Abstract：
PURPOSE OF REVIEW:This review provides a comprehensive insight into the angiogenic profile of hypertensive and normotensive pregnancies compromised by HIV infection. Furthermore, we evaluate the economic implementation of the sFlt-1/PlGF ratio and review the reports on therapeutic apheresis in limiting sFlt-1 production. RECENT FINDINGS:In preeclampsia, an increased expression of sFlt-1 triggers angiogenic imbalance. Women of African ancestry have high levels of angiogenic factors than other racial groups. The sFlt-1/PlGF ratio shows promise in the early assessment of preeclampsia, while sFlt-1 apheresis restores angiogenic imbalance. Studies suggest antiretroviral therapy does not impact the angiogenic shift in preeclampsia development. The angiogenic profile in pregnant women of different races influences preeclampsia development. Despite the opposing immune response in HIV infection and preeclampsia, the HIV tat protein strongly mimics vascular endothelial growth factor (VEGF); hence, it is plausible to assume that HIV infection may ameliorate the angiogenic imbalance in preeclampsia.
journal_name
Curr Hypertens Repjournal_title
Current hypertension reportsauthors
Padayachee S,Moodley J,Naicker Tdoi
10.1007/s11906-019-0970-7subject
Has Abstractpub_date
2019-07-24 00:00:00pages
69issue
9eissn
1522-6417issn
1534-3111pii
10.1007/s11906-019-0970-7journal_volume
21pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:To review latest reports of the food products which might increase blood pressure and therefore might participate in the pathogenesis of hypertension. RECENT FINDINGS:Results of clinical study suggest that consumption of high-sodium food leads to transient increase in plasma sodium concentration. Thi...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-019-1007-y
更新日期：2020-01-08 00:00:00
abstract：:The fact that cardiovascular risk factors cluster among individuals with the insulin resistance syndrome strongly suggests a common pathogenetic denominator. For many years, abnormalities of nonesterified fatty acid metabolism have been implicated in the disturbances of carbohydrate and lipid metabolism that character...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-001-0021-y
更新日期：2001-04-01 00:00:00
abstract：:Vascular changes associated with elevated blood pressure may precede the clinical diagnosis of hypertension. Even after the diagnosis is made, associated coronary heart disease and renal disease continue to progress, despite adequate blood pressure control. Early treatment of blood pressure may reduce the incidence of...
journal_title：Current hypertension reports
pub_type： 临床试验,杂志文章,评审
doi：10.1007/s11906-000-0038-7
更新日期：2000-08-01 00:00:00
abstract：:In the quest for "evidence-based" medicine, an accepted hierarchy of evidence has been proposed. This hierarchy places in vitro studies and animal data at the base, and puts systematic reviews, meta-analyses, and randomized controlled trials at the pinnacle. However, when clinical medicine faces questions that have no...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-006-0054-3
更新日期：2006-06-01 00:00:00
abstract：:Elevation of blood pressure (BP) and the risk for progression to hypertension (HTN) is of increasing concern in children and adolescents. Indeed, it is increasingly recognized that target organ injury may begin with even low levels of BP elevation. Sodium intake has long been recognized as a modifiable risk factor for...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-013-0382-z
更新日期：2013-10-01 00:00:00
abstract：:Nitric oxide is involved in the regulation of resting vascular tone, adaptation of blood flow to metabolic demand of tissue, and adaptation of vessel diameter to volume of inflow, ie, flow-mediated dilation. Arterial hypertension is associated with an increased vascular tone of resistance vessels, a reduced compliance...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-003-0015-z
更新日期：2003-02-01 00:00:00
abstract：:Our understanding of Na(+) transport defects has exploded in the past several years, and has provided unique insights into epithelial transport processes, and unusual clinical syndromes resulting from mutations of specific ion transporters. These genetic disorders affect Na(+) balance, with both Na(+) retaining and Na...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-999-0013-x
更新日期：1999-04-01 00:00:00
abstract：:Masked hypertension refers to the phenomenon of having a non-elevated clinic blood pressure (BP) despite having an elevated out-of-clinic BP. Masked hypertension is a common phenotype with a cardiovascular risk profile similar to that of sustained hypertension, defined as elevated clinic and out-of-clinic BP. Current ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-017-0792-4
更新日期：2017-10-25 00:00:00
abstract：:The discovery of beneficial neuroprotective effects of the angiotensin converting enzyme 2-angiotensin-(1-7)-Mas axis [ACE2-Ang-(1-7)-Mas] in ischemic and hemorrhagic stroke has spurred interest in a more complete characterization of its mechanisms of action. Here, we summarize findings that describe the protective ro...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0512-2
更新日期：2015-02-01 00:00:00
abstract：:LCZ696 is a single molecule which combines the angiotensin receptor blocker valsartan with the neprilysn inhibitor sacubitril (AHU377). In the recently published PARADIGM-HF trial, LCZ696 proved superior to enalapril in reducing overall mortality, heart failure hospitalizations, and other endpoints in patients with sy...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-015-0548-y
更新日期：2015-05-01 00:00:00
abstract：:Diabetes mellitus is one of the leading causes of end-stage renal disease. The pathogenesis of diabetic nephropathy is still poorly understood, but glomerular injury has been ascribed, at least in part, to glomerular hyperfiltration, which occurs early in the course of diabetes mellitus. Therefore, a better understand...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-005-0089-x
更新日期：2005-04-01 00:00:00
abstract：:There is increasing concern that sugar consumption may be linked to the development of metabolic and cardiovascular diseases. There is indeed strong evidence that consumption of energy-dense sugary beverages and foods is associated with increased energy intake and body weight gain over time. It is further proposed tha...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-016-0652-7
更新日期：2016-06-01 00:00:00
abstract：:Aldosterone antagonists have been highly successful in treating congestive heart failure and resistant hypertension. Until recently, therapies targeting the mineralocorticoid receptor in chronic kidney disease (CKD) have received little attention, largely because of the risk of hyperkalemia and the incorrect assumptio...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-011-0202-2
更新日期：2011-08-01 00:00:00
abstract：:The obesity gene product leptin plays an important role in the physiologic regulation of appetite and energy balance. Plasma leptin levels correlate closely with body fat storage and may respond to changes in energy expenditure. Recent evidence has implicated a direct cardiac regulatory action of leptin in addition to...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-008-0084-0
更新日期：2008-12-01 00:00:00
abstract：PURPOSE OF REVIEW:This article introduces the haemodynamic principles that underpin the pathophysiology of hypertension and introduces a rational physiological approach to appropriate pharmacologic treatment. RECENT FINDINGS:Outdated understanding of haemodynamics based on previous measurement systems can no longer be...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-018-0832-8
更新日期：2018-04-10 00:00:00
abstract：:Resistant hypertension is defined as blood pressure that remains uncontrolled despite using at least three antihypertensive medications in effective doses, ideally including a diuretic. Stricter blood pressure goals, higher obesity rates, older age, and increased use of certain exogenous substances are related to an i...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-007-0066-7
更新日期：2007-11-01 00:00:00
abstract：:The underlying pathophysiologic concept of diverse invasive devices to treat resistant hypertension (e.g., sympathetic denervation, carotid sinus nerve stimulation) is known for a long time. Since the pioneering work in the 1940s in humans, innovative techniques have been developed resulting in less invasive treatment...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0488-y
更新日期：2014-11-01 00:00:00
abstract：PURPOSE OF THE REVIEW:In our innate immune system, neutrophils are the first cells to sense signals of infection and to proceed to kill the invading pathogen. This is mediated by their production of neutrophil extracellular traps (NETS) to entrap pathogenic micro-organisms, preventing their amplification and disseminat...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-020-01047-z
更新日期：2020-05-27 00:00:00
abstract：:Hypertension and high serum cholesterol levels are two of the most relevant risk factors for cardiovascular diseases. A combined increase in both risk factors has been reported in a significant proportion of patients with coronary artery disease. Statins are the most widely used drugs to treat hypercholesterolemia, an...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-001-0090-y
更新日期：2001-08-01 00:00:00
abstract：:Angiotensin II (Ang II) has actions on the sympathetic nervous system both as a circulating hormone acting on the circumventricular organs and also as a neurotransmitter/ neuromodulator acting within the brain. Administration of Ang II into the cerebral ventricles has diverse effects on sympathetic nerve activity (SNA...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-013-0355-2
更新日期：2013-08-01 00:00:00
abstract：PURPOSE OF REVIEW:To review the most recent literature on current strategies for the treatment of hypertension associated with pediatric obesity. RECENT FINDINGS:Over the last three decades, childhood and adolescent overweight and obesity prevalence in the USA has continued to rise. Unsurprisingly but rather disturbin...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-019-0922-2
更新日期：2019-02-12 00:00:00
abstract：:Obstructive sleep apnea is a common disorder that is often unrecognized and underappreciated. Emerging evidence suggests that there is a causal link between obstructive sleep apnea and hypertension. This relationship appears to be independent of other comorbidities that have been previously linked to hypertension, suc...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-003-0083-0
更新日期：2003-10-01 00:00:00
abstract：:When a large multicenter research trial is abruptly terminated, it is usually a consequence of significant adverse events. In contrast, when the Randomized Aldactone Evaluation Study (RALES) mortality trial was discontinued 18 months early, it was because of the prominent salutary effect of spironolactone, added to st...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-000-0027-x
更新日期：2000-10-01 00:00:00
abstract：:Peak-systolic blood pressure (SBP) and end-diastolic blood pressure (DBP) have been considered the exclusive mechanical factors predicting cardiovascular (CV) risk in populations of normotensive and hypertensive subjects. The purpose of this review is to show that in addition to SBP and DBP, other hemodynamic indices ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-004-0068-7
更新日期：2004-06-01 00:00:00
abstract：:The kidneys play a central role in the long-term regulation of blood pressure and in the pathogenesis of hypertension. A common defect that has been found in all forms of hypertension examined to date is a hypertensive shift in the pressure-natriuresis relationship. A major objective of this brief review is to highlig...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-006-0068-x
更新日期：2006-08-01 00:00:00
abstract：PURPOSE OF REVIEW:There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer's disease; however, associations between antihypertensive medications (AHMs) and dementia risk are less consistent. An increased interest in AHM has resulted in ex...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-016-0674-1
更新日期：2016-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Use of antihypertensives in older adults can be complicated by the potential for undesired effects on comorbidities, adverse effects of the drugs, and overall medication burden. The purpose of this two-part review is to discuss contemporary issues encountered in the management of hypertension in aged ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-019-0988-x
更新日期：2019-10-10 00:00:00
abstract：:Diabetes mellitus is well recognized as a potent and prevalent risk factor for accelerated atherosclerosis and ischemic heart disease. However, there is also evidence of cardiac dysfunction in diabetes in the absence of coronary atherosclerosis, termed diabetic cardiomyopathy. Changes in ventricular structure and left...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-007-0086-3
更新日期：2007-12-01 00:00:00
abstract：PURPOSE OF REVIEW:This review sought to evaluate the role of exercise in patients with obesity and comorbid hypertension, with a focus on contemporary literature (since January 2015). RECENT FINDINGS:No reviews have included patients classified with both obesity and hypertension and there is a paucity of randomised co...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-020-01087-5
更新日期：2020-09-03 00:00:00
abstract：:Decreased endothelial nitric oxide (NO) bioavailability as it relates to endothelial dysfunction plays an important role in various cardiovascular disorders, including athero-sclerosis. Recent research has provided evidence that endothelial dysfunction in atherosclerosis is not primarily caused by decreased endothelia...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-006-0041-8
更新日期：2006-04-01 00:00:00
