Abstract:
:Individuals with hypertension need to stay on therapy with antihypertensive medication to obtain the full benefits of blood pressure reduction. There are important differences in tolerability across antihypertensive drug classes, and these differences influence the extent to which patients are willing to continue taking their drugs. Three separate sources of evidence--postmarket surveillance studies, medical/prescription database studies, and discontinuation of study medication in long-term endpoint clinical trials--support the proposition that angiotensin II antagonists, the newest class of antihypertensives, are well tolerated, and that patients whose initial treatment is an angiotensin II antagonist are more likely to persist with therapy than patients who use other classes of antihypertensives. Recent landmark trials with losartan in hypertensive patients with left ventricular hypertrophy (Losartan Intervention For Endpoint reduction [LIFE]) and in diabetes (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan [RENAAL]) demonstrated excellent tolerability, a high level of persistence, and clinical benefits exceeding those provided by blood pressure control alone for the prototype angiotensin II antagonist in clinical settings.
journal_name
Curr Hypertens Repjournal_title
Current hypertension reportsauthors
Gerth WCdoi
10.1007/s11906-002-0021-6keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
424-33issue
6eissn
1522-6417issn
1534-3111journal_volume
4pub_type
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journal_title:Current hypertension reports
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更新日期:2012-02-01 00:00:00
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更新日期:2015-05-01 00:00:00
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journal_title:Current hypertension reports
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更新日期:2010-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-09-19 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2012-12-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2004-04-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章
doi:10.1007/s11906-011-0207-x
更新日期:2011-08-01 00:00:00
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journal_title:Current hypertension reports
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journal_title:Current hypertension reports
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更新日期:2008-02-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2019-08-26 00:00:00
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更新日期:2020-09-03 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2003-10-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2014-02-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2015-06-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00
abstract::Nycthemeral changes in renal function have been known for a long time, but our knowledge about the underlying mechanisms is still far from complete. From a theoretical point of view, many physiological systems could be involved in turning the kidney from a sodium-excretory organ during daytime into a sodium-conserving...
journal_title:Current hypertension reports
pub_type: 杂志文章,评审
doi:10.1007/s11906-011-0183-1
更新日期:2011-04-01 00:00:00