ATPase distributes ions between the intracellular and extracellular space and is responsible for total-body sodium homeostasis. The activity of this ion pump is regulated by catecholamines and peptide hormones; by the ligand of Na+,K+-ATPase, ouabain; and by direct interaction with cytoskeleton proteins. This r...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-001-0032-8
更新日期：2001-04-01 00:00:00
abstract：PURPOSE OF REVIEW:We focus on the current understanding of preeclampsia (PE) in order to examine how it mediates glomerular injury and affects the course of glomerulonephritis (GNs). In addition, this review discusses the role of GNs on the development of PE. RECENT FINDINGS:In PE, the dysfunctional utero-placental pe...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-020-1033-9
更新日期：2020-03-21 00:00:00
abstract：:Over the last few decades, there has been increasing emphasis on cardiovascular disease in women and study of female-specific cardiovascular risk factors. Hypertension in pregnancy, and specifically preeclampsia, has been identified as one such risk factor. In this review, we explore the epidemiological evidence for p...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0472-6
更新日期：2014-09-01 00:00:00
abstract：PURPOSE OF REVIEW:To review the latest reports of the contributions of the endothelial mineralocorticoid receptor to endothelial dysfunction and hypertension to begin to determine the clinical potential for this pathway for hypertension treatment. RECENT FINDINGS:Endothelial mineralocorticoid receptor expression is se...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-019-0981-4
更新日期：2019-09-04 00:00:00
abstract：:This review attempts to highlight the potential of calcium-channel blockers in the prevention of sequelae of diabetes mellitus and hypertension in patients who have both disorders. Evidence-based medicine is driven by the results of randomized, clinical trials. Major contributions were therefore derived from post hoc ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-999-0025-6
更新日期：1999-06-01 00:00:00
abstract：:Hypertension is a major cause of morbidity and mortality worldwide. Despite a myriad of oral agents, many patients fail to reach their target blood pressure. Electrical stimulation of the carotid sinus, an old therapeutic concept, lowers blood pressure by initiating the baroreflex and reducing sympathetic tone. Recent...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-006-0089-5
更新日期：2006-10-01 00:00:00
abstract：:Recent guidelines for the treatment of hypertension place great emphasis on tighter blood pressure control, especially in the presence of hypertensive target organ damage and diabetes. In order to achieve these treatment targets, more patients will require a combination of antihypertensive medications. However, resist...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-001-0039-1
更新日期：2001-06-01 00:00:00
abstract：:Young and middle-aged adults (ages ≤50 years) are increasingly prone to stroke, kidney disease, and worsening cardiovascular disease (CVD) mortality. An alarming increase in the prevalence of high blood pressure (BP) may underlie the adverse trend. However, there is often uncertainty in BP management for young and mid...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-016-0686-x
更新日期：2016-11-01 00:00:00
abstract：:Angiotensin II (Ang II) has actions on the sympathetic nervous system both as a circulating hormone acting on the circumventricular organs and also as a neurotransmitter/ neuromodulator acting within the brain. Administration of Ang II into the cerebral ventricles has diverse effects on sympathetic nerve activity (SNA...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-013-0355-2
更新日期：2013-08-01 00:00:00
abstract：:The metabolic syndrome associates metabolic abnormalities such as insulin resistance and dyslipidemia with increased waist circumference and hypertension. It is a major public health concern, as its prevalence could soon reach 30% to 50% in developed countries. Aldosterone, a mineralocorticoid hormone classically invo...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-011-0182-2
更新日期：2011-04-01 00:00:00
abstract：:The fact that cardiovascular risk factors cluster among individuals with the insulin resistance syndrome strongly suggests a common pathogenetic denominator. For many years, abnormalities of nonesterified fatty acid metabolism have been implicated in the disturbances of carbohydrate and lipid metabolism that character...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-001-0021-y
更新日期：2001-04-01 00:00:00
abstract：:Young hypertensive adults demonstrate decreased performance on neurocognitive testing compared with that of normotensive controls. There is emerging, preliminary evidence that children with hypertension also manifest cognitive differences when compared to normotensive controls. These preliminary studies consist mostly...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0508-y
更新日期：2015-01-01 00:00:00
abstract：:The renin-angiotensin system (RAS) plays an important role in the initiation and progression of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. In the past t...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-013-0416-6
更新日期：2014-02-01 00:00:00
abstract：:Obstructive sleep apnea (OSA) is a prevalent sleep disorder which is characterized by recurrent upper closure with oxygen desaturation and sleep disruption. OSA increases the risk of vascular disorders in the form of stroke, myocardial infarction, congestive heart failure, and hypertension. The mechanisms underlying t...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0482-4
更新日期：2014-10-01 00:00:00
abstract：:Levels of urinary albumin excretion that are below the usual limit of detection by qualitative testing, but are above normal levels (microalbuminuria; MA), can be readily identified by simple measures, such as the urinary albumin to creatinine ratio in untimed urine samples. Such measurements, particularly when combin...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-010-0133-3
更新日期：2010-10-01 00:00:00
abstract：PURPOSE OF REVIEW:This review provides a comprehensive insight into the angiogenic profile of hypertensive and normotensive pregnancies compromised by HIV infection. Furthermore, we evaluate the economic implementation of the sFlt-1/PlGF ratio and review the reports on therapeutic apheresis in limiting sFlt-1 productio...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-019-0970-7
更新日期：2019-07-24 00:00:00
