Invasive treatment of resistant hypertension: present and future.

abstract：:Atherosclerotic cardiovascular disease (CVD) is the most common cause of death worldwide. Usually atherosclerosis is caused by the combined effects of multiple risk factors. For this reason, most guidelines on the prevention of CVD stress the assessment of total CVD risk. The most intensive risk factor modification ca...

journal_title：Current hypertension reports

authors： Cooney MT,Cooney HC,Dudina A,Graham IM

更新日期：2010-10-01 00:00:00

abstract：:Primary aldosteronism (PA) is a common cause of arterial hypertension: in the PA Prevalence in Hypertensives (PAPY) Study, the prevalence of PA was 11.2% in consecutive referred hypertensive patients. When adrenal vein sampling (AVS) is available, two thirds of the cases can be attributed to a tumor and one third of c...

journal_title：Current hypertension reports

authors： Rossi GP

更新日期：2010-10-01 00:00:00

abstract：:The metabolic syndrome leads to cardiovascular disease and type 2 diabetes mellitus, through multiple risks, such as insulin resistance, dyslipidemia, hyperinsulinemia, and hypertension. It also represents a disorder of partial genetic background as mutations of the peroxisome proliferator-activated receptor-gamma (PP...

journal_title：Current hypertension reports

authors： Tuck ML

更新日期：2005-08-01 00:00:00

abstract：:The renin-angiotensin system (RAS) plays an important role in the initiation and progression of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. In the past t...

journal_title：Current hypertension reports

authors： Namsolleck P,Recarti C,Foulquier S,Steckelings UM,Unger T

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:We focus on the current understanding of preeclampsia (PE) in order to examine how it mediates glomerular injury and affects the course of glomerulonephritis (GNs). In addition, this review discusses the role of GNs on the development of PE. RECENT FINDINGS:In PE, the dysfunctional utero-placental pe...

journal_title：Current hypertension reports

authors： Di Leo V,Capaccio F,Gesualdo L

更新日期：2020-03-21 00:00:00

abstract：PURPOSE OF REVIEW:Hypertension remains to be a major contributor to global morbidity and mortality. Despite a plethora of pharmacological options available, an abundance of patients have uncontrolled blood pressure thus creating the need for additional strategies, including non-pharmacologic approaches. In this review,...

journal_title：Current hypertension reports

authors： Cernes R,Zimlichman R

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The pathophysiology of preeclampsia is complex and not entirely understood. A key feature in preeclampsia development is an immunological imbalance that shifts the maternal immune response from one of tolerance towards one promoting chronic inflammation and endothelial dysfunction. As a key regulator ...

journal_title：Current hypertension reports

authors： Cubro H,Kashyap S,Nath MC,Ackerman AW,Garovic VD

更新日期：2018-04-30 00:00:00

abstract：PURPOSE OF REVIEW:Use of antihypertensives in older adults can be complicated by the potential for undesired effects on comorbidities, adverse effects of the drugs, and overall medication burden. The purpose of this two-part review is to discuss contemporary issues encountered in the management of hypertension in aged ...

journal_title：Current hypertension reports

authors： Ernst ME,MacLaughlin EJ

更新日期：2019-10-10 00:00:00

abstract：:High blood pressure in the setting of type 1 and type 2 diabetes is commonly associated with the earlier development of target-organ damage, including cardiovascular and cerebrovascular disease and progressive renal insufficiency. The major goal of treating high blood pressure in this population is to prevent or reduc...

journal_title：Current hypertension reports

authors： Lu WX,Lakkis J,Weir MR

更新日期：2003-06-01 00:00:00

abstract：:Levels of urinary albumin excretion that are below the usual limit of detection by qualitative testing, but are above normal levels (microalbuminuria; MA), can be readily identified by simple measures, such as the urinary albumin to creatinine ratio in untimed urine samples. Such measurements, particularly when combin...

journal_title：Current hypertension reports

authors： Glassock RJ

更新日期：2010-10-01 00:00:00

abstract：:Patients with hypertension have a high prevalence of concurrent metabolic abnormalities (eg, obesity, dyslipidemia, and hyperglycemia). Clustering of these risk factors, defined as the metabolic syndrome, is associated with a high cardiovascular risk profile. This review summarizes current knowledge about the prevalen...

journal_title：Current hypertension reports

authors： Fallo F,Federspil G,Veglio F,Mulatero P

更新日期：2007-04-01 00:00:00

abstract：:Women with chronic hypertension and pregnancy-induced hypertension are at substantial risk for developing pre-eclampsia/eclampsia, a disease with high fetomaternal morbidity and mortality. However, the etiology of this disease is still unknown. In this article, recent concepts on the pathophysiology of pre-eclampsia, ...

journal_title：Current hypertension reports

authors： Kashiwagi M,Zimmermann R,Beinder E

更新日期：2003-12-01 00:00:00

abstract：:The publication of the Antihypertensive and Lipid-lowering Treatment to Prevent Heart Attack Trial (ALLHAT) results, when used in conjunction with a new meta-analysis, provides hypertension research with a watershed. Data demonstrate clearly that lowering blood pressure is the most important aspect of hypertension man...

journal_title：Current hypertension reports

authors： Wang JG,Staessen JA,Heagerty AM

更新日期：2003-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide insight into the mechanisms underlying cerebral pathophysiology and to highlight possible methods for evaluation, screening, and surveillance of cerebral complications in preeclampsia. RECENT FINDINGS:The pathophysiology of eclampsia remains enigmatic. Animal studies show that the cerebral...

journal_title：Current hypertension reports

authors： Bergman L,Torres-Vergara P,Penny J,Wikström J,Nelander M,Leon J,Tolcher M,Roberts JM,Wikström AK,Escudero C

更新日期：2019-08-02 00:00:00

abstract：:LCZ696 is a single molecule which combines the angiotensin receptor blocker valsartan with the neprilysn inhibitor sacubitril (AHU377). In the recently published PARADIGM-HF trial, LCZ696 proved superior to enalapril in reducing overall mortality, heart failure hospitalizations, and other endpoints in patients with sy...

journal_title：Current hypertension reports

authors： Gradman AH

更新日期：2015-05-01 00:00:00

abstract：:Diabetes mellitus is one of the leading causes of end-stage renal disease. The pathogenesis of diabetic nephropathy is still poorly understood, but glomerular injury has been ascribed, at least in part, to glomerular hyperfiltration, which occurs early in the course of diabetes mellitus. Therefore, a better understand...

journal_title：Current hypertension reports

authors： Vallon V,Blantz R,Thomson S

更新日期：2005-04-01 00:00:00

abstract：:Vasopeptidase inhibitors are a new class of drugs capable of inhibiting both angiotensin-converting enzyme and neutral endopeptidase 24.11. This involves simultaneous inhibition with a single molecule of two key enzymes, ACE and NEP, which are both involved in the regulation of cardiovascular homeostasis in many ways....

journal_title：Current hypertension reports

authors： d'Uscio LV,Lüscher TF

更新日期：2001-12-01 00:00:00

abstract：:Essential hypertension is associated with impaired endothelium-dependent vasodilation and is caused mainly by production of oxygen free radicals that can destroy nitric oxide (NO), impairing its beneficial and protective effects on the vessel wall. Antihypertensive drugs can improve or restore endothelium-dependent va...

journal_title：Current hypertension reports

authors： Taddei S,Virdis A,Ghiadoni L,Sudano I,Salvetti A

更新日期：2000-02-01 00:00:00

abstract：:Epinephrine is the prototypical stress hormone. Its stimulation of all α and β adrenergic receptors elicits short-term systolic hypertension, hyperglycemia, and other aspects of the metabolic syndrome. Acute epinephrine infusion increases cardiac output and induces insulin resistance, but removal of the adrenal medull...

journal_title：Current hypertension reports

authors： Ziegler MG,Elayan H,Milic M,Sun P,Gharaibeh M

更新日期：2012-02-01 00:00:00

abstract：:With current immunosuppression, elevated blood pressure is found in almost 90% of renal graft recipients. Major causes of this are impairment of renal function (secondary to chronic allograft nephropathy or less frequently recurrence of primary renal disease), the use of calcineurin inhibitors as immunosuppressants, u...

journal_title：Current hypertension reports

authors： Schwenger V,Zeier M,Ritz E

更新日期：2001-10-01 00:00:00

abstract：:Cardiovascular disease is the leading cause of death in women and claims the lives of more than half a million women every year. Hypertension is one of the most prevalent and powerful contributors to atherosclerotic cardiovascular disease. Hypertension affects more men than women until 55 years of age, but after age 5...

journal_title：Current hypertension reports

authors： Harrison-Bernard LM,Raij L

更新日期：2000-04-01 00:00:00

abstract：PURPOSE OF REVIEW:In chronic kidney disease (CKD), plasma uric acid levels are increased because of the decrease in glomerular filtration rate. However, in addition to CKD, hyperuricemia is frequently associated with a number of other conditions such as hypertension, type 2 diabetes, obesity, and heart failure, overwei...

journal_title：Current hypertension reports

authors： Kielstein JT,Pontremoli R,Burnier M

更新日期：2020-10-31 00:00:00

abstract：:Aldosterone antagonists have been highly successful in treating congestive heart failure and resistant hypertension. Until recently, therapies targeting the mineralocorticoid receptor in chronic kidney disease (CKD) have received little attention, largely because of the risk of hyperkalemia and the incorrect assumptio...

journal_title：Current hypertension reports

authors： Volk MJ,Bomback AS,Klemmer PJ

更新日期：2011-08-01 00:00:00

abstract：:Diabetes mellitus is well recognized as a potent and prevalent risk factor for accelerated atherosclerosis and ischemic heart disease. However, there is also evidence of cardiac dysfunction in diabetes in the absence of coronary atherosclerosis, termed diabetic cardiomyopathy. Changes in ventricular structure and left...

journal_title：Current hypertension reports

authors： Karnik AA,Fields AV,Shannon RP

更新日期：2007-12-01 00:00:00

abstract：:Progressive abnormalities of passive stiffness or active relaxation of the myocardium that impair ventricular filling during diastole may be an important contributor to the development of heart failure in patients with preserved ejection fraction. In this review, we discuss the epidemiology and pathophysiology of dias...

journal_title：Current hypertension reports

authors： Janardhanan R,Desai AS,Solomon SD

更新日期：2009-08-01 00:00:00

abstract：:Hypertension is a preventable condition, and the outcomes of clinical trials have established that its treatment reduces cardiovascular morbidity and mortality. Although awareness about the disease has improved in the past two decades, the reality is that many people remain untreated or not adequately controlled. The ...

journal_title：Current hypertension reports

authors： Nunes MI

更新日期：2001-12-01 00:00:00

abstract：:Our understanding of Na(+) transport defects has exploded in the past several years, and has provided unique insights into epithelial transport processes, and unusual clinical syndromes resulting from mutations of specific ion transporters. These genetic disorders affect Na(+) balance, with both Na(+) retaining and Na...

journal_title：Current hypertension reports

authors： Warnock DG

更新日期：1999-04-01 00:00:00

abstract：:Diastolic pressure, systolic pressure, and pulse pressure have all been assigned the role of the best predictor of cardiovascular events during the 20th century. At the dawn of the new millennium, concepts that draw attention to vascular mechanics reconcile the seemingly conflicting results of epidemiologic studies, b...

journal_title：Current hypertension reports

authors： Vlachopoulos C,O'Rourke M

更新日期：2000-06-01 00:00:00

abstract：:Masked hypertension refers to the phenomenon of having a non-elevated clinic blood pressure (BP) despite having an elevated out-of-clinic BP. Masked hypertension is a common phenotype with a cardiovascular risk profile similar to that of sustained hypertension, defined as elevated clinic and out-of-clinic BP. Current ...

journal_title：Current hypertension reports

authors： Anstey DE,Pugliese D,Abdalla M,Bello NA,Givens R,Shimbo D

更新日期：2017-10-25 00:00:00

abstract：:When a large multicenter research trial is abruptly terminated, it is usually a consequence of significant adverse events. In contrast, when the Randomized Aldactone Evaluation Study (RALES) mortality trial was discontinued 18 months early, it was because of the prominent salutary effect of spironolactone, added to st...

journal_title：Current hypertension reports

authors： Soberman JE,Weber KT

更新日期：2000-10-01 00:00:00