Abstract：
:The seventeenth century London neuroanatomical school headed by Thomas Willis published the first images of the sympathetic nervous system. Nineteenth century European physiologists characterised these as the "pressor nerves". Von Euler's demonstration that the sympathetic transmitter was norepinephrine brought the field into the modern era. Sympathetic nervous system responses are regionally differentiated; human regional sympathetic activity is best studied by recording from postganglionic sympathetic efferents directed to the skeletal muscle vasculature (clinical microneurography) and by measurement of organ-specific norepinephrine release to plasma from sympathetic nerves (regional "norepinephrine spillover"). With these techniques, the sympathetic nervous system became accessible to clinical scientists, allowing the demonstration that sympathetic nervous system activation is crucial in the development and outcomes of cardiovascular disorders, most notably heart failure and essential hypertension. Activation of the renal sympathetic outflow is pivotal in the pathogenesis of essential hypertension. An important goal for clinical scientists is translation of knowledge of pathophysiology, such as this, into better treatment for patients. Although disputed, the case is strong that in hypertension, we are now on the cusp of effective "mechanisms to management" transition, with the use of catheter-based renal sympathetic nerve ablation for treating drug-resistant hypertension.
journal_name
Curr Hypertens Repjournal_title
Current hypertension reportsauthors
Esler Mdoi
10.1007/s11906-014-0519-8subject
Has Abstractpub_date
2015-02-01 00:00:00pages
11issue
2eissn
1522-6417issn
1534-3111journal_volume
17pub_type
杂志文章,评审abstract：:Chronic kidney disease is a major public health problem worldwide: it is estimated that in the general population, 1 person in 10 has some degree of renal damage. Adequate blood pressure control represents the mainstay of treatment, to delay deterioration of renal function and prevent cardiovascular complications. Cur...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-010-0141-3
更新日期：2010-10-01 00:00:00
abstract：:Although it is clear that hypertension is a primary cause of stroke, there has been controversy concerning blood pressure management after stroke. Recent studies indicate that lowering systemic blood pressure after stroke reduces the risk for recurrent stroke or vascular events, but other studies provide evidence that...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-005-0058-4
更新日期：2005-02-01 00:00:00
abstract：:Endothelin receptor antagonists (ERAs) have the potential to be a new paradigm in the treatment of chronic kidney disease (CKD). ERAs inhibit the effects of endothelin-1 (ET-1), which is known to promote CKD by causing renal cellular injury, proteinuria, inflammation, fibrosis, and hypertrophy. ERAs have been extensiv...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-015-0568-7
更新日期：2015-07-01 00:00:00
abstract：:Inflammation plays an important role in the pathogenesis of hypertension. Innate and adaptive immune response may contribute to this process. The mechanisms implicating immune response in hypertension are still elusive. To date, the evidence originates in three major areas of data: cytokine production, central nervous...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-011-0224-9
更新日期：2011-12-01 00:00:00
abstract：:Sympathetic nerve activity is involved in the pathogenesis of salt-sensitive hypertension. The central nervous system, which regulates sympathetic nerve activity and blood pressure, plays a pivotal role. Central sympathoexcitation is deeply involved in the pathogenesis of salt-sensitive hypertension, although the prec...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-015-0620-7
更新日期：2016-02-01 00:00:00
abstract：:Cardiovascular disease disproportionately affects minority populations, in part because of multiple sociocultural factors that directly affect compliance with antihypertensive medication regimens. Compliance is a complex health behavior determined by a variety of socioeconomic, individual, familial, and cultural facto...
journal_title：Current hypertension reports
pub_type： 杂志文章
doi：10.1007/BF03215777
更新日期：1999-12-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this meta-analysis is to compare the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on blood pressure of hypertensive individuals. RECENT FINDINGS:Continuous aerobic training programs are successful in health promotion and are effec...
journal_title：Current hypertension reports
pub_type： 杂志文章,meta分析
doi：10.1007/s11906-020-1030-z
更新日期：2020-03-03 00:00:00
abstract：:Hypertension is an established risk factor for stroke, premature coronary artery disease and heart failure. Control of elevated blood pressure has been shown to result in significant reduction of cardiovascular risk. Aldosterone, the final product of the renin-angiotensin-aldosterone system (RAAS), not only causes sal...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-013-0379-7
更新日期：2013-10-01 00:00:00
abstract：:Diabetes mellitus is well recognized as a potent and prevalent risk factor for accelerated atherosclerosis and ischemic heart disease. However, there is also evidence of cardiac dysfunction in diabetes in the absence of coronary atherosclerosis, termed diabetic cardiomyopathy. Changes in ventricular structure and left...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-007-0086-3
更新日期：2007-12-01 00:00:00
abstract：:Diagnosis of resistant hypertension (RH) is currently based upon awake-time office blood pressure (BP). An increasing number of studies have documented abnormally elevated sleep-time BP in most RH patients, indicating that diagnosis of true RH cannot be determined solely by comparison of office BP with either patient ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0445-9
更新日期：2014-07-01 00:00:00
abstract：PURPOSE OF REVIEW:Automated office blood pressure (AOBP) measurements may provide more accurate estimation of blood pressure (BP) than manual office blood pressure (MOBP) measurements. This systematic review investigated the diagnostic performance of AOBP and MOBP using ambulatory blood pressure measurement (ABPM) as r...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-020-01118-1
更新日期：2021-01-15 00:00:00
abstract：PURPOSE OF REVIEW:This meta-analysis and systematic review was conducted to evaluate the effect of probiotics on blood pressure, body mass index (BMI), and blood glucose changes in patients with hypertension. RECENT FINDINGS:We searched the PubMed, Cochrane, Embase, and ProQuest databases using a combination of MeSH a...
journal_title：Current hypertension reports
pub_type： 杂志文章,meta分析
doi：10.1007/s11906-020-01042-4
更新日期：2020-03-21 00:00:00
abstract：PURPOSE OF REVIEW:The renin-angiotensin system (RAS) plays an important role in modulating cardiovascular function and fluid homeostasis. While the systemic actions of the RAS are widely accepted, the role of the RAS in the brain, its regulation of cardiovascular function, and sympathetic outflow remain controversial. ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-018-0810-1
更新日期：2018-02-26 00:00:00
abstract：PURPOSE OF REVIEW:Use of antihypertensives in older adults can be complicated by the potential for undesired effects on comorbidities, adverse effects of the drugs, and overall medication burden. The purpose of this two-part review is to discuss contemporary issues encountered in the management of hypertension in aged ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-019-0988-x
更新日期：2019-10-10 00:00:00
abstract：:Investigations using chronic blood pressure (BP) radiotelemetry in conscious animals have provided substantial insights into the pathophysiology of hypertensive renal damage. Normal renal autoregulation protects the renal microvasculature from significant injury in most patients with primary hypertension, unless BP ex...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-004-0091-8
更新日期：2004-04-01 00:00:00
abstract：:Recent guidelines for the treatment of hypertension place great emphasis on tighter blood pressure control, especially in the presence of hypertensive target organ damage and diabetes. In order to achieve these treatment targets, more patients will require a combination of antihypertensive medications. However, resist...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-001-0039-1
更新日期：2001-06-01 00:00:00
abstract：:Masked hypertension refers to the phenomenon of having a non-elevated clinic blood pressure (BP) despite having an elevated out-of-clinic BP. Masked hypertension is a common phenotype with a cardiovascular risk profile similar to that of sustained hypertension, defined as elevated clinic and out-of-clinic BP. Current ...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-017-0792-4
更新日期：2017-10-25 00:00:00
abstract：:Antiplatelet agents represent a cornerstone in the management of patients at increased cardiovascular risk. Essential hypertension is considered a major public health problem leading to increased cardiovascular morbidity and mortality. The majority of patients with essential hypertension exhibit also additional cardio...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-015-0536-2
更新日期：2015-04-01 00:00:00
abstract：:Blood pressure is typically lower in premenopausal women than in men. However, after menopause, the prevalence of hypertension in women is higher than it is in men. Hypertension is a major risk factor for cardiovascular disease in women and men, but cardiovascular disease is the leading cause of death in women. Furthe...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-012-0260-0
更新日期：2012-06-01 00:00:00
abstract：:Patients with hypertension have a high prevalence of concurrent metabolic abnormalities (eg, obesity, dyslipidemia, and hyperglycemia). Clustering of these risk factors, defined as the metabolic syndrome, is associated with a high cardiovascular risk profile. This review summarizes current knowledge about the prevalen...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-007-0019-1
更新日期：2007-04-01 00:00:00
abstract：:The central nervous system plays a key role in the regulation of cardiovascular function, and alterations in the central neural mechanisms that control blood pressure may underlie the vast majority of cases of primary hypertension. The well-studied baroreceptor reflex powerfully regulates arterial pressure, though its...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-003-0030-0
更新日期：2003-06-01 00:00:00
abstract：:Progressive abnormalities of passive stiffness or active relaxation of the myocardium that impair ventricular filling during diastole may be an important contributor to the development of heart failure in patients with preserved ejection fraction. In this review, we discuss the epidemiology and pathophysiology of dias...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-009-0048-z
更新日期：2009-08-01 00:00:00
abstract：:Vascular changes associated with elevated blood pressure may precede the clinical diagnosis of hypertension. Even after the diagnosis is made, associated coronary heart disease and renal disease continue to progress, despite adequate blood pressure control. Early treatment of blood pressure may reduce the incidence of...
journal_title：Current hypertension reports
pub_type： 临床试验,杂志文章,评审
doi：10.1007/s11906-000-0038-7
更新日期：2000-08-01 00:00:00
abstract：PURPOSE OF REVIEW:To review the current literature on use of telehealth at different stages of the hypertension control cascade in sub-Saharan Africa (SSA) and to discuss opportunities to harness technology infrastructure in SSA to improve population-level blood pressure control. RECENT FINDINGS:Despite the high burde...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-019-0983-2
更新日期：2019-08-26 00:00:00
abstract：:In the quest for "evidence-based" medicine, an accepted hierarchy of evidence has been proposed. This hierarchy places in vitro studies and animal data at the base, and puts systematic reviews, meta-analyses, and randomized controlled trials at the pinnacle. However, when clinical medicine faces questions that have no...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-006-0054-3
更新日期：2006-06-01 00:00:00
abstract：:The concept of "perioperative hypertensive emergency" must be defined differently from that of ambulatory hypertensive emergency in view of its unique clinical considerations in an atypical setting. It should be noted that moderately high normal blood pressure (BP) values in the perioperative setting often trigger sit...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0448-6
更新日期：2014-07-01 00:00:00
abstract：:The various antihypertensive regimens have varying effects on glucose metabolism and the development of diabetes mellitus. Recent large hypertension trials have shown great differences in the development of new-onset diabetes among antihypertensive drug therapies. The incidence of diabetes is unchanged or increased by...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-005-0029-9
更新日期：2005-08-01 00:00:00
abstract：:Atherosclerotic cardiovascular disease (CVD) is the most common cause of death worldwide. Usually atherosclerosis is caused by the combined effects of multiple risk factors. For this reason, most guidelines on the prevention of CVD stress the assessment of total CVD risk. The most intensive risk factor modification ca...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-010-0143-1
更新日期：2010-10-01 00:00:00
abstract：:Individuals with hypertension need to stay on therapy with antihypertensive medication to obtain the full benefits of blood pressure reduction. There are important differences in tolerability across antihypertensive drug classes, and these differences influence the extent to which patients are willing to continue taki...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-002-0021-6
更新日期：2002-12-01 00:00:00
abstract：:Obstructive sleep apnea (OSA) is a prevalent sleep disorder which is characterized by recurrent upper closure with oxygen desaturation and sleep disruption. OSA increases the risk of vascular disorders in the form of stroke, myocardial infarction, congestive heart failure, and hypertension. The mechanisms underlying t...
journal_title：Current hypertension reports
pub_type： 杂志文章,评审
doi：10.1007/s11906-014-0482-4
更新日期：2014-10-01 00:00:00
