Ongoing trials: what should we expect after ALLHAT?

Abstract:

:The publication of the Antihypertensive and Lipid-lowering Treatment to Prevent Heart Attack Trial (ALLHAT) results, when used in conjunction with a new meta-analysis, provides hypertension research with a watershed. Data demonstrate clearly that lowering blood pressure is the most important aspect of hypertension management, and that all agents are similarly effective. There is little sustainable evidence for pressure-independent advantages for any class of drug at this time. Therefore, by combining these findings with additional information on target levels of blood pressure and safety, plus the use of aspirin and statins, we can formulate health care policies that attack hypertension in a holistic risk-based way. The future will focus on gaining extra benefit for patients by testing the efficacy and superiority of drug combinations using novel agents that favorably influence intermediate markers such as arterial stiffness, and arresting the ever-increasing burden of cognitive impairment and dementia.

journal_name

Curr Hypertens Rep

authors

Wang JG,Staessen JA,Heagerty AM

doi

10.1007/s11906-003-0044-7

keywords:

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

340-5

issue

4

eissn

1522-6417

issn

1534-3111

journal_volume

5

pub_type

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