AT(2) receptor and tissue injury: therapeutic implications.

abstract：:The metabolic syndrome leads to cardiovascular disease and type 2 diabetes mellitus, through multiple risks, such as insulin resistance, dyslipidemia, hyperinsulinemia, and hypertension. It also represents a disorder of partial genetic background as mutations of the peroxisome proliferator-activated receptor-gamma (PP...

journal_title：Current hypertension reports

authors： Tuck ML

更新日期：2005-08-01 00:00:00

abstract：:The various antihypertensive regimens have varying effects on glucose metabolism and the development of diabetes mellitus. Recent large hypertension trials have shown great differences in the development of new-onset diabetes among antihypertensive drug therapies. The incidence of diabetes is unchanged or increased by...

journal_title：Current hypertension reports

authors： Aksnes TA,Reims HM,Kjeldsen SE,Mancia G

更新日期：2005-08-01 00:00:00

abstract：:Current national guidelines recommend aggressive lowering of blood pressure (< 130/80 mm Hg) in patients with chronic kidney disease (CKD). In this paper, we summarize recent clinical trial data evaluating the effect of lower blood pressure goals on renal outcomes. The epidemiologic data relating blood pressure to pro...

journal_title：Current hypertension reports

authors： Rahman M,El-Meanawy A,Romanello J

更新日期：2005-10-01 00:00:00

abstract：:Atherosclerotic cardiovascular disease (CVD) is the most common cause of death worldwide. Usually atherosclerosis is caused by the combined effects of multiple risk factors. For this reason, most guidelines on the prevention of CVD stress the assessment of total CVD risk. The most intensive risk factor modification ca...

journal_title：Current hypertension reports

authors： Cooney MT,Cooney HC,Dudina A,Graham IM

更新日期：2010-10-01 00:00:00

abstract：:The renal pressure-natriuresis mechanism is the dominant controller of body fluid balance and long-term arterial pressure. In recent years, it has become clear that the balance of reactive oxygen and nitrogen species within the renal medullary region is a key determinant of the set point of the renal pressure-natriure...

journal_title：Current hypertension reports

authors： O'Connor PM,Cowley AW Jr

更新日期：2010-04-01 00:00:00

abstract：:This paper reviews findings on the relationship between blood pressure control and the progression of renal disease. Experimental studies demonstrate a correlation between systemic blood pressure and histologic glomerular injury and the delay in progression of renal disease with antihypertensive therapy, particularly ...

journal_title：Current hypertension reports

authors： Dworkin LD,Shemin DG

更新日期：1999-10-01 00:00:00

abstract：:Diabetes and hypertension are common coexistent conditions, the combination of which results in an increased risk for cardiovascular and renal disease. Clinical trials have convincingly demonstrated the benefit of tight blood pressure control among patients with diabetes in reducing these risks. Furthermore, the choic...

journal_title：Current hypertension reports

authors： Borzecki AM,Berlowitz DR

更新日期：2005-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes the latest science on hypertensive encephalopathy and posterior reversible encephalopathy syndrome (PRES). We review the epidemiology and pathophysiology of these overlapping syndromes and discuss best practices for diagnosis and management. RECENT FINDINGS:Diagnosis of hyperte...

journal_title：Current hypertension reports

authors： Miller JB,Suchdev K,Jayaprakash N,Hrabec D,Sood A,Sharma S,Levy PD

更新日期：2018-02-26 00:00:00

abstract：:The fact that cardiovascular risk factors cluster among individuals with the insulin resistance syndrome strongly suggests a common pathogenetic denominator. For many years, abnormalities of nonesterified fatty acid metabolism have been implicated in the disturbances of carbohydrate and lipid metabolism that character...

journal_title：Current hypertension reports

authors： Egan BM,Greene EL,Goodfriend TL

更新日期：2001-04-01 00:00:00

abstract：:To further understand chronic heart disease, such as heart failure and cardiomyopathy, we must fully define signaling pathways within the myocardium. Recent studies suggest that some forms of heart disease are associated with a chronic low-grade inflammation that promotes adverse ventricular remodeling and correlates ...

journal_title：Current hypertension reports

authors： Ahn J,Kim J

更新日期：2012-12-01 00:00:00

abstract：:Lipodystrophy (LD) associated with HIV infection is a syndrome of abnormal fat distribution observed in HIV-infected patients treated with various antiretroviral agents. In addition, insulin resistance and dyslipidemia can occur in HIV-infected patients with or without LD. The demonstration of the latter metabolic dis...

journal_title：Current hypertension reports

authors： Mikhail N

更新日期：2003-04-01 00:00:00

abstract：:With current immunosuppression, elevated blood pressure is found in almost 90% of renal graft recipients. Major causes of this are impairment of renal function (secondary to chronic allograft nephropathy or less frequently recurrence of primary renal disease), the use of calcineurin inhibitors as immunosuppressants, u...

journal_title：Current hypertension reports

authors： Schwenger V,Zeier M,Ritz E

更新日期：2001-10-01 00:00:00

abstract：:There is increasing concern that sugar consumption may be linked to the development of metabolic and cardiovascular diseases. There is indeed strong evidence that consumption of energy-dense sugary beverages and foods is associated with increased energy intake and body weight gain over time. It is further proposed tha...

journal_title：Current hypertension reports

authors： Rosset R,Surowska A,Tappy L

更新日期：2016-06-01 00:00:00

abstract：:High-quality medical care requires implementing evidence-based best practices, with continued monitoring to improve performance. Implementation science is beginning to identify approaches to developing, implementing, and evaluating quality improvement strategies across health care systems that lead to good outcomes fo...

journal_title：Current hypertension reports

authors： Goldstein MK

更新日期：2008-06-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) is a major proteolytic system that regulates the degradation of intracellular proteins in the heart. The UPS regulates the turnover of misfolded and damaged proteins, in addition to numerous cellular processes, by affecting the stability of short-lived proteins such as transcripti...

journal_title：Current hypertension reports

authors： Rodríguez JE,Schisler JC,Patterson C,Willis MS

更新日期：2009-12-01 00:00:00

abstract：:Hypertension (HTN) is the most common modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality worldwide. Lower- and middle-income countries (LMICs) are projected to bear the vast majority of this disease burden, but local and regional health care delivery systems in these countries are ill equi...

journal_title：Current hypertension reports

authors： Brody AM,Kumar VA,Levy PD

更新日期：2017-01-01 00:00:00

abstract：:We are used to thinking of angiotensin (Ang) II as a regulatory hormone that stimulates constriction of vascular smooth muscle cells, aldosterone release from the adrenal gland, and sodium reabsorption in the renal tubule. We have also become accustomed to understanding that Ang II may be formed and may act locally as...

journal_title：Current hypertension reports

authors： Luft FC

更新日期：2001-02-01 00:00:00

abstract：PURPOSE OF THE REVIEW:The purpose of this review is to highlight the clinical significance of increased renal risk that has its origins in fetal life. This review will also discuss the critical need to identify therapeutic interventions for use in a pregnancy complicated by placental dysfunction and intrauterine growth...

journal_title：Current hypertension reports

authors： Coats LE,Davis GK,Newsome AD,Ojeda NB,Alexander BT

更新日期：2019-06-21 00:00:00

abstract：:Recent studies have identified key gender differences in cardiovascular function, renal hemodynamics, and the renin-angiotensin system. Extensive epidemiologic evidence has shown a clear gender difference in cardiovascular and renal disease progression, whereby female sex appears to be protective. The mechanisms under...

journal_title：Current hypertension reports

authors： Kang AK,Miller JA

更新日期：2002-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Review the renal nerve anatomy and physiology basics and explore the concept of global vs. selective renal denervation (RDN) to uncover some of the fundamental limitations of non-targeted renal nerve ablation and the potential superiority of selective RDN. RECENT FINDINGS:Recent trials testing the ef...

journal_title：Current hypertension reports

authors： Fudim M,Sobotka AA,Yin YH,Wang JW,Levin H,Esler M,Wang J,Sobotka PA

更新日期：2018-05-01 00:00:00

abstract：:Angiotensin II is the most active hormone of the renin-angiotensin system. In humans, two angiotensin receptors have been identified: AT(1) and AT(2). In adults, most of the effects of angiotensin II are mediated by the AT(1) receptor; the function of the AT(2) receptor is not yet well established. Angiotensin II has ...

journal_title：Current hypertension reports

authors： Siragy HM,Bedigian M

更新日期：1999-08-01 00:00:00

abstract：:Essential hypertension is a very common health condition that is associated with an array of long-term end-organ diseases, including premature cardiovascular disease. Currently, there is no effective method to identify high-risk patients who may develop cardiovascular comorbidities in the future. Clinically, it would ...

journal_title：Current hypertension reports

authors： Xue Y,Iqbal N,Chan J,Maisel A

更新日期：2014-12-01 00:00:00

abstract：:Antiplatelet agents represent a cornerstone in the management of patients at increased cardiovascular risk. Essential hypertension is considered a major public health problem leading to increased cardiovascular morbidity and mortality. The majority of patients with essential hypertension exhibit also additional cardio...

journal_title：Current hypertension reports

authors： Gkaliagkousi E,Gavriilaki E,Douma S

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review sought to evaluate the role of exercise in patients with obesity and comorbid hypertension, with a focus on contemporary literature (since January 2015). RECENT FINDINGS:No reviews have included patients classified with both obesity and hypertension and there is a paucity of randomised co...

journal_title：Current hypertension reports

authors： Keating SE,Coombes JS,Stowasser M,Bailey TG

更新日期：2020-09-03 00:00:00

abstract：:Important new advances have occurred in our understanding and approach to management of high blood pressure in the elderly. New clinical trials have re-emphasized the risk of development of cardiovascular and cerebrovascular complications associated with isolated elevations in systolic blood pressure as well as the sa...

journal_title：Current hypertension reports

authors： Gennari FJ,Gennari AS

更新日期：2000-12-01 00:00:00

abstract：PURPOSE OF REVIEW:In chronic kidney disease (CKD), plasma uric acid levels are increased because of the decrease in glomerular filtration rate. However, in addition to CKD, hyperuricemia is frequently associated with a number of other conditions such as hypertension, type 2 diabetes, obesity, and heart failure, overwei...

journal_title：Current hypertension reports

authors： Kielstein JT,Pontremoli R,Burnier M

更新日期：2020-10-31 00:00:00

abstract：:Although it is clear that hypertension is a primary cause of stroke, there has been controversy concerning blood pressure management after stroke. Recent studies indicate that lowering systemic blood pressure after stroke reduces the risk for recurrent stroke or vascular events, but other studies provide evidence that...

journal_title：Current hypertension reports

authors： Hillis AE

更新日期：2005-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the latest reports of the contributions of the endothelial mineralocorticoid receptor to endothelial dysfunction and hypertension to begin to determine the clinical potential for this pathway for hypertension treatment. RECENT FINDINGS:Endothelial mineralocorticoid receptor expression is se...

journal_title：Current hypertension reports

authors： Faulkner JL,Belin de Chantemèle EJ

更新日期：2019-09-04 00:00:00

abstract：:The prevalence of the metabolic syndrome (MetS) has increased rapidly in North America in recent years. Presently, the MetS is found in 34.3% of the population, and the prevalence is likely to continue to increase in parallel with the obesity epidemic. Losing weight and long-term maintenance of the weight loss are pri...

journal_title：Current hypertension reports

authors： Ferland A,Eckel RH

更新日期：2011-12-01 00:00:00

abstract：:Levels of urinary albumin excretion that are below the usual limit of detection by qualitative testing, but are above normal levels (microalbuminuria; MA), can be readily identified by simple measures, such as the urinary albumin to creatinine ratio in untimed urine samples. Such measurements, particularly when combin...

journal_title：Current hypertension reports

authors： Glassock RJ

更新日期：2010-10-01 00:00:00