Endothelial arginase: a new target in atherosclerosis.

abstract：:Blood pressure is typically lower in premenopausal women than in men. However, after menopause, the prevalence of hypertension in women is higher than it is in men. Hypertension is a major risk factor for cardiovascular disease in women and men, but cardiovascular disease is the leading cause of death in women. Furthe...

journal_title：Current hypertension reports

authors： Lima R,Wofford M,Reckelhoff JF

更新日期：2012-06-01 00:00:00

abstract：:Essential hypertension is associated with impaired endothelium-dependent vasodilation and is caused mainly by production of oxygen free radicals that can destroy nitric oxide (NO), impairing its beneficial and protective effects on the vessel wall. Antihypertensive drugs can improve or restore endothelium-dependent va...

journal_title：Current hypertension reports

authors： Taddei S,Virdis A,Ghiadoni L,Sudano I,Salvetti A

更新日期：2000-02-01 00:00:00

abstract：:High-quality medical care requires implementing evidence-based best practices, with continued monitoring to improve performance. Implementation science is beginning to identify approaches to developing, implementing, and evaluating quality improvement strategies across health care systems that lead to good outcomes fo...

journal_title：Current hypertension reports

authors： Goldstein MK

更新日期：2008-06-01 00:00:00

abstract：:Cardiovascular disease disproportionately affects minority populations, in part because of multiple sociocultural factors that directly affect compliance with antihypertensive medication regimens. Compliance is a complex health behavior determined by a variety of socioeconomic, individual, familial, and cultural facto...

journal_title：Current hypertension reports

authors： Betancourt JR,Carrillo JE,Green AR

更新日期：1999-12-01 00:00:00

abstract：:Excess weight gain is a major cause of essential hypertension, and abnormal kidney function appears to be a cause as well as a consequence of obesity hypertension. Excess renal sodium reabsorption and a hypertensive shift of pressure natriuresis play a major role in mediating increased blood pressure associated with w...

journal_title：Current hypertension reports

authors： Hall JE

更新日期：2000-04-01 00:00:00

abstract：:Epinephrine is the prototypical stress hormone. Its stimulation of all α and β adrenergic receptors elicits short-term systolic hypertension, hyperglycemia, and other aspects of the metabolic syndrome. Acute epinephrine infusion increases cardiac output and induces insulin resistance, but removal of the adrenal medull...

journal_title：Current hypertension reports

authors： Ziegler MG,Elayan H,Milic M,Sun P,Gharaibeh M

更新日期：2012-02-01 00:00:00

abstract：:In the quest for "evidence-based" medicine, an accepted hierarchy of evidence has been proposed. This hierarchy places in vitro studies and animal data at the base, and puts systematic reviews, meta-analyses, and randomized controlled trials at the pinnacle. However, when clinical medicine faces questions that have no...

journal_title：Current hypertension reports

authors： Hawkins RG

更新日期：2006-06-01 00:00:00

abstract：:Diabetes mellitus is one of the leading causes of end-stage renal disease. The pathogenesis of diabetic nephropathy is still poorly understood, but glomerular injury has been ascribed, at least in part, to glomerular hyperfiltration, which occurs early in the course of diabetes mellitus. Therefore, a better understand...

journal_title：Current hypertension reports

authors： Vallon V,Blantz R,Thomson S

更新日期：2005-04-01 00:00:00

abstract：:Hypertension is a preventable condition, and the outcomes of clinical trials have established that its treatment reduces cardiovascular morbidity and mortality. Although awareness about the disease has improved in the past two decades, the reality is that many people remain untreated or not adequately controlled. The ...

journal_title：Current hypertension reports

authors： Nunes MI

更新日期：2001-12-01 00:00:00

abstract：:Although it is clear that hypertension is a primary cause of stroke, there has been controversy concerning blood pressure management after stroke. Recent studies indicate that lowering systemic blood pressure after stroke reduces the risk for recurrent stroke or vascular events, but other studies provide evidence that...

journal_title：Current hypertension reports

authors： Hillis AE

更新日期：2005-02-01 00:00:00

abstract：:The metabolic syndrome associates metabolic abnormalities such as insulin resistance and dyslipidemia with increased waist circumference and hypertension. It is a major public health concern, as its prevalence could soon reach 30% to 50% in developed countries. Aldosterone, a mineralocorticoid hormone classically invo...

journal_title：Current hypertension reports

authors： Briet M,Schiffrin EL

更新日期：2011-04-01 00:00:00

abstract：:The obesity gene product leptin plays an important role in the physiologic regulation of appetite and energy balance. Plasma leptin levels correlate closely with body fat storage and may respond to changes in energy expenditure. Recent evidence has implicated a direct cardiac regulatory action of leptin in addition to...

journal_title：Current hypertension reports

authors： Ren J,Ma H

更新日期：2008-12-01 00:00:00

abstract：:The adverse cardiovascular consequences of high blood pressure (BP) not only depend on absolute BP values, but also on BP variability (BPV). Evidence has been provided that independently of mean BP levels, BP variations in the short- and long-term are associated with the development, progression and severity of cardia...

journal_title：Current hypertension reports

authors： Parati G,Ochoa JE,Bilo G

更新日期：2012-10-01 00:00:00

abstract：:Antiplatelet agents represent a cornerstone in the management of patients at increased cardiovascular risk. Essential hypertension is considered a major public health problem leading to increased cardiovascular morbidity and mortality. The majority of patients with essential hypertension exhibit also additional cardio...

journal_title：Current hypertension reports

authors： Gkaliagkousi E,Gavriilaki E,Douma S

更新日期：2015-04-01 00:00:00

abstract：:Chronic kidney disease is a major public health problem worldwide: it is estimated that in the general population, 1 person in 10 has some degree of renal damage. Adequate blood pressure control represents the mainstay of treatment, to delay deterioration of renal function and prevent cardiovascular complications. Cur...

journal_title：Current hypertension reports

authors： Leoncini G,Viazzi F,Pontremoli R

更新日期：2010-10-01 00:00:00

abstract：:Cardiovascular disease is the leading cause of death in women and claims the lives of more than half a million women every year. Hypertension is one of the most prevalent and powerful contributors to atherosclerotic cardiovascular disease. Hypertension affects more men than women until 55 years of age, but after age 5...

journal_title：Current hypertension reports

authors： Harrison-Bernard LM,Raij L

更新日期：2000-04-01 00:00:00

abstract：:Interpretation of some recent trials in hypertension opened a debate on the clinical value of new-onset diabetes in treated hypertensive patients. It is not completely clear whether certain antihypertensive drug classes are associated with a higher risk for developing type 2 diabetes when compared with other classes. ...

journal_title：Current hypertension reports

authors： Verdecchia P,Angeli F,Reboldi GP,Gattobigio R

更新日期：2005-06-01 00:00:00

abstract：:We are used to thinking of angiotensin (Ang) II as a regulatory hormone that stimulates constriction of vascular smooth muscle cells, aldosterone release from the adrenal gland, and sodium reabsorption in the renal tubule. We have also become accustomed to understanding that Ang II may be formed and may act locally as...

journal_title：Current hypertension reports

authors： Luft FC

更新日期：2001-02-01 00:00:00

abstract：:Elevation of blood pressure (BP) and the risk for progression to hypertension (HTN) is of increasing concern in children and adolescents. Indeed, it is increasingly recognized that target organ injury may begin with even low levels of BP elevation. Sodium intake has long been recognized as a modifiable risk factor for...

journal_title：Current hypertension reports

authors： Hanevold CD

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The overactive renin-angiotensin-aldosterone system (RAAS) plays an important part in many pathologic conditions including hypertension, heart failure, and renal disease. Hyperkalemia, a potentially life-threatening side effect of RAAS inhibitors, limits their use. The recent introduction of new hyper...

journal_title：Current hypertension reports

authors： Rastogi A,Arman F,Alipourfetrati S

更新日期：2016-07-01 00:00:00

abstract：:Prorenin and renin bind to a 350-amino acid protein called the (pro)renin receptor, which is present on the surface and functions intracellularly. When the receptor's N terminus binds either prorenin or renin, intracellular signaling occurs via extracellular-regulated kinases, which can result in plasminogen activator...

journal_title：Current hypertension reports

authors： Müller DN,Luft FC

更新日期：2008-10-01 00:00:00

abstract：:The concept of "perioperative hypertensive emergency" must be defined differently from that of ambulatory hypertensive emergency in view of its unique clinical considerations in an atypical setting. It should be noted that moderately high normal blood pressure (BP) values in the perioperative setting often trigger sit...

journal_title：Current hypertension reports

authors： Aronson S

更新日期：2014-07-01 00:00:00

abstract：:This review is focused on the interplay between two major factors affecting the vascular tree in diabetes, insulin resistance, and hyperglycemia. The implications for vascular function, structure, and the interaction between vascular cells and other tissues by which they are affected under these conditions are reviewe...

journal_title：Current hypertension reports

authors： Stern N,Marcus Y

更新日期：2004-04-01 00:00:00

abstract：:Sympathetic nerve activity is involved in the pathogenesis of salt-sensitive hypertension. The central nervous system, which regulates sympathetic nerve activity and blood pressure, plays a pivotal role. Central sympathoexcitation is deeply involved in the pathogenesis of salt-sensitive hypertension, although the prec...

journal_title：Current hypertension reports

authors： Fujita M,Fujita T

更新日期：2016-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This article introduces the haemodynamic principles that underpin the pathophysiology of hypertension and introduces a rational physiological approach to appropriate pharmacologic treatment. RECENT FINDINGS:Outdated understanding of haemodynamics based on previous measurement systems can no longer be...

journal_title：Current hypertension reports

authors： Smith BE,Madigan VM

更新日期：2018-04-10 00:00:00

abstract：:Hypertension is the leading risk factor for the global burden of disease, yet more than 20% of adults with hypertension are unaware of their condition. Underlying hypertension affects over 25% emergency department attendees, and the condition is more commonly encountered in emergency departments than in primary care s...

journal_title：Current hypertension reports

authors： Chan SS,Graham CA,Rainer TH

更新日期：2016-04-01 00:00:00

abstract：:The research on molecular genetics of human hypertension aims to identify the loci involved in the regulation of blood pressure, detect gene variants within the identified loci, associate them with intermediate phenotypes, and ultimately estimate their quantitative effects on blood pressure level and their interaction...

journal_title：Current hypertension reports

authors： Jeunemaitre X,Gimenez-Roqueplo AP,Célérier J,Corvol P

更新日期：1999-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes the latest science on hypertensive encephalopathy and posterior reversible encephalopathy syndrome (PRES). We review the epidemiology and pathophysiology of these overlapping syndromes and discuss best practices for diagnosis and management. RECENT FINDINGS:Diagnosis of hyperte...

journal_title：Current hypertension reports

authors： Miller JB,Suchdev K,Jayaprakash N,Hrabec D,Sood A,Sharma S,Levy PD

更新日期：2018-02-26 00:00:00

abstract：:The inhibition of angiotensin II through angiotensin converting enzyme inhibitors or angiotensin receptor blockers has become the foundation of medical treatment of progressive chronic renal disease. Although these drugs provide a significant improvement over earlier treatments, they only slow the progression of renal...

journal_title：Current hypertension reports

authors： Gaedeke J,Noble NA,Border WA

更新日期：2002-10-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) is a major proteolytic system that regulates the degradation of intracellular proteins in the heart. The UPS regulates the turnover of misfolded and damaged proteins, in addition to numerous cellular processes, by affecting the stability of short-lived proteins such as transcripti...

journal_title：Current hypertension reports

authors： Rodríguez JE,Schisler JC,Patterson C,Willis MS

更新日期：2009-12-01 00:00:00