Antiplatelet treatment in essential hypertension: where do we stand?

abstract：:How chlorthalidone (CTDN) reduces risk for cardiovascular events (CVEs) can be considered in light of its ability to lower blood pressure (BP) and its non-BP related, pleiotropic effects. The mechanism by which CTDN lowers BP is unclear but may include alterations in whole body regulation and vasodilatory actions on v...

journal_title：Current hypertension reports

authors： Roush GC,Buddharaju V,Ernst ME,Holford TR

更新日期：2013-10-01 00:00:00

abstract：:Levels of urinary albumin excretion that are below the usual limit of detection by qualitative testing, but are above normal levels (microalbuminuria; MA), can be readily identified by simple measures, such as the urinary albumin to creatinine ratio in untimed urine samples. Such measurements, particularly when combin...

journal_title：Current hypertension reports

authors： Glassock RJ

更新日期：2010-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the current literature on use of telehealth at different stages of the hypertension control cascade in sub-Saharan Africa (SSA) and to discuss opportunities to harness technology infrastructure in SSA to improve population-level blood pressure control. RECENT FINDINGS:Despite the high burde...

journal_title：Current hypertension reports

authors： Muiruri C,Manavalan P,Jazowski SA,Knettel BA,Vilme H,Zullig LL

更新日期：2019-08-26 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes the latest science on hypertensive encephalopathy and posterior reversible encephalopathy syndrome (PRES). We review the epidemiology and pathophysiology of these overlapping syndromes and discuss best practices for diagnosis and management. RECENT FINDINGS:Diagnosis of hyperte...

journal_title：Current hypertension reports

authors： Miller JB,Suchdev K,Jayaprakash N,Hrabec D,Sood A,Sharma S,Levy PD

更新日期：2018-02-26 00:00:00

abstract：:This paper critically addresses the issue of the "J-curve" paradox--the finding described in studies performed about 30 years ago indicating that treatment-induced systolic blood pressure values below 120 or 125 mm Hg and diastolic blood pressure values below 75 mm Hg are characterized by an increase, rather than a re...

journal_title：Current hypertension reports

authors： Grassi G,Quarti-Trevano F,Dell'Oro R,Mancia G

更新日期：2010-08-01 00:00:00

abstract：:The nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling system is a well-characterized modulator of cardiovascular function, in general, and blood pressure, in particular. The availability of mice mutant for key enzymes in the NO-cGMP signaling system facilitated the identification of interactions with o...

journal_title：Current hypertension reports

authors： Thoonen R,Sips PY,Bloch KD,Buys ES

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate recent developments in the management of hypertension in obese pregnant women. RECENT FINDINGS:The mainstay of management targets prevention of hypertension with preconception counselling, entering pregnancy with a lower BMI, limiting weight gain, and taking low-dose aspirin to prevent pr...

journal_title：Current hypertension reports

authors： Coroyannakis C,Khalil A

更新日期：2019-03-26 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) is a major proteolytic system that regulates the degradation of intracellular proteins in the heart. The UPS regulates the turnover of misfolded and damaged proteins, in addition to numerous cellular processes, by affecting the stability of short-lived proteins such as transcripti...

journal_title：Current hypertension reports

authors： Rodríguez JE,Schisler JC,Patterson C,Willis MS

更新日期：2009-12-01 00:00:00

abstract：:The discovery of beneficial neuroprotective effects of the angiotensin converting enzyme 2-angiotensin-(1-7)-Mas axis [ACE2-Ang-(1-7)-Mas] in ischemic and hemorrhagic stroke has spurred interest in a more complete characterization of its mechanisms of action. Here, we summarize findings that describe the protective ro...

journal_title：Current hypertension reports

authors： Bennion DM,Haltigan E,Regenhardt RW,Steckelings UM,Sumners C

更新日期：2015-02-01 00:00:00

abstract：:Hypertension is very common in patients with chronic renal failure and contributes to cardiovascular morbidity and mortality. Several mechanisms may contribute to hypertension in these patients, but recently a large body of evidence supports the notion that activation of the sympathetic nervous system (SNS) may play a...

journal_title：Current hypertension reports

authors： Campese VM,Krol E

更新日期：2002-06-01 00:00:00

abstract：:The treatment of hypertension is proven to reduce cardiovascular and renal risk. Combination drug therapy is becoming recognized as a necessity in most patients with hypertension and kidney disease. Allegations about the safe use of calcium antagonists in patients with kidney disease have led to questions and confusio...

journal_title：Current hypertension reports

authors： Tobe S,Epstein M

更新日期：2002-06-01 00:00:00

abstract：:Obesity is recognized as a major health problem throughout the world. Excess weight is a major cause of increased blood pressure in most patients with essential hypertension and greatly increases the risk for diabetes, cardiovascular diseases, and end-stage renal disease. Although the mechanisms by which obesity raise...

journal_title：Current hypertension reports

authors： da Silva AA,do Carmo J,Dubinion J,Hall JE

更新日期：2009-06-01 00:00:00

abstract：:The metabolic syndrome leads to cardiovascular disease and type 2 diabetes mellitus, through multiple risks, such as insulin resistance, dyslipidemia, hyperinsulinemia, and hypertension. It also represents a disorder of partial genetic background as mutations of the peroxisome proliferator-activated receptor-gamma (PP...

journal_title：Current hypertension reports

authors： Tuck ML

更新日期：2005-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine available clinical data on the differences between premenopausal and postmenopausal women with hypertension (HTN). Clinical conditions related to HTN and reproductive status differ in younger women compared with older women. Due to recent changes in the definition of HTN, the prevalence of ...

journal_title：Current hypertension reports

authors： Brahmbhatt Y,Gupta M,Hamrahian S

更新日期：2019-08-26 00:00:00

abstract：:Endothelin receptor antagonists (ERAs) have the potential to be a new paradigm in the treatment of chronic kidney disease (CKD). ERAs inhibit the effects of endothelin-1 (ET-1), which is known to promote CKD by causing renal cellular injury, proteinuria, inflammation, fibrosis, and hypertrophy. ERAs have been extensiv...

journal_title：Current hypertension reports

authors： Tobe S,Kohan DE,Singarayer R

更新日期：2015-07-01 00:00:00

abstract：:The World Health Organization's annual report World Health Statistics 2012 was recently published. In addition to annually published indicators of health, this year's report contains a highlighted new section on non-communicable diseases and their impact on world health. The section gives particular attention to hyper...

journal_title：Current hypertension reports

authors： Owen J,Reisin E

更新日期：2012-12-01 00:00:00

abstract：:There is increasing concern that sugar consumption may be linked to the development of metabolic and cardiovascular diseases. There is indeed strong evidence that consumption of energy-dense sugary beverages and foods is associated with increased energy intake and body weight gain over time. It is further proposed tha...

journal_title：Current hypertension reports

authors： Rosset R,Surowska A,Tappy L

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The major health issue of being overweight or obese relates to the development of hypertension, insulin resistance and diabetic complications. One of the major underlying factors influencing the elevated blood pressure in obesity is increased activity of the sympathetic nerves to particular organs suc...

journal_title：Current hypertension reports

authors： Lim K,Jackson KL,Sata Y,Head GA

更新日期：2017-07-01 00:00:00

abstract：:The central nervous system plays a key role in the regulation of cardiovascular function, and alterations in the central neural mechanisms that control blood pressure may underlie the vast majority of cases of primary hypertension. The well-studied baroreceptor reflex powerfully regulates arterial pressure, though its...

journal_title：Current hypertension reports

authors： Sved AF,Ito S,Sved JC

更新日期：2003-06-01 00:00:00

abstract：:The presence of renin production by the principal cells of the collecting duct has opened new perspectives for the regulation of intrarenal angiotensin II (Ang II). Angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) are present in the tubular fluid coming from the proximal tubule and collecting duct. All th...

journal_title：Current hypertension reports

authors： Gonzalez AA,Lara LS,Prieto MC

更新日期：2017-08-01 00:00:00

abstract：:Angiotensin II (Ang II) has actions on the sympathetic nervous system both as a circulating hormone acting on the circumventricular organs and also as a neurotransmitter/ neuromodulator acting within the brain. Administration of Ang II into the cerebral ventricles has diverse effects on sympathetic nerve activity (SNA...

journal_title：Current hypertension reports

authors： Ramchandra R,Yao ST,May CN

更新日期：2013-08-01 00:00:00

abstract：:Women with chronic hypertension and pregnancy-induced hypertension are at substantial risk for developing pre-eclampsia/eclampsia, a disease with high fetomaternal morbidity and mortality. However, the etiology of this disease is still unknown. In this article, recent concepts on the pathophysiology of pre-eclampsia, ...

journal_title：Current hypertension reports

authors： Kashiwagi M,Zimmermann R,Beinder E

更新日期：2003-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To review latest reports of the food products which might increase blood pressure and therefore might participate in the pathogenesis of hypertension. RECENT FINDINGS:Results of clinical study suggest that consumption of high-sodium food leads to transient increase in plasma sodium concentration. Thi...

journal_title：Current hypertension reports

authors： Adamczak M,Wiecek A

更新日期：2020-01-08 00:00:00

abstract：PURPOSE OF REVIEW:Renal sympathetic denervation (RDN) as treatment option for hypertension has a strong rationale; however, variable effects on blood pressure (BP) have been reported ranging from non-response to marked reductions in BP. The absence of a procedural end point for RDN is one of the potential factors assoc...

journal_title：Current hypertension reports

authors： Hoogerwaard AF,de Jong MR,Elvan A

更新日期：2018-03-19 00:00:00

abstract：:Patients with hypertension have a high prevalence of concurrent metabolic abnormalities (eg, obesity, dyslipidemia, and hyperglycemia). Clustering of these risk factors, defined as the metabolic syndrome, is associated with a high cardiovascular risk profile. This review summarizes current knowledge about the prevalen...

journal_title：Current hypertension reports

authors： Fallo F,Federspil G,Veglio F,Mulatero P

更新日期：2007-04-01 00:00:00

abstract：:The epithelial sodium channel (ENaC) is a membrane protein made of three different but homologous subunits (a, b, and g) present in the apical membrane of epithelial cells of, for example, the distal nephron. This channel is responsible for salt reabsorption in the kidney and can cause human diseases by increasing cha...

journal_title：Current hypertension reports

authors： Hummler E

更新日期：2003-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The overactive renin-angiotensin-aldosterone system (RAAS) plays an important part in many pathologic conditions including hypertension, heart failure, and renal disease. Hyperkalemia, a potentially life-threatening side effect of RAAS inhibitors, limits their use. The recent introduction of new hyper...

journal_title：Current hypertension reports

authors： Rastogi A,Arman F,Alipourfetrati S

更新日期：2016-07-01 00:00:00

abstract：:Oxidative stress is known to be implicated in the pathogenesis of essential hypertension. Glutathione-S-transferase (GST) enzymes are key components of cellular defense against oxidative stress. The present study aimed to clarify the association between polymorphisms in GST and risk of essential hypertension using a m...

journal_title：Current hypertension reports

authors： Eslami S,Sahebkar A

更新日期：2014-06-01 00:00:00

abstract：:Current national guidelines recommend aggressive lowering of blood pressure (< 130/80 mm Hg) in patients with chronic kidney disease (CKD). In this paper, we summarize recent clinical trial data evaluating the effect of lower blood pressure goals on renal outcomes. The epidemiologic data relating blood pressure to pro...

journal_title：Current hypertension reports

authors： Rahman M,El-Meanawy A,Romanello J

更新日期：2005-10-01 00:00:00

abstract：PURPOSE OF REVIEW:In chronic kidney disease (CKD), plasma uric acid levels are increased because of the decrease in glomerular filtration rate. However, in addition to CKD, hyperuricemia is frequently associated with a number of other conditions such as hypertension, type 2 diabetes, obesity, and heart failure, overwei...

journal_title：Current hypertension reports

authors： Kielstein JT,Pontremoli R,Burnier M

更新日期：2020-10-31 00:00:00