Endothelin, the kidney, and hypertension.

abstract：:Hypertension and high serum cholesterol levels are two of the most relevant risk factors for cardiovascular diseases. A combined increase in both risk factors has been reported in a significant proportion of patients with coronary artery disease. Statins are the most widely used drugs to treat hypercholesterolemia, an...

journal_title：Current hypertension reports

authors： Borghi C,Veronesi M,Prandin MG,Dormi A,Ambrosioni E

更新日期：2001-08-01 00:00:00

abstract：:The seventeenth century London neuroanatomical school headed by Thomas Willis published the first images of the sympathetic nervous system. Nineteenth century European physiologists characterised these as the "pressor nerves". Von Euler's demonstration that the sympathetic transmitter was norepinephrine brought the fi...

journal_title：Current hypertension reports

authors： Esler M

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer's disease; however, associations between antihypertensive medications (AHMs) and dementia risk are less consistent. An increased interest in AHM has resulted in ex...

journal_title：Current hypertension reports

authors： Yasar S,Schuchman M,Peters J,Anstey KJ,Carlson MC,Peters R

更新日期：2016-08-01 00:00:00

abstract：:The inhibition of angiotensin II through angiotensin converting enzyme inhibitors or angiotensin receptor blockers has become the foundation of medical treatment of progressive chronic renal disease. Although these drugs provide a significant improvement over earlier treatments, they only slow the progression of renal...

journal_title：Current hypertension reports

authors： Gaedeke J,Noble NA,Border WA

更新日期：2002-10-01 00:00:00

abstract：:With current immunosuppression, elevated blood pressure is found in almost 90% of renal graft recipients. Major causes of this are impairment of renal function (secondary to chronic allograft nephropathy or less frequently recurrence of primary renal disease), the use of calcineurin inhibitors as immunosuppressants, u...

journal_title：Current hypertension reports

authors： Schwenger V,Zeier M,Ritz E

更新日期：2001-10-01 00:00:00

abstract：:The metabolic syndrome leads to cardiovascular disease and type 2 diabetes mellitus, through multiple risks, such as insulin resistance, dyslipidemia, hyperinsulinemia, and hypertension. It also represents a disorder of partial genetic background as mutations of the peroxisome proliferator-activated receptor-gamma (PP...

journal_title：Current hypertension reports

authors： Tuck ML

更新日期：2005-08-01 00:00:00

abstract：:Inflammation plays an important role in the pathogenesis of hypertension. Innate and adaptive immune response may contribute to this process. The mechanisms implicating immune response in hypertension are still elusive. To date, the evidence originates in three major areas of data: cytokine production, central nervous...

journal_title：Current hypertension reports

authors： Leibowitz A,Schiffrin EL

更新日期：2011-12-01 00:00:00

abstract：:The prevalence of the metabolic syndrome (MetS) has increased rapidly in North America in recent years. Presently, the MetS is found in 34.3% of the population, and the prevalence is likely to continue to increase in parallel with the obesity epidemic. Losing weight and long-term maintenance of the weight loss are pri...

journal_title：Current hypertension reports

authors： Ferland A,Eckel RH

更新日期：2011-12-01 00:00:00

abstract：:Primary aldosteronism (PA) is a common cause of arterial hypertension: in the PA Prevalence in Hypertensives (PAPY) Study, the prevalence of PA was 11.2% in consecutive referred hypertensive patients. When adrenal vein sampling (AVS) is available, two thirds of the cases can be attributed to a tumor and one third of c...

journal_title：Current hypertension reports

authors： Rossi GP

更新日期：2010-10-01 00:00:00

abstract：:Excess weight gain is a major cause of essential hypertension, and abnormal kidney function appears to be a cause as well as a consequence of obesity hypertension. Excess renal sodium reabsorption and a hypertensive shift of pressure natriuresis play a major role in mediating increased blood pressure associated with w...

journal_title：Current hypertension reports

authors： Hall JE

更新日期：2000-04-01 00:00:00

abstract：:Administering relaxin to conscious rats and humans elicits systemic and renal vasodilation. The molecular mechanisms vary according to the duration of relaxin exposure-so-called "rapid" (within minutes) or "sustained" (hours to days) vasodilatory responses-both being endothelium-dependent. Rapid responses are mediated...

journal_title：Current hypertension reports

authors： Conrad KP,Shroff SG

更新日期：2011-12-01 00:00:00

abstract：:The incidence and prevalence of obesity and the metabolic syndrome have risen markedly in the past decade, representing a serious cardiovascular health hazard with significant morbidity and mortality. The etiology of the metabolic syndrome and its various pathogenic mechanisms are incompletely defined and under intens...

journal_title：Current hypertension reports

authors： Patel SB,Reams GP,Spear RM,Freeman RH,Villarreal D

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes the most recent and innovative implementation strategies for hypertension control in low- and middle-income countries (LMICs). RECENT FINDINGS:Implementation strategies from Latin America, Africa, and Asia were organized across three levels: community, health system, and policy...

journal_title：Current hypertension reports

authors： Mercer T,Nulu S,Vedanthan R

更新日期：2020-05-13 00:00:00

abstract：PURPOSE OF REVIEW:The pathophysiology of preeclampsia is complex and not entirely understood. A key feature in preeclampsia development is an immunological imbalance that shifts the maternal immune response from one of tolerance towards one promoting chronic inflammation and endothelial dysfunction. As a key regulator ...

journal_title：Current hypertension reports

authors： Cubro H,Kashyap S,Nath MC,Ackerman AW,Garovic VD

更新日期：2018-04-30 00:00:00

abstract：:How chlorthalidone (CTDN) reduces risk for cardiovascular events (CVEs) can be considered in light of its ability to lower blood pressure (BP) and its non-BP related, pleiotropic effects. The mechanism by which CTDN lowers BP is unclear but may include alterations in whole body regulation and vasodilatory actions on v...

journal_title：Current hypertension reports

authors： Roush GC,Buddharaju V,Ernst ME,Holford TR

更新日期：2013-10-01 00:00:00

abstract：:Our understanding of Na(+) transport defects has exploded in the past several years, and has provided unique insights into epithelial transport processes, and unusual clinical syndromes resulting from mutations of specific ion transporters. These genetic disorders affect Na(+) balance, with both Na(+) retaining and Na...

journal_title：Current hypertension reports

authors： Warnock DG

更新日期：1999-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To review studies evaluating renal outcomes based on patient adherence to the Mediterranean diet or to the Dietary Approaches to Stop Hypertension (DASH) diet and to determine which diet is most effective in preventing and managing renal disease. RECENT FINDINGS:Both the DASH and Mediterranean diets ...

journal_title：Current hypertension reports

authors： Yazdi F,Morreale P,Reisin E

更新日期：2020-07-15 00:00:00

abstract：:Vasopeptidase inhibitors are a new class of drugs capable of inhibiting both angiotensin-converting enzyme and neutral endopeptidase 24.11. This involves simultaneous inhibition with a single molecule of two key enzymes, ACE and NEP, which are both involved in the regulation of cardiovascular homeostasis in many ways....

journal_title：Current hypertension reports

authors： d'Uscio LV,Lüscher TF

更新日期：2001-12-01 00:00:00

abstract：:Hypertension that complicates preeclampsia in pregnancy is a disorder that requires special consideration in both prevention and pharmacologic treatment. In recent years, few advances have been made regarding the pathophysiology and prevention of preeclampsia; however, there have been some promising results from studi...

journal_title：Current hypertension reports

authors： Frishman WH,Veresh M,Schlocker SJ,Tejani N

更新日期：2006-12-01 00:00:00

abstract：:Lipodystrophy (LD) associated with HIV infection is a syndrome of abnormal fat distribution observed in HIV-infected patients treated with various antiretroviral agents. In addition, insulin resistance and dyslipidemia can occur in HIV-infected patients with or without LD. The demonstration of the latter metabolic dis...

journal_title：Current hypertension reports

authors： Mikhail N

更新日期：2003-04-01 00:00:00

abstract：:Epinephrine is the prototypical stress hormone. Its stimulation of all α and β adrenergic receptors elicits short-term systolic hypertension, hyperglycemia, and other aspects of the metabolic syndrome. Acute epinephrine infusion increases cardiac output and induces insulin resistance, but removal of the adrenal medull...

journal_title：Current hypertension reports

authors： Ziegler MG,Elayan H,Milic M,Sun P,Gharaibeh M

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of the study is to perform a critical assessment of in vitro models of pre-eclampsia using complementary human and cell line-based studies. Molecular mechanisms involved in spiral uterine artery (SUA) remodelling and trophoblast functionality will also be discussed. RECENT FINDINGS:A number o...

journal_title：Current hypertension reports

authors： McNally R,Alqudah A,Obradovic D,McClements L

更新日期：2017-10-23 00:00:00

abstract：PURPOSE OF REVIEW:This study aims to systematically review existing evidence on the effectiveness of mobile health technology (mHealth) interventions in addressing medication adherence among people with hypertension. RECENT FINDINGS:Twenty-one studies of mHealth interventions were included in the final review after sy...

journal_title：Current hypertension reports

authors： Xiong S,Berkhouse H,Schooler M,Pu W,Sun A,Gong E,Yan LL

更新日期：2018-08-07 00:00:00

abstract：:Nycthemeral changes in renal function have been known for a long time, but our knowledge about the underlying mechanisms is still far from complete. From a theoretical point of view, many physiological systems could be involved in turning the kidney from a sodium-excretory organ during daytime into a sodium-conserving...

journal_title：Current hypertension reports

authors： de Leeuw PW

更新日期：2011-04-01 00:00:00

abstract：:The post-macula densa segments of the renal tubule--that is, the distal convoluted tubule, connecting tubule, and collecting duct--play a central role in determining final urine sodium excretion. The major regulated sodium transporters and channels in these cell types include the thiazide-sensitive (Na-Cl) cotransport...

journal_title：Current hypertension reports

authors： Ecelbarger CA,Tiwari S

更新日期：2006-05-01 00:00:00

abstract：:Hypertension is very common in patients with chronic renal failure and contributes to cardiovascular morbidity and mortality. Several mechanisms may contribute to hypertension in these patients, but recently a large body of evidence supports the notion that activation of the sympathetic nervous system (SNS) may play a...

journal_title：Current hypertension reports

authors： Campese VM,Krol E

更新日期：2002-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Use of antihypertensives in older adults can be complicated by the potential for undesired effects on comorbidities, adverse effects of the drugs, and overall medication burden. The purpose of this two-part review is to discuss contemporary issues encountered in the management of hypertension in aged ...

journal_title：Current hypertension reports

authors： Ernst ME,MacLaughlin EJ

更新日期：2019-10-10 00:00:00

abstract：PURPOSE OF REVIEW:To review the latest reports of the contributions of the endothelial mineralocorticoid receptor to endothelial dysfunction and hypertension to begin to determine the clinical potential for this pathway for hypertension treatment. RECENT FINDINGS:Endothelial mineralocorticoid receptor expression is se...

journal_title：Current hypertension reports

authors： Faulkner JL,Belin de Chantemèle EJ

更新日期：2019-09-04 00:00:00

abstract：PURPOSE OF REVIEW:This meta-analysis and systematic review was conducted to evaluate the effect of probiotics on blood pressure, body mass index (BMI), and blood glucose changes in patients with hypertension. RECENT FINDINGS:We searched the PubMed, Cochrane, Embase, and ProQuest databases using a combination of MeSH a...

journal_title：Current hypertension reports

authors： Chi C,Li C,Wu D,Buys N,Wang W,Fan H,Sun J

更新日期：2020-03-21 00:00:00

abstract：:When a large multicenter research trial is abruptly terminated, it is usually a consequence of significant adverse events. In contrast, when the Randomized Aldactone Evaluation Study (RALES) mortality trial was discontinued 18 months early, it was because of the prominent salutary effect of spironolactone, added to st...

journal_title：Current hypertension reports

authors： Soberman JE,Weber KT

更新日期：2000-10-01 00:00:00